109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
METHODS AND COMPOSITIONS FOR TREATING DISEASES TARGETING MABA
#10202Theranostic imaging agents and methods of use
#10203Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
#10204Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction
#10205RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of cAMP-related ocular disorders
#10206Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
#10207TISSUE-SPECIFIC MICRORNAS AND COMPOSITIONS AND USES THEREOF
#10208Compositions and methods for treatment of tamoxifen resistant breast cancer
#10209Nanotubes as carriers of nucleic acids into cells
#10210RNA interference suppression of neurodegenerative diseases and methods of use thereof
#10211Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
#10212Methods of modulating MicroRNAs in the treatment of pulmonary arterial hypertension
#10213Methods and compositions for controlling efficacy of RNA silencing
#10214Methods for diagnosing bone or cardiovascular disorders
#10215LIPOSOME-CONTAINING PREPARATION UTILIZING DISSOLUTION AID, AND METHOD FOR PRODUCING SAME
#10216Gall wasp control agents
#10217Plants with useful traits and related methods
#10218Therapeutic muscular dystrophy drug having bubble liposome loaded with morpholino as active ingredient
#10219ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10220Treatment of tristetraproline (TTP) related diseases by inhibition of natural antisense transcript to TTP
#10221Spinal muscular atrophy treatment via targeting SMN2 catalytic core
#10222Micro-RNA's that regulate muscle cells
#10223Compositions and Methods for Treating Neoplasia
#10224Compositions and methods for making selenocysteine containing polypeptides
#10225SUPPRESSION OF TLA1 GENE EXPRESSION FOR IMPROVED PHOTOSYNTHETIC PRODUCTIVITY
#10226Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-β
#10227Compositions and methods for treating, diagnosing and monitoring disease
#10228Insect-combating preparation and method based on RNAi technology
#10229Methods and compositions for selecting siRNA of improved functionality
#10230MicroRNA-Based Methods and Compositions For the Diagnosis, Prognosis and Treatment of Breast Cancer
#10231METHODS TO ENHANCE CELL-MEDIATED IMMUNITY
#10232Method for improving plant resistance to insects
#10233Therapeutic compounds
#10234Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#10235Compositions and methods for inhibition of expression of protein C (PROC) genes
#10236Polycomb-associated non-coding RNAs
#10237Production and extraction of MicroRNA precursor as drug for cancer therapy
#10238METHODS FOR TREATING CHRONIC KIDNEY DISEASE
#10239USE OF INVERTASE SILENCING IN POTATO TO MINIMIZE CHIP AND FRENCH FRY LOSSES FROM ZEBRA CHIP AND SUGAR ENDS
#10240BRACHYURY POLYPEPTIDES AND METHODS FOR USE
#10241Small molecule conjugates for intracellular delivery of biologically active compounds
#10242Small molecule conjugates for intracellular delivery of nucleic acids
#10243METHODS FOR ADJUSTING EXPRESSION OF MITOCHONDRIAL GENOME BY MICRORNA
#10244Composition for controlling chromogenesis including microRNA
#10245Individualized cancer therapy
#10246MIR-211 EXPRESSION AND RELATED PATHWAYS IN HUMAN MELANOMA
#10247Composition comprising inhibitors of IRS-1 and of VEGF
#10248STRESS-RESISTANT PLANTS AND THEIR PRODUCTION
#10249METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#10250ANTISENSE DESIGN
#10251Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#10252Nucleic acid modulators of glycoprotein VI
#10253Diagnosis and treatment of friedreich's ataxia
#10254Modulation of apolipoprotein CIII (ApoCIII) expression
#10255OLIGONUCLEOTIDE MODULATION OF SPLICING
#10256Nucleic acid/polysaccharide complex
#10257Oligonucleotide derivative, oligonucleotide derivative-containing pharmaceutical composition for treatment and pharmaceutical composition for diagnosis, and oligonucleotide derivative for regulation of miRNA function
#10258Methods and compositions for the treatment of cancer or other diseases
#10259Nucleic acid silencing sequences
#10260Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
#10261Micro-RNAs and micro-RNA inhibitors to modulate blood vessel growth, patterning, tumor growth and malignant disease and method for making and using them
#10262OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS
#10263Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#10264Microrna (miRNA) and downstream targets for diagnostic and therapeutic purposes
#10265Methods of using microRNA-26a to promote angiogenesis
#10266MIR-155 ENHANCEMENT OF CD8+ T CELL IMMUNITY
#10267GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HAEMOPHILUS INFLUENZAE
#10268Antisense compounds targeting genes associated with usher syndrome
#10269HCV Combination Therapy
#10270Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
#10271METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#10272MicroRNAome
#10273Targeting microRNAs for metabolic disorders
#10274Transposable elements, TDP-43, and neurodegenerative disorders
#10275Method of treating cancer by inhibition of DNA repair proteins
#10276RNA interference in dermal and fibrotic indications
#10277Replication deficient recombinant viruses expressing antigens regulated by transcriptional control elements comprising multiple elements
#10278Plant regulatory elements and uses thereof
#10279RNA CONSTRUCTS
#10280Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#10281Functional nucleic acid molecule and use thereof
#10282MicroRNA compounds and methods for modulating MIR-21 activity
#10283Synthetic mimics of miR-34
#10284Methods and compositions for the specific inhibition of MYC by double-stranded RNA
#10285Compound and method for treating myotonic dystrophy
#10286Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
#10287METHODS AND SYSTEMS FOR IDENTIFYING MICRO-RNA TARGETS AND SYNTHESIZING NOVEL MICRO-RNAS AND USES OF THE SAME
#10288VISTA modulators for diagnosis and treatment of cancer
#10289AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
#10290Compositions and methods for treating musculoskeletal diseases and disorders
#10291Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
#10292Methods for treatment of alport syndrome
#10293TRPM-2 antisense therapy
#10294HIGH POTENCY SIRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
#10295Promoter variants for expressing genes in a fungal cell
#10296CANCER TARGETS AND USES THEREOF
#10297SiRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof
#10298MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#10299siRNA targeting TIE-2
#10300Prokaryotic RNAi-like system and methods of use
#10301Regulators of NFAT and/or store-operated calcium entry
#10302Modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity
#10303Aging marker, method for evaluating aging inhibitor, and cancer inhibitor
#10304Differentially expressed microRNA molecules for the treatment and diagnosis of cancer
#10305METHOD FOR PRODUCING MILK HAVING AN IMMUNOREGULATORY ACTION
#10306Methods for treating castration resistant prostate cancer and metastasis by reducing B-cell number and/or function
#10307NANOPARTICLE, LIPOSOMES, POLYMERS, AGENTS AND PROTEINS MODIFIED WITH REVERSIBLE LINKERS
#10308MiR-33 inhibitors and uses thereof to decrease inflammation
#10309ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10310ENHANCED BIODISTRIBUTION OF OLIGOMERS
#10311SELECTING AND STABILIZING dsRNA CONSTRUCTS
#10312siRNAS Compositions and Method for Manipulating Berry Ripening
#10313CHEMICALLY MODIFIED OLIGONUCLEOTIDES FOR USE IN MODULATING MICRO RNA AND USES THEREOF
#10314COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRABBE AND OTHER NEURODEGENERATIVE DISEASES
#10315Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#10316Methods and compositions for the treatment of cancer or other diseases
#10317Compositions and methods for treatment of ear disorders
#10318Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
#10319CHEMICAL MODIFICATION MOTIFS FOR MIRNA INHIBITORS AND MIMETICS
#10320Lipid formulations for nucleic acid delivery
#10321Agents that reduce neuronal overexcitation
#10322DELIVERY SYSTEM AND CONJUGATES FOR COMPOUND DELIVERY VIA NATURALLY OCCURRING INTRACELLULAR TRANSPORT ROUTES
#10323JAK/STAT INHIBITORS AND MAPK/ERK INHIBITORS FOR RSV INFECTION
#10324Oligomers
#10325Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#10326Compositions and methods for the treatment of cancer
#10327Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
#10328Polynucleotide molecules for gene regulation in plants
#10329Anti-DCLK1 monoclonal antibodies and methods of production and use thereof
#10330Treating hepatitis C virus infection
#10331Optimized miRNA constructs
#10332Methods targeting miR-128 for regulating cholesterol/lipid metabolism
#10333Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair
#10334Method and medicament for inhibiting the expression of a given gene
#10335MiR-150 for the treatment of blood disorders
#10336MULTIFUNCTIONAL NANOPARTICLES
#10337INTERFERING RNAs THAT PROMOTE ROOT GROWTH
#10338Recombinant virus products and methods for inhibition of expression of myotilin
#10339RNAi modulation of ApoB and uses thereof
#10340Transcriptional repression leading to Parkinson's disease
#10341Methods and compositions for the diagnosis, classification, and treatment of cancer
#10342Folate Conjugates
#10343Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
#10344Composition containing antisense oligonucleotide to micro RNA
#10345Splice-region antisense composition and method
#10346Human micrornas and methods for inhibiting same
#10347Molecular marker for cancer stem cell
#10348Organic compositions to treat HSF1-related diseases
#10349Multi-conjugate of siRNA and preparing method thereof
#10350ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES, THE HCHWA-D MUTATION, AND TRINUCLEOTIDE REPEAT EXPANSIONS
#10351COMPOSITIONS AND METHODS FOR TREATING OBESITY
#10352Pancreatic cancer biomarker using the characteristics of pancreatic cancer stem cells, and use thereof
#10353Lipid nano particles comprising cationic lipid for drug delivery system
#10354SYSTEM FOR CARGO DELIVERY INTO THE CELLS
#10355Methods and Compositions for Treating Keratin Hyperproliferation Disorders
#10356Modulation of LRCH4 activity and therapeutic application thereof
#10357Oligonucleotides for modulation of target RNA activity
#10358Methods and compositions involving miRNA and miRNA inhibitor molecules
#10359Method and compositions comprising small RNA agonist and antagonists to modulate inflammation
#10360Method of treatment
#10361Compositions and methods for modulating angiogenesis
#10362COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF INLAMMATORY DISORDERS AND FIBROTIC DISEASE
#10363Recombinant polypeptide production method
#10364Treatment And Screening
#10365Oligonucleotide analogues targeting human LMNA
#10366Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA
#10367FRUIT-SPECIFIC PROMOTER
#10368Methods and compositions for the treatment of eye disorders with increased intraocular pressure
#10369Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
#10370Polynucleotide molecules for gene regulation in plants
#10371MicroRNAs and uses thereof
#10372Method for inducing immune tolerance using viable polymer-modified allogeneic leukocytes
#10373Application of the broccoli wound-inducible promoter of gene in transgenic plants
#10374Methods for genetic control of insect infestations in plants and compositions thereof
#10375Compositions and methods for treating leukemia
#10376COMPOUNDS AND METHODS FOR MODULATING TARGET NUCLEAR AND SUB-NUCLEAR NUCLEIC ACID MOLECULES IN CELLS AND ANIMALS
#10377Antimir-451 for the treatment of polycythemias
#10378Inhibitor of IRS-1 for treating skin disorders
#10379Direct reprogramming of cells to cardiac myocyte fate
#10380UK-2 biosynthetic gene and method for improving UK-2 productivity using the same
#10381Methods for affecting homology-directed DNA double stranded break repair
#10382Reducing levels of nicotinic alkaloids in plants
#10383Methods and Compositions Using Small Interfering RNA (SIRNA) for Nematode Control in Plants
#10384Chimeric oligomeric compounds for modulation of splicing
#10385Compositions and methods for the Delivery of Biologically Active RNAs
#10386Modulation of alpha synuclein expression
#10387MiRNA for treating diseases and conditions associated with neo-angiogenesis
#10388NKX2.2 INHIBITORS AS DRUGS
#10389TREATMENT OF DISORDERS WITH ALTERED VASCULAR BARRIER FUNCTION
#10390Targeted alteration of DNA
#10391Pharmaceutical composition consisting of RNA having alkali metal as counter ion and formulated with dications
#10392Identification and use of target genes for control of plant parasitic nematodes
#10393Compositions and methods for characterizing and treating muscular dystrophy
#10394Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#10395PHARMACEUTICAL COMPOSITION CONTAINING L-DNA
#10396Inhibitors of the miR-15 family of micro-RNAs
#10397Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
#10398Oligonucleotide-based inhibitors comprising locked nucleic acid motif
#10399Repressor on IFN-λ promoter and siRNA against ZEB1 and BLIMP-1 to increase IFN-λ gene activity
#10400TAZ/WWTR1 for diagnosis and treatment of cancer
#10401BACH2 repression in cells
#10402Identification of Therapeutic Targets in Cutaneous SCC
#10403Prognosis and treatment of breast cancer
#10404DIAGNOSTIC AND TREATMENT OF CHRONIC HEART FAILURE
#10405Small interfering RNAS with target-specific seed sequences
#10406UCP1 (thermogenin)—inducing agents for use in the treatment of a disorder of the energy homeostasis
#10407ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10408Methods for modulating the expression and aggregation of a CAG-expanded gene product in cells and methods for identifying agents useful for doing the same
#10409Antisense modulation of kinesin-like 1 expression
#10410Methods for modulating factor 12 expression
#10411miRNA modulators of thermogenesis
#10412DISABLING AUTOPHAGY AS A TREATMENT FOR LYSOSOMAL STORAGE DISEASES
#10413Enabling the use of long dsRNA for gene targeting in mammalian and other selected animal cells
#10414Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features
#10415Composition comprising expression or activity regulators of AKAP12 for treating central nerve system diseases
#10416Treatment of angiogenesis disorders
#10417Production and utilization of a novel anti-cancer drug in therapy
#10418Inhibition of hairless protein mRNA
#10419Pharmacodiagnosis Test Targeting Oncology and Neurodegeneration
#10420Method for the construction of specific promoters
#10421TRIGGERED RNAi
#104225′-end derivatives
#10423Promoters and terminators for use in eukaryotic cells
#10424RNA molecules that upregulate insulin production
#10425Compositions and methods for silencing gene expression
#10426TEST AGENT FOR VISCERAL OBESITY AND USE THEREOF
#10427Inhibition of choroidal neovascularization
#10428Selective reduction of the deleterious activity of extended tri-nucleotide repeat containing genes
#10429Modulation of apolipoprotein C-III expression
#10430Serpinc1 iRNA compositions and methods of use thereof
#10431Modified iRNA agents
#10432Lipid nanoparticle compositions for antisense oligonucleotides delivery
#10433Methods for the treatment of heart failure
#10434Genetic amplification of IQGAP1 in cancer
#10435Methods and compositions for RNAi mediated inhibition of gene expression in mammals
#10436Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of brain tumors
#10437Methods and compositions for enhancing the efficacy and specificity of RNA silencing
#10438Antagonists of GRASP55 for use as a medicament
#10439METHODS AND COMPOSITIONS FOR MAINTENANCE OF A FUNCTIONAL WOUND
#10440Pericarp tissue preferred regulatory region and method of using same
#10441Methods and compositions for the specific inhibition of HIF-1α by double-stranded RNA
#10442METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#10443Therapeutic uses of inhibitors of RTP801L
#10444Oligonucleotide compositions with enhanced efficiency
#10445MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#10446Method of delivering RNA interference and uses thereof
#10447DROUGHT TOLERANT PLANTS AND RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING miR827
#10448Synthetic genes and genetic constructs
#10449Promoters exhibiting endothelial cell specificity and methods of using same
#10450Base modified oligonucleotides
#10451MicroRNA biomarkers for human breast and lung cancer
#10452Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms
#10453Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
#10454Methods and compositions for modified ethanol inducible promoter systems
#10455Down-regulating gene expression in insect pests
#10456ACP promoter
#10457Methods of inducing insulin production
#10458Compositions and methods for treatment of ovarian cancer
#10459Compositions for conferring tolerance to viral disease in social insects, and the use thereof
#10460Oligomers
#10461Synthetic lethality in cancer
#10462Compounds and methods for modulating interaction between proteins and target nucleic acids
#10463Antisense antibacterial method and compound
#10464Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
#10465dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
#10466Plant regulatory elements and uses thereof
#10467iRNA agents with biocleavable tethers
#10468Compositions and their uses directed to huntingtin
#10469Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138
#10470siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
#10471MicroRNA target site for cell- or tissue-specific inhibition of expression of a transgene
#10472Methods and compositions for RNAi-based cancer treatment
#10473PROGNOSTIC, DIAGNOSTIC, AND CANCER THERAPEUTIC USES OF FANCI AND FANCI MODULATING AGENTS
#10474Methods and compositions for RNA interference
#10475Novel Method of Protecting Islet Cells From Apoptosis during the Donor Harvesting Process
#10476DERIVATIVES OF SMALL INTERFERING RNAS AND USE THEREOF
#10477Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#10478RNAi modulation of SCAP and therapeutic uses thereof
#10479MicroRNA fingerprints during human megakaryocytopoiesis
#10480Nucleic acid molecules inducing RNA interference, and uses thereof
#10481METHOD TO INCREASE GENE TARGETING FREQUENCY
#10482ENGRAFTMENT POTENTIAL OF EMBRYONIC STEM CELLS AND PLURIPOTENT STEM CELLS USING MICRO RNAs
#10483Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#10484MODULATION OF GENE EXPRESSION BY LOCKED NUCLEIC ACIDS
#10485MicroRNA fingerprints during human megakaryocytopoiesis
#10486TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES AND USE OF SAME
#10487Agent for treating myelofibrosis
#10488Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
#10489Gene silencing by single-stranded polynucleotides
#10490(NUCLEIC ACID)-POLYSACCHARIDE COMPLEX
#10491Cancer treatment targeting non-coding RNA overexpression
#10492Synthetic arcelin-5 promoter and methods of use thereof
#10493Method to trigger RNA interference
#10494Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
#10495Micro-RNA family that modulates fibrosis and uses thereof
#10496ANCCA as a Diagnostic Biomarker and Therapeutic Target for Breast Cancers
#10497Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
#10498CONFORMATIONALLY RESTRICTED DINUCLEOTIDE MONOMERS AND OLIGONUCLEOTIDES
#10499Method for expression of small RNA molecules within a cell
#10500Micro-RNA family that modulates fibrosis and uses thereof