109193 ⎘
Structure or type of the nucleic acid; Chemical structure; Nature of the modification Conjugate
Compositions comprising an internalizing nucleic acid molecule, and their methods of use
#1202Polynucleotide agents targeting Serpinc1 (AT3) and methods of use thereof
#1203Antibody-siRNA conjugates and uses therefor
#1204UREIDOPYRIMIDONE SUPRAMOLECULAR COMPLEXES FOR COMPOUND DELIVERY INTO CELLS
#1205PDGFR RNA aptamers
#1206DNA aptamers against cancer and uses thereof in delivery of therapy and diagnosis of cancer
#1207Means and Methods for the Treatment of Nephropathy
#1208Twist signaling inhibitor compositions and methods of using the same
#1209Tetragalnac containing conjugates and methods for delivery of oligonucleotides
#1210RNA aptamers against transferrin receptor (TFR)
#1211MicroRNA compounds and methods for modulating miR-122
#1212Antagonistic PD-1 aptamer and its applications in cancer therapy related applications
#1213Antagonistic CTLA-4 aptamers and applications thereof in enhancing immune activity
#1214Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof
#1215Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
#1216Oligomers
#1217Antisense compounds targeting apolipoprotein E receptor 2
#1218Oligonucleotides for inducing paternal UBE3A expression
#1219Angiotensinogen (AGT) iRNA compositions and methods of use thereof
#1220Exosomal loading using hydrophobically modified oligonucleotides
#1221Compositions and methods for modulating PKK expression
#1222Antisense compounds
#1223Compositions and methods for modulating growth hormone receptor expression
#1224DNAzyme-nanoparticle conjugates and methods of use thereof
#1225Compositions and methods for modulating complement factor B expression
#1226Methods and compositions for treating a Serpinc1-associated disorder
#1227COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
#1228Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
#1229Compositions and methods for inhibiting expression of RRM2 genes
#1230Double-stranded oligonucleotides
#1231Organic compositions to treat APOC3-related diseases
#1232Nucleic acid functionalized nanoparticles for therapeutic applications
#1233Stabilised formulations of RNA
#1234Double-stranded oligo RNA targeted to amphiregulin and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases
#1235Aptamers against EGFR and therapeutic uses thereof
#1236Modified oligonucleotides for telomerase inhibition
#1237LINKAGE MODIFIED GAPPED OLIGOMERIC COMPOUNDS AND USES THEREOF
#1238Small molecules that enhance the activity of oligonucleotides
#1239Multifunctional RNA nanoparticles and methods of use
#1240REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
#1241Optimization method of a polynucleotide sequence
#1242Serpina1 iRNA compositions and methods of use thereof
#1243Double-stranded RNA conjugates and their use
#1244Aptamer conjugates with N-heterocyclic carbene metal complexes for targeted drug delivery
#1245Monomers and oligonucleotides comprising cycloaddition adduct(s)
#1246Compounds and methods for trans-membrane delivery of molecules
#1247Compounds and methods for enhanced cellular uptake
#1248Compositions and methods for inhibiting gene expression of LPA
#1249Diblock copolymers and polynucleotide complexes thereof for delivery into cells
#1250Carrier nanoparticles and related compositions, methods and systems
#1251COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
#1252Colorectal cancer drug, and method for predicting prognosis of colorectal cancer patient
#1253RNAi-Mediated Inhibition of Frizzled Related Protein-1 for Treatment of Glaucoma
#1254RNA sequence having anti-tumour activity
#1255Polyethyleneimine polyethyleneglycol vectors
#1256RNA interference in dermal and fibrotic indications
#1257Targeting microRNAs for metabolic disorders
#1258RNA-interference by single-stranded RNA molecules
#1259Metal-particle-based oral-administrating liver-specific nucleic acid delivery system and method of manufacturing the same
#1260METHODS FOR TREATMENT OF DISORDERS IN THE FRONT OF THE EYE UTILIZING NUCLEIC ACID MOLECULES
#1261OLIGONUCLEOTIDE SPECIFIC UPTAKE OF NANOCONJUGATES
#1262Linkage modified oligomeric compounds
#1263Bioactive conjugates for oligonucleotide delivery
#1264NANOPARTICLES FOR TARGETED GENE THERAPY AND METHODS OF USE THEREOF
#1265MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#1266NEAT1 as a prognostic marker and therapeutic target for prostate cancer
#1267OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS
#1268Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#1269COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
#1270Isatoic anhydride derivatives and applications thereof
#1271SPECIFIC VIRUS-LIKE PARTICLE-CpG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
#1272Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#1273Multivalent oligonucleotide assemblies
#1274RNAi agents modified at the 4′-C position
#1275Small molecule conjugates for intracellular delivery of biologically active compounds
#1276Pharmaceutical compositions for high-capacity targeted delivery
#1277Modulation of prekallikrein (PKK) expression
#1278RNAi inhibition of alpha-ENaC expression
#1279Modified L-Nucleic Acid
#1280Functionally-modified oligonucleotides and subunits thereof
#1281Oligonucleotide-ligand conjugates and process for their preparation
#1282RNAi-Mediated Inhibition of Tumor Necrosis Factor Alpha-Related Conditions
#1283Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
#1284Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
#1285Triptolide derivatives and preparation method and use thereof
#1286Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
#1287SDF-1 binding nucleic acids and the use thereof in cancer treatment
#1288RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
#1289Targeted therapeutic nucleosides and their use
#1290Compositions and methods for inhibiting gene expression of Hif2alpha
#1291Saccharide-modified nucleic acid molecules
#1292STAT3 inhibitors and uses thereof
#1293MicroRNA compounds and methods for modulating miR-21 activity
#1294SDF-1 binding nucleic acids and the use thereof
#1295Double-stranded polyC:poly(G/I) RNA for immunostimulation and cancer treatment
#1296SYSTEM FOR CO-DELIVERY OF POLYNUCLEOTIDES AND DRUGS INTO PROTEASE-EXPRESSING CELLS
#1297High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
#12983′end caps for RNAi agents for use in RNA interference
#1299Complement component iRNA compositions and methods of use thereof
#1300COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MYLIP/IDOL GENE
#1301EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#1302Methods for Treating or Preventing Ophthalmological Conditions
#1303APOB Antisense Conjugate Compounds
#1304Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos
#1305MODIFIED DNA QUADRUPLEX-FORMING OLIGONUCLEOTIDES AND METHODS OF USE
#1306MAGNETIC INORGANIC IRON-BASED NANOPARTICLES
#1307Chemical reagents for attaching affinity molecules on surfaces
#1308Multi-arm biodegradable polymers for nucleic acid delivery
#1309Organic compositions to treat beta-ENaC-related diseases
#1310Compositions and methods for inhibiting gene expression of factor XII
#1311Disulfide-containing alkyne linking agents
#1312METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
#1313Compositions and methods for inhibiting expression of the LECT2 gene
#1314RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
#1315Suicide contrast agents targeting HIV reservoirs for theranostic eradication
#1316Small molecule-dependent split aptamer ligation
#1317POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS
#1318Bio-sensor for the detection of small molecules
#1319Hepcidin Binding Nucleic Acids
#1320MicroRNA compounds and methods for modulating miR-122
#1321Antisense compounds targeting genes associated with cystic fibrosis
#1322Compositions and methods for inhibiting expression of the ALAS1 gene
#1323Complement component C5 iRNA compositions and methods of use thereof
#1324RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1325Formats for organic compounds for use in RNA interference
#1326Modulation of apolipoprotein C-III expression
#1327Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
#1328COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#1329Particles with multiple functionalized surface domains
#1330Hypoxia-Targeted Delivery System for Pharmaceutical Agents
#1331Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
#1332Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
#1333Organic compounds to treat hepatitis B virus
#1334MCP-1 binding nucleic acids
#1335Complex containing oligonucleotide having immunopotentiating activity and use thereof
#1336METHODS OF USE OF SPHINGOLIPID POLYALKYLAMINE OLIGONUCLEOTIDE COMPOUNDS
#1337Block copolymers
#1338Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method
#1339COMPOSITIONS AND METHODS FOR MODULATING EXPRESSION OF FRATAXIN
#1340RNA APTAMERS FOR THERAPEUTIC AND DIAGNOSTIC DELIVERY TO PANCREATIC CANCER CELLS
#1341SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOREGULATORY AGENTS
#1342Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#1343Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#1344Compositions and methods for modulating angiopoietin-like 3 expression
#1345Antisense oligonucleotides with improved pharmacokinetic properties
#1346Compositions and methods for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
#1347COMPOSITIONS AND METHODS FOR TREATING BONE CONDITIONS
#1348Antisense molecules for treatment of infection
#1349Antisense molecules and methods for treating pathologies
#1350System for delivering therapeutic agents into living cells and cells nuclei
#1351Sphingolipid-polyalkylamine-oligonucleotide compounds
#1352METHOD FOR CELL MEMBRANE PERMEATION FOR COMPOUND
#1353NOVEL COMPOUNDS
#1354COMPOUND ADMINISTRATION PRECURSOR AND MEDICAMENT CARRIER PREPARATION
#1355Low density lipoprotein receptor-mediated siRNA delivery
#1356TMPRSS6 iRNA compositions and methods of use thereof
#1357NANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF
#1358Compositions and methods for inhibiting expression of TMPRSS6 gene
#1359LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME
#1360Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure
#1361Oligonucleotide conjugates
#1362Method for purifying active GLA-domain coagulation proteins
#1363Double-stranded antisense nucleic acid with exon-skipping effect
#1364Reduced size self-delivering RNAi compounds
#1365Screening of nucleic acid agents via particle display
#1366Compounds and methods for trans-membrane delivery of molecules
#1367RESPIRATORY DISEASE-RELATED GENE SPECIFIC SIRNA, DOUBLE-HELICAL OLIGO RNA STRUCTURE CONTAINING SIRNA, COMPOSITON CONTAINING SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASE
#1368COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS
#1369COMPOSITIONS AND METHODS FOR MODULATING FOXP3 EXPRESSION
#1370Method of nonspecific target capture of nucleic acids
#1371COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
#1372Lipid encapsulating interfering RNA
#1373Compositions and methods for inhibiting expression of the ALAS1 gene
#1374Hydrophobically modified antisense oligonucleotides comprising a triple alkyl chain
#1375Complement component C5 iRNA compositions and methods of use thereof
#1376Compounds and methods for trans-membrane delivery of molecules
#1377Methods and compositions for templated assembly of nucleic acid specific heterocompounds
#1378Compositions and methods for modulating apolipoprotein (a) expression
#1379Compositions and methods for modulating apolipoprotein C-III expression
#1380Non-immunogenic and nuclease resistant nucleic acid origami devices and compositions thereof
#1381Modified TGF-beta oligonucleotides
#1382Compositions and methods
#1383Compositions and methods for modulating HBV expression
#1384Hydrazinyl lipidoids and uses thereof
#1385Modified TGF-beta2 oligonucleotides
#1386Method for evaluating redox activity of nucleic acid molecule and nucleic acid molecule having redox activity
#1387MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
#1388Anti-tumor compositions and methods
#1389RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1390Biocompatible infinite coordination polymer nanoparticle-nucleic acid conjugates for antisense gene regulation
#1391Structure and use of 5′ phosphate oligonucleotides
#1392Targeting microRNAs for metabolic disorders
#1393Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof
#1394Long interfering nucleic acid duplexes targeting multiple RNA targets
#1395Modified TGF-beta oligonucleotide for use in a method of preventing and/or treating an ophthalmic disease
#1396EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#1397COMPOSITIONS AND METHODS FOR DELIVERING THERAPEUTIC AND IMAGING AGENTS TO THE SINUSES AND MIDDLE EAR
#1398Compositions and methods for modulating Tau expression
#1399ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES
#1400Fatty acids and their use in conjugation to biomolecules
#1401Oligomers
#1402LNA antisense oligonucleotides for the modulation of Myc expression
#1403PCSK9 iRNA compositions and methods of use thereof
#1404Serpinc1 iRNA compositions and methods of use thereof
#1405Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#1406Lipohillic oligonucleotide analogs
#1407CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
#1408Oligomers and oligomer conjugates
#1409Organic compositions to treat EPAS1-related diseases
#1410METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS
#1411Compositions and methods for modulation of SMN2 splicing in a subject
#1412Nanoparticles stabilized with nitrophenylboronic acid compositions
#1413Selective antisense compounds and uses thereof
#1414Modified oligonucleotides for telomerase inhibition
#1415Treatment of metastatic tumors
#1416EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY
#1417ECF-BINDING AGENTS AND USES THEREOF
#1418Aptamer against midkine and applications thereof
#1419Peptide-based in vivo siRNA delivery system
#1420Polyvalent RNA-nanoparticle compositions
#1421Methods and compositions involving miRNA and miRNA inhibitor molecules
#1422Methods and compositions involving miRNA and miRNA inhibitor molecules
#1423Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
#1424Methods and compositions to modulate RNA processing
#1425Splice modulating oligonucleotides that inhibit cancer
#1426Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#1427Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#1428Modified oligonucleotides for telomerase inhibition
#1429Modified oligonucleotides for telomerase inhibition
#1430Compositions and methods for functional nucleic acid delivery
#1431Compositions and methods for modulating angiopoietin-like 3 expression
#1432Disulfide masked prodrug compositions and methods
#1433Compositions and methods for modulation of FGFR3 expression
#1434Aptamers, multimeric aptamers and uses thereof
#1435Inhibitory oligonucleotide and use thereof
#1436MICROMIRs
#1437SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
#1438ANTI APOB ANTISENSE CONJUGATE COMPOUNDS
#1439RNAi inhibition of alpha-ENaC expression
#1440METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#1441METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#1442Poly(vinyl ester) polymers for in vivo nucleic acid delivery
#1443Polymeric nanoparticles
#1444Carboxylated polyamine derivatives as transfection reagents
#1445Organic compositions to treat beta-ENaC-related diseases
#1446Oligonucleotide conjugates
#1447POLYMER CONJUGATES FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
#1448Triazine cationic polymers and methods of use thereof
#1449RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1450BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY
#1451Nucleic acid functionalized nonoparticles for therapeutic applications
#1452Hydroxylated polyamine derivatives as transfection reagents
#1453Complement component C5 iRNA compositions and methods of use thereof
#1454Methods and compositions for treating cancer
#1455Polynucleotides having bioreversible groups
#1456SDF-1 binding nucleic acids
#1457Glucagon Binding Nucleic Acids
#1458Methods for use in modulating miR-122A
#1459POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
#1460Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
#1461Anandamide-modified nucleic acid molecules
#1462CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
#1463Tetragalnac containing conjugates and methods for delivery of oligonucleotides
#1464EpCAM aptamer for detection of cancer stem cells
#1465RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells
#1466Modified RNAi agents
#1467Carbohydrate conjugated RNA agents and process for their preparation
#1468Nucleic acid complexes
#1469Methods and compositions for treating prostate cancer
#1470Ligand-conjugated monomers
#1471COMPOSITIONS AND METHODS FOR MODULATING APOA1 AND ABCA1 EXPRESSION
#1472Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
#1473Use of nanodiamonds for generating free radicals for therapeutic purposes under radiation
#1474Oligomeric compounds and methods
#1475Methods for treating hypercholesterolemia
#1476Particle-nucleic acid conjugates and therapeutic uses related thereto
#1477Lipid formulations
#1478COMPOSITIONS AND METHODS FOR MODULATING PTEN EXPRESSION
#1479Compositions and methods for modulating ATP2A2 expression
#1480Aptamer therapeutics useful in the treatment of complement-related disorders
#1481Oligonucleotide compounds comprising non-nucleotide overhangs
#1482Methods of treating vascular inflammatory disorders
#1483RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1484Sugar chain-containing polymer, and sugar chain-containing polymer complex
#1485STABILIZED APTAMERS TO PLATELET DERIVED GROWTH FACTOR AND THEIR USE AS ONCOLOGY THERAPEUTICS
#1486COMPOSITIONS AND METHODS FOR MODULATING BDNF EXPRESSION
#1487Compositions and methods for modulating apolipoprotein (a) expression
#1488Compositions and methods for modulating apolipoprotein C-III expression
#1489Conjugated antisense compounds and their use
#1490Methods for delivery to the central nervous system of nucleic acid nanoparticles to treat central nervous system disorders
#1491Compositions and methods for inhibiting expression of the ALAS1 gene
#1492Composition for gene delivery
#1493MicroRNA compounds and methods for modulating miR-122
#1494Compositions and methods for modulating UTRN expression
#1495RNA-interference by single-stranded RNA molecules
#1496Boronic acid conjugates of oligonucleotide analogues
#1497Micro-RMA inhibitor
#1498Functionalized fluorine containing phthalocyanine molecules
#1499Glycoconjugates of RNA interference agents
#1500BRANCHED POLYMERS