116461 ⎘
Hydrolases acting on ester bonds (3.1); Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21) Type II site-specific deoxyribonuclease (3.1.21.4)
COMPOSITIONS AND METHODS FOR GENOME EDITING
#2METHODS FOR REPROGRAMMING AND GENE EDITING CELLS
#3Methods of Synthesizing Nucleic Acid Molecules
#4LYMPHOCYTE MEDIATED DELIVERY OF INTRACELLULAR TARGET-SPECIFIC PROTEINS
#5DNA IMMORTALIZATION CONSTRUCT AND PERFORMING PRIMARY CELL IMMORTALIZATION
#6METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#7GENOME EDITING TECHNIQUE
#8PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF
#9DNA ASSEMBLY
#10Unconstrained Genome Targeting with near-PAMless Engineered CRISPR-Cas9 Variants
#11NOVEL ZINC FINGER FUSION PROTEINS FOR NUCLEOBASE EDITING
#12MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#13MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#14MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#15RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
#16DETERMINING LINEAR AND CIRCULAR FORMS OF CIRCULATING NUCLEIC ACIDS
#17High Fidelity Restriction Endonucleases
#18NUCLEIC ACID-GUIDED NICKASES
#19Increasing Specificity for RNA-Guided Genome Editing
#20MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#21DEAD GUIDES FOR CRISPR TRANSCRIPTION FACTORS
#22DUAL STRAND NUCLEIC ACID-GUIDED NICKASE EDITING
#23Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
#24RECONSTRUCTION OF SITE SPECIFIC NUCLEASE BINDING SITES
#25RETROTRANSPOSONS AND USE THEREOF
#26METHOD FOR IN VITRO TRANSCRIPTION USING AN IMMOBILIZED RESTRICTION ENZYME
#27DNA-BINDING PROTEINS AND USES THEREOF
#28Dual strand nucleic acid-guided nickase editing
#29METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
#30Nucleic acid-guided nickases
#31MITOCHONDRIAL GENOME EDITING METHODS
#32Artificial nucleases comprising engineered cleavage half-domains
#33RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#34METHODS FOR DESIGNING DNA BINDING PROTEIN CONTAINING PPR MOTIFS, AND USE THEREOF
#35Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
#36Variants of CRISPR from Prevotella and Francisella 1 (Cpf1)
#37PROTECTED GUIDE RNAS (PGRNAS)
#38PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF
#39CRISPR-BASED GENOME MODIFICATION AND REGULATION
#40DNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF
#41Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
#42High fidelity restriction endonucleases
#43CRISPR-BASED GENOME MODIFICATION AND REGULATION
#44Modified cascade ribonucleoproteins and uses thereof
#45Increasing specificity for RNA-guided genome editing
#46CRISPR-BASED GENOME MODIFICATION AND REGULATION
#47Determining linear and circular forms of circulating nucleic acids
#48Protected guide RNAS (pgRNAS)
#49CAS9-nucleic acid complexes and uses related thereto
#50Methods and products for expressing proteins in cells
#51Modified cascade ribonucleoproteins and uses thereof
#52Methods and compositions for targeted cleavage and recombination
#53ANALYSIS OF METHYLATION STATUS AND COPY NUMBER
#54Artifical nucleases comprising engineered cleavage half-domains
#55Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#56CRISPR-BASED GENOME MODIFICATION AND REGULATION
#57TAL effector-mediated DNA modification
#58Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#59Methods and products for expressing proteins in cells
#60Methods and products for expressing proteins in cells
#61Methods and products for expressing proteins in cells
#62Methods and products for expressing proteins in cells
#63Modified cascade ribonucleoproteins and uses thereof
#64Methods and products for expressing proteins in cells
#65Methods and products for expressing proteins in cells
#66Methods and products for expressing proteins in cells
#67Methods and products for expressing proteins in cells
#68Methods and products for expressing proteins in cells
#69RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#70Methods and products for expressing proteins in cells
#71Transcriptional regulatory fusion polypeptide
#72High fidelity restriction endonucleases
#73Analysis of methylation status and copy number
#74DNA-binding proteins and uses thereof
#75DNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF
#76Method for producing DNA vectors from molecular bricks containing sequences of interest
#77Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#78Artificial nucleases including engineered FokI cleavage half-domains
#79TAL effector means useful for partial or full deletion of DNA tandem repeats
#80Protein having nuclease activity, fusion proteins and uses thereof
#81METHOD FOR IN VITRO TRANSCRIPTION USING AN IMMOBILIZED RESTRICTION ENZYME
#82Increasing specificity for RNA-guided genome editing
#83Targeted integration into the PPP1R12C locus
#84Reconstruction of site specific nuclease binding sites
#85Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA
#86Methods and compositions for treatment of a genetic condition
#87High fidelity restriction endonucleases
#88Methods and compositions for treatment of a genetic condition
#89Modified cascade ribonucleoproteins and uses thereof
#90Compositions comprising TALENs and methods of treating HIV
#91TAL effector-mediated DNA modification
#92TAL effector-mediated DNA modification
#93Variants of CRISPR from and 1 (Cpf1)
#94DNA-binding proteins and uses thereof
#95Methods and products for expressing proteins in cells
#96Artificial nucleases comprising engineered cleavage half-domains
#97Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#98DEAD GUIDES FOR CRISPR TRANSCRIPTION FACTORS
#99RNA-targeting system
#100RECONSTRUCTION OF ANCESTRAL CELLS BY ENZYMATIC RECORDING
#101Protected guide RNAS (PGRNAS)
#102Methods and products for expressing proteins in cells
#103METHODS FOR TARGETED MODIFICATION OF GENOMIC DNA
#104Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#105ANTIVIRAL FUSION PROTEINS AND GENES
#106Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#107TAL EFFECTOR MEANS USEFUL FOR PARTIAL OR FULL DELETION OF DNA TANDEM REPEATS
#108Nanoparticle mediated delivery of sequence specific nucleases
#109DNA-binding proteins and uses thereof
#110Methods and products for expressing proteins in cells
#111PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
#112CRISPR-BASED GENOME MODIFICATION AND REGULATION
#113CRISPR-based genome modification and regulation
#114CRISPR-based genome modification and regulation
#115CRISPR-BASED GENOME MODIFICATION AND REGULATION
#116Targeted integration into the PPP1R12C locus
#117High fidelity restriction endonucleases
#118Rare-cutting endonucleases for efficient and specific targeting DNA sequences comprising highly repetitive motives
#119Engineered cleavage half-domains for generating nuclease-mediated genomic modifications in a cell
#120Methods and products for expressing proteins in cells
#121Modified cascade ribonucleoproteins and uses thereof
#122MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#123Use of thermophilic nucleases for degrading nucleic acids
#124Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
#125IMPROVED POLYNUCLEOTIDE SEQUENCES ENCODING TALE REPEATS
#126Methods and compositions for treatment of a genetic condition
#127DNA-binding protein using PPR motif, and use thereof
#128Increasing specificity for RNA-guided genome editing
#129Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#130RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#131Methods and products for expressing proteins in cells
#132METHODS AND COMPOSITIONS FOR REGULATING HIV INFECTION
#133Methods and products for expressing proteins in cells
#134Methods and compositions for treatment of a beta thalessemia
#135Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#136Engineered cleavage half-domains
#137Methods and compositions for treatment of a genetic condition
#138TAL effector-mediated DNA modification
#139TAL EFFECTOR-MEDIATED DNA MODIFICATION
#140Protein having nuclease activity, fusion proteins and uses thereof
#141Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#142Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#143Method for increasing plant biomass using an exogenous gene encoding a thermophilic restriction enzyme
#144Modified DNA-binding proteins and uses thereof
#145Methods and compositions for modification of the HPRT locus
#146Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
#147USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#148USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#149Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#150USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#151USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#152USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#153Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#154Restriction/modification polypeptides, polynucleotides, and methods
#155TAL effector-mediated DNA modification
#156Tal effector-mediated DNA modification
#157TAL effector-mediated DNA modification
#158CUSTOM-MADE MEGANUCLEASE AND USE THEREOF
#159Engineered cleavage half-domains
#160Targeted integration into the PPP1R12C locus
#161Pharmacologically induced transgene ablation system
#162DNA-binding proteins and uses thereof
#163Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#164Engineered cleavage half-domains
#165USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#166High fidelity restriction endonucleases
#167TAL effector-mediated DNA modification
#168CHIMERIC POLYPEPTIDES AND THEIR USE
#169Methods and compositions for targeted cleavage and recombination
#170Nanoparticle mediated delivery of sequence specific nucleases
#171Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#172Targeted integration into the PPP1R12C locus
#173Chimeric polypeptides and their use
#174Custom-made meganuclease and use thereof
#175Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#176Methods and compositions for targeted cleavage and recombination
#177Nucleic acid-guided nickases