109056 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
HER2 nucleic acid aptamers
#1802Methods of preparing targeted aptamer prodrugs
#1803Fractalkine binding polynucleotides and methods of use
#1804METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
#1805RNA aptamers against BAFF-R as cell-type specific delivery agents and methods for their use
#1806Prediction device, prediction method, program, and recording medium
#1807COMPOSITIONS COMPRISING NUCLEIC ACID APTAMERS
#1808PROTEIN COMPLEMENTATION REGULATORS
#1809Nanomotors and motion-based detection of biomolecular interactions
#1810Nucleic acid molecules, polypeptides, antibodies and compositions for treating and detecting influenza virus infection
#1811Modified oligonucleotides for telomerase inhibition
#1812FLT3 receptor antagonists for the treatment or the prevention of pain disorders
#1813Aptamer for NGF and use thereof
#1814P53 MODULATOR AND CANCER TARGET
#1815SDF-1 binding nucleic acids
#1816APTAMER CELL COMPOSITIONS
#1817Aptamer to FGF2 and use thereof
#1818MCP-1 binding nucleic acids
#1819GLYCINE RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH GLYCINE RIBOSWITCHES
#1820Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit
#1821Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#1822Aptamers to β-NGF and their use in treating β-NGF mediated diseases and disorders
#1823DEVICES AND METHODS FOR DETECTING SINGLE NUCLEOTIDE POLYMORPHISMS
#1824Two-way, portable riboswitch mediated gene expression control device
#1825Methods for treating and/or limiting development of diabetes
#1826Modulation of Axon Degeneration
#1827Aptamers to 4-1BB and Their Use in Treating Diseases and Disorders
#1828Aptamer therapeutics useful in the treatment of complement-related disorders
#1829STRUCTURED RNA MOTIFS AND COMPOUNDS AND METHODS FOR THEIR USE
#1830DNA aptamer specifically binding to human cardiac troponin I
#1831DNA aptamer specifically binding to pLDH (plasmodium lactate dehydrogenase)
#1832MYCOBACTERIA-DERIVED DNA MISMATCH REPAIR NUCLEOTIDE SEQUENCES AND USES THEREOF
#1833CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS
#1834Methods for identifying nucleic acid ligands
#1835APTAMERS DIRECTED AGAINST THE MATRIX PROTEIN-1 OF TYPE A INFLUENZA VIRUSES AND USES THEREOF
#1836Stabilized STAT3 decoy oligonucleotides and uses therefor
#1837Methods and reagents for analyzing riboswitches using FRET
#1838METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH ANGIOGENESIS USING A VASCULAR ADHESION PROTEIN-1 (VAP-1) INHIBITOR
#1839Method for purifying active GLA-domain coagulation proteins
#1840Reversible platelet inhibition
#1841Method for purification and identification of sperm cells
#1842Single molecule nucleic acid nanoparticles
#1843Single stranded DNA aptamers binding NF-κB/RelA
#1844RIBOSWITCH BASED INDUCIBLE GENE EXPRESSION PLATFORM
#1845Aptamers for diagnostics
#1846Nucleic acid inhibitors of glutamate receptors
#1847DNA LIGANDS FOR AFLATOXIN AND ZEARALENONE
#1848CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS
#1849Compositions and methods for treating cancer and other diseases
#1850Modified L-Nucleic Acid
#1851HMGB1 binding nucleic acid molecule and applications thereof
#1852Nucleic acid element for use in analysis, and analytical method, analytical reagent, and analytical instrument using same
#1853Multifunctional aptamer-nucleic acid nanostructures for tumor-targeted killing
#1854ANTIVIRAL OLIGONUCLEOTIDES
#1855RNA APTAMERS AND METHODS FOR IDENTIFYING THE SAME
#1856Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
#1857Aptamer for chymase, and use thereof
#1858Particles with multiple functionalized surface domains
#1859Methods and compositions of DNA ligands for arthropod-borne pathogen detection and prophylaxis or therapy
#1860APTAMERS THAT BIND THROMBIN WITH HIGH AFFINITY
#1861Peptides and aptamers for targeting of neuron or nerves
#1862Oligonucleotide end caps
#1863Nucleic acid aptamer capable of binding specifically to pancreatic cancer cells or tissues and use thereof
#1864Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
#1865Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health
#1866MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
#1867Phosphodiesterase 4D7 as marker for malignant, hormone-sensitive prostate cancer
#1868NUCLEIC ACID NANO-BIOSENSORS
#1869Aptamer that recognizes peptide
#1870Delivery method
#1871Therapeutic nucleic acid-3′-conjugates
#1872Targeting MicroRNAs for metabolic disorders
#1873Affinity substrate and methods for selectively purifying a blood plasma protein
#1874Nucleic acid ligands to LL37
#1875Ghrelin binding nucleic acids
#1876Method for generating aptamers with improved off-rates
#1877Oligomers
#1878Oligomers
#1879GEMM RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH GEMM RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH GEMM RIBOSWITCHES
#1880METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
#1881NUCLEIC ACID MODULATORS OF CLEC-2
#1882PRODUCTION PROCESS OF HIGH AFFINITY AND HIGH SPECIFICITY OLIGONUCLEOTIDES FOR ORGANIC AND INORGANIC MOLECULES
#1883METHOD FOR SCREENING FOR DIET PROVIDING PRODUCTION OF MILK HAVING IMMUNOREGULATORY ACTION
#1884Ghrelin binding nucleic acids
#1885Cytotoxic agents
#1886HUMAN PROTEIN SCAFFOLD WITH CONTROLLED SERUM PHARMACOKINETICS
#1887MITOCHONDRIAL LOCALIZATION OF MUC1
#1888Methods and compositions of nucleic acid ligands for detection of foodborne and waterborne pathogens
#1889Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas
#1890C5A binding nucleic acids and the use thereof
#1891Oligomers
#1892Phosphodiesterase 4D7 as prostate cancer marker
#1893Hepcidin binding nucleic acids
#1894NUCLEIC ACIDS SPECIFICALLY BINDING WITH HUMAN FACTOR VII/VIIA AND USES THEREOF
#1895MEANS FOR PURIFYING A COAGULATION PROTEIN, AND METHODS FOR IMPLEMENTING SAME
#1896Target substance detection method using aptamer
#1897Aptamer regulated nucleic acids and uses thereof
#1898Cell and therapeutical and diagnostical methods based thereon
#1899NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACE
#1900Nucleic acid aptamer which specifically binds to bisphenol A
#1901Nucleic acid aptamers
#1902NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE
#1903Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#1904RAPID OLIGO PROBES
#1905STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID
#1906Method of Mycotoxin Detection
#1907EXPONENTIAL ISOTHERMAL SELF-SUSTAINED REPLICATION OF AN RNA ENZYME
#1908High-affinity nucleic acid aptamers against sclerostin protein
#1909NOVEL SYNTHETIC AGONISTS OF TLR9
#19105-POSITION MODIFIED PYRIMIDINES AND THEIR USE
#1911DNA nanostructures that promote cell-cell interaction and use thereof
#1912ANTI-THROMBIN APTAMER FORMULATIONS AND METHODS FOR USE
#1913DIRECT SELECTION OF STRUCTURALLY DEFINED APTAMERS
#1914Compositions, methods, and kits for amplifying nucleic acids
#1915Aptamer for NGF and use thereof
#1916Lariat aptamer: aptamer candidate exclusion by nuclease digestion
#1917Method for generating aptamers with improved off-rates
#1918Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers
#1919Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
#1920Block copolymers and uses thereof
#1921SDF-1 binding nucleic acids and the use thereof
#1922Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy
#1923Nucleic acid ligand complexes
#1924PIRNA AND USES RELATED THERETO
#1925METHOD TO INHIBIT RIBONUCLEASE DICER, RIBONUCLEASE DICER INHIBITOR, AND USE OF RNA APTAMERS AS RIBONUCLEASE DICER INHIBITORS
#1926LYSINE RIBOSWITCH AND COMPOSITIONS AND USES THEREOF
#1927Delivery method
#1928High Affinity Nucleic Acid Ligands of Complement System Proteins
#1929Stimulus-responsive apta chelamers
#1930Inhibition of HRP-3 using modified oligonucleotides
#1931Aptamer Inhibitors of Osteopontin and Methods of Use Thereof
#1932RIBOSWITCHES
#1933RNA Aptamer Specifically Binding to Carcinoembryonic Antigen and Use thereof
#1934Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
#1935Aptamer against IL-17 and use thereof
#1936TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
#1937Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
#1938TARGETING PAX2 FOR THE INDUCTION OF DEFB1-MEDIATED TUMOR IMMUNITY AND CANCER THERAPY
#1939Method for obtaining oligonucleotide aptamers and uses thereof
#1940RNA aptamers and methods for identifying the same
#1941Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives
#1942RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
#1943Riboswitches, methods for their use, and compositions for use with riboswitches
#1944RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
#1945SYSTEM AND METHOD FOR THE RAPID IDENTIFICATION OF BIOLOGICAL AND CHEMICAL ANALYTES
#1946RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
#1947APTAMER INHIBITION OF THROMBUS FORMATION
#1948TREATMENT OF OBESITY
#1949Nucleic acid ligands against infectious prions
#1950MAT II β subunit RNAi and therapeutic methods using same
#1951Antiviral Oligonucleotides Having a Conserved G4 Core Sequence
#1952SAM-II RIBOSWITCH AND USES THEREOF
#1953APTAMER-BASED METHODS FOR IDENTIFYING CELLULAR BIOMARKERS
#1954Nucleic acid based fluorescent sensor for copper detection
#1955REVERSIBLE PLATELET INHIBITION
#1956SDF-1 binding nucleic acids
#1957Nucleic acid ligands against infectious prions
#1958Methods for identifying nucleic acid ligands
#1959Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
#1960Method for purifying or detecting a target protein
#1961PH sensitive biodegradable polymeric particles for drug delivery
#1962REAL-TIME ASSAYS OF NEURO-HUMORAL FACTORS TO ASSESS CARDIOVASCULAR STRESS
#1963Aptamer therapeutics useful in the treatment of complement-related disorders
#1964Branched and multi-chain nucleic acid switches for sensing and screening
#1965C5a binding nucleic acids
#1966Selection of RNA-aptamers as anti-malaria agents
#1967Delivery Method
#1968Nucleolin specific aptamer and use thereof
#1969Nucleic acid modulators of glycoprotein VI
#1970MCP-1 binding nucleic acids and use thereof
#1971USE OF APTAMERS IN PROTEOMICS
#1972Induced internalization of surface receptors
#1973Methods for detecting a target nucleotide sequence in a sample utilising a nuclease-aptamer complex
#1974Methods of Protection from Oxidative Stress
#1975MCP-1 binding nucleic acids
#1976DELIVERY METHOD
#1977Multivalent aptamer complexes
#1978Nucleic acids specifically binding bioactive ghrelin
#1979Compositions comprising nucleic acid aptamers
#1980Modulators of pharmacological agents
#1981APTAMER-TARGETED SIRNA TO PREVENT ATTENUATION OR SUPPRESSION OF A T CELL FUNCTION
#1982Molecular targeting agents
#1983TUNABLE AFFINITY LIGANDS FOR THE SEPARATION AND DETECTION OF TARGET SUBSTANCES
#1984Nucleic acid molecule capable of binding to rabbit-derived IgG antibody
#1985Targeted delivery of siRNA
#1986Modulators of coagulation factors
#1987Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
#1988RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
#1989P53 modulator and cancer target
#1990Small-molecule nucleotide aptamer for hepatitis C virus, preparation method and use thereof
#1991Method of modulating the activity of a nucleic acid molecule
#1992METHODS AND COMPOSITIONS RELATED TO RIBOSWITCHES THAT CONTROL ALTERNATIVE SPLICING
#1993ANTIVIRAL OLIGONUCLEOTIDES TARGETING RSV
#1994ANTIVIRAL OLIGONUCLEOTIDES TARGETING VIRAL FAMILIES
#1995Oligomers
#1996RNA interference mediated treatment of alzheimer's disease using short interfering nucleic acid (siNA)
#1997Novel Oligonucleotide and NF-kB Decoy Comprising the Same
#1998Methods and compositions for inhibition of viral replication
#1999Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon
#2000METHOD FOR OBTAINING OLIGONUCLEOTIDE
#2001SPERM CELL SEPARATION METHODS AND COMPOSITIONS
#2002Nucleic acid inhibitors of glutamate receptors
#2003Cytotoxic agents
#2004Modified L-Nucleic Acid
#2005Inhibition of beta-amyloid peptide aggregation
#2006RIBOSWITCHES, METHODS FOR THEIR USE, AND COMPOSITIONS FOR USE WITH RIBOSWITCHES
#2007High-Affinity RNA Aptamer Molecule Against Glutathione-S-Transferase Protein
#2008Platelet derived growth factor (PDGF) nucleic acid ligand complexes
#2009Dbait and standalone uses thereof
#2010Nucleic acid molecules, polypeptides, antibodies and compositions for treating and detecting influenza virus infection
#2011Aptamer against midkine and use thereof
#2012Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
#2013GENE SILENCING USING SENSE DNA AND ANTISENSE RNA HYBRID CONSTRUCTS COUPLED TO PEPTIDES FACILITATING THE UPTAKE INTO CELLS
#2014Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
#2015Inhibitors of retroviral reverse transcriptase
#2016Compositions and methods relating to target-specific photodynamic therapy
#2017Immuno-RNA-constructs
#2018MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
#2019Protein tyrosine phosphatase inhibitors
#2020Complement Binding Aptamers and Anti-C5 Agents Useful in the Treatment of Ocular Disorders
#2021Nucleic acid ligands capable of binding to internalin B or internalin A
#2022Focused libraries, functional profiling, laser SELEX, and DESELEX
#2023GENE KNOCK-DOWN BY INTRACELLULAR EXPRESSION OF APTAMERS
#2024Methods for Promoting Neurite Outgrowth and Survival of Dopaminergic Neurons
#2025APTAMERS THAT BIND ABNORMAL CELLS
#2026TRANSCRIPTION FACTOR DECOY OLIGODEOXYNUCLEOTIDES HAVING MULTIPLE CIS ELEMENTS
#2027Aptamers that bind thrombin with high affinity
#2028APTAMERS AS AGONISTS
#2029Immunostimulatory Single-Stranded Ribonucleic Acid with Phosphodiester Backbone
#2030IDENTIFICATION OF MOLECULAR INTERACTIONS AND THERAPEUTIC USES THEREOF
#2031vWF aptamer formulations and methods for use
#2032Method of generating branched and multi-chain nucleic acid switches for ligand detection
#2033RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
#2034Use of spiegelmers to inhibit an intracellular target molecule
#2035Nucleic acid compositions and methods of introducing nucleic acids into cells
#2036Methods and compositions for inhibition of viral replication
#2037DEVICE AND SUBSTANCE FOR THE IMMOBILIZATION OF MESENCHYMAL STEM CELLS (MSCs)
#2038Vasopressin-binding L-nucleic acid
#2039Artificial riboswitch for controlling pre-mRNA splicing
#2040METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH ANGIOGENESIS USING A VASCULAR ADHESION PROTEIN-1 (VAP 1) INHIBITOR
#2041Nucleic acid capable of binding to immunoglobulin G and use thereof
#2042STEADY-STATE SUBCUTANEOUS ADMINISTRATION OF APTAMERS
#2043RNA aptamers and methods for identifying the same
#2044RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
#2045Antiviral oligonucleotides targeting viral families
#2046Aptamers to von Willebrand factor and their use as thrombotic disease therapeutics
#2047RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
#2048Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy
#2049Methods of treatment by administering anti-connexin proteins and mimetics
#2050Mitochondrial localization of MUC1
#2051Aptamers comprising arabinose modified nucleotides
#2052Methods, compositions, and kits for modulating tumor cell proliferation
#2053Methods for the production of highly sensitive and specific cell surface probes
#2054Aptamer-based methods for identifying cellular biomarkers
#2055Glycine riboswitches, methods for their use, and compositions for use with glycine riboswitches Cross-Reference to Related Applications
#2056Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
#2057RNA interference mediated inhibition of Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucelic acid (siNA)
#2058RNA interference mediated inhibition of MYC and/or MYB gene expression using short interfering nucleic acid (siNA)
#2059Antiviral oligonucleotides
#2060Higher-order cellular information processing devices
#2061MRI contrast agents and high-throughput screening by MRI
#2062Selex and photoSELEX
#2063Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives
#2064Combined extension and ligation for nucleic acid assembly
#2065Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
#2066Selection of nucleic acid-based sensor domains within nucleic acid switch platform
#2067Aptamers and methods for their in vitro selection and uses thereof
#2068Metabolic profile directed aptamer medicinal chemistry
#2069APTAMERS LABELED WITH 68GA
#2070piRNA and uses related thereto
#2071COMPOUNDS
#2072Methods to create fluorescent biosensors using aptamers with fluorescent base analogs
#2073Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics
#2074Antiviral oligonucleotides targeting HBV
#2075AGE-2 APTAMER
#2076Nucleic Acid Ligands Specific to Immunoglobuline E and Their Use as Atopic Disease Therapeutics
#2077Biosensors based on directed assembly of particles
#2078Method for generating aptamers with improved off-rates
#2079Real-Time Assays Of Neuro-Humoral Factors To Assess Cardiovascular Stress
#2080Methods and compositions for processes of rapid selection and production of nucleic acid aptamers
#2081Therapeutic Agents for the Treatment of Hmgb1-Related Pathologies
#2082SATB1: A DETERMINANT OF MORPHOGENESIS AND TUMOR METASTASIS
#2083Riboswitches, Structure-Based Compound Design with Riboswitches, and Methods and Compositions for Use of and with Riboswitches
#2084Method and kit for detecting a target protein using a DNA aptamer
#2085Chimeric Transcription Factor Decoy Oligonucleotides
#2086RNA aptamers and methods for identifying the same
#2087Platelet derived growth factor (PDGF) nucleic acid ligand complexes
#2088Decoy compositions for treating and preventing brain diseases and disorders
#2089RNA aptamers and methods for identifying the same
#2090RNA aptamers and methods for identifying the same
#2091NOVEL GENES AND RNA MOLECULES THAT CONFER STRESS TOLERANCE
#2092RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
#2093RNA aptamers and methods for identifying the same
#2094Selection of aptamers based on geometry
#2095DNA-based aptamers for human cathepsin G
#2096Therapeutic nucleic acid-3′-conjugates
#2097Methods and reagents for detecting target binding by nucleic acid ligands
#2098Modulators of coagulation factors
#2099Modulators of coagulation factors with enhanced stability
#2100Inhibition of metallo-β-lactamase by RNA