109056 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
SDF-1 binding nucleic acids and the use thereof in cancer treatment
#1502Aptamer construct
#1503ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FOR SEQUENCE MANIPULATION
#1504Blockade of CCL18 signaling via CCR6 as a therapeutic option in treating interstitial lung disease
#1505RNA aptamers against BAFF-R as cell-type specific delivery agents and methods for their use
#1506Compositions and methods for detecting microorganisms
#1507Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
#1508Agents that modulate RGMb-neogenin-BMP signaling and methods of use thereof
#1509METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMAS
#1510Treatment of ocular disorders with anti-connexin proteins and mimetics
#1511SDF-1 binding nucleic acids and the use thereof
#1512Aptamers inhibiting the enzymatic activity of the MMP-9 protein
#1513ANTI-VIRAL THERAPY
#1514Method for Regulating Cell Proliferation
#1515OLIGONUCLEOTIDE PROBES AND USES THEREOF
#1516Synthesis of transcripts using Syn5 RNA polymerase
#1517Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide
#1518Method of rapid isolation of aptamer beacons
#1519Methods and devices for detection and measurement of analytes
#1520METHOD FOR PREPARING NUCLEIC ACID APTAMER
#1521Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions
#1522Peanut-binding nucleic acid molecule and use thereof
#1523PERMANENT GENE CORRECTION BY MEANS OF NUCLEOTIDE-MODIFIED MESSENGER RNA
#1524COMPOSITIONS AND METHODS FOR LONG ACTING MOLECULES
#1525Methods for Treating or Preventing Ophthalmological Conditions
#1526Method for preparing nucleic acid aptamer
#1527NUCLEIC ACID LIGANDS TO LL37
#1528Reversible platelet inhibition
#1529Peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carcinoma (RCC) and other cancers
#1530Peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carcinoma (RCC) and other cancers
#1531Chemical reagents for attaching affinity molecules on surfaces
#1532Kits-of-Parts Comprising Nucleic Acids Able to Form a Kissing Complex and Their uses Thereof
#1533Methods and compositions employing an osteopontin aptamer to deliver nucleic acids into smooth muscle, endothelial, cardiac and progenitor/stem cells
#1534Methods for treating hepatitis C virus infectious disease
#1535COMPOSITIONS AND METHODS RELATING TO C5L2
#1536Methods and compositions for backscattering interferometry
#1537METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
#1538Methods and constructs for compound delivery
#1539Small molecule-dependent split aptamer ligation
#1540Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens
#1541Bio-sensor for the detection of small molecules
#1542Hepcidin Binding Nucleic Acids
#1543Block copolymers and uses thereof
#1544NUCLEIC ACID APTAMER CAPABLE OF SPECIFICALLY BINDING TO TEBUCONAZOLE, MEFENACET AND INABENFIDE, AND USE THEROF
#1545Peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers
#1546Method of modulating the activity of a nucleic acid molecule
#1547Aptamers bound human serum albumin and glycated human serum albumin
#1548Multiaptamer target detection
#1549Particles with multiple functionalized surface domains
#1550Switchable Cas9 nucleases and uses thereof
#1551MCP-1 binding nucleic acids
#1552Targeting microRNAs for metabolic disorders
#1553METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
#1554Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method
#1555RNA APTAMERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY TO PANCREATIC CANCER CELLS
#1556Microbial consortia for programmable output via photoautotroph-heterotroph interactions
#1557G-rich isoDNA sequences forming G-quadruplex structure, their function as aptamers and a process for the preparation thereof
#1558COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS
#1559Methods for treating and/or limiting development of diabetes
#1560THERAPEUTIC TREATMENT FOR DRUG POISONING AND ADDICTION
#1561DNA aptamer specifically binding to EN2 (engrailed-2) and use thereof
#1562Aptamer for detection of alpha-methylacyl-CoA racemase and diagnostic kit thereof
#1563Therapeutic polynucleotides, compositions, and methods
#1564PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
#1565NUCLEIC ACID SENSOR FOR MELAMINE ANALYSIS, DEVICE FOR MELAMINE ANALYSIS, AND METHOD FOR MELAMINE ANALYSIS
#1566Nanobubbles
#1567In-vivo monitoring of molecular targets
#1568Use of aptamers in therapy and/or diagnosis of autoimmune diseases
#1569Aptamers against glioma cells
#1570Aptamers and use of the aptamers in the diagnosis and treatment of cancer
#1571Fluorescence sensor for target analysis, kit for target analysis, and target analysis method using same
#1572MULTIVALENT APTAMER COMPLEXES
#1573Compositions and methods for treating cancer and other diseases
#1574Method for purifying active GLA-domain coagulation proteins
#1575Use of HMGA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells
#1576Materials and methods for rapid and specific detection of cocaine
#1577APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE
#1578Screening of nucleic acid agents via particle display
#1579Treatment and prevention of malaria
#1580Methods and compositions for mobilizing stem cells
#1581Nucleic acid aptamers
#1582SDF-1 binding nucleic acids and the use thereof in cancer treatment
#1583RNA-modulating agents
#1584Intracellular translation of circular RNA
#1585Synthetic lethality in cancer
#1586Aptamer-RNAi therapeutic compositions
#1587Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation
#1588HUMAN PROTEIN SCAFFOLD WITH CONTROLLED SERUM PHARMACOKINETICS
#1589Non-immunogenic and nuclease resistant nucleic acid origami devices and compositions thereof
#1590RNA aptamers against BAFF-R as cell-type specific delivery agents and methods for their use
#1591Aptamer methods and compositions
#1592Ovarian cancer-specific aptamers and applications thereof
#1593DNA aptamers binding the histidine tag and their application
#1594Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#1595Stabilized Aptamers to Platelet Derived Growth Factor and Their Use as Oncology Therapeutics
#1596Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
#1597Composition for controlling stem cells pluripotency, containing LIN28A methylation inhibitor, and method for screening for LIN28A methylation inhibitor
#1598Kit with stabilized thrombin
#1599METHODS TO OBTAIN A NOVEL CLASS OF GRAM NEGATIVE BACTERIA ANTIBIOTICS WHICH TARGET AN UNKNOWN CELL DIVISION ASSOCIATED PROTEIN LOP1
#1600Aptamer to IL-17 and use thereof
#1601Interferon production using short RNA duplexes
#1602Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
#1603Selection of RNA-aptamers as anti-malaria agents
#1604Selection of RNA-aptamers as anti-malaria agents
#1605Aptamer-guided gene targeting
#1606CD7 receptor aptamers
#16072-fluoro-modified RNAs as immunostimulators
#1608Compositions, methods, and kits for amplifying nucleic acids
#1609Oligomers
#1610DNA aptamers for promoting remyelination
#1611Molecules inhibiting the human immunodeficiency virus type 1 (HIV-1), method for the production thereof and applications of same
#1612Aptamers and uses thereof
#1613Nanotubes as Carriers of Nucleic Acids into Cells
#1614Vascular endothelial growth factor-binding aptamers
#1615Aptamers that bind CD271
#1616Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#1617Aptamers for tumor initiating cells
#1618Targeting aptamer for atherosclerosis and preparation method and application thereof
#1619ECF-BINDING AGENTS AND USES THEREOF
#1620Aptamer against midkine and applications thereof
#1621FUNCTIONAL LIGANDS TO TARGET MOLECULES
#1622Aptamer for periostin and anti-cancer composition including same
#1623MATRIX METALLOPROTEINASE 9 (MMP-9) APTAMER AND USES THEREOF
#1624Method for screening for high L-tryptophan producing microorganisms using riboswitch
#1625Aptamers inhibiting the enzymatic activity of tyrosinase
#1626SATB1: A DETERMINANT OF MORPHOGENESIS AND TUMOR METASTATIS
#1627CIRCULATING PROTEOLYTIC BIOMARKERS OF CELL DEATH AND METHODS FOR THE USE THEREOF
#1628FLT3 receptor antagonists for the treatment or the prevention of pain disorders
#1629Aptamers, multimeric aptamers and uses thereof
#1630BIOMARKER COMPOSITIONS AND METHODS
#1631Nucleic acid molecule capable of binding to and use thereof
#1632CD133 aptamers for detection of cancer stem cells
#1633BINDING MOIETIES FOR BIOFILM REMEDIATION
#1634RNA APTAMER ISOLATION VIA DUAL-CYCLE (RAPID) SELECTION
#1635Neutralizing RNA aptamers
#1636Riboregulator compositions and methods of use
#1637Methods for the diagnosis and treatment of sjögren's syndrome
#1638DIAGNOSIS OF TUBERCULOSIS
#1639NUCLEIC ACID LIGANDS TO LL37
#1640Single stranded DNA aptamers binding NF-kB/RelA
#1641Library compositions and methods for acyclic identification of aptamers
#1642Nanotubes as carriers of nucleic acids into cells
#1643Method for production of single-stranded macronucleotides
#1644Methods for treating and/or limiting development of diabetes
#1645Method for the treatment of cardiovascular fibrosis
#1646MODULATORS OF COAGULATION FACTORS
#1647SDF-1 binding nucleic acids
#1648Glucagon Binding Nucleic Acids
#1649MIRNA MODULATORS OF CHRONIC VISCERAL INFLAMMATION
#1650Adeno-associated virus virions with variant capsid and methods of use thereof
#1651Method for regulating cell proliferation
#1652Multiplexed microcolumn devices and processes for selection of nucleic acid aptamers
#1653CTLA-4 aptamer siRNA species
#1654Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
#1655EpCAM aptamer for detection of cancer stem cells
#1656Method for Generating Aptamers with Improved Off-Rates
#1657RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
#1658BINDING MOIETIES FOR BIOFILM REMEDIATION
#1659Aptamer-targetted antigen delivery
#1660Composition comprising material for inhibiting SCF or receptor thereof for treating or preventing diseases associated with vascular permeability
#1661METHODS FOR PREVENTING AND TREATING CHRONIC KIDNEY DISEASE (CKD)
#1662Aptamer method
#1663Oligonucleotide inhibitor of DNA polymerases
#1664ANTAGONIST TO AN ENZYME AND/OR A METABOLITE OF THE KYNURENINE PATHWAY
#1665Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#1666SINGLE MOLECULE NUCLEIC ACID NANOPARTICLES
#1667Nucleic acid aptamer-based diagnostic methods with novel techniques for signal enhancement
#1668Aptamer therapeutics useful in the treatment of complement-related disorders
#1669Modulation of TLR4-signaling pathway
#1670Method for generating aptamers with improved off-rates
#1671MCP-1 Binding Nucleic Acids and Use Thereof
#1672RNA sequences that induce fluorescence of small molecule fluorophores
#1673Single-stranded nucleic acid aptamers specifically binding to and method for detecting using the same
#1674STABILIZED APTAMERS TO PLATELET DERIVED GROWTH FACTOR AND THEIR USE AS ONCOLOGY THERAPEUTICS
#1675METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PANCREATIC CANCER
#1676TREATMENT OF CANCER
#1677Reducing galectin-12 activity to influence the cell function of human sebocytes
#1678Transferrin receptor aptamers and aptamer-targeted delivery
#1679Nucleic acid fragment binding to target protein
#1680Oligonucleotide, glucocorticoid sensitivity enhancer, pharmaceutical composition, and expression vector
#1681Hemoglobin A1c-specific aptamer, hemoglobin-specific aptamer, and applications thereof
#1682Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions
#1683Methods for detection of target using affinity binding
#1684Use of aptamers in proteomics
#1685Aptamers and diagnostic methods for detecting the EGF receptor
#1686Device and method for analyzing streptavidin
#1687MENA AND ALPHA5 INTEGRIN INTERACTION
#1688NON-CATALYTIC DOMAIN TARGETS IN MATRIX METALLOPROTEASE PROTEINS FOR CANCER THERAPIES
#1689Methods and pharmaceutical compositions for the treatment of hypertension
#1690Small molecule-dependent split aptamer ligation
#1691Extended DNA-sensing GRNAS
#1692MRNA-sensing switchable gRNAs
#1693Switchable gRNAs comprising aptamers
#1694Method for detecting target substance, assay kit, and detection apparatus
#1695Treatment of TH17-Mediated Autoimmune Disease Via Inhibition of Stat3
#1696CYTOTOXIC AGENTS
#1697ROBO2 inhibitory compositions comprising SLIT2-binding extracellular domain of ROBO2
#1698Nucleic acids specifically binding CGRP
#1699Aptamer modulators of estrogen receptors
#1700RHOGEF12 IS A THERAPEUTIC TARGET FOR THE TREATMENT OF HEART FAILURE
#1701Methods and devices for detection and measurement of analytes
#1702Aptamer regulated nucleic acids and uses thereof
#1703Fluoride-responsive riboswitches, fluoride transporters, and methods of use
#1704Methods for Treating or Preventing Ophthalmological Conditions
#1705Methods of detecting tumor cells
#1706Aptamer which selectively binds to ERBB2 receptor and uses thereof
#1707Detection of chemical and biological agents using oligonucleotide aptamers
#1708Functionalized graphene substrates
#1709Methods for developing binding-elements and uses thereof
#1710OSTEOPONTIN ISOFORM A INHIBITORS AND METHODS OF USE
#1711Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit
#1712C5a binding nucleic acids
#1713Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method
#1714COMPOUNDS FOR USE IN BOOSTING COAGULATION
#1715Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
#1716Neutral nucleic acid ligands
#1717Switchable aptamers
#1718Aptamers for detection and measurement of analytes
#1719Anti-FH aptamers, method for producing same, and uses thereof
#1720MODULATION OF AXON DEGENERATION
#1721Lin28-mediated control of let-7 biogenesis
#1722Molecule capable of binding to adrenocorticotropic hormone, and use thereof
#1723Method for treating chronic colitis and systemic sclerosis and for eliciting a protective immune reaction against human IL-6
#1724Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated conditions
#1725System for Targeted Delivery of Therapeutic Agents
#1726Stabilized STAT3 decoy oligonucleotides and uses therefore
#1727Method of detecting and/or quantifying an analyte in a biological sample
#1728Aptamers and diagnostic methods for detecting the EGF receptor
#1729Methods and Compositions of Nucleic Acid Ligands for Detection of Clinical Analytes Related to Human Health
#1730CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
#1731Cell and therapeutical and diagnostical methods based thereon
#1732Method of controlling coagulation
#1733ERYTHROPOIETIC ROLE OF RESIDENT MACROPHAGES IN HEMATOPOIETIC ORGANS
#1734COMPOSITIONS AND METHODS FOR SELECTING APTAMERS
#1735NGF aptamer and application thereof
#1736RNA aptamer specifically binding to carcinoembryonic antigen and use thereof
#1737MODULATORS OF 4-1BB AND IMMUNE RESPONSES
#1738RIBOSWITCHES
#1739Method of treating hyperproliferation of cells using a nucleolin specific aptamer
#1740TREATMENT OF OBESITY
#1741Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy
#1742METHOD FOR PREPARING NUCLEIC ACID APTAMER
#1743pRNA multivalent junction domain for use in stable multivalent RNA nanoparticles
#1744Nanotubes as carriers of nucleic acids into cells
#1745Compositions and methods related to tauopathy
#1746METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH ANGIOGENESIS USING A VASCULAR ADHESION PROTEIN-1 (VAP-1) INHIBITOR
#1747Use of Aptamers in Liquid Chromatography and Liquid Chromatography - Mass Spectrometry
#1748Use of aptamers in therapy and/or diagnosis of autoimmune diseases
#1749NUCLEIC ACID APTAMERS
#1750DNA aptamers for promoting remyelination
#1751Apparatus and method for single-cycle selection of aptamers
#1752Aptamers that are specific for immunoglobulin-binding cell wall proteins
#1753Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#1754Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
#1755Nucleic acid modulators of glycoprotein VI
#1756Use of HGMA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells
#1757Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
#1758Methods of X-aptamer generation and compositions thereof
#1759Method of diagnosing cancer using a nucleolin specific aptamer
#1760IMMUNOGENIC COMPOSITIONS AND EXPRESSION SYSTEMS
#1761Aptamers to 4-1BB and their use in treating diseases and disorders
#1762Amyloid protein oligomer-binding aptamer
#17635-position modified pyrimidines and their use
#1764Oligomers
#1765Nucleic acid aptamers
#1766Single-stranded nucleic acid aptamers specifically binding to
#1767Bispecific aptamers mediating tumour cell lysis
#1768Multifunctional Aptamer-Nucleic Acid Nanostructures for Tumor-Targeted Killing
#1769Method of treatment of a solid tumor with interleukin-1 accessory protein antibody
#1770Aptamers for prion diagnostics and aptamer binding detection system
#1771PSA binding aptamer and method for diagnosis of prostate cancer
#1772Use of spiegelmers
#1773Methods for the treatment of heart failure
#1774APTAMER LABELLED WITH F-19 NUCLEUS FOR TARGETED MOLECULAR IMAGING BY MRI
#1775Subunit-selective nucleic acid inhibitors of glutamate receptors
#1776Oligomers
#1777Synthetic lethality in cancer
#1778Multiplex microfluidic device for selecting nucleic acid aptamers, and high throughput selection method for nucleic acid aptamers using same
#1779Methods for identifying nucleic acid ligands
#1780APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THERAPEUTICS
#1781LAR protein-specific ligand
#1782Specific ligand for annexin 2
#1783Functional ligands to target molecules
#1784INDUCED INTERNALIZATION OF SURFACE RECEPTORS
#1785Aptamer therapeutics useful in the treatment of complement-related disorders
#1786DNA origami devices
#1787Library Compositions and Methods for Acyclic Identification of Aptamers
#1788Aptamers to glycoprotein VI
#1789Application of highly conserved domain sequences from viral genome as template to design therapeutic sliRNAs
#1790PEPTIDE APTAMERS FOR MANIPULATING PROTEIN FUNCTION
#1791Axl receptor tyrosine kinase aptamer inhibitor for use in therapy
#1792Modulators of coagulation factors
#1793Nucleotides and aptamers containing boronic acid groups having biased binding to glycosylated proteins, and uses thereof
#1794Treatment and prevention of malaria
#1795EGFR aptamer inhibitor for use in therapy and diagnosis
#1796TARGETING COMPOUNDS
#1797Lipid binding nucleic acids
#1798Small molecule-dependent split aptamer ligation
#1799Method for purifying GLA-domain coagulation proteins
#1800Constructs and methods for the assembly of biological pathways