109218 ⎘
Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
High Throughput Cell-Based Screening For Aptamers
#2TREATMENT OF THYMIC STROMAL LYMPHOPOIETIN (TSLP) RELATED DISEASES BY INHIBITION OF LONG-FORM TSLP TRANSCRIPTS
#3METHODS FOR IDENTIFYING TREATMENT TARGETS BASED ON MULTIOMICS DATA
#4CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#5DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
#6CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#7TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT
#8DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
#9CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#10OVERSUBSCRIPTION SCHEDULING
#11Oligonucleotides
#12USE OF APTAMERS IN PROTEOMICS
#13Materials and Methods for Treatment of Hemoglobinopathies
#14Genome Wide Screen of RNAi Molecules
#15Materials and Methods for Treatment of Human Genetic Diseases Including Hemoglobinopathies
#16EXON SKIPPING OLIGOMERS AND OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY
#17Oligonucleotides
#18METHODS FOR PRODUCTION AND QUANTIFICATION OF UNIQUE MOLECULAR IDENTIFIER-LABELED BEADS
#19Deoxyribozymes Generating Chemiluminescent Signals
#20DNA APTAMER SPECIFICALLY BINDING TO METHYLATED DNA FRAGMENT AND SELECTION METHOD AND USE THEREOF
#21METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
#22PROGRAMMABLE CAS9-RECOMBINASE FUSION PROTEINS AND USES THEREOF
#23RELIABLE IDENTIFICATION OF REGIONS ('A SITES') IN COMPLEX RNA MOLECULES THAT ARE ACCESSIBLE TO NUCLEIC ACIDS OR COMPLEXES OF NUCLEIC ACIDS WITH ENDONUCLEASES
#24Deoxyribozymes Generating Chemiluminescent Signals
#25A SCREENING PLATFORM FOR ADAR-RECRUITING GUIDE RNAS
#26CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING
#27METHODS AND COMPOSITIONS FOR TREATING EPILEPSY
#28DNA-ENCODED AND AFFINITY-TAGGED MASKED-WARHEAD COMPOUNDS AND USE THEREOF IN ASSEMBLING LIBRARIES OF SMALL MOLECULES ENABLED FOR LATE-STAGE PURIFICATION AND MULTIPLEXED SCREENING OF COVALENT LIGANDS
#29Effect of Fuel Doping in ICF Targets
#30COMPOSITIONS AND METHODS FOR INHIBITING GYS2 EXPRESSION
#31COMPOUNDS AND METHODS FOR REDUCING IFNAR1 EXPRESSION
#32BIALLELIC KNOCKOUT OF SARM1
#33NUCLEIC ACID MOLECULE FOR TREATING THROMBOCYTOPENIA AND APPLICATION THEREOF
#34Optimised Methods for Cleavage of Target Sequences
#35Oligonucleotides and methods for preparing
#36TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS
#37COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
#38TREATMENT OF THYMIC STROMAL LYMPHOPOIETIN (TSLP) RELATED DISEASES BY INHIBITION OF LONG-FORM TSLP TRANSCRIPTS
#39High Throughput Cell-Based Screening for Aptamers
#40METHODS FOR THE TREATMENT OF TRINUCLEOTIDE REPEAT EXAPNSION DISORDERS ASSOCIATED WITH OGG1 ACTIVITY
#41APOLIPOPROTEIN B ANTAGONIST
#42Compounds and methods for reducing IFNAR1 expression
#43LIGHT-INDUCIBLE CRISPR/CAS9 SYSTEM FOR GENOME EDITING
#44PPM1A INHIBITORS AND METHODS OF USING SAME
#45CRISPR enabled multiplexed genome engineering
#46EVALUATION OF CAS9 MOLECULE/GUIDE RNA MOLECULE COMPLEXES
#47Use of aptamers in proteomics
#48Methods and Compositions for Selecting siRNA of Improved Functionality
#49COMPOSITIONS AND METHODS FOR CLL1 MODIFICATION
#50COMPOSITIONS AND METHODS FOR INHIBITING PCSK9
#51COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
#52MATERIALS AND METHODS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
#53RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA)
#54VIVO GUIDE RNA LIBRARIES AND METHODS OF MAKING THE SAME
#55Systems and Methods for Designing RNA Nanostructures and Uses Thereof
#56OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
#57CRISPR GUIDE SELECTION
#58Methods for production and quantification of unique molecular identifier-labeled beads
#59Oversubscription scheduling
#60METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF CYP27A1
#61Compositions and Methods for Treatment of Disorders Associated with Repetitive DNA
#62METHOD FOR IDENTIFYING FUNCTIONAL ELEMENTS
#63ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASES
#64CRISPR EFFECTOR SYSTEM BASED MULTIPLEX DIAGNOSTICS
#65CAS12a GUIDE RNA MOLECULES AND USES THEREOF
#66CRISPR enabled multiplexed genome engineering
#67NUCLEOBASE EDITORS HAVING REDUCED NON-TARGET DEAMINATION AND ASSAYS FOR CHARACTERIZING NUCLEOBASE EDITORS
#68TARGETING EGLN1 IN CANCER
#69Treatment of thymic stromal lymphopoietin (TSLP) related diseases by inhibition of long-form TSLP transcripts
#70Methods for measuring and improving CRISPR reagent function
#71Use of aptamers in proteomics
#72Methods and compositions for treatment of cholesteryl ester storage disease
#73METHODS, MODELS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES FOR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
#74METHOD FOR THE MONITORING OF MODIFIED NUCLEASES INDUCED-GENE EDITING EVENTS BY MOLECULAR COMBING
#75MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
#76METHODS AND COMPOSITIONS FOR ASSESSING CRISPR/CAS-MEDIATED DISRUPTION OR EXCISION AND CRISPR/CAS-INDUCED RECOMBINATION WITH AN EXOGENOUS DONOR NUCLEIC ACID IN VIVO
#77CRISPR enabled multiplexed genome engineering
#78METHODS FOR DETERMINING THE PRESENCE OR RISK OF DEVELOPING FACIOSCAPULOHUMERAL DYSTROPHY (FSHD)
#79REAGENTS FOR TREATMENT OF HEPATITIS B VIRUS (HBV) INFECTION AND USE THEREOF
#80Treatment of angiogenesis disorders
#81Methods and compositions for the specific inhibition of Complement Component 5(C5) by double-stranded RNA
#82Structural domains of antisense RNA molecules up-regulating translation
#83Nucleic acid based biosensor and methods thereof
#84Antibodies and fragments thereof that bind hepatitis B virus protein X
#85SYSTEMS AND METHODS FOR ALLERGEN DETECTION
#86TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT
#87EXON SKIPPING OLIGOMERS AND OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY
#88Compositions and methods for inhibiting GYS2 expression
#89Methods and compositions for RNA-guided treatment of HIV infection
#90Materials and methods for treatment of hemoglobinopathies
#91CRISPR enabled multiplexed genome engineering
#92Oversubscription scheduling
#93GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS
#94Oligonucleotide compounds for targeting huntingtin mRNA
#95Methods and compositions for RNA-guided treatment of HIV infection
#96Methods and compositions for selecting siRNA of improved functionality
#97High throughput cell-based screening for aptamers
#98Engineered nucleic acid-targeting nucleic acids
#99Brush polymer-assisted compaction of oligonucleotides
#100CRISPR SYSTEM BASED ANTIVIRAL THERAPY
#101CRISPR enabled multiplexed genome engineering
#102CRISPR enabled multiplexed genome engineering
#103siRNA Targeting LDHA
#104Compositions and methods for the treatment of hemoglobinopathies
#105Methods for identifying treatment targets based on multiomics data
#106CRISPR enabled multiplexed genome engineering
#107Use of aptamers in proteomics
#108CRISPR enabled multiplexed genome engineering
#109Programmable CAS9-recombinase fusion proteins and uses thereof
#110Treatment of angiogenesis disorders
#111Methods and Compositions for Selecting siRNA of Improved Functionality
#112HYBRID NUCLEIC ACID MOLECULES AND THEIR USE
#113Methods and systems for identifying candidate nucleic acid agent
#114Methods and Compositions for Selecting siRNA of Improved Functionality
#115Oligonucleotide compositions with enhanced efficiency
#116Antibodies and fragments thereof that bind hepatitis B virus protein X
#117Transcription modulation in animals using CRISPR/Cas systems
#118CRISPR enabled multiplexed genome engineering
#119CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof
#120Oligonucleotide compounds for targeting huntingtin mRNA
#121INHIBITION OF PCSK9 THROUGH RNAI
#122Methods and compositions for the specific inhibition of complement component 5(C5) by double-stranded RNA
#123RNA PRODUCTS AND USES THEREOF
#124CRISPR enabled multiplexed genome engineering
#125THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#126siRNA targeting LDHA
#127Systems and methods for allergen detection
#128Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#129Compositions and methods of using piRNAS in cancer diagnostics and therapeutics
#130Methods and compositions for assessing CRISPER/Cas-mediated disruption or excision and CRISPR/Cas-induced recombination with an exogenous donor nucleic acid in vivo
#131METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
#132Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
#133Oligonucleotide compositions with enhanced efficiency
#134CRISPR enabled multiplexed genome engineering
#135Targeted augmentation of nuclear gene output
#136THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#137Functional tRNA-aptamer molecules
#138Methods and Compositions for Selecting siRNA of Improved Functionality
#139CRISPR effector system based diagnostics for malaria detection
#140Methods and compositions for RNA-guided treatment of HIV infection
#141Method for identification of anti-HIV human miRNA mimics and miRNA inhibitors and anti-HIV pharmaceutical compounds
#142SYSTEMS AND METHODS FOR SELECTION OF GRNA TARGETING STRANDS FOR CAS9 LOCALIZATION
#143Notch 1 specific siRNA molecule
#144Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers
#145CRISPR enabled multiplexed genome engineering
#146CRISPR enabled multiplexed genome engineering
#147Brush polymer-assisted compaction of oligonucleotides
#148Methods and compositions for selecting siRNA of improved functionality
#149Methods and compositions for selecting siRNA of improved functionality
#150Materials and methods for treatment of human genetic diseases including hemoglobinopathies
#151Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
#152Engineered nucleic acid-targeting nucleic acids
#153Generation of neural stem cells and motor neurons
#154Evaluation of Cas9 molecule/guide RNA molecule complexes
#155METHOD FOR THE MONITORING OF MODIFIED NUCLEASES INDUCED-GENE EDITING EVENTS BY MOLECULAR COMBING
#156Methods and compositions for selecting siRNA of improved functionality
#157Oligonucleotide compounds for targeting huntingtin mRNA
#158COMPETITIVE MODULATION OF MICRORNAS
#159Oligonucleotide compositions with enhanced efficiency
#160NOVEL EXPRESSION REGULATING RNA-MOLECULES AND USES THEREOF
#161RNA products and uses thereof
#162miRNA modulators of thermogenesis
#163Use and production of CHD8+/− transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
#164Use of aptamers in proteomics
#165MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
#166Materials and methods for treatment of hemoglobinopathies
#167Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#168Method for identification of anti-HIV human miRNA mimics and miRNA inhibitors and anti-HIV pharmaceutical compounds
#169MicroRNAs Sensitize Cancers to Therapy
#170Treatment of angiogenesis disorders
#171Methods and Compositions for Selecting siRNA of Improved Functionality
#172RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#173Methods for modulating ATRX-dependent gene repression
#174Oligonucleotide compositions with enhanced efficiency
#175Nucleic acids related to MiR-29B-1-5P and uses thereof
#176Method For Screening Interfering Molecules
#177Methods and compositions for identifying repeating sequences in nucleic acids
#178ALTERATION OF NEURONAL GENE EXPRESSION BY SYNTHETIC piRNAs AND BY ALTERATION OF piRNA FUNCTION
#179Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles
#180Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#181COMPOSITIONS AND METHODS OF SELECTIVELY INHIBITING IRP1 AND TREATING INFLAMMATION
#182CRISPR enabled multiplexed genome engineering
#183RIBOREGULATOR COMPOSITIONS AND METHODS OF USE
#184Inhibition of PCSK9 through RNAI
#185Method of isolating aptamers for minimal residual disease detection
#186Nucleic acid enzyme substrates
#187Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#188Pincers comprising antibody and aptamer conjugated via a linker which binds to the same target material and use thereof
#189MiRNA modulators of thermogenesis
#190Oligonucleotide compounds for targeting huntingtin mRNA
#191DNA vector production system
#192MiRNA for treating diseases and conditions associated with neo-angiogenesis
#193MicroRNAs and uses thereof
#194Targeted augmentation of nuclear gene output
#195Method to trigger RNA interference
#196Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof
#197Methods and compositions for the specific inhibition of complement component 5(C5) by double-stranded RNA
#198Notch 1 specific siRNA molecule
#199Methods and compositions for selecting siRNA of improved functionality
#200Methods and compositions for selecting siRNA of improved functionality
#201Methods and compositions for selecting siRNA of improved functionality
#202Methods and compositions for selecting siRNA of improved functionality
#203Methods and compositions using miR-3151 in the diagnosis and treatment of thyroid cancer
#204Screening of nucleic acid agents via particle display
#205Inhibition of MAP4K4 through RNAi
#206Compositions and methods for inhibiting expression of the HAMP gene
#207Compositions and methods for “resistance-proof” SiRNA therapeutics for influenza
#208PREVENTION OF MUSCULAR DYSTROPHY BY CRISPR/CAS9-MEDIATED GENE EDITING
#209HSA-MIR-146B-5P-related nucleic acids and uses thereof
#210Random RNAi libraries, methods of generating same, and screening methods utilizing same
#211Method for identifying biologically active oligonucleotides capable of modulating the immune system
#212Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#213Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results thereof
#214Methods of inhibiting proliferation of estrogen-independent cancer cells
#215Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#216MiRNA modulators of thermogenesis
#217Competitive modulation of microRNAs
#218Treatment of angiogenesis disorders
#219Antisense antiviral compound and method for treating ss/RNA viral infection
#220RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#221METHOD FOR SCREENING MICRORNAS WITH GENE SILENCING FUNCTION AT BOTH LEVELS OF TRANSCRIPTION AND POST-TRANSCRIPTION
#222Methods and compositions using miR-3151 in the diagnosis and treatment of cancer
#223DOWNREGULATION OF miR-218 MAY BE USED AS A BIOMARKER FOR HUMAN ALS
#224Use of SIRT7 as novel cancer therapy target and method for treating cancer using the same
#225miR-520 microRNAs sensitize cancers to platinum-based therapy
#226Single-stranded nucleic acid aptamers specifically binding to and method for detecting using the same
#227Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
#228RNA products and uses thereof
#229OLIGONUCLEOTIDE COMPOSITIONS WITH ENHANCED EFFICIENCY
#230Rational design of microRNA-siRNA chimeras for multi-functional target suppression
#231Use of aptamers in proteomics
#232Nucleic acid enzyme substrates
#233Generation of neural stem cells and motor neurons
#234MicroRNAs for the generation of astrocytes
#235Method to trigger RNA interference
#236Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#237Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#238Compositions and methods for inhibiting expression of the HAMP gene
#239Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function
#240siRNA useful in the treatment of flavivirus infection
#241MicroRNA-based methods and assays for osteosarcoma
#242Method to trigger RNA interference
#243Downregulation of miR-7 for promotion of beta cell differentiation and insulin production
#244Connective tissue growth factor antisense oligonucleotides
#245Micro-RNA's that regulate muscle cells
#246Methods and compositions for selecting siRNA of improved functionality
#247Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#248MicroRNAome
#249Methods of X-aptamer generation and compositions thereof
#250siRNA targeting TIE-2
#251Melatonin-based treatment and diagnosis of bile duct disease
#252Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#253MicroRNAs and uses thereof
#254Catalytic nucleic acid probes as microbial indicators
#255miRNA modulators of thermogenesis
#256Treatment of angiogenesis disorders
#257Oligonucleotide compositions with enhanced efficiency
#258Methods for alleviating facioscapulohumeral dystrophy (FSHD) by N siRNA molecule inhibiting the expression of DUX4-FL
#259Method for identifying biologically active oligonucleotides capable of modulating the immune system
#260Multiplex microfluidic device for selecting nucleic acid aptamers, and high throughput selection method for nucleic acid aptamers using same
#261Methods for identifying nucleic acid ligands
#262Ultraconserved regions encoding ncRNAs
#263Method to trigger RNA interference
#264Functional ligands to target molecules
#265Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application
#266siRNA targeting myeloid differentiation primary response gene (88) (MYD88)
#267Agent for suppressing expression of dominant mutant gene
#268Inhibition of PCSK9 through RNAi
#269Method to trigger RNA interference
#270THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#271Double-stranded RNA-based nanoparticles for insect gene silencing
#272Nucleic acid molecules that target RPA70 and confer resistance to coleopteran pests
#273Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin
#274Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
#275siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1)
#276Nucleic Acids and Libraries
#277Nucleic Acids and Libraries
#278siRNA Targeting Beta Secretase (BACE)
#279METHOD FOR PROLIFERATING CARDIOMYOCYTES USING MICRO-RNA
#280Influenza targets
#281Antisense antiviral compound and method for treating ssRNA viral infection
#282Compositions and methods for diagnosing and treating melanoma
#283Compositions and methods for inhibiting expression of the HAMP gene
#284Methods for identifying drug effects on a cell by determining changes in the cell's spliced message profile
#285Methods for identifying nucleic acid ligands
#286Method of inhibiting miR-33 using a modified oligonucleotide
#287siRNA Targeting Glucagon Receptor (GCCR)
#288siRNA targeting amyloid beta (A4) precursor protein (APP)
#289Identification of RNAI targets and use of RNAI for rational therapy of chemotherapy-resistant leukemia and other cancers
#290SiRNA targeting apolipoprotein (APOB)
#291siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2)
#292SiRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
#293MicroRNA affinity assay and uses thereof
#294siRNA targeting kinase insert domain receptor (KDR)
#295siRNA Targeting Proto-oncogene MET
#296siRNA Targeting Interleukin-1 Receptor-associated Kinase 4 (IRAK4)
#297Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
#298Methods and systems for identifying micro-RNA targets and synthesizing novel micro-RNAs and uses of the same
#299siRNA targeting catenin, Beat-1 (CTNNB1)
#300MicroRNA Signatures Differentiating Uterine and Ovarian Papillary Serous Tumors