ClassID:

108937

C12N9/22 - page 13 - CPC Classification

Classification description:

Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses

Recent Application in this class:
#3601
20220090088
2022-03-24

Targeted Nuclear RNA Cleavage and Polyadenylation with CRISPR-Cas

#3602
20220090065
2022-03-24

Novel tracrRNA system for Cas9

#3603
20220090064
2022-03-24

METHODS AND COMPOSITIONS FOR DIRECTED GENOME EDITING

#3604
20220090063
2022-03-24

CRISPR/CAS9 IN VITRO KIT

#3605
20220090036
2022-03-24

Compositions and methods for the targeting of SOD1

#3606
20220090035
2022-03-24

Nucleic acid sequence replacement by NHEJ

#3607
20220090034
2022-03-24

Compositions for increasing polypeptide stability and activity, and related methods

#3608
20220090012
2022-03-24

GENETICALLY ENGINEERED T CELLS WITH REGNASE-1 AND/OR TGFBRII DISRUPTION HAVE IMPROVED FUNCTIONALITY AND PERSISTENCE

#3609
20220089978
2022-03-24

Detergent composition

#3610
20220089786
2022-03-24

TREATMENT OF SJOGREN'S DISEASE WITH NUCLEASE FUSION PROTEINS

#3611
20220089687
2022-03-24

Polynucleotides encoding APOA1-PON1 fusion polypeptides

#3612
20220089664
2022-03-24

Treatment Of Ophthalmic Conditions With Angiopoietin-Like 7 (ANGPTL7) Inhibitors

#3613
20220089659
2022-03-24

MESOPHILIC ARGONAUTE SYSTEMS AND USES THEREOF

#3614
20220088078
2022-03-24

Genetically engineered T cells with regnase-1 and/or TGFBRII disruption have improved functionality and persistence

#3615
20220088077
2022-03-24

Genetically engineered t cells with Regnase-1 and/or TGFBRII disruption have improved functionality and persistence

#3616
20220087947
2022-03-24

NANOPARTICLE FOR DELIVERING RIBONUCLEOPROTEIN AND USE THEREOF

#3617
20220081693
2022-03-17

Methods for increasing observed editing in bacteria

#3618
20220081687
2022-03-17

Automated cell processing methods, modules, instruments, and systems

#3619
20220081681
2022-03-17

Engineered proteins

#3620
20220081680
2022-03-17

MATERIALS AND METHODS FOR TREATMENT OF AUTOSOMAL DOMINANT CONE-ROD DYSTROPHY

#3621
20220079972
2022-03-17

CRISPR-BASED METHODS AND NOVEL COMPOSITIONS FOR TREATING VASCULAR DISORDERS

#3622
20220073952
2022-03-10

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#3623
20220073951
2022-03-10

SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES

#3624
20220073937
2022-03-10

Increasing gene editing and site-directed integration events utilizing meiotic and germline promoters

#3625
20220073912
2022-03-10

Systems and methods for modulating CRISPR activity

#3626
20220073892
2022-03-10

Cascade/dCas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells

#3627
20220073891
2022-03-10

Systems, methods, and compositions for RNA-guided RNA-targeting CRISPR effectors

#3628
20220073890
2022-03-10

NOVEL CRISPR-CAS SYSTEMS FOR GENOME EDITING

#3629
20220073866
2022-03-10

Materials and methods for modifying and paratransformation of arthropods

#3630
20220073845
2022-03-10

Endonuclease 1 ribonucleases for cleaning

#3631
20220072537
2022-03-10

Programmable nuclease compositions and methods of use thereof

#3632
20220072160
2022-03-10

Compositions and methods for promoting homology directed repair

#3633
20220064722
2022-03-03

Enzyme-pore constructs

#3634
20220064688
2022-03-03

CELL-FREE PRODUCTION OF RIBONUCLEIC ACID

#3635
20220064676
2022-03-03

Pharmaceutical compositions comprising gene-corrected primary cells

#3636
20220064667
2022-03-03

UNIVERSAL DONOR CELLS

#3637
20220064653
2022-03-03

Targeted non-viral DNA insertions

#3638
20220064652
2022-03-03

Treatment Of Sepsis With PCSK9 And LDLR Modulators

#3639
20220064651
2022-03-03

TALEN-BASED AND CRISPR/CAS-BASED GENE EDITING FOR BRUTON'S TYROSINE KINASE

#3640
20220064635
2022-03-03

CRISPR COMPOSITIONS AND METHODS FOR PROMOTING GENE EDITING OF ADENOSINE DEAMINASE 2 (ADA2)

#3641
20220064633
2022-03-03

COMPOSITIONS AND METHODS FOR HIGHLY EFFICIENT GENETIC SCREENING USING BARCODED GUIDE RNA CONSTRUCTS

#3642
20220064626
2022-03-03

Inhibition of unintended mutations in gene editing

#3643
20220064614
2022-03-03

DNase variants

#3644
20220064613
2022-03-03

CRISPR gene therapy of fusion gene related cancers

#3645
20220064612
2022-03-03

PaCas9 nuclease

#3646
20220064596
2022-03-03

T cells with improved functionality

#3647
20220064266
2022-03-03

Cleaving pre-fusion state SARS-CoV-2 spike protein

#3648
20220064229
2022-03-03

METHODS FOR DESIGNING DNA BINDING PROTEIN CONTAINING PPR MOTIFS, AND USE THEREOF

#3649
20220062146
2022-03-03

COMPOSITIONS AND METHODS FOR REMOVING DENTAL CALCULI

#3650
20220056483
2022-02-24

CELL MEMBRANE PENETRATING CONJUGATES FOR GENE EDITING

#3651
20220056482
2022-02-24

Methods for making genetic edits

#3652
20220056457
2022-02-24

CIS CONJUGATIVE PLASMID SYSTEM

#3653
20220056440
2022-02-24

CRISPR GENE EDITING FOR AUTOSOMAL DOMINANT DISEASES

#3654
20220056439
2022-02-24

Compositions and methods of modifying a plant genome to produce a MS9, MS22, MS26, or MS45 male-sterile plant

#3655
20220056438
2022-02-24

GENE-EDITING COMPOSITIONS AND METHODS TO MODULATE FAAH FOR TREATMENT OF NEUROLOGICAL DISORDERS

#3656
20220056437
2022-02-24

METHODS AND COMPOSITIONS FOR INHIBITION OF CRISPR RE-CLEAVAGE EVENTS

#3657
20220056433
2022-02-24

Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression

#3658
20220056428
2022-02-24

Simultaneous multiplex genome editing in yeast

#3659
20220056427
2022-02-24

Polynucleotides encoding optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome

#3660
20220056097
2022-02-24

SYSTEMS AND METHODS FOR COMPARTMENT SPATIAL ORGANIZATION

#3661
20220049280
2022-02-17

Method for promoting n-acetylglucosamine synthesis by using GlcN6P responsive element

#3662
20220049276
2022-02-17

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#3663
20220049274
2022-02-17

COMPOSITION FOR INDUCING DEATH OF CELLS HAVING MUTATED GENE, AND METHOD FOR INDUCING DEATH OF CELLS HAVING MUTATED GENE BY USING COMPOSITION

#3664
20220049273
2022-02-17

NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS

#3665
20220049247
2022-02-17

Materials and methods for treatment of usher syndrome type 2A and/or non-syndromic autosomal recessive retinitis pigmentosa (ARRP)

#3666
20220049241
2022-02-17

PROGRAMMABLE NUCLEASES AND METHODS OF USE

#3667
20220049233
2022-02-17

NOVEL MAD NUCLEASES

#3668
20220049232
2022-02-17

TRANSCRIPTIONAL RECORDING BY CRISPR SPACER ACQUISITION FROM RNA

#3669
20220049223
2022-02-17

BIOMARKER FOR PREDICTING ABILITY OF MESENCHYMAL STEM CELLS TO PROLIFERATE AND MIGRATE

#3670
20220048962
2022-02-17

SYSTEMS AND METHODS FOR MODULATING RNA

#3671
20220047723
2022-02-17

Optimized mRNA encoding CAS9 for use in LNPs

#3672
20220047637
2022-02-17

SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES

#3673
20220042071
2022-02-10

Detection method using kit for detecting plurality of target nucleic acids

#3674
20220042048
2022-02-10

NONVIRAL GENERATION OF GENOME EDITED CHIMERIC ANTIGEN RECEPTOR T CELLS

#3675
20220042047
2022-02-10

COMPOSITIONS AND METHODS FOR MODIFYING A TARGET NUCLEIC ACID

#3676
20220042019
2022-02-10

COMPOSITIONS AND METHODS OF USE FOR SMALL-MOLECULE REGULATION OF CRISPR-CAS9 ACTIVITY USING RNA APTAMERS

#3677
20220042017
2022-02-10

METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163

#3678
20220042010
2022-02-10

METHODS FOR DETERMINING INCREASED RISK OF CANCER DEVELOPMENT AND TREATING THE SAME

#3679
20220042002
2022-02-10

Engineered human extracellular DNASE enzymes

#3680
20220033879
2022-02-03

TARGETED ENRICHMENT BY ENDONUCLEASE PROTECTION

#3681
20220033856
2022-02-03

METHODS FOR INCREASING FETAL HEMOGLOBIN CONTENT IN EUKARYOTIC CELLS AND USES THEREOF FOR THE TREATMENT OF HEMOGLOBINOPATHIES

#3682
20220033855
2022-02-03

ARRAYED NUCLEIC ACID-GUIDED NUCLEASE OR NICKASE FUSION EDITING

#3683
20220033846
2022-02-03

APP MODIFICATION VIA BASE EDITING USING THE CRISPR/CAS9 SYSTEM

#3684
20220033833
2022-02-03

COMPOSITIONS AND METHODS FOR TRANSFERRING BIOMOLECULES TO WOUNDED CELLS

#3685
20220033829
2022-02-03

PEPTIDE BARCODES FOR CORRELATING NUCLEIC ACID-GUIDED NUCLEASE OR NICKASE FUSION EDITING AND PROTEIN TRANSLATION IN A POPULATION OF CELLS

#3686
20220033808
2022-02-03

METHODS AND COMPOSITIONS FOR NUCLEIC ACID-GUIDED NUCLEASE CELL TARGETING SCREEN

#3687
20220033801
2022-02-03

COMPOSITIONS AND METHODS FOR NON-ANTIBIOTIC TREATING OF BACTERIAL INFECTIONS BY BLOCKING OR DISRUPTING BACTERIAL GENES INVOLVED IN VIRULENCE OR VIABILITY

#3688
20220033793
2022-02-03

CRISPR DNA targeting enzymes and systems

#3689
20220033792
2022-02-03

METHODS AND COMPOSITIONS FOR CELLULAR REPROGRAMMING

#3690
20220033791
2022-02-03

Enzymes with RuvC domains

#3691
20220033785
2022-02-03

RNA PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND USES THEREOF

#3692
20220033764
2022-02-03

Engineered microorganisms and methods of making and using same

#3693
20220033738
2022-02-03

Polypeptides having nuclease activity

#3694
20220031865
2022-02-03

COMBINATION THERAPY FOR TREATING MUSCULAR DYSTROPHY

#3695
20220031749
2022-02-03

MULTIPLEX GENOME EDITING OF IMMUNE CELLS TO ENHANCE FUNCTIONALITY AND RESISTANCE TO SUPPRESSIVE ENVIRONMENT

#3696
20220028491
2022-01-27

BIOLOGICALLY INFORMED AND ACCURATE SEQUENCE ALIGNMENT

#3697
20220025463
2022-01-27

CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS

#3698
20220025409
2022-01-27

Nuclease-mediated genome editing of primary cells

#3699
20220025407
2022-01-27

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#3700
20220025405
2022-01-27

PRODUCTION METHOD FOR GENOME-EDITED CELLS

#3701
20220025403
2022-01-27

REDUCED AND MINIMAL MANIPULATION MANUFACTURING OF GENETICALLY-MODIFIED CELLS

#3702
20220025382
2022-01-27

HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION

#3703
20220025381
2022-01-27

Inducible control of gene expression

#3704
20220025365
2022-01-27

METHODS FOR NOMINATION OF NUCLEASE ON-/OFF-TARGET EDITING LOCATIONS, DESIGNATED "CTL-seq" (CRISPR Tag Linear-seq)

#3705
20220025363
2022-01-27

SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES

#3706
20220025360
2022-01-27

Methods of making unbiased phage libraries

#3707
20220025359
2022-01-27

Cure all for nucleic acid-guided cell editing in E. Coli

#3708
20220025353
2022-01-27

NANOPORE MEMBRANE DEVICE AND METHODS OF USE THEREOF

#3709
20220025347
2022-01-27

Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)

#3710
20220025346
2022-01-27

Optimized protein linkers and methods of use

#3711
20220025345
2022-01-27

RNA-guided endonuclease fusion polypeptides and methods of use thereof

#3712
20220025003
2022-01-27

REAGENTS AND METHODS FOR CONTROLLING PROTEIN FUNCTION AND INTERACTION

#3713
20220023444
2022-01-27

Gene editing-based method of attenuating the beta-amyloid pathway

#3714
20220023340
2022-01-27

gRNA targeting HPK1 and a method for editing HPK1 gene

#3715
20220017948
2022-01-20

DETECTION OF SPECIFIC HLA ALLELES

#3716
20220017927
2022-01-20

Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA

#3717
20220017926
2022-01-20

METHOD FOR GENE EDITING OF CELL ON THE BASIS OF CRISPR/CAS SYSTEM

#3718
20220017921
2022-01-20

IMPROVED VECTOR SYSTEMS FOR CAS PROTEIN AND SGRNA DELIVERY, AND USES THEREFOR

#3719
20220017910
2022-01-20

Genomic editing vector for , method for editing genome of using the same, and transgenic strains using the same

#3720
20220017908
2022-01-20

COMPOSITIONS AND METHODS FOR INCREASING FETAL HEMOGLOBIN AND TREATING SICKLE CELL DISEASE

#3721
20220017897
2022-01-20

GUIDE RNA FOR HSV-1 GENE EDITING AND METHOD THEREOF

#3722
20220017896
2022-01-20

DNA CUTTING MEANS BASED ON CAS9 PROTEIN FROM DEFLUVIIMONAS SP.

#3723
20220017888
2022-01-20

METHOD FOR INDUCING DELETION IN GENOMIC DNA

#3724
20220017883
2022-01-20

Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)

#3725
20220017882
2022-01-20

COMPOSITIONS AND METHODS FOR MODIFYING A TARGET NUCLEIC ACID

#3726
20220017881
2022-01-20

MODIFIED Cas9 PROTEIN AND USE THEREOF

#3727
20220017865
2022-01-20

THERAPEUTIC GENE EDITING FOR ELANE-ASSOCIATED DISEASE

#3728
20220017864
2022-01-20

METHODS OF IDENTIFYING IMMUNOMODULATORY GENES

#3729
20220016173
2022-01-20

Genetically engineered t cells with regnase-1 and/or TGFBRII disruption have improved functionality and persistence

#3730
20220016166
2022-01-20

T-CELL EXPRESSING CHIMERIC RECEPTOR

#3731
20220015342
2022-01-20

GENE EDITING OF REPRODUCTIVE HORMONES TO REDUCE FERTILITY IN ICTALURUS PUNCTATUS

#3732
20220015341
2022-01-20

STERILE FISH

#3733
20220015340
2022-01-20

METHODS FOR PROTECTING PORCINE FETUSES FROM INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)

#3734
20220010339
2022-01-13

PROTECTED GUIDE RNAS (PGRNAS)

#3735
20220010338
2022-01-13

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#3736
20220010337
2022-01-13

TARGETED ACTIVE GENE EDITING AGENT AND METHODS OF USE

#3737
20220010336
2022-01-13

Gene editing

#3738
20220010321
2022-01-13

DUAL GUIDE RNA FOR CRISPR/CAS GENOME EDITING IN PLANTS CELLS

#3739
20220010313
2022-01-13

CRISPR/CAS-related methods and compositions for treating herpes simplex virus

#3740
20220010293
2022-01-13

NOVEL CAS9 ORTHOLOGS

#3741
20220010292
2022-01-13

METHOD FOR THE GENERATION OF COMPACT TALE-NUCLEASES AND USES THEREOF

#3742
20220010285
2022-01-13

CELLS FOR THE PRODUCTION OF VIRUSES AND METHODS OF USING THE SAME

#3743
20220010278
2022-01-13

Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

#3744
20220009977
2022-01-13

Methods of treating mitochondrial disorders

#3745
20220009968
2022-01-13

CRISPR-CAS-BASED COMPOSITION FOR GENE CORRECTION

#3746
20220009878
2022-01-13

IONIZABLE AMINE LIPIDS

#3747
20220008476
2022-01-13

Genetically engineered hematopoietic stem cells and uses thereof

#3748
20220003783
2022-01-06

MYB-RELATED TRANSCRIPTION FACTOR (MYPOP) AS DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR TUMOR THERAPY

#3749
20220002907
2022-01-06

Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells

#3750
20220002757
2022-01-06

PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF

#3751
20220002756
2022-01-06

RNA-guided nucleases and active fragments and variants thereof and methods of use

#3752
20220002755
2022-01-06

NUCLEIC ACID WATERMARKS TO ASSESS AND IMPROVE NUCLEIC ACID-GUIDED NUCLEASE OR NICKASE FUSION EDITING

#3753
20220002753
2022-01-06

SYSTEMS AND METHODS FOR POLYNUCLEOTIDE SPATIAL ORGANIZATION

#3754
20220002740
2022-01-06

MUTATIONS IN MADS-BOX GENES AND USES THEREOF

#3755
20220002725
2022-01-06

NUCLEIC ACID-GUIDED NUCLEASE OF NICKASE FUSION EDITING OF METHYLATED NUCLEOTIDES

#3756
20220002717
2022-01-06

PROGRAMMABLE NUCLEASES AND BASE EDITORS FOR MODIFYING NUCLEIC ACID DUPLEXES

#3757
20220002715
2022-01-06

COMPOSITIONS AND METHODS FOR SELECTING BIALLELIC GENE EDITING

#3758
20220002714
2022-01-06

CRISPR SYSTEM FOR GENOME EDITING

#3759
20220002706
2022-01-06

Methods for increasing gene-editing frequencies in maize cells

#3760
20220002695
2022-01-06

TARGETED ACTIVE GENE EDITING AGENT AND METHODS OF USE

#3761
20220002694
2022-01-06

Simultaneous multiplex genome editing in yeast

#3762
20220002693
2022-01-06

CRISPR/CPF1 SYSTEMS AND METHODS

#3763
20220002692
2022-01-06

DNA cutting means based on Cas9 protein from biotechnologically significant bacterium Clostridium cellulolyticum

#3764
20220002691
2022-01-06

CRISPR/CAS12J ENZYME AND SYSTEM

#3765
20220002681
2022-01-06

METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM

#3766
20220002639
2022-01-06

POLYPEPTIDES HAVING RNASE ACTIVITY

#3767
20220002358
2022-01-06

Endogenous Gag-based capsids and uses thereof

#3768
20220001030
2022-01-06

Genome editing methods and constructs

#3769
20220001023
2022-01-06

CATIONIC LIPID COMPOSITIONS FOR TISSUE-SPECIFIC DELIVERY

#3770
20220000933
2022-01-06

COMPOSITIONS AND METHODS FOR NHEJ-MEDIATED GENOME EDITING

#3771
20210403942
2021-12-30

SYSTEMS FOR CELL CONTROL

#3772
20210403926
2021-12-30

METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS

#3773
20210403925
2021-12-30

Nucleic acids encoding CRISPR-associated proteins and uses thereof

#3774
20210403924
2021-12-30

Method for selecting cells based on CRISPR/Cas-mediated integration of a detectable tag to a target protein

#3775
20210403922
2021-12-30

NON-TOXIC CAS9 ENZYME AND APPLICATION THEREOF

#3776
20210403906
2021-12-30

GENE-EDITING SYSTEMS FOR EDITING A CYSTIC FIBROSIS TRANSMEMBRANE REGULATOR (CFTR) GENE

#3777
20210403905
2021-12-30

Materials and methods for treatment of usher syndrome type 2A

#3778
20210403889
2021-12-30

CRISPR-CAS SYSTEM FOR CLOSTRIDIUM GENOME ENGINEERING AND RECOMBINANT STRAINS PRODUCED THEREOF

#3779
20210403888
2021-12-30

CRISPR-Cas12J effector polypeptides and methods of use thereof

#3780
20210403887
2021-12-30

Evolution of TALENs

#3781
20210403861
2021-12-30

NUCLEOTIDE-SPECIFIC RECOGNITION SEQUENCES FOR DESIGNER TAL EFFECTORS

#3782
20210403537
2021-12-30

Binding agents to pre-fusion state SARS-CoV-2 spike protein

#3783
20210403519
2021-12-30

METHODS AND COMPOSITIONS TO INDUCE OR SUPPRESS IMMUNE RESPONSES THROUGH THE USE OF MEMBRANE BOUND COMPLEMENT SPLIT PRODUCTS

#3784
20210401950
2021-12-30

COMPOSITIONS FOR TREATING PATHOLOGICAL CALCIFICATION CONDITIONS, AND METHODS USING SAME

#3785
20210401762
2021-12-30

Compositions and methods for organ specific delivery of nucleic acids

#3786
20210395799
2021-12-23

METHODS FOR VARIANT DETECTION

#3787
20210395784
2021-12-23

CRISPR/CAS12F ENZYME AND SYSTEM

#3788
20210395774
2021-12-23

NOVEL VIRUS VECTOR AND METHODS FOR PRODUCING AND USING SAME

#3789
20210395767
2021-12-23

METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT

#3790
20210395761
2021-12-23

Serine recombinases mediating stable integration into plant genomes

#3791
20210395760
2021-12-23

COMPOSITIONS AND METHODS FOR OCHROBACTRUM-MEDIATED GENE EDITING

#3792
20210395732
2021-12-23

TRANS-ACTIVATED FUNCTIONAL RNA BY STRAND DISPLACEMENT AND USES THEREOF

#3793
20210395730
2021-12-23

Selective Curbing of Unwanted RNA Editing (SECURE) DNA Base Editor Variants

#3794
20210395711
2021-12-23

Therapeutic Nuclease Compositions and Methods

#3795
20210395710
2021-12-23

CAS9-CAS9 FUSION PROTEINS

#3796
20210395709
2021-12-23

METHODS AND COMPOSITIONS INVOLVING THERMOSTABLE CAS9 PROTEIN VARIANTS

#3797
20210392864
2021-12-23

Genetically modified rat models for severe combined immunodeficiency (SCID)

#3798
20210392863
2021-12-23

DWARFISM ANIMAL MODEL HAVING IGF-1 GENETIC MUTATION AND METHOD FOR PRODUCING SAME

#3799
20210392862
2021-12-23

Cas-ready mouse embryonic stem cells and mice and uses thereof

#3800
20210389324
2021-12-16

Methods and Compositions for the Detection of Host Protein Cleavage by Group IV Viral Proteases

#3801
20210389303
2021-12-16

TRANSIENT REPORTERS AND METHODS FOR BASE EDITING ENRICHMENT

#3802
20210388437
2021-12-16

Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs

#3803
20210388434
2021-12-16

Compositions and methods for detecting molecular targets on chromosomal DNA

#3804
20210388415
2021-12-16

METHODS AND KITS FOR DEPLETION AND ENRICHMENT OF NUCLEIC ACID SEQUENCES

#3805
20210388414
2021-12-16

Optimization of in vitro isolation of nucleic acids using site-specific nucleases

#3806
20210388396
2021-12-16

CRISPR-BASED GENOME MODIFICATION AND REGULATION

#3807
20210388395
2021-12-16

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#3808
20210388394
2021-12-16

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#3809
20210388393
2021-12-16

PLGA-PEG/PEI NANOPARTICLES AND METHODS OF USE

#3810
20210388392
2021-12-16

CRISPR-LpCas9 GENE EDITING SYSTEM AND APPLICATION THEREOF

#3811
20210388391
2021-12-16

Nucleic acid-guided nucleases

#3812
20210388373
2021-12-16

Methods for genetic modification of plants

#3813
20210388362
2021-12-16

TARGETED NON-VIRAL DNA INSERTIONS

#3814
20210388351
2021-12-16

ARTIFICIAL RNA-GUIDED SPLICING FACTORS

#3815
20210388349
2021-12-16

Gene-regulating compositions and methods for improved immunotherapy

#3816
20210388348
2021-12-16

MODIFIED GUIDE RNAS FOR CRISPR GENOME EDITING

#3817
20210388333
2021-12-16

RNA-GUIDED NUCLEASES AND DNA BINDING PROTEINS

#3818
20210388332
2021-12-16

GENE EDITING SYSTEM FOR CORRECTING SPLICING DEFECTS

#3819
20210388327
2021-12-16

Synthetic reverse transcriptases and uses thereof

#3820
20210386915
2021-12-16

COMPOSITIONS AND METHODS FOR AIRWAY TISSUE REGENERATION

#3821
20210386854
2021-12-16

Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same

#3822
20210381038
2021-12-09

METHOD FOR DETECTING NUCLEIC ACID

#3823
20210381018
2021-12-09

Methods and systems for monomer chain formation

#3824
20210381007
2021-12-09

METHODS AND COMPOSITIONS FOR CRISPR EDITING OF CELLS AND CORRELATING THE EDITS TO A RESULTING CELLULAR NUCLEIC ACID PROFILE

#3825
20210380990
2021-12-09

Synthetic immunomodulation with a CRISPR super-repressor in vivo

#3826
20210380987
2021-12-09

CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING CYSTIC FIBROSIS

#3827
20210380975
2021-12-09

RNA-GUIDED TRANSCRIPTIONAL REGULATION AND METHODS OF USING THE SAME FOR THE TREATMENT OF BACK PAIN

#3828
20210380967
2021-12-09

Methods of Identifying Adenosine-to-Inosine Edited RNA

#3829
20210380957
2021-12-09

CRISPR-Cas effector polypeptides and methods of use thereof

#3830
20210380956
2021-12-09

CRISPR-associated transposases and uses thereof

#3831
20210380955
2021-12-09

METHODS OF EDITING SINGLE NUCLEOTIDE POLYMORPHISM USING PROGRAMMABLE BASE EDITOR SYSTEMS

#3832
20210380953
2021-12-09

Pharmaceutical compositions comprising bacterial delivery vehicles and uses thereof

#3833
20210379105
2021-12-09

GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS -- CORRECTION OF X-LINKED AGAMMAGLOBULINEMIA (XLA)

#3834
20210371926
2021-12-02

CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS

#3835
20210371883
2021-12-02

Methods of use of CRISPR CPF1 hybrid DNA/RNA polynucleotides

#3836
20210371873
2021-12-02

METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT

#3837
20210371859
2021-12-02

RNA MEDIATED GENE REGULATING METHODS

#3838
20210371858
2021-12-02

METHODS OF SUPPRESSING PATHOGENIC MUTATIONS USING PROGRAMMABLE BASE EDITOR SYSTEMS

#3839
20210371857
2021-12-02

Compositions for genome editing

#3840
20210371855
2021-12-02

METHODS OF INHIBITING PROLIFERATIVE CELLS

#3841
20210371854
2021-12-02

Composition for modifying target gene

#3842
20210371838
2021-12-02

Non-standard amino acid containing compositions and uses thereof

#3843
20210371471
2021-12-02

Antibody-evading virus vectors

#3844
20210371469
2021-12-02

Virus vectors for targeting ophthalmic tissues

#3845
20210369865
2021-12-02

Exosomes Comprising RNA Therapeutics

#3846
20210369859
2021-12-02

Nanoliposome-microbubble conjugate having complex of Cas9 protein, guide RNA inhibiting SRD5A2 gene expression and cationic polymer encapsulated in nanoliposome and composition for ameliorating or treating hair loss containing the same

#3847
20210366572
2021-11-25

METHODS, MODELS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES FOR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF

#3848
20210363571
2021-11-25

Determination of base modifications of nucleic acids

#3849
20210363547
2021-11-25

DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS ELANE GENE

#3850
20210363546
2021-11-25

IN VIVO HOMOLOGY DIRECTED REPAIR IN HEART, SKELETAL MUSCLE, AND MUSCLE STEM CELLS

#3851
20210363522
2021-11-25

CRISPR/CAS-RELATED METHODS AND COMPOSITIONS TARGETING VIRUS GENOMES

#3852
20210363521
2021-11-25

CRISPR/CAS Systems For Treatment of DMD

#3853
20210363520
2021-11-25

Target sequence specific alteration technology using nucleotide target recognition

#3854
20210363518
2021-11-25

MODIFIED GUIDE RNAS FOR CRISPR GENOME EDITING

#3855
20210363509
2021-11-25

Genome Editing by Directed Non-Homologous DNA Insertion Using a Retroviral Integrase-Cas9 Fusion Protein

#3856
20210363508
2021-11-25

Cell data recorders and uses thereof

#3857
20210363507
2021-11-25

Gene Targeting

#3858
20210363260
2021-11-25

Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway

#3859
20210363212
2021-11-25

GENETICALLY ENGINEERED CAR T CELLS THAT SECRET INTERLEUKIN-12 AND THERAPEUTIC USES THEREOF

#3860
20210361779
2021-11-25

DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING VIRAL COMPONENTS

#3861
20210355522
2021-11-18

INHIBITORS OF RNA-GUIDED NUCLEASE ACTIVITY AND USES THEREOF

#3862
20210355509
2021-11-18

ALTERNATIVE SPLICING REGULATION OF GENE EXPRESSION AND THERAPEUTIC METHODS

#3863
20210355508
2021-11-18

Method for Modulating RNA Splicing by Inducing Base Mutation at Splice Site or Base Substitution in Polypyrimidine Region

#3864
20210355502
2021-11-18

MATERIALS AND METHODS FOR THE CORRECTION OF RETINITIS PIGMENTOSA

#3865
20210355492
2021-11-18

CARGO LOADED EXTRACELLULAR VESICLES

#3866
20210355488
2021-11-18

Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas Effector Enzymes

#3867
20210355487
2021-11-18

Methods and kits for identifying cancer treatment targets

#3868
20210355480
2021-11-18

Method For Creating Reference Cell Lines With Simultaneous Genetic Variants And Accurate Quantification Of Alelle Frequency

#3869
20210355476
2021-11-18

Bifunction chemical epigenetic modifiers and methods of use

#3870
20210355475
2021-11-18

OPTIMIZED BASE EDITORS ENABLE EFFICIENT EDITING IN CELLS, ORGANOIDS AND MICE

#3871
20210355467
2021-11-18

Cascade/dCas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells

#3872
20210355466
2021-11-18

Optimized protein linkers and methods of use

#3873
20210355465
2021-11-18

Engineered CRISPR-Cas9 Nucleases

#3874
20210355464
2021-11-18

Method for treating muscular dystrophy by targeting utrophin gene

#3875
20210355463
2021-11-18

Messenger RNA encoding Cas9 for use in genome-editing systems

#3876
20210355462
2021-11-18

Nucleic acid molecules encoding nuclease-albumin fusion proteins

#3877
20210355440
2021-11-18

Engineered red blood cells having rare antigen phenotypes

#3878
20210353678
2021-11-18

Targeted replacement of endogenous T cell receptors

#3879
20210350875
2021-11-11

HIGH THROUGHPUT METHOD AND SYSTEM FOR MAPPING INTRACELLULAR PHASE DIAGRAMS

#3880
20210348243
2021-11-11

RAPID FIELD-DEPLOYABLE DETECTION OF SARS-CoV-2 VIRUS

#3881
20210348230
2021-11-11

DETECTION OF NUCLEIC ACIDS

#3882
20210348212
2021-11-11

HIV or HCV detection with CRISPR-CAS13A

#3883
20210348189
2021-11-11

METHOD FOR FAST GENE EDITING AND CONSTRUCTING PRIMATE DISEASE MODEL

#3884
20210348188
2021-11-11

Universal donor cells

#3885
20210348177
2021-11-11

GENERATION OF HERITABLY GENE-EDITED PLANTS WITHOUT TISSUE CULTURE

#3886
20210348175
2021-11-11

Genetic toolbox for metabolic engineering of non-conventional yeast

#3887
20210348165
2021-11-11

Pig with a genetically modified CD163 gene resistant to PRRSv

#3888
20210348161
2021-11-11

GENE EDITING BASED CANCER TREATMENT

#3889
20210348159
2021-11-11

COMPOSITIONS AND METHODS FOR DELIVERING TRANSGENES

#3890
20210348157
2021-11-11

NOVEL CRISPR ENZYMES AND SYSTEMS

#3891
20210348156
2021-11-11

NOVEL CRISPR ENZYMES AND SYSTEMS

#3892
20210348144
2021-11-11

sp. CAS12A mutants with enhanced cleavage activity at non-canonical TTTT protospacer adjacent motifs

#3893
20210348143
2021-11-11

NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION

#3894
20210347847
2021-11-11

THERAPEUTIC TARGETING OF MALIGNANT CELLS USING TUMOR MARKERS

#3895
20210347829
2021-11-11

Endogenous Gag-based capsids and uses thereof

#3896
20210344631
2021-11-04

RNA targeting methods and compositions

#3897
20210344630
2021-11-04

RNA targeting methods and compositions

#3898
20210344629
2021-11-04

RNA targeting methods and compositions

#3899
20210344628
2021-11-04

RNA targeting methods and compositions

#3900
20210344627
2021-11-04

RNA targeting methods and compositions