109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Antisense antiviral compounds and methods for treating a filovirus infection
#9302Riboregulator compositions and methods of use
#9303Compositions and methods for regulating arterial tone
#9304Triazine cationic polymers and methods of use thereof
#9305Modulation of CCR10 signals for treatment of skin and intestinal inflammatory diseases and infection
#9306Lipidosome preparation, preparation method and application thereof
#9307Methods and compositions for plant pest control
#9308RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#9309METHODS AND COMPOSITIONS FOR MODULATING ANGIOGENESIS
#9310Methods for treating apolipoprotein E4-associated disorders
#9311Methods for modulating C9ORF72 expression
#9312BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY
#9313Oligomeric compounds comprising bicyclic nucleosides and uses thereof
#9314Double-stranded oligonucleotide molecules to DDIT4 and methods of use thereof
#9315MicroRNAs and Methods of Using Same
#9316Lipids and compositions for the delivery of therapeutics
#9317Method for diagnosing a molecular phenotype of a patient suffering from an illness accompanied by chronic inflammation
#9318GALL WASP CONTROL AGENTS
#9319Transgenic Plants With RNA Interference-Mediated Resistance Against Root-Knot Nematodes
#9320NICKED OR GAPPED NUCLEIC ACID MOLECULES AND USES THEREOF
#9321Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2
#9322Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#9323AGENT FOR TREATING RENAL FIBROSIS
#9324Gene silencing methods
#9325Oligomeric compounds comprising tricyclic nucleosides and methods for their use
#9326Nucleic acid functionalized nonoparticles for therapeutic applications
#9327Compositions for modulating C9ORF72 expression
#9328Hydroxylated polyamine derivatives as transfection reagents
#9329SiRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
#9330Double-stranded nucleic acid compounds
#9331Short interfering ribonucleic acid (siRNA) for oral administration
#9332Antibodies and processes for preparing the same
#9333MIR-21 PROMOTER DRIVEN TARGETED CANCER THERAPY
#9334Nanotubes as carriers of nucleic acids into cells
#9335MODULATION OF PODOPLANIN MEDIATED PLATELET ACTIVATION
#9336Nanocarriers and their processing for diagnostics and therapeutics
#9337Use of miR-221 and 222 lowering agents to prevent cardiovascular disease in diabetic subjects
#9338Targets in multiple myeloma and other disorders
#9339Modulation of transthyretin expression
#9340Identification and use of target genes for control of plant parasitic nematodes
#9341METHOD FOR SCREENING MICRORNAS WITH GENE SILENCING FUNCTION AT BOTH LEVELS OF TRANSCRIPTION AND POST-TRANSCRIPTION
#9342Compositions and methods for modulating SMN gene family expression
#9343CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
#9344RNA trans-splicing molecule (RTM) for use in the treatment of cancer
#9345Use of isocitrate dehydrogenase 1 as a diagnostic and prognostic biomarker and therapeutic target for lung cancers
#9346Method for the treatment of cardiovascular fibrosis
#9347Root specific expression conferred by chimeric gene regulatory elements
#9348Piggy back delivery of nucleic acids into organisms
#9349METHODS FOR MODULATING RNA USING 3' TARGETING OLIGONUCLEOTIDES
#9350METHODS FOR MODULATING RNA USING PSEUDOCIRCULARIZATION OLIGONUCLEOTIDES
#9351Complement component C5 iRNA compositions and methods of use thereof
#9352ANTISENSE COMPOUNDS HAVING ENHANCED ANTI-MICRORNA ACTIVITY
#9353MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
#9354Biotin complexes for treatment and diagnosis of alzheimer's disease
#9355Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
#9356LYVE-1 ANTAGONISTS FOR PREVENTING OR TREATING A PATHOLOGICAL CONDITION ASSOCIATED WITH LYMPHANGIOGENESIS
#9357Sorafenib-microRNA combination therapy for liver cancer
#9358RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
#9359Compositions and methods for controlling
#9360MSF REPROGRAMS MYOFIBROBLASTS TOWARD LACTATE PRODUCTION AND FUEL ANAERBOIC TUMOR GROWTH
#9361THERAPEUTIC RNA SWITCHES COMPOSITIONS AND METHODS OF USE
#9362Recombinant RNA particles and methods of use
#9363Methods for producing a population of pancreatic beta-cells
#9364Methods and compositions for the specific inhibition of MYC by double-stranded RNA
#9365Use of regulatory T cell-specific surface protein LRIG-1
#9366Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
#9367POLYMERIC CARRIER
#9368Pharmaceutical composition comprising MicroRNA-30B, MicroRNA-133A, or MicroRNA-202-5P inhibitor for inhibiting cancer
#9369Polynucleotides having bioreversible groups
#9370ORGANIC COMPOSITIONS TO TREAT KRAS-RELATED DISEASES
#9371Nucleic acid Construct
#9372Plant regulatory elements and uses thereof
#9373Oligonucleotide—containing pharmacological compositions and their use
#9374Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
#9375UNA oligomers targeting micro-RNA for therapeutics
#9376Treatment of insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to IRS2 and transcription factor E3 (TFE3)
#9377UNA duplex oligomers for therapeutics
#9378Methods targeting miR-128 for regulating cholesterol/lipid metabolism
#9379TARGETING OLIGONUCLEOTIDES AND RELATED METHODS FOR MODULATING FXN RNA
#9380PSEUDOCIRCULARIZATION OLIGONUCLEOTIDES FOR MODULATING RNA
#93815' TARGETING OLIGONUCLEOTIDES FOR MODULATING RNA
#9382METHODS FOR MODULATING RNA USING 5' TARGETING OLIGONUCLEOTIDES
#9383Compositions and methods for treatment of prostate and other cancers
#9384Treatment of fibrotic conditions
#9385Methods for use in modulating miR-122A
#9386Methods and compositions for treating neurological disease
#9387Splice-region antisense composition and method
#9388EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS
#9389MIRNA MODULATORS OF CHRONIC VISCERAL INFLAMMATION
#9390COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION
#9391POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
#9392Transgenic plant of the species solanum tuberosum with resistance to phytophthora
#9393Drought-tolerance in plants
#9394Strong constitutive promoters for heterologous expression of proteins in plants
#9395Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
#9396Treatment of adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an adiponectin (ADIPOQ)
#9397Gene nanocomposite, and cellular internalization method of gene using same
#9398METHODS FOR SELECTIVE TARGETING OF HETEROCHROMATIN FORMING NON-CODING RNA
#9399Methods and compositions using miR-3151 in the diagnosis and treatment of cancer
#9400RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
#9401PHARMACEUTICAL COMPOSITION FOR TREATING LIVER DISEASES
#9402Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
#9403Selective reactivation of genes on the inactive X chromosome
#9404MiRNA for treating head and neck cancer
#9405Adeno-associated virus virions with variant capsid and methods of use thereof
#9406Pharmaceutical composition and uses thereof
#9407TREATMENT OF NEUROLOGICAL DISORDERS
#9408Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
#9409WOUND TREATMENT
#9410COMPOSITIONS FOR MODULATING GENE EXPRESSION
#9411MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#9412MicroRNA compounds and methods for modulating miR-21 activity
#9413RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3′-end
#9414Compositions and methods for treating peripheral arterial disease
#9415Synthetic promoter for modulating gene expression
#9416Artificial nucleic acid molecules for improved protein or peptide expression
#9417RNAI BASED SELECTION SYSTEM
#9418GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HEAMOPHILUS INFLUENZAE
#9419Compositions for the delivery of RNA and drugs into cells
#9420Exosome-based therapeutics against neurodegenerative disorders
#9421CELL-SPECIFIC DELIVERY OF MIRNA MODULATORS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS
#9422Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers
#9423Lipid assemblies comprising anionic lysolipids and use thereof
#9424Diagnosis and treatment of brain tumor
#9425MIR-18B for use as a marker of cancer progression and target for therapies to treat cancer
#9426COMPOSITIONS AND METHODS FOR ANALYZING HETEROGENEOUS SAMPLES
#9427Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#9428Restoration of the CFTR function by splicing modulation
#9429MicroRNA-198 as a tumor suppressor in ovarian cancer
#9430Post-synthetic chemical modification of RNA at the 2′-position of the ribose ring via “click” chemistry
#9431Selective inhibition of polyglutamine protein expression
#9432Chiral control
#9433MIRNA MODULATORS OF THERMOGENESIS
#9434RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES
#9435COMPLEMENT ANTAGONISTS AND USES THEREOF
#9436EXON REPLACEMENT WITH STABILIZED ARTIFICIAL RNAS
#9437Anandamide-modified nucleic acid molecules
#9438CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
#9439Method for inducing immune tolerance using non-proliferative polymer-modified allogeneic leukocytes
#9440MicroRNA-based approach to treating malignant pleural mesothelioma
#9441Use of monosaccharide-like glycylated sugar alcohol compositions for designing and developing anti-diabetic drugs
#9442Combination Therapy III
#9443PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS
#9444Compositions and methods for controlling
#9445Oligonucleotide comprising an inosine for treating DMD
#9446CTLA-4 aptamer siRNA species
#9447CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION
#9448Treatment of Myelodysplastic Syndrome by Inhibition of NR2F6
#9449Double-stranded oligonucleotide molecules to P53 and methods of use thereof
#9450Exosomes and micro-ribonucleic acids for tissue regeneration
#9451Tetragalnac containing conjugates and methods for delivery of oligonucleotides
#9452IMMUNE SYSTEM MEDIATOR
#9453Treatment of spinal cord injury or traumatic brain injury by inhibition of synuclein protein aggregation
#9454DOWNREGULATION OF miR-218 MAY BE USED AS A BIOMARKER FOR HUMAN ALS
#9455Gamma-PNA miniprobes for fluorescent labeling
#9456EpCAM aptamer for detection of cancer stem cells
#9457Multi-conjugate of siRNA and preparing method thereof
#9458RNAI EXPRESSION CONSTRUCTS
#9459Treatment of ‘IQ motif containing gtpase activating protein’ (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
#9460Structurally designed shRNAs
#9461Oral delivery of nucleic acid-based gene interfering agents by
#9462Agent for treating cancer
#9463Modified RNAi agents
#9464Carbohydrate conjugated RNA agents and process for their preparation
#9465Nucleic acid complexes
#9466Methods and compositions for treating prostate cancer
#9467Acellular pro-tolerogenic compositions for treatment/prevention of graft rejection
#9468Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same
#9469Composition comprising material for inhibiting SCF or receptor thereof for treating or preventing diseases associated with vascular permeability
#9470Recombinant DNA for gene suppression
#9471BICYCLIC CYCLOHEXOSE NUCLEIC ACID ANALOGS
#9472Ligand-conjugated monomers
#9473Oligonucleotide for the Treatment of Muscular Dystrophy Patients
#9474U1 snRNP regulates gene expression and modulates oncogenicity
#9475Modulation of UBE3A-ATS expression
#9476COMPOSITIONS AND METHODS FOR MODULATING APOA1 AND ABCA1 EXPRESSION
#9477Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
#9478Lipid compositions
#9479INHIBITORS OF NKX2.5 FOR VASCULAR REMODELLING
#9480Simultaneous detection of cannibalism and senescence as prognostic marker for cancer
#9481Recombinant DNA constructs and methods for controlling gene expression
#9482Bacteria mediated gene silencing
#9483Immunosuppression compound and treatment method
#9484MODULATION OF APOLIPOPROTEIN (a) EXPRESSION
#9485METHODS FOR PREVENTING AND TREATING CHRONIC KIDNEY DISEASE (CKD)
#9486NEW TREATMENT FOR NEURODEGENERATIVE DISEASES
#9487Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#9488Oligonucleotide inhibitor of DNA polymerases
#9489Ras opposite (ROP) and related nucleic acid molecules that confer resistance to coleopteran and/or hemipteran pests
#9490TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES AND USE OF SAME
#9491Methods of identifying and treating glioblastoma
#9492Methods of inducing insulin production
#9493Compositions and methods for modulating HBV expression
#9494Nucleic acids for down-regulation of gene expression
#9495Modulation of enhancer RNA mediated gene expression
#9496Highly efficient method for establishing induced pluripotent stem cell
#9497Cationic lipid
#9498MODIFICATION OF THE IMMUNOMODULATORY EFFECTS OF CELLS
#9499Acellular pro-tolerogenic compositions and process for making same
#9500Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy
#9501Plant regulatory elements and uses thereof
#9502Repressor on IFN-λ promoter and siRNA against GATA1, EVI1, and CRX to alter IFN-λ gene activity
#9503Methods and means for efficient skipping of at least one of the exons 51-53, 55, 57 and 59 of the human duchenne muscular dystrophy gene
#9504Antisense nucleic acids
#9505Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
#9506Plant microRNAs and methods of use thereof
#9507Compositions and methods for inhibition of nucleic acids function
#9508METHODS FOR TREATING MDS1-EVI1 MEDIATED CANCER
#9509Therapeutic oligonucleotides comprising pyrazolotriazine nucleotide analogues
#9510Particle-nucleic acid conjugates and therapeutic uses related thereto
#9511METHODS AND COMPOSITIONS FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-1alpha (PGC1alpha) AS A TARGET OF CIRCULATING TUMOR CELLS
#9512Soluble TNF Receptors and Their Use in Treatment of Disease
#9513Lipid formulations
#9514Low density lipoprotein receptor-mediated siRNA delivery
#9515Stable non-aggregating nucleic acid lipid particle formulations
#9516Wnt signaling inhibitor comprising insulin-like growth factor-binding protein
#9517Acellular pro-tolerogenic compositions for the treatment/prevention of auto-immune diseases
#9518Methods and compositions for the inhibition of gene expression
#9519Lipid formulations for nucleic acid delivery
#9520METHODS AND COMPOSITIONS RELATED TO THE SMCHD1 GENE
#9521Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
#9522miR-520 microRNAs sensitize cancers to platinum-based therapy
#9523MicroRNAs
#9524Compositions and methods for controlling arthropod parasite and pest infestations
#9525Modulation of huntingtin expression
#9526Oligonucleotide compounds comprising non-nucleotide overhangs
#9527Treatments of oxidative stress conditions
#9528Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery
#9529Generation of human induced pluripotent stem cells using nucleic acid sequences that inhibit Δ-NP63 and DGCR8
#9530Skin lightening composition
#9531Method for expression of small RNA molecules within a cell
#9532Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4
#9533Treatment of Methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
#9534Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
#9535MIRNAS AS THERAPEUTIC TARGETS IN CANCER
#9536Compounds and methods for altering RSV replication rate
#9537Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3
#9538Methods of treating vascular inflammatory disorders
#9539Treatment of filaggrin (FLG) related diseases by modulation of FLG expression and activity
#9540NUCLEIC ACID MOLECULES AND COLLECTIONS THEREOF, THEIR APPLICATION AND MODIFICATION
#9541MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#9542Chemical modification of short small hairpin RNAs for inhibition of gene expression
#9543Composition and Method for In Vivo and In Vitro Attenuation of Gene Expression Using Double Stranded RNA
#9544siRNA compounds comprising terminal substitutions
#9545METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION
#9546COMPOSITIONS AND METHODS FOR MODULATING MECP2 EXPRESSION
#9547THERAPIES FOR CANCER USING RLIP76
#9548Modulation of TLR4-signaling pathway
#9549Inhibitors of thioredoxin-interacting protein (TXNIP) for therapy
#9550METHODS AND PRODUCTS RELATED TO LUNG CANCER
#9551AEROSOL DELIVERY SYSTEMS, COMPOSITIONS AND METHODS
#9552NUCLEIC ACID COMPLEX AND NUCLEIC ACID-POLYSACCHARIDE COMPLEX
#9553Expression Construct for a Lin28-Resistant Let-7 Precursor MicroRNA
#9554RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
#9555Compositions and methods for controlling leptinotarsa
#9556OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOSIDES AND HAVING REDUCED TOXICITY
#9557DIFFERENTIAL EXPRESSION OF MICRORNAS IN NONFAILING VERSUS FAILING HUMAN HEARTS
#9558RNA interference mediating small RNA molecules
#9559Therapeutic targets for Alzheimer's disease
#9560Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them
#9561Small molecule inhibitors of RNA binding motif (RBM) proteins for the treatment of acute cellular injury
#9562Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
#9563Composition comprising miRNA for enhancing radiation sensitivity
#9564PROGNOSIS AND TREATMENT OF LUNG CANCER USING miRNA-135b
#9565Sustained release siRNA for ocular drug delivery
#9566Compound and method for treating myotonic dystrophy
#9567COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION
#9568CELL ENGINEERING USING RNAs
#9569Lipidated glycosaminoglycan particles for the delivery of nucleic acids
#9570Therapeutic micro RNA targets in chronic pulmonary diseases
#9571Molecular Determinants of Myeloma Bone Disease and Uses Thereof
#9572COMPOSITIONS AND METHODS FOR THE TREATMENT OF RADIATION EXPOSURE
#9573TREATMENT OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
#9574Compositions and methods for the control of root lesion nematode
#9575Compositions for controlling mites in bees
#9576Compositions and methods for modulating hemoglobin gene family expression
#9577Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
#9578METHOD FOR DOWN-REGULATING GENE EXPRESSION IN FUNGI
#9579Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto
#9580Inhibitors of microRNAs that regulate production of atrial natriuretic peptide (ANP) as therapeutics and uses thereof
#9581Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
#9582COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION
#9583High complexity siRNA pools
#9584Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
#9585Composition and methods for reduced scarring and treatment of fibrosis
#9586Nuclease-mediated regulation of gene expression
#9587TREATMENT OF CANCER
#9588Transgenic plant-based methods for plant pests using RNAI
#9589Ubiquitin regulatory elements
#9590Compositions and methods for modulating apolipoprotein (a) expression
#9591Compositions and methods for modulating apolipoprotein C-III expression
#9592Conjugated antisense compounds and their use
#9593Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63
#9594Combination therapy for treating hearing and balance disorders
#9595Materials and methods related to MicroRNA-21, mismatch repair, and colorectal cancer
#9596Reducing galectin-12 activity to influence the cell function of human sebocytes
#9597Micro-RNA inhibitors and their uses in disease
#9598Modified small activating RNA molecules and methods of use
#9599Modulation of sphingosine 1-phosphate metabolizing enzymes for the treatment of negative-strand RNA virus infections
#9600AMPK activator screening method, and AMPK activator