109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Blood biomarkers for respiratory infections
#4802Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4803Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4804Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4805Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4806Interfering RNA molecules
#4807Plant sRNA extract or plant miRNA for use as an immunosuppressive agent
#4808Hippo and dystrophin complex signaling in cardiomyocyte renewal
#4809Extended dicer substrate agents and methods for the specific inhibition of gene expression
#4810Compositions and uses for treatment thereof
#4811CAS9 mutant genes and polypeptides encoded by same
#4812Compositions and methods for treating and preventing inflammation
#4813Targeted intracellular delivery of large nucleic acids
#4814Asialoglycoprotein Receptor mediated delivery of therapeutically active conjugates
#4815Sequence specific antimicrobials
#4816Sequence specific antimicrobials
#4817Development of polylysine:epigallocatechin-3-o-gallate and dsRNA polyplexes for control of mosquitoes
#4818Delivery across cell plasma membranes
#4819DELIVERY ACROSS CELL PLASMA MEMBRANES
#4820GENOME EDITING IN PLANTS
#4821YEAST FOR PRODUCING AND DELIVERING RNA BIOACTIVE MOLECULES AND METHODS AND USES THEREOF
#4822Nucleic acid simultaneously inhibiting expression of mTOR gene and STAT3 gene
#4823ANTISENSE OLIGONUCLEOTIDE REDUCED IN TOXICITY
#4824Expression of FOXP3 in edited CD34+ cells
#4825NOVEL SRNA PLATFORM FOR INHIBITING PROKARYOTIC EXPRESSION AND USE THEREOF
#4826Antitumor compounds and tumor diagnosis
#4827METHODS AND COMPOSITIONS FOR TARGETED EDITING OF POLYNUCLEOTIDES
#4828Chimeric genome engineering molecules and methods
#4829RNA-programmable endonuclease systems and uses thereof
#4830Tale RVD specifically recognizing DNA base modified by methylation and application thereof
#4831CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
#4832Bicistronic AAV vector for RNA interference in ALS
#4833PEPTIDE-MEDIATED INTRAVESICAL DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS
#4834Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
#4835Cancer stem cell growth inhibitor using miRNA
#4836Liposomal particles, methods of making same and uses thereof
#4837COMPOSITIONS AND METHODS FOR REGULATING A BIOLOGICAL PROCESS
#4838GENE EDITING USING HOMOLOGY-INDEPENDENT UNIVERSAL GENOME ENGINEERING TECHNOLOGY
#4839Pharmaceutical composition for treatment of diseases associated with upregulated periostin expression or periostin splice variant switching
#4840Variant RNAi
#4841COMPOSITIONS AND METHODS FOR TREATING HYPERTRIGLYCERIDEMIA
#4842Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction
#4843CRISPR-BASED DOWNREGULATION OF ALPHA-SYNUCLEIN EXPRESSION AS A NOVEL PARKINSON'S DISEASE THERAPEUTIC
#4844CRISPR KNOCK-OUT OF THE ALPHA-SYNUCLEIN TRIPLICATION MODEL OF PARKINSON'S DISEASE
#4845LENTIVIRAL-BASED VECTORS AND RELATED SYSTEMS AND METHODS FOR EUKARYOTIC GENE EDITING
#4846Angiotensinogen (AGT) iRNA compositions and methods of use thereof
#4847Fungal immunogens and related materials and methods
#4848Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
#4849Method of treating infection or its associated symptoms
#4850SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
#4851Methods of treating spinal muscular atrophy
#4852NOVEL CRISPR ENZYMES AND SYSTEMS
#4853PARALLEL LIQUID-PHASE HYBRID CAPTURE METHOD FOR SIMULTANEOUSLY CAPTURING SENSE AND ANTISENSE DOUBLE STRANDS OF GENOMIC TARGET REGION
#4854Method for increasing efficiency of homologous recombination-based gene editing in plant
#4855Curing for recursive nucleic acid-guided cell editing
#4856Antisense molecules and methods for treating pathologies
#48572′F-ANA-LET7 mediated utrophin upregulation for DMD therapy
#4858Compounds and methods for the modulation of amyloid-β precursor protein
#4859Method to enhance the transcription regulation of SUPT4H on genes containing repetitive nucleotide sequences
#4860Method of fixing and expressing physiologically active substance
#4861Oligonucleic acid variant libraries and synthesis thereof
#4862METHODS FOR TREATING PARKINSON'S DISEASE
#4863Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
#4864METHODS FOR TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
#4865Compounds and methods for modulating GFAP
#4866DNA mapping and sequencing on linearized DNA molecules
#4867METHOD FOR SCREENING COMPOUND FOR CONTROLLING RNA FUNCTION
#4868MicroRNA-based compositions and methods used in disease treatment
#4869Compositions and Methods for Correcting Limb Girdle Muscular Dystrophy Type 2C Using Exon Skipping
#4870Transgenic microalgae and use thereof as a feed for delivery of interfering RNA molecules
#4871Compositions and methods for modulation of SMN2 splicing in a subject
#4872Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
#4873SELF-INACTIVATING (SIN) CRISPR/CAS OR CRISPR/CPF1 SYSTEMS AND USES THEREOF
#4874Oligonucleotide compositions and methods thereof
#4875CRISPR/Cas9 Systems, and Methods of Use Thereof
#4876Peptides and nanoparticles for intracellular delivery of molecules
#4877Nucleic acid complex, method for forming nucleic acid hybridization, pharmaceutical composition, nucleic acid probe, and complementary-strand nucleic acid complex
#4878Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
#4879Compositions and methods for transport across the blood brain barrier
#4880COMPOSITIONS AND METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
#4881TREATING COGNITIVE DECLINE AND OTHER NEURODEGENERATIVE CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM NEUROLOGICAL TISSUE
#4882Topical silk compositions and methods of using
#4883Use of FUBP1 inhibitors for treating hepatitis B virus infection
#4884Splint nucleic acid molecule for cyclizing single-stranded nucleic acid molecule and use thereof
#4885Splice-switching oligonucleotides and methods of use
#4886METHOD FOR INDUCING RNA SILENCING
#4887Method of producing hairpin single-stranded RNA molecule
#4888Nucleic acid complex
#4889C/EBP ALPHA SARNA COMPOSITIONS AND METHODS OF USE
#4890CHIMERIC PROMOTER WITH HIGH TRANSCRIPTIONAL ACTIVITY IN T-CELLS
#4891Fully stabilized asymmetric siRNA
#4892Oligonucleotides for modulating ATXN2 expression
#4893Nuclease systems for genetic engineering
#4894COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION
#4895Therapeutic method for huntington's disease
#4896Using nucleosome interacting protein domains to enhance targeted genome modification
#4897Complex for genome editing having stability and few side-effects, and nucleic acid coding same
#4898Gene therapeutics for treating bone disorders
#4899Block copolymers
#4900MLK-regulated microRNAs in angiogenesis and tumor development
#4901TREATMENT OF CANCER BY SYSTEMIC ADMINISTRATION OF DBAIT MOLECULES
#4902EMBRYONIC ZEBRAFISH MODELS USING DNAZYME MEDIATED KNOCKDOWN
#4903Preparation and use of nanoparticle-doped RNA hydrogel targeting to triple negative breast cancer
#4904Systems, methods and composition of using RNase III mutants to produce sRNA to control host pathogen infection
#4905COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
#4906Inhibitors of micro-RNA 22
#4907Micro-RNA and obesity
#4908Modified double-stranded RNA agents
#4909Modified compounds and uses thereof
#4910Gene Editing for Autosomal Dominant Diseases
#4911CasZ compositions and methods of use
#4912Compositions and methods for cellular reprogramming
#4913COLON DISEASE TARGETS AND USES THEREOF
#4914Inhibition of a lncRNA for treatment of neuroblastoma
#4915Nucleic acid molecules and methods of using the same
#4916T CELLS EXPRESSING A RECOMBINANT RECEPTOR, RELATED POLYNUCLEOTIDES AND METHODS
#4917Compositions and methods for the treatment of a beta-catenin-associated disease or disorder
#4918Artificially synthesized sphingosine derivative lipoid monomer and use of same for delivering nucleic acid
#4919Methods of Novel Therapeutic Candidate Identification Through Gene Expression Analysis in Vascular-Related Diseases
#4920Gene therapies for lysosomal disorders
#4921Nucleic acid molecules for pseudouridylation
#4922Oligonucleotide analogues targeting human LMNA
#4923Nucleic acid with reduced toxicity
#4924Amphiphilic polynucleotides
#4925Materials and methods for treatment of hemoglobinopathies
#4926Modulating lactogenic activity in mammalian cells
#4927Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
#4928Systems methods, and compositions for targeted nucleic acid editing
#4929Cardiomyocyte maturation promoter
#4930Models of tauopathy
#4931COMPOSITION FOR GENE THERAPY OF THE CENTRAL NERVOUS SYSTEM, PROCESS OF PRODUCTION AND USE THEREOF
#4932Immunotherapeutic constructs and methods of their use
#4933Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
#4934Methods and compositions for modulating apolipoprotein (a) expression
#4935Methods for modulating FMR1 expression
#4936COMPOSITIONS AND METHODS FOR TREATING GRAVES DISEASE
#4937LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS FOR SURVIVAL OF MOTOR NEURON (SMA) INHIBITORS
#4938Neurodegenerative disorders
#4939Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof
#4940Pharmaceutical composition for preventing or treating angiogenesis relating ocular diseases comprising inhibitors of MCT expression or activity
#4941Selective antisense compounds and uses thereof
#4942Engineered cascade components and cascade complexes
#4943MODIFIED LYMPHOCYTES
#4944Method of synthesis of an ionizable cationic lipid
#4945EXOSOME TRANSFER OF NUCLEIC ACIDS TO CELLS
#4946Fatty acids and their use in conjugation to biomolecules
#4947COMPOSITIONS AND METHODS FOR TREATING PARKINSON'S DISEASE
#4948Stem cell-derived exosomes for the treatment of corneal scarring
#4949Immunomodulatory small hairpin RNA molecules
#4950Method for controlling pest infestations
#4951Methods and compositions for macrophage polarization
#4952COMPOUNDS OF CHEMICALLY MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE THEREOF
#4953A DBAIT MOLECULE AGAINST ACQUIRED RESISTANCE IN THE TREATMENT OF CANCER
#4954CONTROL OF INSECT PESTS USING RNA MOLECULES
#4955Antisense oligonucleotides rescue aberrant splicing of ABCA4
#4956Method of modulating cell proliferation
#4957COMPOSITIONS AND METHODS FOR INHIBITION OF ALPHAVIRUS INFECTION
#4958Compositions and methods of treating muscle atrophy and myotonic dystrophy
#4959METHODS AND COMPOSITIONS FOR CONTROLLING PLANT VIRAL INFECTION
#4960MODELING TDP-43 PROTEINOPATHY
#4961Nourin gene-based RNA molecular network: novel early diagnostic and prognostic biomarkers for coronary artery disease, unstable angina, STEMI/NSTEMI and heart failure
#4962MATERIALS AND METHODS FOR PREVENTING TRANSMISSION OF A PARTICULAR CHROMOSOME
#4963Oligonucleotides matching COL7A1 exon 73 for epidermolysis bullosa therapy
#4964Loss of function alleles of PtEPSP-TF and its regulatory targets in rice
#4965Deoxynucleic Guanidines (DNG)- Modified Oligonucleotides and Methods of Synthesizing Deoxynucleic Guanidine Strands
#4966SLIT AND BONE GROWTH MODULATION
#4967Methods and compositions for treating obesity
#4968TMPRSS6 iRNA compositions and methods of use thereof
#4969Conjugated antisense compounds and their use
#4970RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS
#4971METHODS FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE
#4972AAV-based treatment of cholesterol-related disorders
#4973Short interfering nucleic acid (siNA) compositions
#4974POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS
#4975METHODS AND COMPOSITIONS FOR DETECTING AND PROMOTING CARDIOLIPIN REMODELING AND CARDIOMYOCYTE MATURATION AND RELATED METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION
#4976Oligonucleotides, manufacturing method for same, and target RNA site-specific editing method
#4977Nucleic acids for inhibiting expression of a target gene comprising phosphorodithioate linkages
#4978Compounds and methods for reducing SNCA expression
#4979Oligomeric compounds comprising bicyclic nucleotides and uses thereof
#4980Modulating Immune Responses
#4981Method of Preparing Oligonucleotide Compounds
#4982Compounds and methods for trans-membrane delivery of molecules
#4983Uses for prevention or treatment of brain diseases using microrna
#4984Thermostable RNA-guided endonucleases and methods of use thereof
#4985Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
#4986Compositions and methods for treating HIF-1a over-expressing cancers
#4987Modified oligomeric compounds comprising tricyclo-DNA nucleosides and uses thereof
#4988Methods for modulating splicing
#4989MANIPULATION OF THE RETINOIC ACID SIGNALING PATHWAY
#4990COMPOSITE PARTICLES
#4991Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
#4992Method for inhibiting the expression of inflammation promoting factors
#4993COMPOSITIONS COMPRISING CURONS AND USES THEREOF
#4994Curing for recursive nucleic acid-guided cell editing
#4995Micro-RNA profiling, compositions, and methods of treating diseases
#4996Compositions and methods for treatment of cardiac diseases
#4997Antisense oligonucleotides targeting ATXN3
#4998Oversubscription scheduling
#4999Una amidites and uses thereof
#5000Frameshift suppressor tRNA compositions and methods of use
#5001Anti-C9ORF72 oligonucleotides and related methods
#50025′ modified nucleosides and oligomeric compounds prepared therefrom
#5003DELIVERING CRISPR THERAPEUTICS WITH LIPID NANOPARTICLES
#5004RNA-programmable endonuclease systems and their use in genome editing and other applications
#5005KISSPEPTIN 1 (KISS1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
#5006Non-human papillomaviruses for gene delivery in vitro and in vivo
#5007Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#5008MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION
#5009COMPOSITIONS AND METHODS FOR ALTERING BACTERIA FITNESS
#5010OLIGONUCLEOTIDES FOR MODULATING FNDC3B EXPRESSION
#5011Nucleoside derivative and use thereof
#5012Nucleic acid-polypeptide compositions and uses thereof
#5013Gene editing for hemophilia A with improved factor VIII expression
#5014Methods for attenuating viral infection and for treating lung injury
#5015Complex of nucleic acid medicine and multibranched lipid
#5016Selective Reduction of Allelic Variants
#5017Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
#5018ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS
#5019DIRECTED GENOME ENGINEERING USING ENHANCED TARGETED EDITING TECHNOLOGIES
#5020Reprogramming of non-neuronal cells into neurons and methods and compositions to treat neurodegenerative diseases and disorders
#5021CTLA-4 aptamer conjugates
#5022Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases
#5023RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
#5024COMPOSITIONS AND METHODS OF TREATING HUNTINGTON'S DISEASE
#5025EXON SKIPPING OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY
#5026COMPOSITIONS AND METHODS FOR THE GENERATION OF NEURONS AND USES THEREOF
#5027CRISPR fluorescent guide RNA (fgRNA) to understanding gRNAs expressed from pol II promotors
#5028Antisense oligonucleotides for modulating the function of a T cell
#5029Reducing beta-catenin expression to potentiate immunotherapy
#5030Methods of Genome Engineering by Nuclease-Transposase Fusion Proteins
#5031Concatemeric RNA molecules, compositions, and methods and uses thereof
#5032Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
#5033Genetically engineered hematopoietic stem cell as a platform for systemic protein expression
#5034GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS
#5035C/EBP alpha saRNA compositions and methods of use
#5036miR29 MIMICS FOR THE TREATMENT OF OCULAR FIBROSIS
#5037COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT
#5038NANOCARRIERS AND THEIR PROCESSING FOR DIAGNOSTICS AND THERAPEUTICS
#5039METHODS UTILIZING SINGLE CELL GENETIC DATA FOR CELL POPULATION ANALYSIS AND APPLICATIONS THEREOF
#5040Plant regulatory elements and uses thereof
#5041NON-HUMAN ANIMALS HAVING A HEXANUCLEOTIDE REPEAT EXPANSION IN A C9ORF72 LOCUS
#5042Compositions and methods to treating hemoglobinopathies
#5043Gene knockout of NRF2 for treatment of cancer
#5044Angelman syndrome antisense treatment
#5045METHOD OF TREATING TYPE II DIABETES AND OBESITY AND METHOD OF SCREENING A MEDICAMENT FOR THE SAME
#5046METHODS AND COMPOSITIONS FOR EXPANSION OF CELL POPULATION
#5047CasZ compositions and methods of use
#5048Modified oligonucleotides and compound that can be used for synthesizing same
#5049Nucleic acid-containing lipid nanoparticle
#5050Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5051Gene Expression or Activity Enhancing Elements
#5052Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
#5053Methods of inducing insulin production
#5054Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
#5055USE OF SINGLE-STRANDED ANTISENSE OLIGONUCLEOTIDE IN PREVENTION OR TREATMENT OF GENETIC DISEASES INVOLVING A TRINUCLEOTIDE REPEAT EXPANSION
#5056Antisense oligonucleotides targeting alpha-synuclein and uses thereof
#5057GENOME EDITING USING CRISPR IN CORYNEBACTERIUM
#5058Engineered post-poly A signal RNA and uses thereof
#5059Modifications of mammalian cells using artificial micro-RNA to alter their properties and the compositions of their products
#5060METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#5061Therapeutic targeting of a microRNA to treat Duchenne muscular dystrophy
#5062OLIGONUCLEOTIDES FOR TISSUE SPECIFIC APOE MODULATION
#5063Modulating apolipoprotein (a) expression
#5064PROCESSES FOR PREPARING PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS VIA FAST-FLOW SYNTHESIS
#5065Modified polynucleotide
#5066OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
#5067Antisense oligonucleotides that bind to exon 51 of human dystrophin pre-mRNA
#5068Peptide phosphorodiamidate morpholino oligomers plant delivery to reduce pathogens and insect pests
#5069Molecular sensor selection
#5070BIOLOGICAL MATERIALS AND USES THEREOF
#5071Nucleic acid, composition and conjugate containing same, preparation method, and use thereof
#5072Compositions and methods for treating motor neuron diseases
#5073Engineered chimeric guide RNA and uses thereof
#5074ROR2 inhibitors and use thereof in treating and/or preventing cartilage loss
#5075Engineered CAS9 systems for eukaryotic genome modification
#5076Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5077Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5078Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5079CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
#5080Antisense oligonucleotides targeting alpha-synuclein and uses thereof
#50815-halouracil-modified microRNAs and their use in the treatment of cancer
#5082FMRP and cancer treatment
#5083METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
#5084Modified EC7 cells having low toxicity to viral production payloads
#5085Modified pluripotent cells
#5086COMPOSITIONS AND METHODS OF USE THEREOF FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
#5087Motor neuron-specific expression vectors
#5088Modified RNAi agents
#5089Prevention and/or treatment of hearing loss or impairment
#5090Intracellular genomic transplant and methods of therapy
#5091MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
#5092ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF LEBER CONGENITAL AMAUROSIS
#5093Genetically modified cells, tissues, and organs for treating disease
#5094RNA targeting methods and compositions
#5095RNA targeting methods and compositions
#5096Oligonucleotides for inducing paternal UBE3A expression
#5097SPLIT SINGLE-BASE GENE EDITING SYSTEMS AND APPLICATION THEREOF
#5098TRANSGENIC PLANT OF THE SPECIES SOLANUM TUBEROSUM WITH RESISTANCE TO PHYTOPHTHORA
#5099GENES AND GENE COMBINATIONS FOR ENHANCED CROPS
#5100COMPOSITIONS AND METHODS FOR GENERATING DIVERSITY AT TARGETED NUCLEIC ACID SEQUENCES