109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Combined hairpin-antisense compositions and methods for modulating expression
#9902Methods of incorporating amino acid analogs into proteins
#9903Methods of inhibiting Alu RNA and therapeutic uses thereof
#9904Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
#9905Systems and methods for diminishing cell growth and inducing selective killing of target cells
#9906ISOLATED MCPIP AND METHODS OF USE
#9907METHODS AND COMPOSITIONS TO MODULATE ANTIVIRAL AND IMMUNE ACTIVITY RESPONSES
#9908Nanoparticles and Uses Thereof
#9909siRNA molecule for inhibiting growth of melanin and application thereof
#9910Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#9911Lipid Formulated Compositions and Methods for Inhibiting Expression of Eg5 and VEGF Genes
#9912Micro-RNA scaffolds and non-naturally occurring micro-RNAs
#9913Compositions and methods for prognosis and treatment of prostate cancer
#9914Method of treating hyperlipidemia and atherosclerosis with miR-30C
#9915Compositions and methods for modulating myeloid derived suppressor cells
#9916Antisense oligonucleotides for the treatment of Leber congenital amaurosis
#9917Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#9918TARGETING EN2, PAX2, AND/OR DEFB1 FOR TREATMENT OF PROSTATE CONDITIONS
#9919Anti-microRNA oligonucleotide molecules
#9920Nucleic acid assembly, vector, cell, methods and kit thereof
#9921Compositions and methods for modulating an immune response
#9922Inducible cell-based model for the study of Friedreich's Ataxia
#9923DELIVERY OF RNA INTERFERING AGENTS
#9924Liposomes and its production method
#9925METHODS AND FORMULATIONS TO ACHIEVE TUMOR TARGETED DOUBLE STRANDED RNA MEDIATED CELL DEATH
#9926Methods and pharmaceutical compositions for treating cancer
#9927Use Of Complement Inhibitors To Treat Ocular Diseases
#9928Drug delivery product and methods
#9929GENE SILENCING
#9930Culicinae mosquito Tra-2 RNA interference technique to genetically produce maleness population
#9931OLIGONUCLEOTIDE
#9932MicroRNA compounds and methods for modulating miR-21 activity
#9933Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides
#9934Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#9935EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#9936Exonuclease resistant polynucleotide and related duplex polynucleotides, constructs, compositions, methods and systems
#9937Oligonucleotide modulators of the toll-like receptor pathway
#9938Induced exon inclusion in spinal muscle atrophy
#9939COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#9940Development of novel macromolecule transduction domain with improved cell permeability and method for using same
#9941USE OF CTBP1 siRNA FOR THE TREATMENT OF GASTRIC CANCER
#9942NUCLEIC ACID PARTICLES, METHODS AND USE THEREOF
#9943Means for inhibiting the expression of ANG2
#9944METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING AIRWAY HYPERRESPONSE
#9945MITIGATION OF DISEASE BY INHIBITION OF GALECTIN-12
#9946OLIGONUCLEOTIDE AND THERAPEUTIC AGENT FOR HYPERLIPIDEMIA CONTAINING SAME AS ACTIVE INGREDIENT
#9947Selective antisense compounds and uses thereof
#9948COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION AND USES THEREOF
#9949tRNA derived small RNAs (tsRNAs) involved in cell viability
#9950Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
#9951Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
#9952TARGETING MICRORNAS MIR-409-5P, MIR-379 AND MIR-154* TO TREAT PROSTATE CANCER BONE METASTASIS AND DRUG RESISTANT LUNG CANCER
#9953INTESTINAL FIBROSIS TREATMENT AGENT
#9954Exon skipping compositions for treating muscular dystrophy
#9955Treatment of Prostate Cancer with eIF4E Antisense Compounds
#9956Targeting domain and related signal activated molecular delivery
#9957Method for De-Differentiating A Cell
#9958Methods of novel therapeutic candidate identification through gene expression analysis in vascular related diseases
#9959Methods and compositions for enhancing the efficacy and specificity of RNA silencing
#9960Alpha-aminoamidine polymers and uses thereof
#9961Methods of regulating angiogenesis by administering agents which increase apoB-100 polypeptide
#9962Expanding hematopoietic stem cells
#9963Methods of using ZSCAN4 for rejuvenating human cells
#9964Recombinant virus products and methods for inhibition of expression of DUX4
#9965RNA MOLECULES AND USES THEREOF
#9966Modified iRNA agents
#9967ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors
#9968Methods and compounds useful in conditions related to repeat expansion
#9969Methods and compositions for the specific inhibition of met by double stranded RNA
#9970Double-stranded nucleic acid molecule for gene expression control
#9971Tetrahydropyran nucleic acid analogs
#9972Compositions and methods for treatment of prostate and other cancers
#9973EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#9974Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
#9975RNA interference in skin indications
#9976Compositions for treating muscular dystrophy
#9977RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
#9978Methods and products for treating preeclampsia and modulating blood pressure
#9979Genome-wide Antisense Oligonucleotide and RNAi
#9980METHODS AND COMPOSITIONS FOR RNAi-BASED CANCER TREATMENT
#9981Nanoparticulate systems prepared from sorbitan esters
#9982Functionalized nanodiamonds as delivery platforms for nucleic acids
#9983Methods and compositions involving miRNA and miRNA inhibitor molecules
#9984Recombinant polypeptides for membrane fusion and uses thereof
#9985Stabilized STAT3 decoy oligonucleotides and uses therefore
#9986METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES
#9987Covalently functionalized nanodiamond-based MALDI matrices and methods of use thereof
#9988Modified parvovirus useful for gene silencing
#9989Therapeutic compositions
#9990Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9991Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9992Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#9993Compositions and methods for modulation of LMNA expression
#9994Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
#9995LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
#9996Methods and compositions for regulation of cell aging, carcinogenesis and reprogramming
#9997Targeted self-assembly of functionalized carbon nanotubes on tumors
#9998Reduction of off-target RNA interference toxicity
#9999Oligonucleotides for treating expanded repeat diseases
#10000Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP)
#10001Control of whole body energy homeostasis by microRNA regulation
#10002LINKAGE MODIFIED GAPPED OLIGOMERIC COMPOUNDS AND USES THEREOF
#10003METHODS FOR THE MODULATION OF ANGIOGENESIS
#10004Pharmaceutical composition comprising NANOG SHRNA, and method of using NANOG SHRNA to treat cancer
#10005Delaying the progression of diabetes
#10006Antisense antiviral compound and method for treating influenza viral infection
#10007Chimeric double-stranded nucleic acid
#10008Process for purifying VLPs
#10009Pharmaceutical composition for treating cancer using carbonate apatite nanoparticles
#10010MICROVESICLES CARRYING SMALL INTERFERING RNAS PREPARATION METHODS AND USES THEREOF
#10011Inhibitors of metastasis
#10012MCPIP protection against osteoclast production
#10013Complement antagonists and uses thereof
#10014Nucleic acid agents for overexpressing or downregulating RNA interference targets and uses of same in improving nitrogen use efficiency, abiotic stress tolerance, biomass, vigor or yield of a plant
#10015ISOLATED POLYNUCLEOTIDES EXPRESSING OR MODULATING dsRNAs, TRANSGENIC PLANTS COMPRISING SAME AND USES THEREOF IN IMPROVING NITROGEN USE EFFICIENCY, ABIOTIC STRESS TOLERANCE, BIOMASS, VIGOR OR YIELD OF A PLANT
#10016Nucleic acid molecules that confer resistance to coleopteran pests
#10017VEGETABILE MATERIAL, PLANTS AND A METHOD OF PRODUCING A PLANT HAVING ALTERED LIGNIN PROPERTIES
#10018PHENOCOPY MODEL OF DISEASE
#10019Isolated dsRNA molecules and methods of using same for silencing target molecules of interest
#10020Antisense design
#10021Tricyclo-phosphorothioate DNA
#10022CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
#10023Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
#10024Use Of siRNA To Achieve Down Regulation Of An Endogenous Gene In Combination With The Use of A Sense Construct To Achieve Expression Of A Polynucleotide
#10025Composition for promoting apoptosis or inhibiting cell growth, comprising epstein-barr virus microrna
#10026SUPPRESSION OF TLA2-CpFTSY GENE EXPRESSION FOR IMPROVED SOLAR ENERGY CONVERSION EFFICIENCY AND PHOTOSYNTHETIC PRODUCTIVITY IN ALGAE
#10027Methods for multiplexing recombinase polymerase amplification
#10028Methods of using microRNA 195 in providing neuroprotection
#10029Compositions and methods for inhibiting expression of the HAMP gene
#10030Cationic lipids for therapeutic agent delivery formulations
#10031Compositions for delivery of cargo such as drugs proteins and/or genetic materials
#10032Synthetic nanostructures including nucleic acids and/or other entities
#10033Potent LNA oligonucleotides for the inhibition of HIF-1a expression
#10034Immune tolerance inducer
#10035METHODS OF MODULATING THE NEGATIVE CHEMOTAXIS OF IMMUNE CELLS
#10036Targets for regulation of angiogenesis
#10037EXPRESSION OF MIRNAS IN PLACENTAL TISSUE
#10038Dosage compensating transgenes and cells
#10039Methods and compositions for the specific inhibition of beta-catenin by double stranded RNA
#10040Compounds and methods for modulating protein expression
#10041ANTISENSE DESIGN
#10042Modified RNAi agents
#10043METHODS FOR THE TREATMENT AND DIAGNOSIS OF ATHEROSCLEROSIS
#10044Exon skipping therapy for dystrophic epidermolysis bullosa
#10045Lipid Formulated Compositions and Methods for Inhibiting Expression of Eg5 And VEGF Genes
#10046Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
#10047Treatment of ‘C terminus of HSP7O-interacting protein’ (CHIP) related diseases by inhibition of natural antisense transcript to CHIP
#10048Preventive or therapeutic agent for fibrosis
#10049Dendronized polymers for nucleic acid delivery
#10050MIR-142 AND ANTAGONISTS THEREOF FOR TREATING DISEASE
#10051RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
#10052METHODS OF MANIPULATING THE FATE OF CELLS
#10053Methods and compositions for the treatment of cancer or other diseases
#10054SUPER-ENHANCERS AND METHODS OF USE THEREOF
#10055RNA interference suppression of neurodegenerative diseases and methods of use thereof
#10056Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
#10057Methods of treating allergic inflammatory conditions by administering an anti-cadherin-like 26-based therapeutic
#10058TRANS-SPLICING RIBOZYMES AND SILENT RECOMBINASES
#10059TARGETING OF MIRNA PRECURSORS
#10060miRNA-212/132 family as a therapeutic target
#10061Uses of the human ZFX gene and drugs associated with same
#10062Compositions and methods for treating cancer
#10063Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function
#10064Anti-clusterin monotherapy for cancer treatment
#10065Custirsen treatment with reduced toxicity
#10066Methods and Compositions for Plant Pest Control
#10067Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#10068Compositions and methods to control insect pests
#10069Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
#10070TRANSCRIPTION FACTOR DECOYS FOR THE TREATMENT AND PREVENTION OF INFECTIONS CAUSED BY BACTERIA INCLUDING CLOSTRIDIUM DIFFICILE
#10071Epigenetic biomarker ZNF545 for diagnosing and prognosis of gastric cancer
#10072Synthetic lariat RNA for RNA interference
#10073Methods of treating colorectal cancer
#10074Targeting CLPTM1L by RNA interference for treatment and prevention of cancer
#10075Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
#10076COMBINATORIAL COMPOSITIONS AND METHODS OF TREATING HEMOGLOBINOPATHIES
#10077Semaphorin 7a Induced Lung Fibrogenesis Occurs in a CD-4-Dependent, Macrophage Dependent Manner
#10078Modulation of transthyretin expression
#10079Compounds for the treatment of ischemic injury
#10080Compositions and Methods for Inhibiting Expression of XBP-1 Gene
#10081Composition and methods for modulating cell proliferation and cell death
#10082COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF Nav 1.8
#10083MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of ovarian cancer using a real-time PCR platform
#10084Methods and compositions for the treatment of huntington's disease
#10085Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features
#10086Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
#10087Genetic element that enhances protein translation
#10088BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS
#10089PREPARATION COMPRISING HEXOSE-6-PHOSPHATE-MODIFIED CHOLESTEROL DERIVATIVE
#10090Compositions and methods to control insect pests
#10091LONG INTERFERING DSRNA SIMULTANEOUSLY INDUCING AN IMMUNE REACTION AND THE INHIBITION OF THE EXPRESSION OF TARGET GENES
#10092METHODS FOR DETECTING A POLYMORPHISM IN THE NFKB1 GENE PROMOTER
#10093Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#10094Methods for the treatment and prevention of liver disease
#10095Oligonucleotides for modulation of target RNA activity
#10096Activation of quiescent stem cells
#10097IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA
#10098WNT4 AND MED12 FOR USE IN THE DIAGNOSIS AND TREATMENT OF TUMOR DISEASES
#10099Antibody against mutant α-actinin-4
#10100Transcription factors that regulate nicotine biosynthesis in tobacco
#10101ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10102ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10103Methods of diagnosing and treating motor neuron diseases
#10104MicroRNA-based methods and assays for osteosarcoma
#10105PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF
#10106Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#10107ANTISENSE OLIGONUCLEOTIDES THAT TARGET A CRYPTIC SPLICE SITE IN USH1C AS A THERAPEUTIC FOR USHER SYNDROME
#10108Compounds and methods for the treatment of muscular disease, and related screening methods
#10109Construction of bifunctional short hairpin RNA
#10110Clusterin antisense therapy for treatment of cancer
#10111METHODS AND COMPOSITIONS FOR MODULATING THE INNATE IMMUNE RESPONSE AND/OR MYOGENESIS IN A MAMMALIAN SUBJECT
#10112KRT19 stabilizing HER2 and use thereof
#10113Gene therapy vectors and cytosine deaminases
#10114Therapeutic nanoparticles and methods of use thereof
#10115Methods and compositions for enhancing the therapeutic effect of anti-tumor T cells
#10116SPL16 compositions and methods to increase agronomic performance of plants
#10117Micrornas in neurodegenerative disorders
#10118INHIBITION OF MICRORNA-134 FOR THE TREATMENT OF SEIZURE-RELATED DISORDERS AND NEUROLOGIC INJURIES
#10119Modulation of HSP47 expression
#10120SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
#10121Method of identifying abnormal cells by expression levels of ETFB
#10122Method to trigger RNA interference
#10123Methods of introducing dsRNA to plant seeds for modulating gene expression
#10124Ribozyme for identifying modification on RNA sequence and RNA cleavage method using same
#10125Albumin production and cell proliferation
#10126BIOMARKERS AND THERAPY FOR CANCER
#10127Methods for modulating factor 12 expression
#10128MicroRNA and methods for inhibiting same
#10129Pharmaceutical anti-angiogenic composition including a MicroRNA-382 inhibitor
#10130Pharmaceutical angiogenic composition including a microRNA-382 activator
#10131Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene
#10132MicroRNA inhibitors
#10133Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
#10134METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#10135Targeting p63 to re-activate dormant reserve stem cells in olfactory epithelium
#10136Extended Dicer Substrate Agents and Methods for the Specific Inhibition of Gene Expression
#10137Method and medicament for inhibiting the expression of a given gene
#10138Methods for treating Niemann-Pick type C disease
#10139Method and medicament for inhibiting the expression of a given gene
#10140MicroRNA inhibition for the treatment of inflammation and myeloproliferative disorders
#10141Compositions of a peptide targeting system for treating cancer
#10142Gene signature for predicting prognosis of patients with solid tumors
#10143ApoIII and the treatment and diagnosis of diabetes
#10144LRP1 as key receptor for the transfer of sterified cholesterol from very-low-density lipoproteins (VLDL) to ischaemic cardiac muscle
#10145METHODS FOR INDUCING CARDIOMYOCYTE PROLIFERATION
#10146Antibacterial antisense oligonucleotide and method
#10147Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#10148METHOD FOR PROLIFERATION CARDIOMYOCYTES USING MICRO-RNA
#10149METHOD FOR PROLIFERATION CARDIOMYOCYTES USING MICRO-RNA
#10150Methods for modulating kallikrein (KLKB1) expression
#10151Nuclear targeting sequences
#10152METHODS AND COMPOSITIONS FOR TREATING ATRIAL FIBRILLATION
#10153Downregulation of miR-7 for promotion of beta cell differentiation and insulin production
#10154Targeting microRNAs for the treatment of liver cancer
#10155Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
#10156MODULATION OF APOLIPOPROTEIN (a) EXPRESSION
#10157Compositions and methods for inhibiting expression of factor V
#10158Methods for modulating kallikrein (KLKB1) expression
#10159Rotationally sequestered translators
#10160Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles
#10161METHODS AND COMPOSITIONS FOR MONITORING AND ENHANCING EARLY EMBRYO DEVELOPMENT
#10162RNAi-MEDIATED INHIBITION OF SELECT RECEPTOR TYROSINE KINASES FOR TREATMENT OF PATHOLOGIC OCULAR NEOVASCULARIZATION-RELATED CONDITIONS
#10163Methods and Means for Treatment of Osteoarthritis
#10164NOVEL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
#10165METHODS AND COMPOSITIONS FOR REGULATING IRON HOMEOSTASIS BY MODULATION OF BMP-6
#10166Methods and Means for Monitoring and Modulating Gene Silencing
#10167Immunosuppression compound and treatment method
#10168Compositions and methods for inhibiting expression of transthyretin
#10169MODULATION OF MICRORNA-138 FOR THE TREATMENT OF BONE LOSS
#10170Sequence-specific inhibition of small RNA function
#10171Interfering RNA delivery system and uses thereof
#10172Control of gene expression
#10173Modulation of angiopoietin-like 3 expression
#10174Exonic splicing enhancers and exonic splicing silencers
#10175Methods and compositions for treating and diagnosing diseases
#10176Methods used in sensitizing invasive glioblastoma to therapeutic treatment
#10177Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis
#10178Optical Sorting Method
#10179THERAPEUTIC POLYNUCLEOTIDES, COMPOSITIONS, AND METHODS
#10180METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs
#10181Mitochondrial ribosomal proteins as aging regulators
#10182Connective tissue growth factor antisense oligonucleotides
#10183Mutator Activity Induced by microRNA-155 (miR-155) Links Inflammation and Cancer
#10184Inhibitor of neuronal connectivity linked to schizophrenia susceptibility and cognitive dysfunction
#10185Methods of modulating compliance of the trabecular meshwork
#10186Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
#10187MICRORNA INHIBITORS COMPRISING LOCKED NUCLEOTIDES
#10188Cochleate compositions directed against expression of proteins
#10189Targeted pre-mRNA/mRNA modification and gene regulation
#10190Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
#10191Methods for the treatment of Leber congenital amaurosis
#10192Phase changing formulations of nucleic acid payloads
#10193DUAL TARGETING OF MIR-208 AND MIR-499 IN THE TREATMENT OF CARDIAC DISORDERS
#10194Reduction of ALMS1 gene expression or inhibition of altröm protein to induce cardiomyocyte proliferation
#10195In vivo production of small interfering RNAs that mediate gene silencing
#10196Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene
#10197pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles
#10198Modified siRNA molecules and uses thereof
#10199Alternative export pathways for vector expressed RNA interference
#10200Terminator sequence-containing reverse primer for overexpression and linear DNA