G-rich polynucleotides as a novel therapeutic for the treatment of huntington's disease

Modulators of pharmacological agents

Polycationic compositions for cellular delivery of polynucleotides

RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)

REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING

SAM Riboswitch and Uses Thereof

Method for manufacturing specific binding molecules against selected target molecules, kit, and binding molecules

Modulation of telomere length by oligonucleotides having a G-core sequence

Catalytic Polynucleotide and Its Use for Determination of Analytes

COMPOSITIONS, METHODS, AND KITS FOR AMPLIFYING NUCLEIC ACIDS

MULTIPLEXED ANALYSES OF TEST SAMPLES

RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)

Detection, monitoring and treatment of cancer

Oligonucleotides targeting prion diseases

Anti-apoptotically active apatamers

Materials and methods for the generation of fully 2′-modified nucleic acid transcripts

Nucleic acid aptamer-based compositions and methods

Modulators of coagulation factors with enhanced stability

G-rich polynucleotides for the treatment of Huntington's Disease

RNA interference mediated of inhibition of influenza virus gene expression using short interfering nucleic acid (siNA)

Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)

NF-kB oligonucleotide decoy molecules

Aptamer medicinal chemistry

Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics

Ligands

Nucleic acid molecules, polypeptides, antibodies and compositions for treating and detecting influenza virus infection

Method and apparatus to facilitate transmission of an encrypted rolling code

Aptamer therapeutics useful in the treatment of complement-related disorders

Nucleic acids specifically binding bioactive ghrelin

Methods and compositions for treating macular degeneration

Aptamers to human epidermal growth factor receptor-3

Methods and compositions for treatment of tumors using nucleic acid ligands to platelet-derived growth factor

Antiviral oligonucleotides having a conserved G4 core sequence

NF-kappaB oligonucleotide decoy molecules

Nucleic acid ligands to integrins

Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics

Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same

Methods and compositions for treating ocular disorders

Combinatorial selection of phosphorothioate aptamers for RNases

Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics

Ghrelin binding nucleic acids

Agglomeration protein cascades, compositions and methods regarding the same

Ghrelin binding nucleic acids

Oligonucleotide mimetics

Nucleic acid ligands and uses therefor

High affinity oligonucleotide ligands to growth factors

Cross reactive arrays of three-way junction sensors for steroid determination

Methods for identifying small molecules that bind specific RNA structural motifs

Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics

Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics

CGRP binding nucleic acids

Modular aptametric sensors without covalently attached fluorophores

Nucleic acid inhibitors of glutamate receptors

DNA-based aptamers for human cathepsin G

RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)

Antiviral oligonucleotides

Decoy compositions for treating and preventing brain diseases and disorders

Aptamer-mediated regulation of gene expression

Use of mob-5 in pain

RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)

High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens

Cytotoxic agents

Aptamer therapeutics useful in the treatment of complement-related disorders

Tenascin-C nucleic acid ligands

Trap-tagging: a novel method for the identification and purification of rna-protein complexes

Systematic evolution of ligands by exponential enrichment: Chemi-SELEX

Aptamer regulated nucleic acids and uses thereof

High affinity TGFbeta nucleic acid ligands and inhibitors

Regulated aptamer therapeutics

High affinity nucleic acid ligands of complement system proteins

Devices coated with substances which mediate the adhesion of biological material

Method of immobilizing nucleic acid aptamers

Omega-amino-PEG-phosphoramidites and conjugates thereof

Methods and reagents for detecting target binding by nucleic acid ligands

Modulators of coagulation factors

Controlled modulation of the pharmacokinetics and biodistribution of aptamer therapeutics

Branched and multi-chain nucleic acid switches for sensing and screening

Aptamer therapeutics useful in the treatment of complement-related disorders

Aptamer-nanoparticle conjugates and method of use for target analyte detection

Aptamer capable of specifically adsorbing to verotoxin-1 and method for obtaining the aptamer

Modified L-nucleic acid

Modular design and construction of nucleic acid molecules, aptamer-derived nucleic acid constructs, RNA scaffolds, their expression, and methods of use

Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives

RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)

Gene knock-down by intracellular expression of aptamers

Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes

Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein

Identification and use of effectors and allosteric molecules for the alteration of gene expression

RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)

Modulate aptamer and method of detecting target protein by using the same

Aptamer constructs

Polycationic compositions for cellular delivery of polynucleotides

Thio modified aptamer synthetic methods and compositions

Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity

RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)

Immobilized nuckeic acids and uses thereof

RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)

Antiviral oligonucleotides targeting viral families

Therapeutic nucleic acid-3' -conjugates

RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)

Method for inhibiting NF-kappa B signaling and use to treat or prevent human diseases

RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)

NF-kappaB oligonucleotide decoy molecules

RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA)

Aptamers and antiaptamers

RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA)

Antiviral oligonucleotides

RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of cholesteryl ester transfer protein (CEPT) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)

Nucleic acid ligand complexes

RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)

Nucleic acid ligands to the prostate specific membrane antigen

RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA)

Antiviral oligonucleotides targeting viral families

Nucleic acid compositions and methods of introducing nucleic acids into cells

RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)

Aptamers and methods for their in vitro selection and uses thereof

Methods for identifying small molecules that bind specific rna structural motifs

Truncation SELEX method

Functional molecule and process for producing the same

RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA)

RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)

RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)

Modified oligonucleotides for telomerase inhibition

Methods for identifying antimicrobial agents, the agents identified therewith and methods of using same

Sp1 and Sp3 targeted cancer therapies and therapeutics

In vitro selection of aptamer beacons

5'-and 3'-capped aptamers and uses therefor

Signalling aptamer complexes

RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)

Modulate aptamer and method for detecting target protein by using the same

RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)

RNA-based transcriptional regulators

RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)

Riboswitches, methods for their use, and compositions for use with riboswitches

High affinity RNA ligands of basic fibroblast growth factor

Methods and compositions for treating macular degeneration

Platelet derived growth factor (PDGF) nucleic acid ligand complexes

RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)

Cross reactive arrays of three-way junction sensors for steriod determination

FUS proteolysis-targeting chimera, preparation method and applications thereof

Aptamers for binding to a membrane-based lipid

Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers

Functional ligands to colistin

Full-length and truncated anti-coagulant Dabigatran etexilate specific DNA aptamers for electrochemical and fluorescence sensing applications

Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands

Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands

Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands

Aptamers of surface proteins of periodontal pathogens and uses thereof

Electrochemical screening for the selection of DNA aptamers

Programmable alternative splicing devices and uses thereof

Aptamers comprising CPG motifs

Methods for identifying aptamer regulators