109181 ⎘
Structure or type of the nucleic acid; Chemical structure of the base; Modified C 5-Methylcytosine
Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, HAO1) and methods of use thereof
#602Modulation of huntingtin expression
#603Modulation of alpha synuclein expression
#604RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Neuromuscular Disorders
#605Compositions and methods for modulating Tau expression
#606ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#607Compositions and methods for modulating TTR expression
#608METHODS FOR MODULATING MECP2 EXPRESSION
#609Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#610Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#611IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
#612Compositions for modulating expression of C9ORF72 antisense transcript
#613Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#614Compounds and methods for the modulation of proteins
#615Antisense oligonucleotides for modulating HTRA1 expression
#616Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#617COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#618COMPOSITIONS AND METHODS
#619MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
#620EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#621REVERSIR TM COMPOUNDS
#622Methods for treating spinal muscular atrophy
#623Methods and means of generating IL-17 associated antitumor effector cells by inhibition of NR2F6 inhibition
#624ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
#625Conjugated antisense compounds and their use
#626Compositions for modulating C9ORF72 expression
#627ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF
#628Modulation of AGPAT5 expression
#629Modulation of prekallikrein (PKK) expression
#630ANTISENSE COMPOUNDS AND USES THEREOF
#631MODULATION OF APOLIPOPROTEIN C-III EXPRESSION
#632TOLL-LIKE RECEPTOR 9 ANTAGONIST AND METHODS OF USE THEREOF
#633Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#634Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#635PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
#636ISOTOPOLOGUES OF SMAD7 ANTISENSE OLIGONUCLEOTIDES
#637Methods and compositions for treating a subject with a SMAD7 antisense oligonucleotide
#638Polynucleotide agents targeting Serpinc1 (AT3) and methods of use thereof
#639MicroRNA compounds and methods for modulating miR-21 activity
#640IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
#641MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPOPROTEIN LIPASE DEFICIENT (LPLD) POPULATIONS
#642Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof
#643Oligonucleotides for inducing paternal UBE3A expression
#644Compositions and methods for modulating PKK expression
#645Antisense compounds
#646Compositions and methods for decreasing tau expression
#647Compositions for modulating Ataxin 2 expression
#648Methods for modulating Ataxin 2 expression
#649Compositions and methods for modulating growth hormone receptor expression
#650Nucleic acid compounds for binding to complement component 3 protein
#651Compositions and methods for modulating complement factor B expression
#652COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
#653Cancer treatment
#654Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
#655Targeting microRNAS for the treatment of liver cancer
#656Alternative nucleic acid molecules and uses thereof
#657Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#658Methods and compositions for modulating apolipoprotein (a) expression
#659MODULATORS OF GROWTH HORMONE RECEPTOR
#660Modulation of TMPRSS6 expression
#661RNA interference in dermal and fibrotic indications
#662RNA containing modified nucleosides and methods of use thereof
#663Compositions for modulating SOD-1 expression
#664MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#665OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS
#666Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#667MODULATION OF FACTOR 11 EXPRESSION
#668RNA modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
#669METHOD OF TREATING KELOIDS OR HYPERTROPHIC SCARS USING ANTISENSE COMPOUNDS TARGETING CONNECTIVE TISSUE GROWTH FACTOR (CTGF)
#670Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer
#671RNA interference in skin indications
#672System of interdependent anticancer antisense oligonucleotides targeting mRNAs the targets of which are NADPH-dependent, combined with one or more inhibitors of the Pentose Phosphate Pathway to deplete NADPH
#673Short interfering RNA (siRNA) analogues
#674Modulation of prekallikrein (PKK) expression
#675Modulation of transthyretin expression
#676Compositions and their uses directed to huntingtin
#677Methods and compositions for modulating alpha-1 antitrypsin expression
#678Aptamer construct
#679Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#680Multiplex guide RNAs
#681Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
#682Modulation of huntingtin expression
#683COMPOUNDS AND METHODS FOR MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
#684Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#685Compositions for modulating C9ORF72 expression
#686Targeted augmentation of nuclear gene output
#687PERMANENT GENE CORRECTION BY MEANS OF NUCLEOTIDE-MODIFIED MESSENGER RNA
#688Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
#689Compositions for modulating C9ORF72 expression
#690Method for reducing circulating leukocytes in a human subject
#691Reduced size self-delivering RNAI compounds
#692MicroRNA compounds and methods for modulating miR-21 activity
#693Toll-like receptor 9 antagonist and methods of use thereof
#694Modulation of apolipoprotein C-III expression
#695METHODS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#696COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#697MODULATORS OF COMPLEMENT FACTOR B
#698miR-92 inhibitors and uses thereof
#699Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
#700Compositions and methods for modulating angiopoietin-like 3 expression
#701PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
#702Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#703Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
#704Compositions for modulating Tau expression
#705COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS
#706Targeting microRNAs for the treatment of fibrosis
#707OLIGOMERS TARGETING HEXANUCLEOTIDE REPEAT EXPANSION IN HUMAN C9ORF72 GENE
#708Antisense compounds and uses thereof
#709Compositions and methods for modulating apolipoprotein (a) expression
#710Compositions and methods for modulating apolipoprotein C-III expression
#711Compositions and methods
#712Phosphorous-linked oligomeric compounds and their use in gene modulation
#713Compositions and methods for modulating HBV expression
#714Compositions and methods for modulation nucleic acids through nonsense mediated decay
#715Modulation of androgen receptor expression
#716Modulation of dystrophia myotonica-protein kinase (DMPK) expression
#717MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#718COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
#719Modulation of hepatitis B virus (HBV) expression
#720Targeting microRNAs for the treatment of liver cancer
#721DNAI FOR THE MODULATION OF GENES
#722Oral delivery of therapeutically effective LNA oligonucleotides
#723Inhibitors of MYH7B and uses thereof
#724Compositions and methods for modulating Tau expression
#725Methods for monitoring C9ORF72 expression
#726Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#727Oligomers and oligomer conjugates
#728Multiple exon skipping compositions for DMD
#729Multiple exon skipping compositions for DMD
#730Multiple exon skipping compositions for DMD
#731Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#732Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#733METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS
#734Cancer treatment
#735Selective antisense compounds and uses thereof
#736Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#737Multiple exon skipping compositions for DMD
#738Multiple exon skipping compositions for DMD
#739Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#740Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#741Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
#742EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#743Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#744Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#745Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#746Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#747Methods and compositions for modulating apolipoprotein (a) expression
#748SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION
#749COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#750Antisense modulation of PTP1B expression
#751Compositions and methods for modulating angiopoietin-like 3 expression
#752Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#753Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
#754RNA preparations comprising purified modified RNA for reprogramming cells
#755Compositions and their uses directed to huntingtin
#756In vivo gene silencing by chemically modified and stable siRNA
#757MICROMIRs
#758MODULATION OF RENIN-ANGIOTENSIN SYSTEM (RAS) RELATED DISEASES BY ANGIOTENSINOGEN
#759MODULATION OF CD40 EXPRESSION
#760Antisense compounds targeting genes associated with fibronectin
#761Methods of treating kennedy's disease
#762Methods and compositions for inhibition of immune responses and autoimmunity
#763Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
#764Methods for modulating C9ORF72 expression
#765Compositions for modulating C9ORF72 expression
#766MicroRNA compounds and methods for modulating miR-21 activity
#767Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#768Modulation of UBE3A-ATS expression
#769ANTISENSE MODULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR 4 EXPRESSION
#770MODULATION OF APOLIPOPROTEIN (a) EXPRESSION
#771Compositions and methods for modulating HBV expression
#772Modulation of enhancer RNA mediated gene expression
#773Antisense modulation of superoxide dismutase 1, soluble expression
#774OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES
#775Methods and compositions for the inhibition of gene expression
#776Modulation of huntingtin expression
#777METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION
#778RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
#779Antisense modulation of GCCR expression
#780Compositions and methods for modulating hemoglobin gene family expression
#781Compositions and methods for modulating apolipoprotein (a) expression
#782Compositions and methods for modulating apolipoprotein C-III expression
#783Conjugated antisense compounds and their use
#784Antisense modulation of GCGR expression
#785Methods and compositions for modulating alpha-1-antitrypsin expression
#786Engineered nucleic acids and methods of use thereof
#787RNA containing modified nucleosides and methods of use thereof
#788METHODS AND COMPOSITIONS FOR MODULATING FACTOR VII EXPRESSION
#789MODULATION OF RNA BY REPEAT TARGETING
#790RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#791Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1 (MALAT-1) expression
#792Modulation of hepatitis B virus (HBV) expression
#793Conjugated antisense compounds and their use
#794Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#795Modulation of signal transducer and activator of transcription 3 (STAT3) expression
#796Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#797Selective antisense compounds and uses thereof
#798Methods and compounds useful in conditions related to repeat expansion
#799Modulation of TMPRSS6 expression
#800Gapped oligomeric compounds comprising 5′-modified deoxyribonucleosides in the gap and uses thereof
#801Complement antagonists and uses thereof
#802Anti-clusterin monotherapy for cancer treatment
#803Custirsen treatment with reduced toxicity
#804Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#805Clusterin antisense therapy for treatment of cancer
#806Short interfering RNA (siRNA) analogues
#807Antisense modulation of PTP1B expression
#808Methods for modulating factor 12 expression
#809Methods for modulating kallikrein (KLKB1) expression
#810Targeting microRNAs for the treatment of liver cancer
#811Modulation of angiopoietin-like 3 expression
#812Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
#813Connective tissue growth factor antisense oligonucleotides
#814Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#815Antisense compounds targeting genes associated with usher syndrome
#816RNA interference in dermal and fibrotic indications
#817Modulation of hepatitis B virus (HBV) expression
#818Modulation of androgen receptor expression
#819TRPM-2 antisense therapy
#820Antisense modulation of fibroblast growth factor receptor 4 expression
#821Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#822Modulation of alpha synuclein expression
#823Methods for modulating factor 12 expression
#824Modulation of apolipoprotein C-III expression
#825MicroRNA compounds and methods for modulating miR-21 activity
#826Compounds and methods for modulating interaction between proteins and target nucleic acids
#827Compositions and their uses directed to huntingtin
#828Antisense modulation of fibroblast growth factor receptor 4 expression
#829Antagonat compositions and methods of use
#830RNA containing modified nucleosides and methods of use thereof
#831Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#832Compositions and their uses directed to huntingtin
#833In vivo gene silencing by chemically modified and stable siRNA
#834Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
#835Antisense modulation of GCGR expression
#836Compositions and methods for modulation of SMN2 splicing
#837MODULATION OF GLUCOSE-6-PHOSPHATASE TRANSLOCASE EXPRESSION
#838Modulation of growth hormone receptor expression and insulin-like growth factor expression
#839Selective reduction of allelic variants
#840Modulation of Hepatitis B virus (HBV) expression
#841Modulation of forkhead box O1A expression
#842DOSING REGIMENS FOR TREATING AND PREVENTING OCULAR DISORDERS USING C-RAF ANTISENSE
#843Modulation of angiopoietin-like 3 expression
#844Oral delivery of therapeutically effective LNA oligonucleotides
#845TRPM-2 antisense therapy
#846LNA OLIGONUCLEOTIDES AND THE TREATMENT OF CANCER
#847COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
#848MODULATION OF APOLIPOPROTEIN(A) EXPRESSION
#849Targeting microRNAs for the treatment of liver cancer
#850MODULATION OF HEPATITIS B VIRUS (HBV) EXPRESSION
#851Modulation of glucagon receptor expression
#852RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF HER3
#853Proinflammatory nucleic acids
#854Antisense modulation of PTP1B expression
#855Method of inhibiting miR-33 using a modified oligonucleotide
#856Modulation of eIF4E expression
#857Modulation of signal transducer and activator of transcription 3 (STAT3)expression
#858MODULATION OF TTC39 EXPRESSION TO INCREASE HDL
#859Oligomeric compounds for the modulation of HIF-1A expression
#860Modulation of huntingtin expression
#861Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (CTGF)
#862ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
#863MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 1 EXPRESSION
#864Methods for slowing familial ALS disease progression
#865MODULATION OF FACTOR 7 EXPRESSION
#866COMPOSITIONS AND METHODS FOR THE MODULATION OF JNK PROTEINS
#867Antisense oligonucleotide modulation of STAT3 expression
#868MODULATION OF SGLT-2 EXPRESSION
#869ANTISENSE INHIBITION VIA RNASE H-INDEPENDENT REDUCTION IN MRNA
#870Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#871ANTISENSE OLIGONUCLEOTIDE MODULATION OF RAF GENE EXPRESSION
#872MODULATION OF TRANSTHYRETIN EXPRESSION
#873ANTISENSE OLIGONUCLEOTIDES (ODN) AGAINST SMAD7 AND USES THEREOF IN MEDICAL FIELD
#874Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
#875Antisense oligomers targeting PCSK9
#876Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#877Modulation of STAT 6 expression
#878COMPOSITIONS AND THEIR USES DIRECTED TO HEPCIDIN
#879ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
#880METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION
#881MODULATION OF INFLAMMATORY RESPONSES BY FACTOR XI
#882Antisense modulation of C-reactive protein expression
#883Antisense modulation of PTP1B expression
#884METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES
#885Treatment of neurological disorders by dsRNA administration
#886Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#887Reduced size self-delivering RNAi compounds
#888Method for inhibiting the activity of mir-155
#889Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#890Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#891Antisense Oligonucleotides for Inducing Exon Skipping and Methods of Use Thereof
#892Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#893Antisense modulation of superoxide dismutase 1, soluble expression
#894Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#895Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#896ANTISENSE MODULATION OF CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION
#897COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION
#898RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF EXPRESSION OF MITOCHONDRIAL GLYCEROL-3 PHOSPHATE ACYLTRANSFERASE 1 (MTGPAT1)
#899LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR
#900SNPs of apolipoprotein B and modulation of their expression