112290 ⎘
Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
MODIFIED PROMOTER SEQUENCES
#2Hepatocyte Based Insulin Gene Therapy for Diabetes
#3SYSTEMS, METHODS, AND COMPOSITIONS FOR AN INDUCIBLE PROMOTER SYSTEM
#4GENE THERAPY
#5SYSTEMS AND METHODS TO PRODUCE B CELLS THAT EXPRESS SELECTED ANTIBODIES AND GENE PRODUCTS
#6ENGINEERED LIVER-SPECIFIC CORE PROMOTERS AND THEIR APPLICATIONS
#7CELL-SPECIFIC TRANSCRIPTIONAL REGULATORY SEQUENCES AND USES THEREOF
#8Chimeric Antigen Receptors Targeting HER2
#9USE OF RS1 GENE IN PREPARING THERAPEUTIC AGENT FOR XLRS, AND THERAPEUTIC AGENT
#10SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS VECTOR AND ITS USE IN TREATMENT OF MUSCULAR DYSTROPHY
#11LENTIVIRAL VECTORS AND USES THEREOF
#12CELL-SPECIFIC TRANSCRIPTIONAL REGULATORY SEQUENCES AND USES THEREOF
#13SYNERGISTIC PROMOTER ACTIVATION BY COMBINING CPE AND CRE MODIFICATIONS
#14PROMOTER SWITCHES FOR TISSUE-SPECIFIC EXPRESSION
#15COMPOSITIONS AND METHODS FOR TREATING HER2 POSITIVE METASTATIC BREAST CANCER AND OTHER CANCERS
#16ULTRASOUND-MEDIATED GENE THERAPY FOR DEEP VEIN THROMBOSIS AND POST-THROMBOTIC SYNDROME
#17MODULAR VECTOR (MODVEC) SYSTEM: A PLATFORM FOR CONSTRUCTION OF NEXT GENERATION EXPRESSION VECTORS
#18ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN DOPAMINERGIC NEURONS
#19INTRON FRAGMENTS
#20PLASMID FOR PRODUCTION OF RECOMBINANT PROTEIN IN MAMMALIAN CELL
#21GENERATION OF DEOXYADENOSINE TRIPHOSPHATE DONOR CELLS AND USES THEREOF
#22METHODS FOR USE OF VIRAL VECTOR CONSTRUCTS FOR THE TREATMENT OF FABRY DISEASE
#23COMPOSITIONS AND METHODS FOR TREATING SIALIDOSIS
#24ENGINEERED MULTIPARTITE TRANSCRIPTIONAL EFFECTORS SOURCED FROM HUMAN PROTEIN DOMAINS
#25NON-VIRAL B CELL ENGINEERING METHODS
#26BCMA CHIMERIC ANTIGEN RECEPTORS
#27NOVEL 5'-UNTRANSLATED REGION ELEMENT AND USE THEREOF
#28GENE THERAPY FOR GALACTOSEMIA
#29ADENO-ASSOCIATED VIRUS VECTORS FOR TREATMENT OF RETT SYNDROME
#30METHODS AND MATERIALS FOR NT-3 GENE THERAPY
#31SYSTEMS AND METHODS FOR THE TARGETED PRODUCTION OF A THERAPEUTIC PROTEIN WITHIN A TARGET CELL
#32NFAT-RESPONSIVE REPORTER SYSTEMS FOR ASSESSING CHIMERIC ANTIGEN RECEPTOR ACTIVATION AND METHODS OF MAKING AND USING THE SAME
#33Compositions and Methods for Treating Fabry Disease
#34GLOBIN GENE THERAPY FOR TREATING HEMOGLOBINOPATHIES
#35METHODS OF ALTERING GENE EXPRESSION BY PERTURBING TRANSCRIPTION FACTOR MULTIMERS THAT STRUCTURE REGULATORY LOOPS
#36COMPACT PROMOTERS FOR GENE EDITING
#37COMPACT PROMOTERS FOR GENE EXPRESSION
#38FUNCTIONAL NUCLEIC ACID MOLECULE AND METHOD
#39RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS WITH CD14 PROMOTER AND USE THEREOF
#40GLOBIN GENE THERAPY FOR TREATING HEMOGLOBINOPATHIES
#41DNA VECTORS AND ELEMENTS FOR SUSTAINED GENE EXPRESSION IN EUKARYOTIC CELLS
#42SYNTHETIC PROMOTERS FOR GENE THERAPY AND PROTEIN EXPRESSION
#43POLYNUCLEOTIDE FOR PHYSIOLOGICAL EXPRESSION IN T-CELLS
#44COMPOSITIONS AND METHODS FOR INHIBITING ALPHA-SYNUCLEIN AGGREGATION
#45GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE I
#46Gene Expression System
#47VECTORIZED FACTOR XII ANTIBODIES AND ADMINISTRATION THEREOF
#48COMPOSITION AND METHODS FOR MODULATING TCF4 GENE EXPESSION AND TREATING PITT HOPKINS SYNDROME
#49MUSCLE-SPECIFIC HYBRID PROMOTER
#50ADENO-ASSOCIATED VIRUS VECTORS FOR TREATMENT OF RETT SYNDROME
#51Liver-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
#52COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION
#53ONCOLYTIC ADENOVIRUS WITH REPLICATION SELECTIVITY BASED ON STATUS OF P53 TRANSCRIPTIONAL ACTIVITY
#54Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy
#55ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN NON-NEURONAL BRAIN CELLS
#56TREATMENT OF MUCOPOLYSACCHARIDOSIS IVA
#57Novel Erythroid Specific Enhancers and Uses Thereof
#58METHODS AND SYSTEM OF MANAGING RESOURCE COMPETITION IN SYNTHETIC GENE CIRCUITS
#59Methods and compositions for reducing the immunogenicity of chimeric notch receptors
#60METHODS AND COMPOSITIONS FOR REDUCING THE IMMUNOGENICITY OF CHIMERIC NOTCH RECEPTORS
#61COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS
#62GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE II
#63COMPOSITIONS AND METHODS FOR TREATING CANCER
#64Recombinant adeno-associated virus vectors with CD14 promoter and use thereof
#65Adeno-associated virus vectors for treatment of Rett syndrome
#66Cell specific transcriptional regulatory sequences and uses thereof
#67INDUCIBLE EXPRESSION CASSETTE, AND USES THEREOF
#68Intron fragments
#69Muscle-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
#70Hepatocyte based insulin gene therapy for diabetes
#71Optimized Liver-Specific Expression Systems for FVIII and FIX
#72GENE THERAPY FOR TREATING MUCOPOLYSACCHARIDOSIS TYPE I
#73Potent and balanced bidirectional promoter
#74METHOD FOR INCREASING THE EXPRESSION LEVEL OF A NUCLEIC ACID MOLECULE OF INTEREST IN A CELL
#75Gene expression system
#76BCMA chimeric antigen receptors
#77BCMA chimeric antigen receptors
#78Primate retinal pigment epithelium cell-specific promoter
#79BCMA chimeric antigen receptors
#80Compositions and methods for enhanced gene expression
#81PROMOTER AND CARRIER COMPOSED OF SAME AND APPLICATION THEREOF
#82BCMA chimeric antigen receptors
#83CHIMERIC PROMOTER WITH HIGH TRANSCRIPTIONAL ACTIVITY IN T-CELLS
#84Muscle-specific nucleic acid regulatory elements and methods and use thereof
#85Methods and materials for NT-3 gene therapy
#86BCMA chimeric antigen receptors
#87Globin gene therapy for treating hemoglobinopathies
#88DNA vectors and elements for sustained gene expression in eukaryotic cells
#89Transcriptionally targeted and CpG-free plasmid for theranostic gene therapy
#90Expression of recombinant proteins in pupae
#91Engineered Cellular Pathways for Programmed Autoregulation of Differentiation
#92INTEGRATION OF MESA RECEPTORS AND PROMOTORS TO IMPLEMENT CUSTOMIZED CELLULAR FUNCTION
#93Liver-specific nucleic acid regulatory elements and methods and use thereof
#94Compositions and methods for enhanced gene expression
#95EXPRESSION VECTORS COMPRISING CHIMERIC CYTOMEGALOVIRUS PROMOTER AND ENHANCER SEQUENCES
#96BCMA chimeric antigen receptors
#97BCMA chimeric antigen receptors
#98BCMA chimeric antigen receptors
#99BCMA chimeric antigen receptors
#100Methods of altering gene expression by perturbing transcription factor multimers that structure regulatory loops
#101Adenoassociated virus vectors for the treatment of mucopolysaccharidoses
#102Potent and balanced bidirectional promoter
#103INDUCIBLE EXPRESSION CASSETTE, AND USES THEREOF
#104DEVICES, SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF ACTION POTENTIALS IN TARGET CELLS
#105TRANSGENE EXPRESSION IN AVIANS
#106Gene therapy for treating mucopolysaccharidosis type II
#107Compositions and methods useful in treating Stargardt's disease and other ocular disorders
#108Hybrid promoter and uses thereof
#109Liver-specific nucleic acid regulatory elements and methods and use thereof
#110Gene therapy for treating mucopolysaccharidosis type I
#111Methods and compositions for reducing the immunogenicity of chimeric notch receptors
#112Chimeric antigen receptors targeting HER2
#113Methods of Inducibly Targeting Chromatin Effectors and Compositions for Use in the Same
#114Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
#115Cassette encoding a FPV/brachyury fusion protein
#116Inducible eukaryotic expression system
#117Gene therapy methods
#118Compositions and methods for treating cancer
#119Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
#120Transgenic animal for visualization of ATP and use thereof
#121BCMA chimeric antigen receptors
#122Optimized liver-specific expression systems for FVIII and FIX
#123rAAV vector compositions, methods for targeting vascular endothelial cells and use in treatment of type I diabetes
#124VECTORS AND METHODS TO TREAT ISCHEMIA
#125METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS
#126Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
#127Hepatocyte based insulin gene therapy for diabetes
#128Muscle-specific nucleic acid regulatory elements and methods and use thereof
#129Promoter and regulatory elements for improved expression of heterologous genes in host cells
#130Liver-specific nucleic acid regulatory elements and methods and use thereof
#131GENE EXPRESSION SYSTEM
#132Globin gene therapy for treating hemoglobinopathies
#133Promoters for high level expression
#134Lentiviral vectors
#135METHOD AND COMPOSITION TO INCREASE RADIATION-INDUCED TUMOR THERAPEUTIC EFFECTS
#136Synthetic genes and genetic constructs
#137Transgenic non-human mammal that expresses human MMP2
#138Method of using a transgenic chicken to produce exogenous proteins in its eggs
#139Muscle-specific nucleic acid regulatory elements and methods and use thereof
#140Inducible eukaryotic expression system
#141Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
#142Placental like alkaline phosphatase (PLAP) promoter mediated cell targeting
#143Vectors and methods to treat ischemia
#144Devices, systems and methods for optogenetic modulation of action potentials in target cells
#145Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
#146TRANSGENIC NON-HUMAN ANIMAL AND USES THEREOF
#147Gene therapy methods
#148Transcription units and the use thereof in expression vectors
#149Compositions and methods for generating an immune response
#150Inducible eukaryotic expression system
#151Transcription unit and use thereof in expression vectors
#152Engineered cellular pathways for programmed autoregulation of differentiation
#153Control of gene expression
#154Hepatocyte based insulin gene therapy for diabetes
#155REIC-expressing adenovirus vector
#156Hybrid promoter and recombinant vector comprising the same
#157Gene delivery system having enhanced tumor-specific expression, and recombinant gene expression regulating sequence
#158Synthetic genes and genetic constructs
#159Promoters exhibiting endothelial cell specificity and methods of using same
#160Nucleic acids encoding FOXD3 promoter and methods to isolate FOXD3 expressing cells
#161Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulations of angiogenesis and anticancer therapy
#162Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
#163Ecdysone receptor-based inducible gene expression system
#164Hepatocyte Based Insulin Gene Therapy For Diabetes
#165CONTROL OF GENE EXPRESSION
#166Transgenic avians and protein production
#167Transgenic non-human animal and uses thereof
#168Method and Composition to Increase Radiation-Induced Tumor Therapeutic Effects
#169Cardiac-specific nucleic acid regulatory elements and methods and use thereof
#170Promoters exhibiting endothelial cell specificity and methods of using same
#171Synthetic genes and genetic constructs
#172Nucleic acid construct having an ovalbumin promotor
#173CHROMOSOME-BASED PLATFORMS
#174Gene delivery system and method of use
#175USE OF APOPTOSIS INHIBITING COMPOUNDS IN DEGENERATIVE NEUROLOGICAL DISORDERS
#176Expression of factor IX in gene therapy vectors
#177Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
#178PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS
#179PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME
#180Liver-specific nucleic acid regulatory elements and methods and use thereof
#181MVA expressing modified HIV envelope, GAG, and POL genes
#182Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator
#183Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
#184MVA expressing modified HIV envelope, gag, and pol genes
#185Optimized high yield synthetic plasmids
#186Novel Ecdysone Receptor-Based Inducible Gene Expression System
#187Ecdysone receptor-based inducible gene expression system
#188Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
#189Nucleic acids encoding SOX10 promoter and methods to isolate SOX10 expressing cells
#190Antibodies produced in the avian oviduct
#191Promoter inducible by reactive oxygen species and vector comprising the same
#192Engineered cellular pathways for programmed autoregulation of differentiation
#193Selectively replicating viral vectors
#194NUCLEIC ACID CONSTRUCTS
#195DNA for eukaryotic expression of CymR
#196Inducible fluorescently-tagged protein expression system
#197Synthetic expression vectors for insect cells
#198TARGETED TUMOR THERAPY BY USE OF RECOMBINANT ADENOVIRUS VECTORS THAT SELECTIVELY REPLICATE IN HYPOXIC REGIONS OF TUMORS
#199Genetically modified animal for use in evaluating harmfulness of test substance
#200Optimized core promoters and uses thereof
#201Production of heterologous protein in the avian oviduct
#202Novel Vectors for Production of Interferon
#203Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
#204Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
#205Composition comprising isolated human CTLA4-Fc fusion protein produced in a transgenic chicken
#206Promoters exhibiting endothelial cell specificity and methods of using same
#207Methods for producing a protein using an avian lysozyme promoter
#208Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
#209Antibodies produced in a transgenic avian egg white
#210Recombinant virus and use thereof
#211Recombinant protein production in a human cell
#212Tissue Specific Expression of Exogenous Proteins in Transgenic Chickens
#213VACCINIA VIRUS HOST RANGE GENES TO INCREASE THE TITER OF AVIPOXVIRUSES
#214Inducible eukaryotic expression system
#215Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
#216PATHOTROPIC TARGETED GENE DELIVERY SYSTEM FOR CANCER AND OTHER DISORDERS
#217Glycosylated erythropoietin
#218Composition and method for killing of tumours
#219Methods of Identifying Synthetic Transcriptional and Translational Regulatory Elements, and Compositions Related to Same
#220MVA expressing modified HIV envelope, gag, and pol genes
#221Avian derived erythropoietin
#222Stocks of replication-deficient adenovirus
#223Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator
#224Replication competent hepatitis C virus and methods of use
#225Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
#226Polynucleotides and Polypeptides of the IFNalpha-21 Gene
#227Host Cells Containing Multiple Integrating Vectors
#228Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
#229Recombinant protein production in a human cell
#230Transgenic mammal carrying GANP gene transferred thereinto and utilization thereof
#231CODON OPTIMIZED SYNTHETIC PLASMIDS
#232Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes
#233Nucleic acid constructs
#234Expression of factor IX in gene therapy vectors
#235Vectors and methods for genetic immunization
#236Ecdysone receptor-based inducible gene expression system
#237Methods And Compositions For Combinatorial Approaches To Cancer Gene Therapy
#238REGULATORY ELEMENTS FOR DELIVERY TO THE LIVER
#239Transgene expression in a avians
#240Lentiviral LTR-deleted vector
#241New Expression Tools for Multiprotein Applications
#242Treatment of diabetes with synthetic beta cells
#243Tumor-Specific Expression of Reporter Genes
#244Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same
#245Glycosylated G-CSF obtained from a transgenic chicken
#246Production of a transgenic avian by cytoplasmic injection
#247Lentiviral vectors featuring liver specific transcriptional enhancer and methods of using same
#248Self-rearranging DNA vectors
#249Methods for producing minus-strand RNA viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken β-actin promoter
#250Ecdysone receptor-based inducible gene expression system
#251HUMAN DISEASE MODELING USING SOMATIC GENE TRANSFER
#252Sequences upstream of the carp gene, vectors containing them and uses thereof
#253Adenovirus packaging cell lines
#254Method for producing immortalised antibodies-secreting cells
#255Avians containing a lysozyme promoter transgene
#256hTMC promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes
#257Methods of obtaining neural stem cells
#258Recombinant protein production in a human cell
#259HYBRID VECTOR HAVING A CYTOMEGALOVIRUS ENHANCER AND MYELOPROLIFERATIVE SARCOMA VIRUS PROMOTER
#260Glucose inducible insulin expression and methods of treating diabetes
#261Interferon-beta gene therapy using an improved, regulated expression system
#262Cell lines for production of replication-defective adenovirus
#263Chromosome-based platforms
#264Cell-specific molecule and method for importing DNA into osteoblast nuclei
#265Nucleotide sequences of shrimp beta-actin and actin promoters and their use in gentic transformation technology
#266Adiponectin gene therapy
#267Transgenic mammal carrying GANP gene transferred thereinto and utilization thereof
#268Inducible plasmid vector encoding TGF-β and use thereof
#269Vectors with viral insulators
#270Use of apotosis inhibiting compounds in degenerative neurological disorders
#271Lentiviral vectors carrying synthetic bi-directional promoters and uses thereof
#272Optimized high yield synthetic plasmids
#273Glycosylated interferon α
#274Lentiviral LTR-deleted vector
#275Composition and method for killing of tumours
#276Gene trap system
#277Glycosylated interferon alpha obtained from a transgenic chicken
#278Nucleic acid sequences encoding proteins capable of associating into a virus-like particle
#279High yield heterologous expression cell lines for expression of gene products with human glycosylation pattern
#280Method of expressing gene in transgenic birds using retrovirus vector and transgenic birds thus obtained
#281MVA expressing modified HIV envelope, gag, and pol genes
#282Use of negative regulatory elements for the neurospecific expression of transgenes
#283Episomal expression system
#284Sequences upstream of the CARP gene, vectors containing them and uses thereof
#285Inducible eukaryotic expression system
#286Recombinant adeno-associated virus virions for the treatment of lysosomal disorders
#287Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene
#288Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors
#289Recombinant expression of factor VIII in human cells
#290Nuclear factors associated with transcriptional regulation
#291Tissue specific expression of exogenous proteins in transgenic chickens
#292Isolated avian cell that expresses Vaccinia virus host range genes
#293Adenovirus packaging cell lines
#294Chromosome-based platforms
#295Selective killing of cancerous cells
#296Method of making protein in an egg of a transgenic chicken
#297Control of gene expression
#298Methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
#299Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same
#300Control of gene expression