RNA-guided human genome engineering

Artificial genome manipulation for gene expression regulation

MODEL EDITING SYSTEMS AND METHODS RELATING TO THE SAME

CURING FOR RECURSIVE NUCLEIC ACID-GUIDED CELL EDITING

CRISPR-CAS BASED SYSTEM FOR TARGETING SINGLE-STRANDED SEQUENCES

Targeted Sequence Insertion Compositions and Methods

CAS9 PROTEIN FOR GENOME EDITING

Engineered meganucleases that target human mitochondrial genomes

Compositions comprising a variant Cas12i4 polypeptide and uses thereof

METHODS FOR TREATING INFLAMMATORY BOWEL DISEASE BASED ON HOST-MYCOBIOTA INTERACTIONS

Compositions and Methods for Kallikrein (KLKB1) Gene Editing

TARGETED DISRUPTION OF T CELL AND/OR HLA RECEPTORS

LASER-ACTUATED SUPERCRITICAL INJECTOR

GENE EDITING-BASED METHOD OF ATTENUATING THE BETA-AMYLOID PATHWAY

Gene therapy for haploinsufficiency

COMPOSITION AND METHOD FOR INHIBITING PROLIFERATION HEPATITIS B VIRUS

PRECISE BREEDING METHODS FOR GENE-EDITED NON-HUMAN ANIMALS

PLATFORM FOR EXPRESSING PROTEIN OF INTEREST IN LIVER

MAMMALIAN CELLS COMPRISING INTEGRATED CAS9 GENES TO PRODUCE STABLE INTEGRATION SITES, AND MAMMALIAN CELLS COMPRISING STABLE INTEGRATION SITES AND OTHER SITES

SINGLE GENERATION TARGETED GENE INTEGRATION

TYPE I-C CRISPR SYSTEM FROM NEISSERIA LACTAMICA AND METHODS OF USE

COMPOSITIONS COMPRISING A CAS12I POLYPEPTIDE AND USES THEREOF

SEQUENTIAL GENE EDITING IN PRIMARY IMMUNE CELLS

PROGRAMMABLE INSERTION APPROACHES VIA REVERSE TRANSCRIPTASE RECRUITMENT

GUIDE-RNA EXPRESSION SYSTEM FOR A HOST CELL

Compositions comprising a variant polypeptide and uses thereof

RNA GUIDED COMPOSITIONS FOR PREVENTING AND TREATING HEPATITIS B VIRUS INFECTIONS

Modified guide RNAs

KRAB FUSION REPRESSORS AND METHODS AND COMPOSITIONS FOR REPRESSING GENE EXPRESSION

CRISPR/CAS FUSION PROTEINS AND SYSTEMS

IMMOBILIZED ENZYME COMPOSITIONS AND METHODS

CRISPR-Cas effector polypeptides and methods of use thereof

Targeted DNA demethylation method, fusion protein and application thereof preliminary class

Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation

NOVEL, NON-NATURALLY OCCURRING CRISPR-CAS NUCLEASES FOR GENOME EDITING

SEQUENCE SPECIFIC DEGRADATION OF SINGLE-STRANDED POLYNUCLEOTIDES WITH CARD1 NUCLEASE

NOVEL CAS ENZYMES AND METHODS OF PROFILING SPECIFICITY AND ACTIVITY

A NEW, NON-SPECIFIC THERMOLABILE NUCLEASE ACTIVE AT LOW TEMPERATURE, IN WIDE PH RANGE AND HIGH CONCENTRATION IN SALTS

CRISPR-CAS SYSTEM FOR GENE THERAPY

MATERIALS AND METHODS FOR MAKING SEXUAL STAGE PLASMODIUM PARASITES

SUPPRESSION OF SHADE AVOIDANCE RESPONSE IN PLANTS

CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS

ENGINEERED CAS9-NUCLEASES AND METHOD OF USE THEREOF

GENOMIC SAFE HARBORS FOR GENETIC THERAPIES IN HUMAN STEM CELLS AND ENGINEERED NANOPARTICLES TO PROVIDE TARGETED GENETIC THERAPIES

MATERIALS AND METHODS FOR TREATMENT OF PAIN RELATED DISORDERS

BASE EDITING APPROACHES FOR THE TREATMENT OF BETAHEMOGLOBINOPATHIES

MODIFYING THE SPECIFICITY OF PLANT NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION

GENE EDITED SOYBEAN PLANTS WITH ENHANCED TRAITS

Repressible control of gene expression

Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)

Sequence-Specific Targeted Transposition and Selection and Sorting of Nucleic Acids

Methods and compositions for treating angiopoietin-like 3 (ANGPTL3) related conditions

SIGNAL BOOST CASCADE ASSAY

Modified CAS9 protein, and use thereof

NOVEL CRISPR ENZYMES, METHODS, SYSTEMS AND USES THEREOF

DETERGENT COMPOSITIONS CONTAINING ENZYMES

Methods of Prevention or Treatment of Alzheimer's Disease by Blocking or Decreasing STING Signaling Activation

CHIMERIC RECEPTOR BINDING PROTEINS FOR USE IN BACTERIAL DELIVERY VEHICLES

DETECTION ASSAYS

DISCOVERY AND ENGINEERING OF INTEGRASES FOR HIGH-EFFICIENCY GENE INTEGRATION

GENOMIC EDITING WITH SITE-SPECIFIC RETROTRANSPOSONS

Enhancing Utrophin Expression in Cell by Inducing Mutations Within Utrophin Regulatory Elements and Therapeutic Use Thereof

COMPOSITIONS OF DNA MOLECULES, METHODS OF MAKING THEREFOR, AND METHODS OF USE THEREOF

METHODS AND COMPOSITIONS FOR EDITING THE B2M LOCUS IN B CELLS

METHODS AND COMPOSITIONS FOR MODULATING A GENOME

MODIFICATION OF BLOOD TYPE ANTIGENS

METHODS AND COMPOSITIONS FOR CORRECTION OF DMD MUTATIONS

METHODS AND COMPOSITIONS FOR EVOLVING BASE EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)

GENETIC MODIFICATION OF CYTOKINE INDUCIBLE SH2-CONTAINING PROTEIN (CISH) GENE

PLASTID TRANSFORMATION BY COMPLEMENTATION OF PLASTID MUTATIONS

Polypeptides useful for gene editing and methods of use

METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163

RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX

Engineered Guide RNA Sequences for In Situ Detection and Sequencing

ENRICHMENT OF MUTATED CELL FREE NUCLEIC ACIDS FOR CANCER DETECTION

METHODS OF GENOME EDITING INCLUDING CONTROLLED OPENING OF CHROMATIN

ENHANCED hAT FAMILY MEMBER SPIN TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS

Stabilized Nucleic Acids Encoding Messenger Ribonucleic Acid (mRNA)

Inhibitors of the Artemin Pathway for Treatment of Cancer

COMPOSITIONS AND METHODS COMPRISING PLANTS WITH MODIFIED ANTHOCYANIN CONTENT

HETEROZYGOUS CENH3 MONOCOTS AND METHODS OF USE THEREOF FOR HAPLOID INDUCTION AND SIMULTANEOUS GENOME EDITING

COLOR-BASED AND/OR VISUAL METHODS FOR IDENTIFYING THE PRESENCE OF A TRANSGENE AND COMPOSITIONS AND CONSTRUCTS RELATING TO THE SAME

Compositions and methods for targeting, editing, or modifying genes

A MODULAR AND POOLED APPROACH FOR MULTIPLEXED CRISPR GENOME EDITING

CANNABIS WITH ALTERED CANNABINOID CONTENT

REMOVABLE PLANT TRANSGENIC LOCI WITH COGNATE GUIDE RNA RECOGNITION SITES

INCORPORATION OF INTERNAL POLYA-ENCODED POLY-LYSINE SEQUENCE TAGS AND THEIR VARIATIONS FOR THE TUNABLE CONTROL OF PROTEIN SYNTHESIS IN BACTERIAL AND EUKARYOTIC CELLS

Type II CRISPR/Cas9 genome editing system and the application thereof

CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS AND METHODS OF USE THEREOF

ENGINEERED NUCLEASES AND METHODS OF USE THEREOF

ENGINEERED MAD7 DIRECTED ENDONUCLEASE

Genetically engineered T cells with Regnase-1 and/or TGFBRII disruption have improved functionality and persistence

Treatment Of Increased Lipid Levels With Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Inhibitors

Encoded Dual-Probe Endonuclease Assays

ENZYMATIC OLIGONUCLEOTIDE ASSEMBLY USING HAIRPINS AND ENZYMATIC CLEAVAGE

Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing

Inducible CRISPR system expression and applications thereof

GENE EDITING TO IMPROVE JOINT FUNCTION

PLANT METABOLITE-MEDIATED INDUCTION OF BIOFILM FORMATION IN SOIL BACTERIA TO INCREASE BIOLOGICAL NITROGEN FIXATION AND PLANT NITROGEN ASSIMILATION

Compositions and methods for TTR gene editing and treating ATTR amyloidosis

RNA-guided nucleases and active fragments and variants thereof and methods of use

EFFECTOR PROTEINS AND METHODS OF USE

COMPOSITIONS AND METHODS FOR DIRECTING PROTEINS TO SPECIFIC LOCI IN THE GENOME

NON-STANDARD AMINO ACID CONTAINING COMPOSITIONS AND USES THEREOF

CRISPR/CAS9 THERAPIES FOR CORRECTING DUCHENNE MUSCULAR DYSTROPHY BY TARGETED GENOMIC INTEGRATION

Nucleases for genome editing

CULTURE OF ORGANOIDS

GENE EDITING FOR THE TREATMENT OF EPIDERMOLYSIS BULLOSA

MULTIPLEX NUCLEIC ACID DETECTION SYSTEM

HOMOGENOUS ASSAYS IN MICRODROPLETS

Transposition-based therapies

TRANSPOSITION-BASED THERAPIES

UNIVERSAL DONOR CELLS

INHT26 TRANSGENIC SOYBEAN

Treatment of uveitis with endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitors

GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES

COMPOSITIONS, METHODS, MODULES AND INSTRUMENTS FOR AUTOMATED NUCLEIC ACID-GUIDED NUCLEASE EDITING IN MAMMALIAN CELLS USING MICROCARRIERS

SILENCING OF DUX4 BY RECOMBINANT GENE EDITING COMPLEXES

T-CELLS EXPRESSING IMMUNE CELL ENGAGERS IN ALLOGENIC SETTINGS

METHOD FOR TREATING ALZHEIMER'S DISEASE BY TARGETING MAPT GENE

SUPRAMOLECULAR NANOSUBSTRATE-MEDIATED DELIVERY SYSTEM ENABLES CRISPR/CAS9 KNOCKIN OF HEMOGLOBIN BETA GENE-A POTENTIAL THERAPEUTIC SOLUTION FOR HEMOGLOBINOPATHIES

Systems and Methods for Stable and Heritable Alteration by Precision Editing (SHAPE)

FLUORESCENT CROSS-LINKED RNASE H MUTANT CONJUGATE, MIRNA COMBINATION AND APPLICATION THEREOF

COMPOSITIONS FOR EXPOSING FILM-FORMING MICROBES AND METHODS FOR USE OF THE COMPOSITIONS

METHODS AND PRODUCTS FOR TRANSFECTING CELLS

DUAL PROMOTER SYSTEMS

METHOD FOR INCREASING METHIONINE CONTENT IN GRAINS BY GENE KNOCKOUT

Compositions and methods for modifying genomes

GENE EDITING TOOLS

METHODS AND COMPOSITIONS FOR MODULATING A GENOME

NOVEL TRANSPLANTATION CELLS HAVING REDUCED IMMUNOGENICITY

NOVEL TYPE I-C CRISPR-CAS SYSTEM FROM CLOSTRIDIA

CRISPR DNA and RNA targeting enzymes and systems

COMPOSITIONS AND METHODS FOR ENGRAFTMENT OF BASE EDITED CELLS

COMPOSITIONS AND METHODS FOR INCREASING OR ENHANCING TRANSDUCTION OF GENE THERAPY VECTORS AND FOR REMOVING OR REDUCING IMMUNOGLOBULINS

NUCLEIC ACID-GUIDED EDITING OF EXOGENOUS POLYNUCLEOTIDES IN HETEROLOGOUS CELLS

ISCAN: AN RT-LAMP-COUPLED CRISPR-CAS MODULE FOR RAPID, SENSITIVE DETECTION OF SARS-COV-2

Compositions of matter for detection assays

Engineered retrons and methods of use

METHODS AND MEANS FOR GENETIC ALTERATION OF GENOMES UTILIZING DESIGNER DNA RECOMBINING ENZYMES

CRISPR SYSTEMS WITH ENGINEERED DUAL GUIDE NUCLEIC ACIDS

Compositions and methods for targeting, editing, or modifying genes

METHOD OF CONTAINMENT OF NUCLEIC ACID VECTORS INTRODUCED IN A MICROBIOME POPULATION

RNA-guided nucleases and active fragments and variants thereof and methods of use

HOST DEFENSE SUPPRESSING METHODS AND COMPOSITIONS FOR MODULATING A GENOME

COMPOSITIONS AND METHODS FOR ALTERING PLANT DETERMINACY

PLANT CELL TREATMENTS TO IMPROVE PLANT TRANSFORMATION

METHODS FOR PRODUCING A COMPLEX TRANSGENIC TRAIT LOCUS

Gene Editing System of Escherichia Coli and Gene Editing Method Thereof

CIRCULAR RNA PLATFORMS, USES THEREOF, AND THEIR MANUFACTURING PROCESSES FROM ENGINEERED DNA

Compositions and Methods for Treating Huntington's Disease and Related Disorders

GENE EDITING TO IMPROVE JOINT FUNCTION

DIRECTED EVOLUTION METHOD BASED ON PRIMARY AND SECONDARY REPLICON OF GEMINI VIRUS

ARGONAUTE PROTEIN FROM EUKARYOTES AND APPLICATION THEREOF

CELLS MODIFIED BY A CAS12I POLYPEPTIDE

COMPOSITIONS COMPRISING A CRISPR NUCLEASE AND USES THEREOF

TARGETING BCL11A ENHANCER FUNCTIONAL REGIONS FOR FETAL HEMOGLOBIN REINDUCTION

MATERIALS AND METHODS FOR TREATMENT OF TITIN-BASED MYOPATHIES AND OTHER TITINOPATHIES

LIGHT-INDUCIBLE GENE ACTIVATION SYSTEMS AND METHODS FOR MAKING AND USING THEM

Compositions and Methods for Suppressing MSUT2

COMPOSITIONS AND METHODS FOR THE IMPROVED PRODUCTION AND DELIVERY OF RNA BY EFFICIENT TRANSCRIPTION TERMINATION

METHOD FOR PRODUCING AN ANIMAL COMPRISING A GERMLINE GENETIC MODIFICATION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

CLASS II, TYPE V CRISPR SYSTEMS

SELECTION BY ESSENTIAL-GENE KNOCK-IN

Materials and Methods for Treatment of Myotonic Dystrophy Type 1 (DM) and Other Related Disorders

METHOD FOR BASE EDITING IN PLANTS

Enhanced virus-like particles and methods of use thereof for delivery to cells

Transcriptional control in prokaryotic cells using DNA-binding repressors

ENHANCED PURIFICATION OF ADENO-ASSOCIATED VIRUS TO MORE EFFECTIVELY REMOVE CONTAMINATING DNA

GENETICALLY MODIFIED NON-HUMAN ANIMAL EXPRESSING A B2M/FCRN FUSION PROTEIN

ELIMINATION OF COLONIC BACTERIAL DRIVING LETHAL INFLAMMATORY CARDIOMYOPATHY

METHOD FOR REJUVENATING GLIAL PROGENITOR CELLS AND REJUVENATED GLIAL PROGENITOR CELLS PER SE

COMPOSISTIONS AND METHODS FOR CRISPR ENABLED DNA SYNTHESIS

PAM-REDUCED AND PAM-ABOLISHED CAS DERIVATIVES COMPOSITIONS AND USES THEREOF IN GENETIC MODULATION

RAPID REMOVAL OF A SELF-REPLICATING FUNGAL PLASMID FOR EFFICIENT MARKER CYCLING

ALTERATION OF SEED COMPOSITION IN PLANTS

Lettuce with increased shelf life

PRECISE INTRODUCTION OF DNA OR MUTATIONS INTO THE GENOME OF WHEAT

GENE-REGULATING COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY

HIGH PURITY gRNA SYNTHESIS PROCESS

Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

CRISPR-CAS9 MEDIATED DISRUPTION OF ALCAM GENE INHIBITS ADHESION AND TRANS-ENDOTHELIAL MIGRATION OF MYELOID CELLS

GRNA TARGETING CTGF GENE AND USE THEREOF

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA DIRECTED MODULATION OF TRANSCRIPTION

METHODS FOR TARGETED INSERTION OF EXOGENOUS SEQUENCES IN CELLULAR GENOMES

GENOME EDITING SYSTEM AND METHOD

METHODS AND COMPOSITIONS FOR EFFICIENT AND PRECISE GENE EDITING IN MAMMALIAN BRAIN TO PREVENT OR TREAT NERVOUS SYSTEM DISORDERS

METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT

Generation of site specific integration sites for complex trait loci in corn and soybean, and methods of use

Methods and Systems of Molecular Recording by Crispr-Cas System

CRISPR DNA targeting enzymes and systems

Gene editing systems comprising an RNA guide targeting hydroxyacid oxidase 1 (HAO1) and uses thereof

Gene editing systems comprising an RNA guide targeting lactate dehydrogenase a (LDHA) and uses thereof

USE OF A NUCLEASE FOR REDUCING THE VISCOSITY AND/OR PREVENTING AN INCREASE IN VISCOSITY OF A FERMENTATION BROTH

METHODS FOR INTEGRATING DNA INTO GENES WITH GAIN-OF-FUNCTION OR LOSS-OF-FUNCTION MUTATIONS

COMPOSITIONS AND METHODS FOR EPIGENOME EDITING

RNA-Guided Systems for In Vivo Gene Editing

SARS-COV-2-SPECIFIC T CELLS

GENE-EDITED BASIL PLANTS RESISTANT TO DOWNY MILDEW

OPTIMIZED GENE EDITING UTILIZING A RECOMBINANT ENDONUCLEASE SYSTEM

GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING STATHMIN 2 (STMN2) AND USES THEREOF

SYSTEMS AND METHODS FOR CELLULAR REPROGRAMMING OF A PLANT CELL

Modified excisable DAS81419-2 soybean transgenic insect resistance locus

Mutations in Cas9 discovered by broad scanning mutagenesis demonstrate enhancement of DNA cleavage activity

EFFECTOR PROTEINS AND METHODS OF USE

LIPID NANOPARTICLE FORMULATIONS FOR CRISPR/CAS COMPONENTS

Method for digesting nucleic acid in a sample

Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing

RNA-GUIDED NUCLEASES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USE

MODIFIED ENDONUCLEASES AND RELATED METHODS

HYPOIMMUNOGENIC CELLS

TARGETED GENOMIC INTEGRATION TO RESTORE NEUROFIBROMIN CODING SEQUENCE IN NEUROFIBROMATOSIS TYPE 1 (NF1)

CRISPR-MEDIATED GENOME EDITING WITH VECTORS

PRECISE DELETION OF CHROMOSOMAL SEQUENCES IN VIVO AND TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS USING ENGINEERED NUCLEASES

Modified excisable MON89034 transgenic maize insect resistance locus

DETERMINATION OF BASE MODIFICATIONS OF NUCLEIC ACIDS

CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE

CAS9 Fusion Proteins and Related Methods

METHODS FOR INCREASING THE EFFICIENCY OF HOMOLOGY DIRECTED REPAIR (HDR) IN THE CELLULAR GENOME

SELF-LIMITING VIRAL VECTORS ENCODING NUCLEASES

UNIVERSAL DONOR CELLS

Incorporation of unnatural amino acids into proteins using base editing

COMPOSITIONS AND METHODS FOR TREATING FABRY DISEASE

Treatment Of Kidney Diseases With Angiopoietin Like 3 (ANGPTL3) Inhibitors

METHODS AND COMPOSITIONS FOR IMPROVED TYPE I-E CRISPR BASED GENE SILENCING

TAT-INDUCED CRISPR/ENDONUCLEASE-BASED GENE EDITING

SYSTEM AND METHOD FOR GENE EDITING BY USING ENGINEERED CELL

ENZYME REACTION SOLUTION FOR CONSTRUCTING SEQUENCING LIBRARY AND USE THEREOF

IMPROVED HIGH-THROUGHPUT COMBINATORIAL GENETIC MODIFICATION SYSTEM AND OPTIMIZED CAS9 ENZYME VARIANTS

CAS12B SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED DNA BASE EDITING

ENGINEERED GENE-EDITING PROTEINS

TREATMENT OF RETINITIS PIGMENTOSA USING IMPROVED ENGINEERED MEGANUCLEASES

Applications of Recombined ScCas9 Enzymes for PAM-free DNA Modification

UNIVERSAL DONOR CELLS

UNIVERSAL DONOR CELLS

METHODS FOR TREATING GAIN-OF-FUNCTION DISORDERS COMBINING GENE EDITING AND GENE THERAPY

AAV Vector for Disrupting Coagulation Factor-Related Gene on Liver Genome

COMPOSITIONS AND METHODS FOR TREATING AN INHERITED RETINAL DISEASE

GENE EDITING OF ANTICOAGULANT FACTORS

ALTERNATIVE GENERATION OF ALLOGENEIC HUMAN T CELLS

A METHOD FOR CRISPR LIBRARY SCREENING

IMPROVED DETECTION ASSAYS

Systems, methods, and compositions for correction of frameshift mutations

Methods of in Vitro Cell Delivery

COMPLEXES FOR GENE DELETION AND EDITING

HDR ENHANCERS

HDR ENHANCERS

GENETIC PHYSICAL UNCLONABLE FUNCTIONS AND METHODS OF USE THEREOF

METHODS FOR IMPROVING FLORET FERTILITY AND SEED YIELD

Optimized CRISPR-Cas nucleases and base editors and methods of use thereof

MULTI-FUNCTIONAL GSH-RESPONSIVE SILICA NANOPARTICLES FOR DELIVERY OF BIOMOLECULES INTO PLANT CELLS

Particle delivery systems

CRISPR DNA targeting enzymes and systems

MODIFIED GUIDE RNAS FOR NEISSERIA MENINGITIDIS CAS9

CURE ALL FOR NUCLEIC ACID-GUIDED CELL EDITING IN E. COLI

SELF-LIMITING VIRAL VECTORS ENCODING NUCLEASES

ISOLATED CHIMERIC ANTIGEN RECEPTOR, MODIFIED T CELL COMPRISING SAME AND USE THEREOF

Materials and methods for treatment of Duchenne Muscular Dystrophy

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME

ANTIBODY GENE EDITING IN B LYMPHOCYTES AND CO-EXPRESSION OF CARGO PROTEIN

COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA

Production of Human Cells, Tissues, and Organs in a Growth Factor Receptor-Deficient Animal Host

Compositions and methods for promoting gene editing of CXCR4 gene

SCALABLE TRIO GUIDE RNA APPROACH FOR INTEGRATION OF LARGE DONOR DNA

RNA-GUIDED NUCLEASES AND ACTIVE FRAGMENTS AND VARIANTS THEREOF AND METHODS OF USE

IMMUNOSUPPRESSIVE AGENTS AND VIRAL DELIVERY RE-DOSING METHODS FOR GENE THERAPY

COMPOSITIONS AND METHODS FOR REDUCING NUCLEASE EXPRESSION AND OFF-TARGET ACTIVITY USING A PROMOTER WITH LOW TRANSCRIPTIONAL ACTIVITY

COMPOSITIONS AND METHODS FOR BASE SPECIFIC MITOCHONDRIAL GENE EDITING

A PLANT FERTILITY-ASSOCIATED PROTEIN AND ITS APPLICATION THEREOF

METHODS AND COMPOSITIONS FOR INCREASING RESISTANCE TO EAR ROT AND STEM ROT DISEASE IN MAIZE

GRNA FOR KNOCKING OUT PIG XENOANTIGEN GENE, AND APPLICATION THEREOF

METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION

SYSTEMS AND METHODS FOR VIRAL GENOME TARGETING

Differential knockout of an allele of a heterozygous bestrophin 1 gene

Assays For Measuring Nucleic Acid Modifying Enzyme Activity

DONOR REPAIR TEMPLATES MULTIPLEX GENOME EDITING

TRANSCRIPTIONAL ROADBLOCKS FOR GENE EDITING AND METHODS OF USING THE SAME

USE OF A DEFICIENT FUSION PROTEIN FOR NUCLEASE ACTIVITY SO AS TO INDUCE MEIOTIC RECOMBINATIONS

PLANT GENOME EDITING TECHNIQUE NOT RELYING ON GENE RECOMBINATION UTILIZING CELL MEMBRANE-PERMEABLE PEPTIDE

CRISPR-INHIBITION FOR FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

ENGINEERED CELLS SECRETING THERAPEUTIC ENZYMES

Guide RNA that targets a mutant human inosine monophosphate deyhydrogenase I allele

Guide RNA that targets a mutant human guanylate cyclase 2A allele

DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS RHODOPSIN GENE

METHOD FOR TREATING MUSCULAR DYSTROPHY BY TARGETING LAMA1 GENE

COMPOSITIONS AND METHODS FOR SEQUENTIAL STACKING OF NUCLEIC ACID SEQUENCES INTO A GENOMIC LOCUS

AN ULTRASENSITIVE RAPID AND PORTABLE CASE13D-BASED DIAGNOSTIC ASSAY

CRISPR CASCADE ASSAY

COMPOSITIONS AND METHODS FOR REDUCING NUCLEASE EXPRESSION AND OFF-TARGET ACTIVITY USING A PROMOTER WITH LOW TRANSCRIPTIONAL ACTIVITY

DESIGN OF TWO-PART GUIDE RNAS FOR CRISPRa APPLICATIONS

Optimised Methods for Cleavage of Target Sequences

Segmented Nucleic Acids

COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ANGELMAN SYNDROME

COMPOSITIONS FOR TREATING CANCER WITH KRAS MUTATIONS AND USES THEREOF

AUTOINDUCER-2 (AI-2) MOLECULAR RESPONSE-BASED STARTING ELEMENT AND ESCHERICHIA COLI (E. COLI) DYNAMIC REGULATION SYSTEM AND METHOD CONSTRUCTED THEREBY

TAGGED GENE EDITING TECHNOLOGY FOR CLINICAL CELL SORTING AND ENRICHMENT

ANTI-CRISPR COMPOUNDS AND METHODS OF USE

RNA GUIDED ERADICATION OF VARICELLA ZOSTER VIRUS