109207 ⎘
Structure or type of the nucleic acid; Chemical structure; Nature of the modification linked to the nucleic acid via an atom other than carbon Halogen
5-HALOURACIL-MODIFIED MICRORNAS AND THEIR USE IN THE TREATMENT OF CANCER
#217ß-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#3INHIBITORS OF EXPRESSION AND/OR FUNCTION
#4HIGH MOBILITY GROUP BOX-1 (HMGB1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
#5Antisense Nucleic Acids
#6TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES
#7RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
#8COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#9COMPOSITIONS AND METHODS FOR INHIBITING COMPLEMENT COMPONENT 3 EXPRESSION
#10NOVEL THERAPEUTIC DELIVERY MOIETIES AND USES THEREOF
#11CRISPR-BASED COMPOSITIONS AND METHODS OF USE
#12TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#13GLUCOKINASE (GCK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#14COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#15MODIFIED NUCLEIC ACIDS, HYBRID GUIDE RNAS, AND USES THEREOF
#16DEFINED MULTI-CONJUGATES OLIGONUCLEOTIDES
#17METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS
#185-HALOURACIL-MODIFIED MICRORNAS AND THEIR USE IN THE TREATMENT OF CANCER
#19SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#20Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#21COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#22RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA)
#23Defined multi-conjugates oligonucleotides
#24COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
#25HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP/VIGILIN) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#26TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#27ANTISENSE NUCLEIC ACIDS
#28OLIGONUCLEOTIDES FOR HTT-1A MODULATION
#29Bi specific aptamer
#30CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF
#3117ß-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13) iRNA Compositions And Methods Of Use Thereof
#32GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
#33Aptamer therapeutics useful in the treatment of complement-related disorders
#34MINIATURIZED HAIRPIN RNAi TRIGGERS (mxRNA) AND METHODS OF USES THEREOF
#35TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#36SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#37Glucokinase (GCK) iRNA compositions and methods of use thereof
#38TMPRSS6 iRNA compositions and methods of use thereof
#39COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#40TMPRSS6 iRNA compositions and methods of use thereof
#41Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#42RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (SINA)
#43HIGH MOBILITY GROUP BOX-1 (HMGB1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
#44TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#45SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#46COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#47Antisense nucleic acids
#48Myostatin iRNA compositions and methods of use thereof
#49Methods of reducing expression of x-inactivation escapee genes and autosomal genes
#50Modified nucleic acids, hybrid guide RNAs, and uses thereof
#51Compositions and methods for modulation of IKBKAP splicing
#52MODIFIED CRISPR RNA AND USES THEREOF
#53METHODS FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES USING TRANSTHYRETIN (TTR) iRNA COMPOSITIONS
#54Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#55Bi-specific aptamer
#56TMPRSS6 iRNA compositions and methods of use thereof
#57MOLECULAR RE-ENGINEERING OF EXCITATION-INHIBITION BALANCE IN MEMORY CIRCUITS
#58COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#59TMPRSS6 iRNA compositions and methods of use thereof
#60Aptamer therapeutics useful in the treatment of complement-related disorders
#61Allele-specific gene suppression
#62GLP-1 Receptor Ligand Moiety Conjugated Oligonucleotides and Uses Thereof
#63COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
#64Defined multi-conjugate oligonucleotides
#65Pharmaceutical Composition
#665-halouracil-modified microRNAs and their use in the treatment of cancer
#67TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#68Modified RNAi agents
#69High density lipoprotein binding protein (Hdlbp/Vigilin) iRNA compositions and methods of use thereof
#70RNA interference in dermal and fibrotic indications
#71Compositions and methods for modulation of IKBKAP splicing
#72RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
#73Serpina1 iRNA compositions and methods of use thereof
#74Methods of reducing expression of X-inactivation escapee genes and autosomal genes
#75RIG-I ligands and methods for producing them
#76Compositions and Methods for Inhibiting Gene Expression of Alpha-1 AntiTrypsin
#77Notch 1 specific siRNA molecule
#78Modified TGF-beta oligonucleotides
#79Compositions and methods for inhibiting gene expression of Hif2alpha
#80Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
#81COMPOUNDS AND METHODS FOR MODULATING TARGET NUCLEAR AND SUB-NUCLEAR NUCLEIC ACID MOLECULES IN CELLS AND ANIMALS
#82Micromirs
#832′ fluoro-modified RNAs as immunostimulators
#84Glucokinase (GCK) iRNA compositions and methods of use thereof
#85RNA interference mediated inhibition of hepatitis B Virus (HBV) gene expression using short interfering nucleic acid (siNA)
#86Pharmaceutical Composition
#87CRISPR-BASED COMPOSITIONS AND METHODS OF USE
#88RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#89UNA oligomers and compositions for treating amyloidosis
#90Compositions and methods for inhibiting expression of the LECT2 gene
#91Antisense compounds targeting genes associated with cystic fibrosis
#92Short interfering nucleic acid (siNA) compositions
#93RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA)
#94Oligonucleotide compounds for targeting huntingtin mRNA
#95TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#96MODIFIED TGF-BETA2 OLIGONUCLEOTIDES
#97Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
#98RNA interference mediated therapy for neurodegenerative diseases
#99Compositions and methods for modulating Tau expression
#100Composition for treating cancer associated with HPV infection
#101Compositions and methods for inhibiting expression of the ALAS1 gene
#102APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
#103Disulfide-containing alkyne linking agents
#104TMPRSS6 iRNA compositions and methods of use thereof
#105Selective Reactivation of Genes on the Inactive X Chromosome
#106Post-selec modification methods
#107RAS exon 2 skipping for cancer treatment
#108TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#109Antisense compounds targeting apolipoprotein E receptor 2
#110Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
#111Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#112Molecular re-engineering of excitation-inhibition balance in memory circuits
#113RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
#114Compositions and methods for inhibiting expression of the LECT2 gene
#115RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION
#116SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#117Antisense compounds targeting genes associated with cystic fibrosis
#118Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#119Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#120Compositions and methods for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
#121RIG-I ligands and methods for producing them
#122TMPRSS6 iRNA compositions and methods of use thereof
#123Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure
#124Cell-specific internalizing RNA aptamers against human CCR5 and uses therefore
#125Aptamer to IL-17 and use thereof
#126Selection of RNA-aptamers as anti-malaria agents
#127Selection of RNA-aptamers as anti-malaria agents
#128DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#129Composition for treating cancer associated with HPV infection
#130RNA TARGETED TO BETA CATENIN
#131RIG-I ligands and methods for producing them
#132Neutralizing RNA aptamers
#133Selective reactivation of genes on the inactive X chromosome
#134Aptamer therapeutics useful in the treatment of complement-related disorders
#135Methods for Treating or Preventing Ophthalmological Conditions
#136Methods and compounds useful in conditions related to repeat expansion
#137Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
#138Oligonucleotides for modulation of target RNA activity
#139Subunit-selective nucleic acid inhibitors of glutamate receptors
#140Compounds and methods for modulating interaction between proteins and target nucleic acids
#141RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA)
#142DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#143Aptamer therapeutics useful in the treatment of complement-related disorders
#144Modulation of eIF4E expression
#145Reversible platelet inhibition
#146Duplex oligonucleotides with enhanced functionality in gene regulation
#147Antisense oligonucleotides for inhibition of microRNA-21
#148Lipid formulation
#149Aptamer for chymase, and use thereof
#150Potent anti APOB antisense compounds
#151METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES
#152NUCLEIC ACID MODULATORS OF CLEC-2
#153Pharmaceutical Composition
#154RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
#155Lipids and compositions for the delivery of therapeutics
#156miR-33 INHIBITORS AND USES THEREOF
#157RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA)
#158Short interfering ribonucleic acid (siRNA) for oral administration
#159Short interfering ribonucleic acid (siRNA) for oral administration
#160RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA)
#161RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
#162Short interfering ribonucleic acid (siRNA) for oral administration
#163RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
#164Optimized Methods For Delivery Of DSRNA Targeting The PCSK9 Gene
#165Nucleic acid aptamers
#166RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
#167RNA Interference Mediated Inhibition of the Intercellular Adhesion Molecule 1 (ICAM-1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
#168RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA)
#169RNA interference mediated inhibition of the FCεR1α gene
#170TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#171Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
#172Aptamer therapeutics useful in the treatment of complement-related disorders
#173DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#174Chimeric oligomeric compounds for modulation of splicing
#175CCR2 INHIBITORS FOR TREATING CONDITIONS OF THE EYE
#176RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA)
#177Selection of RNA-aptamers as anti-malaria agents
#178Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon
#179Lipid formulation
#180RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
#181MicromiRs
#182Pharmaceutical composition comprising anti-mirna antisense oligonucleotide
#183Combination treatment for the treatment of hepatitis C virus infection
#184Molecular targeting agents
#185Chemically modified oligonucleotides for use in modulation micro RNA and uses thereof
#186Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
#187RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#188Methods and Compositions for Prevention or Treatment of RSV Infection Using Modified Duplex RNA Molecules
#189MODULATION OF eIF4E EXPRESSION
#190COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENES
#191COMPOUNDS AND METHODS FOR MODULATING PROTEIN EXPRESSION
#192Short interfering ribonucleic acid (siRNA) with improved pharmacological properties
#193Optimized Methods For Delivery Of DSRNA Targeting The PCSK9 Gene
#194COMPOSITIONS AND METHODS FOR SPECIFICALLY SILENCING A TARGET NUCLEIC ACID
#195Pharmaceutical Composition
#196CONJUGATED DOUBLE STRAND COMPOSITIONS FOR USE IN GENE MODULATION
#197Silencing of polo-like kinase expression using interfering RNA
#198Compositions and methods for delivering RNAI using lipoproteins
#199RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA)
#2002' Deoxy-2'-Alkylnucleotide Containing Nucleic Acid
#201Duplex oligonucleotides with enhanced functionality in gene regulation
#2022'-Modified Oligonucleotides
#203Modulation of eIF4E expression
#204RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA)
#205MicroRNAs
#206RNA Interference Mediated Inhibition of Acetyl-CoA-Carboxylase Gene Expression Using Short Interfering Nucleic Acid (siNA)
#207RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#208Lipophilic conjugated iRNA agents
#209POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION
#2102'-MODIFIED OLIGONUCLEOTIDES
#211Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
#212Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
#213Modulation of eIF4E expression
#214Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
#215Nucleic acid ligands to integrins
#216Synthesis, deprotection, analysis & purification of RNA & ribozymes
#2172'-deoxy-2'alkylnucleotide containing nucleic acid
#218Aptamer therapeutics useful in the treatment of complement-related disorders
#219Double stranded constructs comprising one or more short strands hybridized to a longer strand
#220Polymearase III-based expression of therapeutic RNAs
#221RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#222RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#223Gapped 2' modified oligonucleotides
#224RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
#225Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
#226Binding and catalytic molecules built from expanded DNA