116458 ⎘
Hydrolases acting on ester bonds (3.1); Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21) Deoxyribonuclease I (3.1.21.1)
ENGINEERING OF DNASE ENZYMES FOR MANUFACTURING AND THERAPY
#2METHODS OF TREATING PULMONARY SARCOIDOSIS WITH DNA NUCLEASES
#3COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING DISEASES AND/OR DISORDERS
#4IMMUNOMODULATION OF TUMOR MICROENVIRONMENT
#5METHOD FOR PREPARING OLIGONUCLEOTIDE BY USING RNA LIGASE
#6POLYPEPTIDES
#7METHODS FOR TREATING NETOSIS AND NEUTROPHIL ACTIVATION
#8COMPOSITIONS AND METHODS FOR TREATING VENOUS BLOOD CLOTS
#9METHODS FOR THE MOLECULAR SUBTYPING OF TUMORS FROM ARCHIVAL TISSUE
#10ENZYME BASED COMPOSITIONS AND METHODS FOR REMOVING DENTAL CALCULI
#11CONTINUOUS IN VITRO TRANSCRIPTION PROCESS AND APPARATUS
#12COMPOSITION AND METHODS FOR TREATMENT OR PROPHYLAXIS OF CORONAVIRUS AND CANCERS
#13POLYPEPTIDES
#14IMMOBILIZED ENZYME NANOGEL AND PREPARATION METHOD AND APPLICATION THEREOF
#15METHOD FOR DECELLULARIZATION OF A TISSUE, DECELLULARIZED TISSUE MATRIX AND A SCAFFOLD FOR USE THEREOF IN TISSUE REPAIR
#16METHODS FOR TREATING AND PREVENTING NEUTROPHIL-DERIVED NET TOXICITY AND THROMBOSIS
#17ANTI-NET COMPOUNDS FOR TREATING AND PREVENTING FIBROSIS AND FOR FACILITATING WOUND HEALING
#18DNASE ENZYMES ENGINEERED FOR IMPROVED STABILITY
#19RNASE-PON1 FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS
#20METHODS FOR TREATING RHEUMATOID ARTHRITIS USING CTLA4-PON1 FUSION PROTEINS
#21NUCLEIC ACID MOLECULES ENCODING NUCLEASE-ALBUMIN FUSION PROTEINS
#22CIRCULAR PERMUTANTS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USE THEREOF
#23ENGINEERED HUMAN EXTRACELLULAR DNASE ENZYMES
#24METHOD TO IMPROVE SAFETY AND EFFICACY OF ANTI-CANCER THERAPY
#25Polynucleotides encoding paraoxonase fusion polypeptides
#26POLYPEPTIDES
#27ENDONUCLEASES THAT SELECTIVELY CLEAVE SINGLE-STRANDED NUCLEIC ACIDS AND USES THEREOF
#28OPTIMIZED BINUCLEASE FUSIONS AND METHODS
#29OPTIMIZED BINUCLEASE FUSIONS AND METHODS
#30DNASE ENZYMES ENGINEERED FOR IMPROVED STABILITY
#31ENGINEERED HUMAN EXTRACELLULAR DNASE ENZYMES FOR DRUG CANDIDATE SELECTION
#32DNASE FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS
#33IMMUNOMODULATION OF TUMOR MICROENVIRONMENT
#34METHODS FOR TREATING AND PREVENTING NEUTROPHIL-DERIVED NET TOXICITY AND THROMBOSIS
#35ENZYME COMPOSITIONS AND USES THEREOF
#36CLEANING COMPOSITIONS CONTAINING POLYPEPTIDE VARIANTS
#37THERAPEUTIC REGIMEN WITH DNASE
#38ENGINEERING OF DNASE ENZYMES FOR MANUFACTURING AND THERAPY
#39TARGETED DNA DEMETHYLATION AND METHYLATION
#40Paraoxonase fusion polypeptides and related compositions and methods
#41VIRUS-LIKE PARTICLES AND METHODS OF PRODUCTION THEREOF
#42Polypeptide variants
#43Polypeptides
#44Polypeptides
#45USE OF DEOXYRIBONUCLEASE I IN THE TREATMENT OF ENDOMETRIOSIS IN PATIENTS WITH AN EPIGENETIC SIGNATURE OF ENDOMETRIOSIS ON CELL-FREE DNA
#46COMBINATION OF DEOXYRIBONUCLEASE ENZYME AND CELL THERAPIES FOR TREATMENT OF CANCER
#47METHODS FOR CO-ACTIVATING IN VITRO NON-STANDARD AMINO ACID (nsAA) INCORPORATION AND GLYCOSYLATION IN CRUDE CELL LYSATES
#48LONG-ACTING DNASE
#49MEDICAL CLEANING COMPOSITION, USE AND METHOD OF CLEANING
#50ORAL CARE COMPOSITION COMPRISING A FRUCTANASE
#51DNase variants
#52MATERIALS AND METHODS FOR TREATMENT OF FRIEDREICH ATAXIA AND OTHER RELATED DISORDERS
#53METHODS FOR TREATING OR PREVENTING TISSUE ADHESIONS
#54COMPOSITIONS COMPRISING A CAS12I POLYPEPTIDE AND USES THEREOF
#55NON-STANDARD AMINO ACID CONTAINING COMPOSITIONS AND USES THEREOF
#56COMPOSITION AND METHODS FOR TREATMENT OR PROPHYLAXIS OF CORONAVIRUS AND CANCERS
#57ANTI-NET COMPOUNDS FOR TREATING AND PREVENTING FIBROSIS AND FOR FACILITATING WOUND HEALING
#58ENGINEERED CELLS SECRETING THERAPEUTIC ENZYMES
#59ENZYME COMPOSITIONS AND USES THEREOF
#60Polypeptides
#61INJECTABLE HIGH CONCENTRATION PHARMACEUTICAL FORMULATIONS AND METHODS OF MANUFACTURING AND USE THEREOF
#62BASIC DOMAIN-DELETED DNASE1-LIKE 3 AND USES THEREOF
#63DNASE FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS
#64DEOXYRIBONUCLEASE VARIANTS AND USES THEREOF
#65Cleaning Compositions and Uses Thereof
#66POLYPEPTIDE VARIANTS
#67ENGINEERED HUMAN EXTRACELLULAR DNASE ENZYMES
#68Method for isolating and culturing neural stem cells with high efficiency
#69ENGINEERED NUCLEASES USEFUL FOR TREATMENT OF HEMOPHILIA A
#70Engineering of DNASE enzymes for manufacturing and therapy
#71Derivatisation of Insulin with Polysaccharides
#72Optimized binuclease fusions and methods
#73DNase variants
#74COMPOSITION AND METHOD FOR TREATING OR PROPHYLAXIS OF CORONAVIRUS AND CANCERS
#75Engineered human extracellular DNASE enzymes
#76ENGINEERED HUMAN EXTRACELLULAR DNASE ENZYMES FOR DRUG CANDIDATE SELECTION
#77NUCLEASE-ASSOCIATED END SIGNATURE ANALYSIS FOR CELL-FREE NUCLEIC ACIDS
#78METHODS OF TREATING DISEASES RELATED TO NET FORMATION WITH PARENTERAL ADMINISTRATION OF POLYSIALYLATED DNASE I
#79Non-standard amino acid containing compositions and uses thereof
#80HUMAN DNASE FOR LUNG DISEASE
#81Nucleic acid molecules encoding nuclease-albumin fusion proteins
#82ENGINEERED DNASE ENZYMES AND USE IN THERAPY
#83Use of Polypeptide
#84Engineering of DNASE enzymes for manufacturing and therapy
#85Detergent composition comprising a DNase
#86Polypeptides
#87Detergent composition
#88Methods for co-activating in vitro non-standard amino acid (nsAA) incorporation and glycosylation in crude cell lysates
#89METHODS FOR TREATING NETOSIS AND NEUTROPHIL ACTIVATION
#90METHOD OF TREATING A FABRIC
#91Detergent composition
#92DNase therapy for intravascular accumulation of extracellular DNA
#93Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
#94DNase therapy for intravascular accumulation of extracellular DNA
#95Polypeptide variants
#96Engineered CAS9 systems for eukaryotic genome modification
#97Engineered DNase enzymes and use in therapy
#98Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
#99Cleaning compositions and uses thereof
#100CLEANING COMPOSITIONS AND USES THEREOF
#101METHOD TO IMPROVE SAFETY AND EFFICACY OF ANTI-CANCER THERAPY
#102Polypeptides
#103Manufacturing and engineering of DNASE enzymes for therapy
#104Biofilm disrupting composition for use on chronic wounds
#105Targeted DNA demethylation and methylation
#106Use of Polypeptide
#107Engineered DNase enzymes and use in therapy
#108BIOFILM DISRUPTING COMPOSITION
#109DNASE VARIANTS
#110Methods for treating or preventing tissue adhesions
#111Composition and method for treating nucleic acid-related eye disease
#112METHODS OF DEPLETING OR ISOLATING TARGET RNA FROM A NUCLEIC ACID SAMPLE
#113METHODS OF DEPLETING OR ISOLATING TARGET RNA FROM A NUCLEIC ACID SAMPLE
#114Polypeptide variants
#115Engineered CAS9 systems for eukaryotic genome modification
#116OPTIMIZED BINUCLEASE FUSIONS AND METHODS
#117Methods of enhancing chromosomal homologous recombination
#118TARGETED ENHANCED DNA DEMETHYLATION
#119Derivatisation of Insulin with Polysaccharides
#120Polypeptide variants
#121COMPOSITION COMPRISING AT LEAST ONE ENZYME AND AT LEAST ONE MICROBICIDAL MOLECULE FOR THE PREVENTION OR TREATMENT OF POST-IMPLANT INFECTIONS
#122Materials and methods for treatment of friedreich ataxia and other related disorders
#123COLICINS FOR TREATING BACTERIAL INFECTIONS
#124Engineered nucleases useful for treatment of hemophilia A
#125METHODS OF TREATING DISEASES RELATED TO NET FORMATION WITH PARENTERAL ADMINISTRATION OF POLYSIALYLATED DNASE I
#126Methods for treating netosis and neutrophil activation
#127Technology for the Preparation of Microparticles
#128Detergent composition comprising a DNase
#129Use of Polypeptide Having DNase Activity for Treating Fabrics
#130Anti-neutrophil activity on innate immune response
#131Extracellular DNA as a therapeutic target in neurodegeneration
#132N-Terminal Polysialylation
#133Anti-NET compounds for treating and preventing fibrosis and for facilitating wound healing
#134Polypeptides
#135Compositions for the Restoration of a Fecal Microbiota and Methods for Making and Using Them
#136DNase variants
#137DETERGENT COMPOSITION
#138Method to improve safety and efficacy of anti-cancer therapy
#139Technology for the Preparation of Microparticles
#140METHODS OF TREATING PULMONARY SARCOIDOSIS
#141CLEANING COMPOSITIONS INCLUDING NUCLEASE ENZYME AND MALODOR REDUCTION MATERIALS
#142Compositions for the Restoration of a Fecal Microbiota and Methods for Making and Using Them
#143Production for recombinant human DNase I
#144Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases
#145Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
#146Therapeutic conjugates with sulfated dendrimers for intracellular targeting
#147Deoxyribonuclease Enzymes
#148Composition and method for treating nucleic acid-related eye disease
#149METHOD TO IMPROVE SAFETY AND EFFICACY OF ANTI-CANCER THERAPY
#150ADIPOSE-DERIVED STEM CELL PRODUCT
#151Use of Polypeptide
#152Technology for the Preparation of Microparticles
#153N-terminal derivatisation of proteins with polysaccharides
#154METHOD FOR TREATING SYSTEMIC DNA MUTATION DISEASE
#155METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VASO-OCCLUSIVE CRISIS
#156Process for bone tissue decellularization
#157Endonucleases
#158METHOD FOR INCREASING THE BIOAVAILABILITY OF INHALED COMPOUNDS
#159DETERGENT COMPOSITION
#160Method of treating a fabric
#161METHOD OF TREATING A FABRIC
#162Method for treating systemic DNA mutation disease
#163Treating Bacterial Infections of the Lung
#164Therapeutic nuclease-albumin fusions and methods
#165Technology for the Preparation of Microparticles
#166Cytolethal distending toxin subunit B conjugated or fused to toxin lethal factor
#167Derivatisation of erythropoietin (EPO)
#168Derivatisation of erythropoietin (EPO)
#169Derivatisation of granulocyte colony-stimulating factor
#170Methods of treating pulmonary sarcoidosis
#171Therapeutic for treating clostridium difficile infection
#172Compositions and Methods for Treatment of Stroke
#173Technology for the Preparation of Microparticles
#174CHIMERA COMPRISING BACTERIAL CYTOTOXIN AND METHODS OF USING THE SAME
#175Derivatisation of granulocyte colony-stimulating factor
#176Cell-free DNA as a therapeutic target for female infertility and diagnostic marker
#177Colicins for Treating Bacterial Infections
#178Derivatisation of erythropoietin (EPO)
#179N-terminal derivatisation of proteins with polysaccharides
#180Therapeutic for treating infection
#181Dry powder formulations of dNase I
#182Inhalable liquid formulations of DNase I
#183DNASE I POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, METHODS OF PRODUCING DNASE I AND USES THEREOF IN THERAPY
#184Composition and method for treating nucleic acid-related eye disease
#185Method for monitoring development of somatic mosaicism
#186Endonucleases
#187Derivatisation of erythropoietin (EPO)
#188Anti-cancer therapeutic strategy to overcome cancer resistance and to enable tailoring treatment to patients
#189Technology for the Preparation of Microparticles
#190Chimera comprising bacterial cytotoxin and methods of using the same
#191DispersinB™, 5-fluorouracil, deoxyribonuclease I and proteinase K-based antibiofilm compositions and uses thereof
#192Method for treating systemic DNA mutation disease
#193Method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and a medicinal preparation for carrying out said method
#194N-terminal derivatisation of proteins with polysaccharides
#195Derivatisation of erythropoietin (EPO)
#196N-terminal polysialylation
#197Derivatisation of granulocyte colony-stimulating factor
#198Compositions and methods for the treatment and prevention of infections caused by staphylococcus aureus bacteria
#199Technology for the Preparation of Microparticles
#200Method for treating a reduction of fertility
#201Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases
#202Method for Treating Oncological, Virulent and Somatic Diseases, Method for Controlling Treatment Efficiency, Pharmaceutical Agents and Composition for Carrying Out Said Treatment
#203Methods of treatment for meconium aspiration syndrome
#204Method for treating diseases associated with changes of qualitative and/quantitative composition of blood extracellular dna
#205Method for treating oncological diseases
#206Monobactam compositions and methods of use thereof