ClassID:

109048

C12N15/113 - page 16 - CPC Classification

Classification description:

Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Recent Application in this class:
#4501
20210169876
2021-06-10

Treating liver disease by selectively eliminating senescent cells

#4502
20210169875
2021-06-10

Treating cardiovascular disease by selectively eliminating senescent cells

#4503
20210169804
2021-06-10

NANOMATERIALS

#4504
20210169689
2021-06-10

Ophthalmic Delivery Device And Ophthalmic Active Agent Containing Compositions

#4505
20210169083
2021-06-10

Alkali-resistant calcium phosphate/nucleic acids hybrid carrier for pest control and method to produce the particles

#4506
20210163984
2021-06-03

Compositions for reducing sarcolipin expression and preventing and treating muscular dystrophy and cardiomyopathy and methods of use

#4507
20210163949
2021-06-03

Modulation of alternative MDM2 splicing

#4508
20210163944
2021-06-03

NOVEL CAS12B ENZYMES AND SYSTEMS

#4509
20210163943
2021-06-03

Compositions and Methods for Hydroxyacid Oxidase 1 (HAO1) Gene Editing for Treating Primary Hyperoxaluria Type 1 (PH1)

#4510
20210163942
2021-06-03

Agents useful in treating facioscapulohumeral muscular dystrophy

#4511
20210163941
2021-06-03

AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

#4512
20210163940
2021-06-03

COMPOSITIONS AND METHODS FOR NICKING TARGET DNA SEQUENCES

#4513
20210163939
2021-06-03

CRISPR therapy

#4514
20210163938
2021-06-03

MRNA driven expression of RNA editors for treatment of pathologies

#4515
20210163937
2021-06-03

ENRICHMENT OF GENOME-EDITED CELLS

#4516
20210163936
2021-06-03

METHOD FOR SCREENING AND IDENTIFYING FUNCTIONAL LNCRNAS

#4517
20210163935
2021-06-03

Targeted Critical Fluid Nanoparticles Platform for Delivery of Nucleic Acids for Treatment of HIV-1 and Other Diseases

#4518
20210163934
2021-06-03

BBB-crossing lipid ligand of hetero nucleic acid

#4519
20210163933
2021-06-03

ARC PROTEIN EXTRACELLULAR VESICLE NUCLEIC ACID DELIVERY PLATFORM

#4520
20210163932
2021-06-03

CELLULAR COMPOSITIONS AND METHODS OF TREATMENT I

#4521
20210163931
2021-06-03

Compositions and methods for treating facioscapulohumeral dystrophy

#4522
20210163930
2021-06-03

METHODS OF CHANGING TRANSCRIPTIONAL OUTPUT

#4523
20210163910
2021-06-03

CRISPR/Cas fusion proteins and systems

#4524
20210163895
2021-06-03

Enhanced immune effector cells and use thereof

#4525
20210163598
2021-06-03

Tumor immunotherapy target and application thereof

#4526
20210163555
2021-06-03

Targeting P18 for mTOR-related disorders

#4527
20210163540
2021-06-03

POLYPEPTIDES SELF-ASSEMBLING INTO NANOPARTICLES

#4528
20210162076
2021-06-03

Aptamer Compositions and Methods of Use Thereof

#4529
20210162068
2021-06-03

Treatment of primary ciliary dyskinesia with synthetic messenger RNA

#4530
20210162067
2021-06-03

Composition and Methods of Controllable Co-Coupling Polypeptide Nanoparticle Delivery System for Nucleic Acid Therapeutics

#4531
20210162066
2021-06-03

RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF

#4532
20210162065
2021-06-03

MULTI-FUNCTIONAL CANCER DRUG DELIVERY NANODEVICE FOR PRECISION MEDICINE

#4533
20210162056
2021-06-03

Targeting macula densa cells as a new therapeutic approach for kidney disease

#4534
20210162053
2021-06-03

NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS

#4535
20210162022
2021-06-03

Sequence specific antimicrobials

#4536
20210162005
2021-06-03

Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide

#4537
20210161967
2021-06-03

EXTRACELLULAR VESICLES AND USES THEREOF

#4538
20210161922
2021-06-03

Antisense-induced exon exclusion in type VII collagen

#4539
20210161111
2021-06-03

FACTOR VIII OR FACTOR IX GENE KNOCKOUT RABBIT, METHOD FOR PREPARING SAME AND USE THEREOF

#4540
20210155954
2021-05-27

CRISPR logic circuits for safer and controllable gene therapies

#4541
20210155936
2021-05-27

Modulation of gene expression and screening for deregulated protein expression

#4542
20210155934
2021-05-27

ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS

#4543
20210155932
2021-05-27

Compositions and methods to treat cancer

#4544
20210155930
2021-05-27

MICRORNA TARGETING AGENT FOR TREATMENT OF HEART DISEASE

#4545
20210155929
2021-05-27

DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS ELANE GENE - II

#4546
20210155928
2021-05-27

RNA-AIDED IMMUNOTHERAPEUTICS

#4547
20210155927
2021-05-27

METHODS FOR TREATING SICKLE CELL DISEASE

#4548
20210155926
2021-05-27

siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS

#4549
20210155925
2021-05-27

Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease

#4550
20210154329
2021-05-27

ANTI-TUMOR COMPOSITION COMPRISING GM-CSF GENE, Flt3L-TRAIL FUSION GENE, shRNA INHIBITING TGF-ß EXPRESSION, AND shRNA INHIBITING HSP EXPRESSION

#4551
20210154326
2021-05-27

CRISPR-Based Synthetic Gene Circuits as Next Generation Gene Therapy of Inner Ear

#4552
20210154236
2021-05-27

HAEMATOPOIETIC STEM CELL TREATMENT

#4553
20210154222
2021-05-27

Methods for treating NLRP3 inflammasome-associated diseases, and methods of identifying agents useful therefor

#4554
20210154187
2021-05-27

Compositions and methods for treating pulmonary vascular disease

#4555
20210148917
2021-05-20

Beta-catenin inhibitors in cancer immunotherapy

#4556
20210147945
2021-05-20

MiRNAs for treatment and in vitro diagnosis of drug resistant tumors

#4557
20210147873
2021-05-20

TRIPLE FUNCTION ADENO-ASSOCIATED VIRUS (AAV)VECTORS FOR THE TREATMENT OF C9ORF72 ASSOCIATED DISEASES

#4558
20210147862
2021-05-20

COMPOSITIONS AND METHODS FOR RNA-TEMPLATED EDITING IN PLANTS

#4559
20210147861
2021-05-20

Optimized CRISPR-Cas nucleases and base editors and methods of use thereof

#4560
20210147858
2021-05-20

Methods for increasing observed editing in bacteria

#4561
20210147856
2021-05-20

Gene editing methods with increased knock-in efficiency

#4562
20210147853
2021-05-20

Use of trinucleotide repeat RNAs to treat cancer

#4563
20210147849
2021-05-20

REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS

#4564
20210147848
2021-05-20

PLANT SRNA EXTRACT FOR USE AS AN IMMUNOSUPPRESSIVE AGENT

#4565
20210147846
2021-05-20

Synthetic near-threshold translational repressors

#4566
20210147845
2021-05-20

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES

#4567
20210147844
2021-05-20

Method for Site-Specific Mutagenesis of Medicago Sativa Genes by Using CRISPR/Cas9 System

#4568
20210147843
2021-05-20

Systems, methods, and compounds for providing chaperone activity to proteins

#4569
20210147842
2021-05-20

METHODS AND COMPOSITIONS FOR INHIBITING NECROPTOSIS IN NEUROVASCULAR AND/OR NEURODEGENERATIVE DISEASES OR DISORDERS

#4570
20210147841
2021-05-20

COMPOSITIONS AND METHODS FOR MODIFYING REGULATORY T CELLS

#4571
20210147840
2021-05-20

SiRNAs with vinylphosphonate at the 5′ end of the antisense strand

#4572
20210147839
2021-05-20

Antisense nucleic acids

#4573
20210147838
2021-05-20

Selective Antisense Compounds and Uses Thereof

#4574
20210147837
2021-05-20

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#4575
20210147836
2021-05-20

Use of thermostable RNA polymerases to produce RNAs having reduced immunogenicity

#4576
20210147798
2021-05-20

Artificially manipulated immune cell

#4577
20210145976
2021-05-20

CD71 binding fibronectin type III domains

#4578
20210145883
2021-05-20

Modification of Immune Cells to Increase Activity

#4579
20210145859
2021-05-20

Mir-17˜92 as therapeutic or diagnostic target of motor neuron (MN) degeneration diseases

#4580
20210145745
2021-05-20

Targeted delivery of therapeutic agents to human adipocytes

#4581
20210145006
2021-05-20

Altering microbial populations and modifying microbiota

#4582
20210140943
2021-05-13

Fusions and method for detecting same

#4583
20210139997
2021-05-13

Treatment of angiogenesis disorders

#4584
20210139994
2021-05-13

Methods and compositions related to T-cell activity

#4585
20210139926
2021-05-13

PLANT GENOME EDITING

#4586
20210139925
2021-05-13

MAIZE FEMALE PARENT HAPLOID MAJOR EFFECT INDUCING GENE AND APPLICATION

#4587
20210139918
2021-05-13

Compositions and methods for gene editing

#4588
20210139916
2021-05-13

FIDGETIN-LIKE 2 AS A TARGET TO ENHANCE WOUND HEALING

#4589
20210139914
2021-05-13

Methods and compositions for reducing immunosuppression by tumor cells

#4590
20210139907
2021-05-13

Materials and methods for the delivery of therapeutic nucleic acids to tissues

#4591
20210139906
2021-05-13

COMPOUNDS AND METHODS FOR REDUCING SPDEF EXPRESSION

#4592
20210139905
2021-05-13

Oligonucleotide therapy for Leber congenital amaurosis

#4593
20210139904
2021-05-13

METHODS AND MEANS FOR EFFICIENT SKIPPING OF AT LEAST ONE OF THE FOLLOWING EXONS OF THE HUMAN DUCHENNE MUSCULAR DYSTROPHY GENE: 43, 46, 50-53

#4594
20210139903
2021-05-13

Methods and compositions for the specific inhibition of Complement Component 5(C5) by double-stranded RNA

#4595
20210139902
2021-05-13

RNAI TARGET GENE THAT IS HIGHLY LETHAL TO APHIDS AND USE THEREOF

#4596
20210139901
2021-05-13

Two-tailed self-delivering siRNA

#4597
20210139900
2021-05-13

Modulation of Huntington expression

#4598
20210139899
2021-05-13

Cancer chemoprevention with STAT3 blockers

#4599
20210139898
2021-05-13

Structural domains of antisense RNA molecules up-regulating translation

#4600
20210139897
2021-05-13

OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS

#4601
20210139896
2021-05-13

Peptide oligonucleotide conjugates

#4602
20210139895
2021-05-13

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER

#4603
20210139894
2021-05-13

Treatment of Fuchs' endothelial corneal dystrophy

#4604
20210139893
2021-05-13

G-quadruplex-containing antisense oligonucleotides

#4605
20210139890
2021-05-13

NOVEL CRISPR RNA TARGETING ENZYMES AND SYSTEMS AND USES THEREOF

#4606
20210138213
2021-05-13

TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH AN IMMUNE MODULATORY AGENT RELEASED USING AN INGESTIBLE DEVICE

#4607
20210138079
2021-05-13

Exon skipping oligomer conjugates for muscular dystrophy

#4608
20210138078
2021-05-13

Exon skipping oligomer conjugates for muscular dystrophy

#4609
20210137991
2021-05-13

GENE EDITING FOR AUTOIMMUNE DISORDERS

#4610
20210137963
2021-05-13

Treatment of aberrant fibroblast proliferation

#4611
20210137960
2021-05-13

COMPOSITIONS AND METHODS FOR INHIBITION OF NUCLEAR-PENETRATING ANTIBODIES

#4612
20210137839
2021-05-13

COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DELIVERY

#4613
20210130903
2021-05-06

Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment

#4614
20210130858
2021-05-06

Structuring fats and methods of producing structuring fats

#4615
20210130847
2021-05-06

Method for reducing the expression of NKCC1 in a subject

#4616
20210130835
2021-05-06

Compositions and methods for RNA-encoded DNA-replacement of alleles

#4617
20210130828
2021-05-06

GIN RECOMBINASE VARIANTS

#4618
20210130827
2021-05-06

TYPE V CRISPR-CAS BASE EDITORS AND METHODS OF USE THEREOF

#4619
20210130826
2021-05-06

METHODS OF MODULATING ANTISENSE ACTIVITY

#4620
20210130825
2021-05-06

Ischemic-lesion-site-specific gene therapy

#4621
20210130824
2021-05-06

COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING FIBRINOGEN-ALPHA

#4622
20210130823
2021-05-06

COMPOSITIONS AND METHODS

#4623
20210130822
2021-05-06

Antisense oligomer compounds

#4624
20210130821
2021-05-06

Chiral control

#4625
20210130820
2021-05-06

Method for producing nucleic acid molecule, biomaterial, and method for producing biomaterial

#4626
20210130819
2021-05-06

Increasing RNAi efficiency through single nucleotide mismatches

#4627
20210130779
2021-05-06

CLOSED PROCESS FOR EXPANSION AND GENE EDITING OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY

#4628
20210130775
2021-05-06

CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR OR ENGINEERED TCR AND COMPRISING A NUCLEOTIDE SEQUENCE WHICH IS SELECTIVELY EXPRESSED

#4629
20210130403
2021-05-06

Inhibitors of metastasis

#4630
20210128634
2021-05-06

EXOSOMES DERIVED FROM CORTICAL BONE STEM CELLS CAN AUGMENT HEART FUNCTION AFTER CARDIAC INJURY

#4631
20210128613
2021-05-06

Engineered immune cells resistant to tumor microenvironment

#4632
20210128602
2021-05-06

Methods for treatment or prevention of leukemia

#4633
20210128532
2021-05-06

Heterocyclic carboxylate compounds as glycolate oxidase inhibitors

#4634
20210128488
2021-05-06

Lipids for use in lipid nanoparticle formulations

#4635
20210127683
2021-05-06

METHODS AND COMPOSITIONS OF INSECT CONTROL

#4636
20210123904
2021-04-29

METHODS FOR IDENTIFYING THERAPEUTIC AGENTS WHICH INTERACT WITH STK24

#4637
20210123054
2021-04-29

Oligonucleotides for modulating Tau expression

#4638
20210123053
2021-04-29

Mammalian cells for producing a secreted protein

#4639
20210123052
2021-04-29

METHODS FOR THE IN VIVO PRODUCTION OF SINGLE STRANDED DNA AND USES THEREOF

#4640
20210123051
2021-04-29

Uses for prevention or treatment of brain diseases using microRNA

#4641
20210123050
2021-04-29

Antisense oligonucleotides for the treatment of usher syndrome type 2

#4642
20210123049
2021-04-29

POLYNUCLEOTIDE AGENTS TARGETING SERPINC1 (AT3) AND METHODS OF USE THEREOF

#4643
20210123048
2021-04-29

Nucleic acids for inhibiting expression of LPA in a cell

#4644
20210123035
2021-04-29

Modified double-stranded donor templates

#4645
20210122703
2021-04-29

Lipids for use in lipid nanoparticle formulations

#4646
20210122702
2021-04-29

Lipids for use in lipid nanoparticle formulations

#4647
20210121581
2021-04-29

METHODS AND COMPOSITIONS FOR TREATING TUMOR CELLS

#4648
20210121495
2021-04-29

Methods for treating triple-negative breast cancer

#4649
20210115485
2021-04-22

METHOD FOR PRODUCING SINGLE-STRAND RNA

#4650
20210115467
2021-04-22

Ras opposite (ROP) and related nucleic acid molecules that confer resistance to coleopteran and/or hemipteran pests

#4651
20210115461
2021-04-22

MODULATING AMINO ACID CONTENT IN A PLANT

#4652
20210115446
2021-04-22

Regulation of translation of expressed genes

#4653
20210115445
2021-04-22

CHANNEL MODULATORS

#4654
20210115444
2021-04-22

Chiral design

#4655
20210115443
2021-04-22

Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof

#4656
20210115442
2021-04-22

O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES

#4657
20210115441
2021-04-22

Targeting cancer-associated long non-coding RNAs

#4658
20210115440
2021-04-22

Composition for delivering nucleic acid and nucleic acid-containing composition

#4659
20210115439
2021-04-22

Antisense oligonucleotides for the treatment of Stargardt disease

#4660
20210115438
2021-04-22

Thiophosphoramidites

#4661
20210115421
2021-04-22

Variants of CAS12A nucleases and methods of making and use thereof

#4662
20210115419
2021-04-22

CRISPR/Cas9-Mediated Exon-Skipping Approach for USH2A-Associated Usher Syndrome

#4663
20210115083
2021-04-22

RNA nanoparticles for brain tumor treatment

#4664
20210113687
2021-04-22

METHODS FOR TREATING INFLAMMATION

#4665
20210113641
2021-04-22

Extraction of plant source “medicinal soup” and manual preparation of “herbal medicine” and related products

#4666
20210113605
2021-04-22

Methods for modulating regulatory T cells, regulatory b cells, and immune responses using modulators of the april-taci interaction

#4667
20210113604
2021-04-22

Methods of attenuating an immune response by inhibition of BFL1

#4668
20210113603
2021-04-22

MicroRNA (miRNA) and Downstream Targets for Diagnostic and Therapeutic Purposes

#4669
20210113573
2021-04-22

COMPOSITIONS AND METHODS TO PROMOTE THYMIC REGENERATION

#4670
20210113483
2021-04-22

Cationic polymers

#4671
20210108261
2021-04-15

Detection of nucleic acids

#4672
20210108231
2021-04-15

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4673
20210108220
2021-04-15

Simultaneous gene silencing and suppressing gene silencing in ihe same cell

#4674
20210108208
2021-04-15

TARGETED AUGMENTATION OF NUCLEAR GENE OUTPUT

#4675
20210108206
2021-04-15

RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS

#4676
20210108205
2021-04-15

MicroRNA Compounds and Methods for Modulating MIR-122

#4677
20210108204
2021-04-15

RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy

#4678
20210108203
2021-04-15

Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

#4679
20210108202
2021-04-15

COMPOSITIONS COMPRISING EICOSAPENTAENOIC ACID AND MIPOMERSEN AND METHODS OF USE THEREOF

#4680
20210108201
2021-04-15

FN3 domain-siRNA conjugates and uses thereof

#4681
20210108200
2021-04-15

BRANCHED LIPID CONJUGATES OF siRNA FOR SPECIFIC TISSUE DELIVERY

#4682
20210108199
2021-04-15

Treatment for aggressive cancers by targeting C9ORF72

#4683
20210108198
2021-04-15

APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF

#4684
20210108197
2021-04-15

SHRNA EXPRESSION CASSETTE, POLYNUCLEOTIDE SEQUENCE CARRYING SAME, AND APPLICATION THEREOF

#4685
20210108188
2021-04-15

NON-COVALENT SYSTEMS AND METHODS FOR DNA EDITING

#4686
20210106525
2021-04-15

FORMULATIONS FOR GASTROINTESTINAL DELIVERY OF OLIGONUCLEOTIDES

#4687
20210102242
2021-04-08

Programmable nuclease compositions and methods of use thereof

#4688
20210102241
2021-04-08

Method for confirming introduction of foreign gene into cells and method for manufacturing introduction foreign gene into cells

#4689
20210102221
2021-04-08

Methods and compositions for a HIV based delivery system

#4690
20210102216
2021-04-08

Nucleic acid construct for in vitro and in vivo gene expression

#4691
20210102212
2021-04-08

Cancer treatment by MALAT1 inhibition

#4692
20210102208
2021-04-08

COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER

#4693
20210102207
2021-04-08

Rotationally sequestered translators

#4694
20210102206
2021-04-08

TARGETED GENE ACTIVATION USING MODIFIED GUIDE RNA

#4695
20210102205
2021-04-08

EXON SKIPPING OLIGOMERS AND OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY

#4696
20210102204
2021-04-08

SIRT1-saRNA compositions and methods of use

#4697
20210102203
2021-04-08

Compositions and methods for modulating MECP2 expression

#4698
20210102202
2021-04-08

Promotion of cardiomyocyte proliferation and regenerative treatment of the heart by inhibition of microRNA-128

#4699
20210102197
2021-04-08

DESIGNING SENSITIVE, SPECIFIC, AND OPTIMALLY ACTIVE BINDING MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS

#4700
20210102185
2021-04-08

Protein macrocyclization

#4701
20210102183
2021-04-08

Engineered cascade components and cascade complexes

#4702
20210102176
2021-04-08

Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same

#4703
20210101966
2021-04-08

Pharmaceutical composition comprising expression or activity inhibitor of c-src for preventing or treating synucleinopathy

#4704
20210100905
2021-04-08

APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS

#4705
20210100829
2021-04-08

RNAi agents for hepatitis B virus infection

#4706
20210100828
2021-04-08

Methods for Treatment of Alport Syndrome

#4707
20210100774
2021-04-08

Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis

#4708
20210095342
2021-04-01

FUNCTIONAL TARGETS OF MIR-6891-5P & APPLICATIONS THEREOF

#4709
20210095312
2021-04-01

MULTICISTRONIC EXPRESSION CONSTRUCTS

#4710
20210095309
2021-04-01

High efficient delivery of plasmid DNA into human and vertebrate primary cells in vitro and in vivo by nanocomplexes

#4711
20210095292
2021-04-01

Use of MIR101 or MIR128 in the treatment of seizure disorders

#4712
20210095288
2021-04-01

METHODS OF MODULATING NKX6.3

#4713
20210095287
2021-04-01

MicroRNA-based logic gates and uses thereof

#4714
20210095286
2021-04-01

Trans-activated functional RNA by strand displacement and uses thereof

#4715
20210095285
2021-04-01

Methods for treating brain injury

#4716
20210095284
2021-04-01

Modified oligonucleotides for use in treatment of tauopathies

#4717
20210095283
2021-04-01

HETERODUPLEX NUCLEIC ACID MOLECULES AND USES THEREOF

#4718
20210095282
2021-04-01

Modified Oligonucleotides for Treatment of Polycystic Kidney Disease

#4719
20210095281
2021-04-01

Modulation of transthyretin expression

#4720
20210095280
2021-04-01

Trimethylglycylglycerin compositions and their use in developing anti-cancer drugs and RNA vaccines

#4721
20210095279
2021-04-01

Methods and compositions for the specific inhibition of antithrombin 3 (AT3) by double-stranded RNA

#4722
20210095278
2021-04-01

Micro RNA expression constructs and uses thereof

#4723
20210095277
2021-04-01

ANTISENSE OLIGONUCLEOTIDES TARGETING SREBP1

#4724
20210095276
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING ERC1 EXPRESSION

#4725
20210095275
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING GSK3B EXPRESSION

#4726
20210095274
2021-04-01

OLIGONUCLEOTIDES FOR MODULATING PIAS4 EXPRESSION

#4727
20210093725
2021-04-01

INTEGRIN TARGETING LIGANDS AND USES THEREOF

#4728
20210093679
2021-04-01

ENGINEERED GUT MICROBES AND USES THEREOF

#4729
20210093654
2021-04-01

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER CANCER

#4730
20210093568
2021-04-01

LOADING OF EXTRACELLULAR VESICLES THROUGH IMPARTING OF MECHANICAL SHEAR

#4731
20210087588
2021-03-25

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4732
20210087568
2021-03-25

Modified Guide RNAs for Gene Editing

#4733
20210087567
2021-03-25

Therapeutic oligonucleotides

#4734
20210087566
2021-03-25

Compositions and methods for modulating apolipoprotein (a) expression

#4735
20210087565
2021-03-25

ANTISENSE ANTIBIOTICS AND BACTERIAL SECRETION BASED DELIVERY SYSTEM TO ELIMINATE DRUG-RESISTANT BACTERIA

#4736
20210087564
2021-03-25

TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma

#4737
20210087563
2021-03-25

Methods and compositions for treating inflammatory diseases

#4738
20210087562
2021-03-25

Modulation of alpha synuclein expression

#4739
20210087561
2021-03-25

Inhibitors Of Lactate Transporters For Use In The Treatment Of Inflammatory Diseases

#4740
20210087560
2021-03-25

OLIGODENDROCYTE-SPECIFIC PROMOTER, MIRNA SPECIFIC TO PLP1 GENE,VECTOR INCLUDING SAID PROMOTER AND/OR MIRNA, AND PHARMACEUTICAL COMPOSITION INCLUDING SAID VECTOR

#4741
20210087559
2021-03-25

Modulation of frataxin expression

#4742
20210087558
2021-03-25

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#4743
20210087557
2021-03-25

Methods and compositions for targeted genomic insertion

#4744
20210087556
2021-03-25

Therapeutic agent for fibrosis

#4745
20210087555
2021-03-25

Method for inducing exon skipping by genome editing

#4746
20210087554
2021-03-25

Means and methods to treat inflammatory diseases

#4747
20210087537
2021-03-25

ENHANCED IMMUNE EFFECTOR CELLS AND USE THEREOF

#4748
20210087262
2021-03-25

Medicine for treating disorders of glucose and/or lipid metabolism and a method of treating glucose and/or lipid metabolic disorders

#4749
20210087247
2021-03-25

MPS PEPTIDES AND USE THEREOF

#4750
20210087218
2021-03-25

COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS

#4751
20210085806
2021-03-25

Use of miR-21 in preparation of drug for treating intrauterine adhesion and/or thin endometrium

#4752
20210085793
2021-03-25

Branched oligonucleotides

#4753
20210085744
2021-03-25

Edible plant-derived nanoparticles for regulation of gut microbiota

#4754
20210085721
2021-03-25

Compositions and methods for the treatment of cancer using a CD8 engineered T cell therapy

#4755
20210085720
2021-03-25

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TET2 ENGINEERED T CELL THERAPY

#4756
20210085707
2021-03-25

IMPROVED BCL11A MICRORNAS FOR TREATING HEMOGLOBINOPATHIES

#4757
20210085706
2021-03-25

Microrna and uses thereof in prevention and/or treatment of fibroplasia medical sign and/or syndrome

#4758
20210079428
2021-03-18

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4759
20210079407
2021-03-18

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

#4760
20210079397
2021-03-18

Nucleic acid linked to a trivalent glycoconjugate

#4761
20210079396
2021-03-18

Anti-connexin compounds targeted to connexins and methods of use thereof

#4762
20210079395
2021-03-18

Modulators of APOL1 expression

#4763
20210079394
2021-03-18

TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS DELIVERED BY LIPID NANOPARTICLES

#4764
20210079393
2021-03-18

ANTISENSE OLIGONUCLEOTIDES FOR RNA EDITING

#4765
20210079392
2021-03-18

Inhibition of mir-22 miRNA by APT-110

#4766
20210079391
2021-03-18

Antisense oligonucleotide compositions

#4767
20210079390
2021-03-18

Nucleic acid inhibiting expression of the MEX3B gene, MEX3B gene expression inhibitor, method for inhibiting MEX3B gene expression, and prophylactic or therapeutic agent for disease caused by MEX3B gene expression

#4768
20210079389
2021-03-18

GUIDE RNA WITH CHEMICAL MODIFICATIONS

#4769
20210079373
2021-03-18

Near-infrared photothermally activated CRISPR/CAS9 genome editing machine

#4770
20210079347
2021-03-18

GENETICALLY ENGINEERED T CELLS HAVING IMPROVED PERSISTENCE IN CULTURE

#4771
20210079075
2021-03-18

NOVEL MEANS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES

#4772
20210079050
2021-03-18

COMPOSITIONS AND METHODS FOR DELIVERY AND EXPRESSION OF SMALL INHIBITORY PEPTIDES AND USE THEREOF

#4773
20210077628
2021-03-18

Exon skipping oligomer conjugates for muscular dystrophy

#4774
20210077622
2021-03-18

Motile sperm domain containing protein 2 and inflammation

#4775
20210077594
2021-03-18

Sequence-specific in vivo cell targeting

#4776
20210077553
2021-03-18

COMPOSITIONS FOR DRG-SPECIFIC REDUCTION OF TRANSGENE EXPRESSION

#4777
20210077520
2021-03-18

Vesicles comprising a PTEN inhibitor and uses of same

#4778
20210072248
2021-03-11

Biomarkers predictive of anti-immune checkpoint response

#4779
20210072228
2021-03-11

Methods for immunoregulation by modulating plasminogen-apple-nematode (PAN) domain-containing proteins

#4780
20210071260
2021-03-11

TREATMENT TARGETING ONCOLOGY AND NEURODEGENERATION

#4781
20210071255
2021-03-11

METHODS FOR IDENTIFICATION OF GENES AND GENETIC VARIANTS FOR COMPLEX PHENOTYPES USING SINGLE CELL ATLASES AND USES OF THE GENES AND VARIANTS THEREOF

#4782
20210071200
2021-03-11

Delivery across cell plasma membranes

#4783
20210071181
2021-03-11

PHARMACEUTICAL COMPOSITION

#4784
20210071180
2021-03-11

MICRORNA 584-5P COMPOSITIONS AND METHODS FOR TREATING CANCER

#4785
20210071179
2021-03-11

Mobile-CRISPRi plasmids and related methods

#4786
20210071178
2021-03-11

Targeted trans-splicing using CRISPR/Cas13

#4787
20210071177
2021-03-11

Modified oligonucleotides targeting SNPs

#4788
20210071176
2021-03-11

Compositions for modulating Tau expression

#4789
20210071175
2021-03-11

MicroRNA hsa-miR-665 in cardiac hypertrophy

#4790
20210071140
2021-03-11

Gene-regulating compositions and methods for improved immunotherapy

#4791
20210071139
2021-03-11

Identifying Epigenetic And Transcriptional Targets To Prevent And Reverse T Cell Exhaustion

#4792
20210070820
2021-03-11

NFAT binding polynucleotides

#4793
20210070812
2021-03-11

Fermentation process

#4794
20210069347
2021-03-11

GENE AUGMENTATION THERAPIES FOR INHERITED RETINAL DEGENERATION CAUSED BY MUTATIONS IN THE PRPF31 GENE

#4795
20210069345
2021-03-11

Hexameric tetrahedral RNA nanostructures

#4796
20210069306
2021-03-11

MODIFIED FACTOR VII POLYPEPTIDES FOR SUBCUTANEOUS ADMINISTRATION AND ON-DEMAND TREATMENT

#4797
20210069292
2021-03-11

RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION

#4798
20210069233
2021-03-11

Blockade of miR4661-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease

#4799
20210069231
2021-03-11

Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer

#4800
20210068402
2021-03-11

Methods and compositions for control of arthropod pests