ClassID:

112627

C12Q1/6897 - page 4 - CPC Classification

Classification description:

Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Recent Application in this class:
#901
20080213803
2008-09-04

Method for screening for agents that affect food intake

#902
20080207540
2008-08-28

Method For the Identification of Compounds Modulating Reverse Transport of Cholesterol

#903
20080199864
2008-08-21

METHODS FOR CELL SCREENING OF COMPOUNDS CAPABLE OF MODULATING THE ACTIVITY OF UBIQUITIN-LIGASE SCF COMPLEXES AND THEIR USES

#904
20080194421
2008-08-14

Screening system for identifying drug-drug interactions and methods of use thereof

#905
20080187927
2008-08-07

USING HUG1 PROMOTER AND A REPORTER GENE TO DETECT GENOTOXICITY AND GENOPROTECTION

#906
20080181877
2008-07-31

Method For Monitoring the Effect of Compounds on Foxc2 Expression

#907
20080176225
2008-07-24

MEMBRANE BOUND REPORTER GENE SYSTEM

#908
20080167259
2008-07-10

Materials and methods for detecting interaction of CFTR polypeptides

#909
20080166711
2008-07-10

Assays for TERT promoter modulatory agents

#910
20080153764
2008-06-26

System and Methods For Short Rna Expression

#911
20080153101
2008-06-26

Compositions and methods for identifying agents that alter expression of survivin

#912
20080152618
2008-06-26

Identification and use of agents that modulate oncogenic transcription agent activity

#913
20080146456
2008-06-19

Methods For Improving a Binding Characteristic of a Molecule

#914
20080138820
2008-06-12

METHOD FOR DETERMINING GENOTOXICITY

#915
20080138818
2008-06-12

Gene reporter assay, kit and cells with improved sensitivity and/or specificity for determining the level of an extracellular signal

#916
20080132427
2008-06-05

CELL SYSTEMS AND METHODS FOR DETECTING PROLIFERATION ACITVITY

#917
20080125465
2008-05-29

Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex

#918
20080118494
2008-05-22

Compositions For Detection Of Latent Hiv Reactivation And Methods Of Using The Same

#919
20080115238
2008-05-15

HEDGEHOG INHIBITOR ASSAY

#920
20080108139
2008-05-08

COMPOSITION OF MATTER COMPRISING PRIMARY NUCLEIC ACID COMPONENT

#921
20080104726
2008-05-01

FRUIT REGULATORY REGIONS

#922
20080104723
2008-05-01

Development of Mammalian Genome Modification Technique Using Retrotransposon

#923
20080076116
2008-03-27

Kits for detection of segmented negative strand RNA viruses

#924
20080064040
2008-03-13

Monitoring gene silencing and annotating gene function in living cells

#925
20080050720
2008-02-28

Methods for Using a Sterol Biosynthesis Pathway Reporter Gene to Screen for Antifungal or Lipid Lowering Compounds

#926
20080045472
2008-02-21

TARGETS FOR HUMAN MICRO RNAS IN AVIAN INFLUENZA VIRUS (H5N1) GENOME

#927
20080044829
2008-02-21

Biosensor Utilizing Pigment-Synthesizing Gene Of A Purple Non-Sulfur Bacterium And A Method For Preparing Such A Biosensor

#928
20080044815
2008-02-21

Genetic Screen for Interaction Interface Mapping

#929
20080044810
2008-02-21

Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS

#930
20080034445
2008-02-07

Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists

#931
20080009438
2008-01-10

Screening methods for compounds useful in the regulation of body weight

#932
20080009060
2008-01-10

Methods of discovering chemicals capable of functioning as gene expression modulators

#933
20080003658
2008-01-03

Method for expression of small antiviral RNA molecules within a cell

#934
20070298412
2007-12-27

Fluorescent proteins and chromoproteins from non-species and methods for using same

#935
20070292840
2007-12-20

Replication competent hepatitis C virus and methods of use

#936
20070287153
2007-12-13

Methods for the identification and validation of functional intracellular targets with intramers or in vivo selection

#937
20070275376
2007-11-29

Tumor-Specific Expression of Reporter Genes

#938
20070264674
2007-11-15

Cytochrome P450 Induction Assay

#939
20070259341
2007-11-08

Prion-like form of CPEB and related compositions and methods

#940
20070258948
2007-11-08

Tissue modeling in embryonic stem (ES) cell system

#941
20070253954
2007-11-01

Epha4 As Therapeutic Target Of Prc And Pdaca

#942
20070248967
2007-10-25

Reporter Assay Using Secrectory Luminescent Enzymes

#943
20070244061
2007-10-18

Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-spondins) and/or Wnt

#944
20070243541
2007-10-18

Compositions and methods for generating antigen-binding units

#945
20070243202
2007-10-18

Antibodies to tumor necrosis factor receptor associated factor polypeptides

#946
20070238127
2007-10-11

Methods of identifying and isolating stem cells and cancer stem cells

#947
20070224621
2007-09-27

Sequential reporter enzyme luminescence (SRL) methods and compositions for practicing the same

#948
20070224615
2007-09-27

METHODS FOR ASSAYING PROTEIN-PROTEIN INTERACTIONS

#949
20070218470
2007-09-20

Method for selective inactivation of viral replication

#950
20070217999
2007-09-20

Excretable Reporter Systems

#951
20070212685
2007-09-13

Methods for identifying analgesic agents

#952
20070202505
2007-08-30

Methods for gene function analysis

#953
20070202492
2007-08-30

Viral Assay

#954
20070190532
2007-08-16

Assay for identifying compounds which affect stability of mrna

#955
20070184513
2007-08-09

Substrates for beta-lactamase and uses thereof

#956
20070178456
2007-08-02

Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules

#957
20070166716
2007-07-19

Method for evaluating rnai activity and mirna activity

#958
20070166711
2007-07-19

Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof

#959
20070166710
2007-07-19

Methods for inhibiting adipogenesis and for treating type 2 diabetes

#960
20070161031
2007-07-12

Functional arrays for high throughput characterization of gene expression regulatory elements

#961
20070141673
2007-06-21

Tool for quantitative real-time analysis of viral gene expression dynamics in single living cells

#962
20070141568
2007-06-21

Method for determining the presence of one or more ligands in a sample

#963
20070136827
2007-06-14

Cis/trans riboregulators

#964
20070134767
2007-06-14

Hiv-dependent expression constructs and uses therefor

#965
20070128717
2007-06-07

DNA sequences comprising gene transcription regulatory qualities and methods for detecting and using such DNA sequences

#966
20070111203
2007-05-17

Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same

#967
20070099296
2007-05-03

Compositions and methods for determining susceptibility of hepatitis C virus to anti-viral drugs

#968
20070087371
2007-04-19

Zinc finger domains and methods of identifying same

#969
20070087333
2007-04-19

Method to detect antigen-specific cytolytic activity

#970
20070077205
2007-04-05

Use of non-invasive imaging technologies to monitor in vivo gene-expression

#971
20070072186
2007-03-29

Methods and agents for screening for compounds capable of modulating her2 expression

#972
20070072174
2007-03-29

Bioreporter for detection of microbes

#973
20070065839
2007-03-22

Method of identifying agents to prevent or treat diabetes

#974
20070059797
2007-03-15

Upstream control elements of the proopiomelanocortin gene and their use

#975
20070059731
2007-03-15

Ubiquitin mediated fluorescence complementation assay

#976
20070054303
2007-03-08

Expression Vectors and Methods

#977
20070054292
2007-03-08

Bacteriophage linked immunosorbent assay for rapid, sensitive detection of multiple analytes

#978
20070050859
2007-03-01

Method of making a genetically modified mammalian cell

#979
20070042404
2007-02-22

Compositions and method for detecting endonuclease activity

#980
20070037256
2007-02-15

Nucleic acid sequences having gene transcription regulatory qualities

#981
20070037188
2007-02-15

Methods for modulating transcriptional activation using mint proteins

#982
20070037178
2007-02-15

Endocrine cell lines and method of using the same

#983
20070036787
2007-02-15

Insulin-induced gene as therapeutic target in diabetes

#984
20070036721
2007-02-15

Methods and compositions for in vivo inflammation monitoring

#985
20070031936
2007-02-08

Nucleic acid sequences having gene transcription regulatory qualities

#986
20070031935
2007-02-08

Nucleic acid sequences having gene transcription regulatory qualities

#987
20070031934
2007-02-08

Nucleic acid sequences having gene transcription regulatory qualities

#988
20070031933
2007-02-08

Nucleic acid sequences having gene transcription regulatory qualities

#989
20070031874
2007-02-08

Modulating SOS response induction by antimicrobial agents

#990
20070031410
2007-02-08

POP2: NKκB-inhibiting polypeptides, nucleic acids and methods of use

#991
20070026499
2007-02-01

Nucleic acid sequences having gene transcription regulatory qualities

#992
20070026498
2007-02-01

Nucleic acid sequences having gene transcription regulatory qualities

#993
20070026445
2007-02-01

Steroid-activated nuclear receptors and uses therefor

#994
20070025971
2007-02-01

Substances causing differentiation

#995
20070020673
2007-01-25

Model of autoimmune disease and methods for identifying agents against autoimmune disease

#996
20070020630
2007-01-25

Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents

#997
20070010018
2007-01-11

Methods of screening for introduction of DNA into a target cell

#998
20070003980
2007-01-04

Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior

#999
20070003532
2007-01-04

Mechanism for identifying drugs for the treatment of type II diabetes

#1000
20060286671
2006-12-21

Efficient generation of expression cell lines through the use of scorable homeostatic reporter genes

#1001
20060281704
2006-12-14

Regulation of endogenous gene expression in cells using zinc finger proteins

#1002
20060281081
2006-12-14

Method of diagnosing colon and gastric cancers

#1003
20060277615
2006-12-07

Method of determining xenograft responses

#1004
20060276427
2006-12-07

Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins

#1005
20060275823
2006-12-07

Selection of peptides with antibody-like properties

#1006
20060275770
2006-12-07

Heart failure gene determination and therapeutic screening

#1007
20060269950
2006-11-30

Method of identifying compounds that modulate interaction of androgen receptor with beta-catenin

#1008
20060269923
2006-11-30

Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-fungal agents

#1009
20060252154
2006-11-09

Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter

#1010
20060246586
2006-11-02

Chromosome-based platforms

#1011
20060246424
2006-11-02

Self-replicating RNA molecule from hepatitis C virus

#1012
20060240505
2006-10-26

Identification of Targets of Antimicrobial Compounds

#1013
20060223757
2006-10-05

Zinc finger binding domains for GNN

#1014
20060223141
2006-10-05

Transcription amplification system for molecular imaging

#1015
20060223089
2006-10-05

Reverse two-hybrid systems

#1016
20060205017
2006-09-14

Microorganism genomics, compositions and methods related thereto

#1017
20060204981
2006-09-14

Compositions for modulation of PARP and methods for screening for same

#1018
20060199171
2006-09-07

Assays for TERT promoter modulatory agents

#1019
20060194248
2006-08-31

Method of measuring human CYP3A inducibility

#1020
20060194218
2006-08-31

Inducible fluorescence assay

#1021
20060189525
2006-08-24

DADD, death activator death domain protein

#1022
20060183189
2006-08-17

Regulatable gene expression in mammalian cells and mammals

#1023
20060183163
2006-08-17

Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement

#1024
20060183110
2006-08-17

Methods of evaluating cell surface receptor binding of a patient derived population of viral envelope protein constructs

#1025
20060171923
2006-08-03

Methods of identifying modulators of human retrovirus replication

#1026
20060166196
2006-07-27

Reporter gene assay method

#1027
20060160762
2006-07-20

Methods for the treatment, diagnosis, and prognosis of cancer

#1028
20060160185
2006-07-20

Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs

#1029
20060160108
2006-07-20

Reporter transcription unit populations and kits comprising same

#1030
20060154287
2006-07-13

High-content screening for drugs against cancer and age-related diseases

#1031
20060154266
2006-07-13

Assays for TERT promoter modulatory agents using a telomerase structural RNA component

#1032
20060150284
2006-07-06

Gene expression element specific for Ah receptor ligands and heterologous gene expression systems dependent on the element

#1033
20060148030
2006-07-06

Nuclear receptor err y 3

#1034
20060147978
2006-07-06

Methods and compositions for screening for altered cellular phenotypes

#1035
20060147904
2006-07-06

Use of resveratrol to regulate expression of apolipoprotein A1

#1036
20060147377
2006-07-06

Animal model for the fast identification of pharmaceutical active compounds in vivo

#1037
20060135401
2006-06-22

Novel method of selecting immunosuppressant having little thrombocytopenic effect

#1038
20060134681
2006-06-22

Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay

#1039
20060134629
2006-06-22

Methods and compositions for elucidating protein expression profiles in cells

#1040
20060121527
2006-06-08

Oncoprotein protein kinase

#1041
20060121517
2006-06-08

Screening methods involving the detection of short-lived proteins

#1042
20060121509
2006-06-08

Generation of replication competent viruses for therapeutic use

#1043
20060121488
2006-06-08

Glutamate transport modulatory compounds and methods

#1044
20060121469
2006-06-08

Screening for anti-ovulatory compounds

#1045
20060110768
2006-05-25

Method for determining genotoxicity

#1046
20060107351
2006-05-18

Cell visual characteristic-modifying sequences

#1047
20060105385
2006-05-18

Xenobiotic related induction of gene expression

#1048
20060105341
2006-05-18

Trap-tagging: a novel method for the identification and purification of rna-protein complexes

#1049
20060100132
2006-05-11

Method for diagnosing inflammatory bowel disease

#1050
20060094868
2006-05-04

System for cell-based screening

#1051
20060094030
2006-05-04

Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics

#1052
20060094002
2006-05-04

Eukaryotic biosensor making use of a calcium regulated light emitting enzyme

#1053
20060088874
2006-04-27

Methods and kits for detecting mutations

#1054
20060088864
2006-04-27

Aptamer regulated nucleic acids and uses thereof

#1055
20060088859
2006-04-27

Reporter assay screens for protein targets in

#1056
20060088838
2006-04-27

Methods for improving a binding characteristic of a molecule

#1057
20060078911
2006-04-13

Oxidative DNA damage protection

#1058
20060078902
2006-04-13

Method and compositions for RNA interference

#1059
20060078878
2006-04-13

Regulation of endogenous gene expression in cells using zinc finger proteins

#1060
20060073497
2006-04-06

Juvenile hemochromatosis gene (HFE2A) cleavage products and uses thereof

#1061
20060069245
2006-03-30

Screening methods for cognitive enhancers

#1062
20060068388
2006-03-30

Method for the identification of modulators of a secretase activity

#1063
20060063709
2006-03-23

Nuclear factors associated with transcriptional regulation

#1064
20060057568
2006-03-16

Method of identifying compounds that alter bag-1 mediated down-regulation of glucocorticoid-receptor transactivation

#1065
20060055273
2006-03-16

Screening assay based on rhe sod-3 promotor for the identification of compounds modulating akt or upstream regulators such as insulin igf-1 receptors

#1066
20060052326
2006-03-09

Werner's syndrome helicase as a target for anti -HIV/AIDS therapy

#1067
20060040259
2006-02-23

Method for inhibition of viral infection

#1068
20060035813
2006-02-16

Methods and formulations comprising agonists and antagonists of nuclear hormone receptors

#1069
20060035268
2006-02-16

Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements

#1070
20060035249
2006-02-16

Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS

#1071
20060035214
2006-02-16

Screening methods for identifying inhibitors of herpesviral replication

#1072
20060034843
2006-02-16

Interaction of Smad6 with Hox proteins and uses thereof

#1073
20060029962
2006-02-09

Assays for TERT promoter modulatory agents

#1074
20060025582
2006-02-02

Promoter sequences for corticotropin releasing-factor receptor CRF2α and method of identifying agents that alter the activity of the promoter sequences

#1075
20060024820
2006-02-02

Chromosome-based platforms

#1076
20060024680
2006-02-02

Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation

#1077
20060019383
2006-01-26

Chemical inhibitors of mismatch repair

#1078
20060019238
2006-01-26

Method for identifying protein-protein interactions

#1079
20060014290
2006-01-19

Inhibition of biofilm formation

#1080
20060008839
2006-01-12

UTR tag assay for gene function discovery

#1081
20060003311
2006-01-05

In vitro screening of cellular events using 3d cell culture systems

#1082
20050277150
2005-12-15

Compositions and methods for identifying agents which regulate autolytic processes in bacteria

#1083
20050272090
2005-12-08

Nucleic acid binding of multi-zinc finger transcription factors

#1084
20050272035
2005-12-08

Functional screening method

#1085
20050271637
2005-12-08

BMP-2 estrogen responsive element and methods of using the same

#1086
20050266552
2005-12-01

Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi

#1087
20050266447
2005-12-01

Method for identifying activators of gene transcription

#1088
20050265975
2005-12-01

Method for selective inactivation of viral replication

#1089
20050260661
2005-11-24

Assays for the identification of modulators of MHC class II expression

#1090
20050260629
2005-11-24

Differential drug sensitivity

#1091
20050260602
2005-11-24

Detection of phenols using engineered bacteria

#1092
20050260575
2005-11-24

Method for identifying substances useful for treating inflammation using the response element to the ikbalpha ROR receptor

#1093
20050260568
2005-11-24

Hepatitis C virus assays

#1094
20050255458
2005-11-17

Drug discovery assays based on the biology of chronic disease

#1095
20050244842
2005-11-03

Promoter sequences

#1096
20050244822
2005-11-03

Method of monitoring gene expression

#1097
20050239157
2005-10-27

High throughput screen for inhibitors of fatty acid biosynthesis in bacteria

#1098
20050239080
2005-10-27

Mismatch repair detection

#1099
20050239069
2005-10-27

Screening method for identifying protective substances for treating neurodegenerative and/or ischemic disorders

#1100
20050233327
2005-10-20

Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay

#1101
20050227256
2005-10-13

Sequence-specific inhibition of small RNA function

#1102
20050227245
2005-10-13

Reagents and methods for identifying and modulating expression of genes regulated by retinoids

#1103
20050227226
2005-10-13

Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease

#1104
20050226853
2005-10-13

Skin substitutes and uses thereof

#1105
20050221491
2005-10-06

In vivo selection method for determining inhibitory RNA molecules

#1106
20050221425
2005-10-06

Temperature regulated promoters from for expression of proteins

#1107
20050221343
2005-10-06

Nucleic acid encoding a self-assembling split-fluorescent protein system

#1108
20050221335
2005-10-06

Reporter gene

#1109
20050221313
2005-10-06

Methods of identifying latent splice sites

#1110
20050215502
2005-09-29

Regulation of endogenous gene expression in cells using zinc finger proteins

#1111
20050214746
2005-09-29

Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

#1112
20050214743
2005-09-29

Compositions and methods for evaluating viral receptor/co-receptor usage and inhibitors of virus entry using recombinant virus assays

#1113
20050214739
2005-09-29

Expression of G protein coupled receptors in yeast

#1114
20050208533
2005-09-22

Modulators of morphogen expression and methods of identifying the same

#1115
20050197311
2005-09-08

Compositions and methods for detecting intracellular glucose and analogs thereof

#1116
20050191693
2005-09-01

Methods and cell populations for identifying and validating genomic targets, and for drug screening

#1117
20050191659
2005-09-01

Molecular regulatory circuits to achieve sustained activation of genes of interest by a single stress

#1118
20050191622
2005-09-01

Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture

#1119
20050186624
2005-08-25

Method of detection in vitro of a target substance in a sample comprising the labelling of said substance with a reporter gene and with the sequences necessary for the expression of said reporter gene in vitro

#1120
20050186617
2005-08-25

Gene screening method using nuclear receptor

#1121
20050186604
2005-08-25

Aberrant Myc/TIP60 interactions as a target for anti-cancer therapeutics

#1122
20050186596
2005-08-25

Methods for screening for proteins comprising a signal sequence

#1123
20050181506
2005-08-18

Chromosome-based platforms

#1124
20050181469
2005-08-18

Beta-lactamase substrates having phenolic ethers

#1125
20050181457
2005-08-18

FcyrIII signaling inhibitor assay

#1126
20050181356
2005-08-18

Hepatitis C virus assay systems

#1127
20050176008
2005-08-11

Polynucleotide for target gene

#1128
20050173249
2005-08-11

Microelectronic arrays for cell-based functional genomics/high throughput phenotyping by electrokinetic assembly

#1129
20050166282
2005-07-28

Method and polynucleotides for determining translational efficiency of a codon

#1130
20050164393
2005-07-28

Method for identifying genes encoding signal sequences

#1131
20050164282
2005-07-28

Synthetic cell-or tissue-specific transcriptional regulatory regions

#1132
20050164210
2005-07-28

Regulated polymerase III expression systems and related methods

#1133
20050164167
2005-07-28

Method of discovery and development of broad-spectrum antiviral drugs

#1134
20050158705
2005-07-21

Gene screening method using nuclear receptor

#1135
20050153304
2005-07-14

Multivariate profiling of complex biological regulatory pathways

#1136
20050153302
2005-07-14

Method for comprehensive identification of cell lineage specific genes

#1137
20050148075
2005-07-07

Zinc finger binding domains for GNN

#1138
20050142064
2005-06-30

Method of measuring human cyp3a inducibility

#1139
20050136460
2005-06-23

Multiple antibiotic resistance operon assays

#1140
20050136445
2005-06-23

Recombinant DNA vector, recombinant bio-luminescent bacterium and method for detecting bio-inhibitory substances using same

#1141
20050136399
2005-06-23

Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture

#1142
20050130928
2005-06-16

Method of screening a midkine modulating agent

#1143
20050130304
2005-06-16

Regulation of endogenous gene expression in cells using zinc finger proteins

#1144
20050130219
2005-06-16

Method of identifying a gene product

#1145
20050123996
2005-06-09

Assembly and screening of highly complex and fully human antibody repertoire in yeast

#1146
20050118669
2005-06-02

Fluorogenic substrates for BETA-lactamase gene expression

#1147
20050118601
2005-06-02

Enhancer sequence of the 5-aminolevulinic acid synthase gene

#1148
20050118567
2005-06-02

Method for determining sensitivity to a bacteriophage

#1149
20050112752
2005-05-26

Method for the purification of alphavirus replicon particles

#1150
20050112667
2005-05-26

Microscope system and methods for intracellular studies

#1151
20050112573
2005-05-26

Method of detecting toxic substance

#1152
20050112551
2005-05-26

Dual assay for evaluating activity and cytotoxicity of compounds in the same population of cells

#1153
20050106730
2005-05-19

Compositions and methods utilizing stable reporter cell lines for detection of pathway-specific signal transduction

#1154
20050106609
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