ClassID:

109048

C12N15/113 - page 18 - CPC Classification

Classification description:

Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Recent Application in this class:
#5101
20200347360
2020-11-05

Method for producing exosomes and exosomes obtained thereby

#5102
20200345993
2020-11-05

Medical devices for delivery of siRNA

#5103
20200345866
2020-11-05

Method for treating or preventing heart failure

#5104
20200345786
2020-11-05

Direct reprogramming of cells to cardiac myocyte fate

#5105
20200345758
2020-11-05

Serum amyloid P component (APCS) iRNA compositions and methods of use thereof

#5106
20200345757
2020-11-05

Use of specific siRNA against protein S for the treatment of hemophilia

#5107
20200345640
2020-11-05

Liposomes for modulating Wiskott-Aldrich syndrome protein

#5108
20200344983
2020-11-05

Genetically modified non-human animals and methods for producing heavy chain-only antibodies

#5109
20200340976
2020-10-29

Use of leucine-zipper protein for diagnosis or treatment of fatty liver

#5110
20200340058
2020-10-29

COMPOSITIONS AND METHODS FOR ENHANCING CELL TRANSPLANTATION EFFICACY

#5111
20200340042
2020-10-29

IN VITRO SELECTION FOR NUCLEIC ACID APTAMERS

#5112
20200340028
2020-10-29

Enzymatic methods to generate high yields of sequence specific rna with extreme precision

#5113
20200340013
2020-10-29

METHODS AND COMPOSITIONS FOR INHIBITION OF INNATE IMMUNE RESPONSE ASSOCIATED WITH AAV TRANSDUCTION

#5114
20200340012
2020-10-29

CRISPR-CAS GENOME ENGINEERING VIA A MODULAR AAV DELIVERY SYSTEM

#5115
20200340009
2020-10-29

CENH3 DELETION MUTANTS

#5116
20200339992
2020-10-29

RNAi induced huntingtin gene suppression

#5117
20200339991
2020-10-29

Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof

#5118
20200339990
2020-10-29

RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF

#5119
20200339989
2020-10-29

NUCLEIC ACID NANOSTRUCTURES WITH CORE MOTIFS

#5120
20200339988
2020-10-29

RAAV-based compositions and methods

#5121
20200339987
2020-10-29

ASSAYS AND METHODS FOR DETERMINING EXPRESSION OF THE LECT2 GENE

#5122
20200339986
2020-10-29

Treatment of HER-2 dependent cancer using an agent that modulates the activity of a miRNA

#5123
20200339985
2020-10-29

EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY

#5124
20200339984
2020-10-29

Multivalent oligonucleotide assemblies

#5125
20200339975
2020-10-29

Methods of polynucleotide preparation using multivalent cation salt compositions

#5126
20200339958
2020-10-29

Generation of induced pluripotent cells by CRISPR activation

#5127
20200338213
2020-10-29

Systems and methods for treating hyper-igm syndrome

#5128
20200338112
2020-10-29

METHODS AND MATERIALS FOR TREATING CANCER

#5129
20200338110
2020-10-29

Reducing beta-catenin and IDO expression to potentiate immunotherapy

#5130
20200338109
2020-10-29

Methods for treating hepatitis B infection

#5131
20200338108
2020-10-29

Methods for treating hepatitis B infection

#5132
20200338043
2020-10-29

Compositions and methods for treating allergic inflammatory conditions

#5133
20200337313
2020-10-29

Altering microbial populations and modifying microbiota

#5134
20200337279
2020-10-29

Large animal model for developing therapeutic agents to treat impaired ophthalmic function in usher syndrome

#5135
20200332300
2020-10-22

MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS

#5136
20200332298
2020-10-22

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS

#5137
20200332294
2020-10-22

Use of MIR-92A or MIR-145 in the treatment of Angelman syndrome

#5138
20200332293
2020-10-22

ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN OR PEPTIDE EXPRESSION

#5139
20200332292
2020-10-22

Dual Targeting siRNA Agents

#5140
20200332291
2020-10-22

Use of p38 inhibitors to reduce expression of DUX4

#5141
20200332290
2020-10-22

miRNA as biomarker for Parkinson's disease and diagnostic kit using same

#5142
20200332289
2020-10-22

GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE

#5143
20200332275
2020-10-22

Variant CAS12 proteins with improved dna cleavage selectivity and methods of use

#5144
20200332274
2020-10-22

Enzymes with RuvC domains

#5145
20200332273
2020-10-22

Enzymes with RuvC domains

#5146
20200332272
2020-10-22

SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING

#5147
20200332259
2020-10-22

METHOD TO BIOENGINEER DESIGNER RED BLOOD CELLS USING GENE EDITING AND STEM CELL METHODOLOGIES

#5148
20200331841
2020-10-22

CATIONIC LIPIDS

#5149
20200330599
2020-10-22

Liposomal system for drug delivery

#5150
20200330517
2020-10-22

TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY

#5151
20200330400
2020-10-22

METHODS FOR THE TREATMENT OF CANCER USING COENZYME Q10 AND FATTY ACID METABOLISM INHIBITORS

#5152
20200330269
2020-10-22

Ophthalmic delivery device and ophthalmic drug compositions

#5153
20200325597
2020-10-15

Pig genome-wide specific sgRNA library, preparation method therefor and application thereof

#5154
20200325545
2020-10-15

CD133 related to anticancer agent resistance in colon cancer and use thereof

#5155
20200325539
2020-10-15

CANCER BIOMARKERS AND METHODS OF USE

#5156
20200325495
2020-10-15

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5157
20200325480
2020-10-15

Antisense Oligonucleotides (ODN) Against SMAD7 and Uses Thereof in Medical Field

#5158
20200325478
2020-10-15

Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro

#5159
20200325474
2020-10-15

RNA-GUIDED DNA INTEGRATION USING TN7-LIKE TRANSPOSONS

#5160
20200325473
2020-10-15

Compositions and methods for modulating Ataxin 3 expression

#5161
20200325468
2020-10-15

Mammalian cell line for protein production and library generation

#5162
20200325454
2020-10-15

VECTORS CONTAINING AIMP2-DX2 AND TARGET NUCLEIC ACIDS FOR miR 142 AND USES THEREOF

#5163
20200325189
2020-10-15

COLON DISEASE TARGETS AND USES THEREOF

#5164
20200325178
2020-10-15

PEPTIDE NUCLEIC ACID MOLECULES FOR TREATMENT OF GRAM POSITIVE BACTERIAL INFECTION

#5165
20200323924
2020-10-15

MicroRNA-294 and Lin28A as a driver of cardiac tissue proliferation in response to pathological injury

#5166
20200323180
2020-10-15

METHODS FOR THE PRODUCTION OF STERILE FISH AND OTHER EGG-PRODUCING AQUATIC ANIMALS AND COMPOUNDS FOR USE IN THE METHODS

#5167
20200322297
2020-10-08

RNA targeting methods and compositions

#5168
20200318193
2020-10-08

Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions

#5169
20200318173
2020-10-08

CRISPR enzymes and systems

#5170
20200318172
2020-10-08

NOVEL CRISPR ENZYMES AND SYSTEMS

#5171
20200318128
2020-10-08

Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants

#5172
20200318123
2020-10-08

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

#5173
20200318122
2020-10-08

Unnatural base pair compositions and methods of use

#5174
20200318116
2020-10-08

Compositions and their uses directed to huntingtin

#5175
20200318115
2020-10-08

Gene therapy for neurodegenerative disorders

#5176
20200318114
2020-10-08

C/EBP ALPHA SHORT ACTIVATING RNA COMPOSITIONS AND METHODS OF USE

#5177
20200318113
2020-10-08

POLYNUCLEOTIDE CONJUGATES AND USES THEREOF

#5178
20200318112
2020-10-08

CANCER TREATMENT

#5179
20200318111
2020-10-08

RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES

#5180
20200318110
2020-10-08

A COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS ANTI-CANCER DRUGS FOR TREATING HUMAN LUNG CANCER

#5181
20200318109
2020-10-08

LNA-G process

#5182
20200318106
2020-10-08

CONTROLLING PHENOTYPE OF ORGANISMS WITH CRISPR/CAS GENE TARGETING

#5183
20200318088
2020-10-08

Engineered nucleic-acid targeting nucleic acids

#5184
20200317780
2020-10-08

METHODS FOR ENHANCING TCRab+ CELL DEPLETION

#5185
20200316210
2020-10-08

Cell-penetrating peptides for antisense delivery

#5186
20200316201
2020-10-08

Compositions and methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression

#5187
20200316070
2020-10-08

Compositions and methods for inhibiting PTPN22

#5188
20200308607
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5189
20200308606
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5190
20200308605
2020-10-01

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5191
20200308603
2020-10-01

IN VITRO METHOD OF MRNA DELIVERY USING LIPID NANOPARTICLES

#5192
20200308588
2020-10-01

HIGH MOBILITY GROUP BOX-1 (HMGB1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#5193
20200308587
2020-10-01

Composition for delivery of genetic material

#5194
20200308586
2020-10-01

Thiomorpholino oligonucleotides for the treatment of muscular dystrophy

#5195
20200308585
2020-10-01

TARGETING GLIOBLASTOMA STEM CELLS THROUGH THE TLX-TET3 AXIS

#5196
20200308584
2020-10-01

Oligonucleotide compounds for targeting huntingtin mRNA

#5197
20200308583
2020-10-01

Composition for genome editing using CRISPR/CPF1 system and use thereof

#5198
20200308582
2020-10-01

KCNK3-BASED GENE THERAPY OF CARDIAC ARRHYTHMIA

#5199
20200308581
2020-10-01

CRISPR/Cas system and method for genome editing and modulating transcription

#5200
20200308580
2020-10-01

Combinations for the modulation of SMN expression

#5201
20200308579
2020-10-01

Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA

#5202
20200308572
2020-10-01

Modification of D- and T-arms of tRNA enhancing D-amino acid and β-amino acid uptake

#5203
20200308571
2020-10-01

Adenine DNA base editor variants with reduced off-target RNA editing

#5204
20200308561
2020-10-01

Cas9 variants and methods of use

#5205
20200306378
2020-10-01

Trialkyl cationic lipids and methods of use thereof

#5206
20200306310
2020-10-01

Intracellular genomic transplant and methods of therapy

#5207
20200306309
2020-10-01

INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY

#5208
20200300875
2020-09-24

ApoCIII and the Treatment and Diagnosis of Diabetes

#5209
20200299734
2020-09-24

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#5210
20200299733
2020-09-24

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#5211
20200299732
2020-09-24

RNA-Guided Transcriptional Regulation

#5212
20200299730
2020-09-24

PRIMARY CELL GENE EDITING

#5213
20200299695
2020-09-24

Gene silencing kills emerald ash borer, an exotic, invasive tree-killing insect

#5214
20200299694
2020-09-24

Components and methods for producing toxic RNAs in eukaryotic cells

#5215
20200299693
2020-09-24

RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES

#5216
20200299692
2020-09-24

Oligonucleotide compositions and methods thereof

#5217
20200299691
2020-09-24

RNAi agents for inhibiting expression of alpha-ENaC and methods of use

#5218
20200299690
2020-09-24

RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3)

#5219
20200299689
2020-09-24

MODIFIED CPF1 GUIDE RNA

#5220
20200299688
2020-09-24

POLYNUCLEOTIDE COMPLEXES HAVING IMPROVED DELIVERY INTO CELLS

#5221
20200299682
2020-09-24

CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation

#5222
20200299681
2020-09-24

CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation

#5223
20200299660
2020-09-24

CASZ compositions and methods of use

#5224
20200299659
2020-09-24

CRISPR-associated systems and components

#5225
20200299658
2020-09-24

ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A

#5226
20200299415
2020-09-24

Method and carrier complexes for delivering molecules to cells

#5227
20200297966
2020-09-24

Therapy specific, pre-programmed auto injection device

#5228
20200297826
2020-09-24

Fungal immunogens and related materials and methods

#5229
20200297779
2020-09-24

METHODS, SYSTEMS, AND COMPOSITIONS RELATING TO TREATMENT OF NEUROLOGICAL CONDITIONS, DISEASES, AND INJURIES AND COMPLICATIONS FROM DIABETES

#5230
20200291479
2020-09-17

miR-133a as a marker for colorectal cancer

#5231
20200291428
2020-09-17

Engineered Herpes Simplex Virus-1 (HSV-1) vectors and uses thereof

#5232
20200291407
2020-09-17

TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF

#5233
20200291406
2020-09-17

PREVENTIVE OR THERAPEUTIC AGENT FOR FIBROSIS

#5234
20200291403
2020-09-17

ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES

#5235
20200291402
2020-09-17

Methods for the treatment of Leber congenital amaurosis

#5236
20200291401
2020-09-17

Methods of rescuing stop codons via genetic reassignment with ACE-tRNA

#5237
20200291400
2020-09-17

MicroRNA Compounds and Methods for Modulating MIR-21 Activity

#5238
20200291399
2020-09-17

Oligonucleotide comprising an inosine for treating DMD

#5239
20200291398
2020-09-17

Gapmers and methods of using the same for the treatment of muscular dystrophy

#5240
20200291396
2020-09-17

METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING

#5241
20200291395
2020-09-17

CRISPR-associated transposon systems and components

#5242
20200291129
2020-09-17

Methods and compositions for diagnosing and treating diseases

#5243
20200291057
2020-09-17

Method for polyalkoxylation of nucleic acids that enables recovery and reuse of excess polyalkoxylation reagent

#5244
20200289628
2020-09-17

Compositions and methods for expressing factor IX

#5245
20200289571
2020-09-17

TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY

#5246
20200289570
2020-09-17

Tumor infiltrating lymphocytes and methods of therapy

#5247
20200289542
2020-09-17

Methods for treating chondrosarcoma using microrna(miR)

#5248
20200289417
2020-09-17

Delivery method of target material into extracellular vesicles using extracorporeal shockwave

#5249
20200283849
2020-09-10

METHODS FOR GENDER DETERMINATION OF AVIAN EMBRYOS IN UNHATCHED EGGS AND MEANS THEREOF

#5250
20200283841
2020-09-10

Mutant cell-free DNA isolation kit and mutant cell-free DNA isolation method using the same

#5251
20200283800
2020-09-10

GENE THERAPIES FOR NEURODEGENERATIVE DISEASES

#5252
20200283792
2020-09-10

Nucleotide sequence and application thereof in enhancing plant pest resistance

#5253
20200283780
2020-09-10

Iterative genome editing in microbes

#5254
20200283772
2020-09-10

Antisense oligonucleotides for inducing exon skipping and methods of use thereof

#5255
20200283771
2020-09-10

ALBUMIN PRODUCTION AND CELL PROLIFERATION

#5256
20200283770
2020-09-10

METHODS AND COMPOSITIONS TO TREAT DRUG-INDUCED DISEASES AND CONDITIONS

#5257
20200283769
2020-09-10

RNA-guided DNA integration using Tn7-like transposons

#5258
20200283768
2020-09-10

ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS

#5259
20200283767
2020-09-10

as a diagnostic and therapeutic target for NAFLD, NASH, metabolic syndrome, and hepatic fibrosis

#5260
20200283766
2020-09-10

Compositions and Methods for Inhibiting Expression of Transthyretin

#5261
20200283765
2020-09-10

Methods for Treatment of Alport Syndrome

#5262
20200283764
2020-09-10

Oligonucleotide inhibiting the expression of Chop

#5263
20200283763
2020-09-10

Composition for preventing or treating liver fibrosis, containing exosome or exosome-derived ribonucleic acid

#5264
20200283737
2020-09-10

Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same

#5265
20200282074
2020-09-10

NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND METHODS OF INDUCING EXON SKIPPING

#5266
20200282069
2020-09-10

BIOTIN COMPLEXES FOR TREATMENT AND DIAGNOSIS OF ALZHEIMER'S DISEASE

#5267
20200282060
2020-09-10

NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF

#5268
20200282044
2020-09-10

H5 avian influenza vaccine strain which differentiates infected from vaccinated animals, preparation method therefor, and application

#5269
20200282027
2020-09-10

SEQUENCE SPECIFIC ANTIMICROBIALS

#5270
20200282026
2020-09-10

Sequence specific antimicrobials

#5271
20200282012
2020-09-10

Combination therapy for C3 inhibition

#5272
20200281982
2020-09-10

Methods of using anti-MIR126 compounds

#5273
20200281975
2020-09-10

Methods and compositions for gene editing in hematopoietic stem cells

#5274
20200281174
2020-09-10

MicroRNA inhibitor therapy in systemic lupus erythematosus

#5275
20200277631
2020-09-03

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5276
20200277630
2020-09-03

Gene manipulation for treatment of retinal dysfunction disorder

#5277
20200277608
2020-09-03

RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS

#5278
20200277607
2020-09-03

RNA targeting of mutations via suppressor tRNAs and deaminases

#5279
20200277605
2020-09-03

Synthetic bacteriophages and bacteriophage compositions

#5280
20200277604
2020-09-03

Modulators of MALAT1 expression

#5281
20200277603
2020-09-03

Use of miR-18b for prevention, treatment, or diagnosis of muscle disease and neuromuscular disease

#5282
20200277602
2020-09-03

Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing

#5283
20200277601
2020-09-03

SYNTHETIC HAMMERHEAD RIBOZYMES WITH LIGAND-RESPONSIVE TERTIARY INTERACTIONS

#5284
20200277600
2020-09-03

Multi-effector CRISPR based diagnostic systems

#5285
20200277599
2020-09-03

Insulin-like growth factor binding protein, acid labile subunit (IGFALS) and insulin-like growth factor 1 (IGF-1) iRNA compositions and methods of use thereof

#5286
20200277598
2020-09-03

Peptide oligonucleotide conjugates

#5287
20200277588
2020-09-03

Engineered cascade components and cascade complexes

#5288
20200277586
2020-09-03

Modified Cas9 protein and use thereof

#5289
20200277363
2020-09-03

Recombinant EGFL7, EGFL7 antibodies, and uses thereof

#5290
20200277289
2020-09-03

Methods and compositions for modulating splicing

#5291
20200276329
2020-09-03

METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DISEASES

#5292
20200276263
2020-09-03

Treatments of oxidative stress conditions

#5293
20200276252
2020-09-03

Isolated recombinant oncolytic adenoviruses, pharmaceutical compositions, and uses thereof for drugs for treatment of tumors and/or cancers

#5294
20200276235
2020-09-03

Combination immunotherapies for treatment of cancer

#5295
20200276224
2020-09-03

METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION

#5296
20200276221
2020-09-03

ANTISENSE COMPOUNDS

#5297
20200275641
2020-09-03

GENERATION AND CORRECTION OF A HUMANIZED MOUSE MODEL WITH A DELETION OF DYSTROPHIN EXON 44

#5298
20200270680
2020-08-27

Methods for analyzing nucleic acid sequences

#5299
20200270635
2020-08-27

MODULATORY POLYNUCLEOTIDES

#5300
20200270634
2020-08-27

USE OF MEDEA ELEMENTS FOR BIOCONTROL OF D. SUZUKII POPULATIONS

#5301
20200270632
2020-08-27

MULTIPLEX PRODUCTION AND BARCODING OF GENETICALLY ENGINEERED CELLS

#5302
20200270631
2020-08-27

Method for modifying target site in double-stranded DNA in cell

#5303
20200270618
2020-08-27

COMPOSITIONS AND METHODS FOR TREATING ALPHA-1 ANTITRYPSIN DEFICIENCY

#5304
20200270617
2020-08-27

COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION FROM AN ALBUMIN LOCUS

#5305
20200270612
2020-08-27

Cancer-specific trans-splicing ribozymes and use thereof

#5306
20200270609
2020-08-27

Single-Stranded RNAI Oligonucleotides Targeting APOC-III

#5307
20200270608
2020-08-27

Modulation of huntingtin expression

#5308
20200270607
2020-08-27

Methods and compositions for selecting siRNA of improved functionality

#5309
20200270606
2020-08-27

Beta catenin nucleic acid inhibitor molecule

#5310
20200270605
2020-08-27

Dynamic pharmacokinetic-modifying anchors

#5311
20200270604
2020-08-27

MODIFYING THE SPECIFICITY OF NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION IN EUKARYOTIC CELLS

#5312
20200270603
2020-08-27

USE OF ANTI-CRISPR POLYPEPTIDES FOR SPECIFIC ACTIVATION OF CAS NUCLEASES

#5313
20200270602
2020-08-27

RNA SEQUENCE-SPECIFIC MEDIATORS OF RNA INTERFERENCE

#5314
20200270337
2020-08-27

Pharmaceutical use of FAM19A5 involved in regulating gliogenesis

#5315
20200268905
2020-08-27

RNA-modulating agents

#5316
20200268898
2020-08-27

GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF

#5317
20200268858
2020-08-27

Glaucoma treatment

#5318
20200268848
2020-08-27

Compositions and methods for inducing a treg phenotype and methods for use for the same

#5319
20200267992
2020-08-27

Altering microbial populations and modifying microbiota

#5320
20200264163
2020-08-20

Cell-based assay for quantifying the potency and efficacy of cannabinoids and/or terpenoids, and methods of use thereof

#5321
20200263250
2020-08-20

ACTIVITY-DEPENDENT GENE PAIRS AS THERAPEUTIC TARGETS AND METHODS AND DEVICES TO IDENTIFY THE SAME

#5322
20200263206
2020-08-20

TARGETED INTEGRATION SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES

#5323
20200263202
2020-08-20

Genomic insulator elements and uses thereof

#5324
20200263198
2020-08-20

Methods and compositions for in situ germline genome engineering

#5325
20200263190
2020-08-20

NOVEL CRISPR ENZYMES AND SYSTEMS

#5326
20200263188
2020-08-20

Methods for genetic engineering host cells

#5327
20200263180
2020-08-20

RNA targeting of mutations via suppressor tRNAs and deaminases

#5328
20200263179
2020-08-20

COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF LPA

#5329
20200263178
2020-08-20

Compositions and methods for treating hepatic fibrosis

#5330
20200263177
2020-08-20

Riboswitch-mediated regulatory control of gene expression in thermophilic bacteria

#5331
20200263176
2020-08-20

Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes

#5332
20200263175
2020-08-20

CHANNEL MODULATORS

#5333
20200263174
2020-08-20

RNA molecules

#5334
20200263173
2020-08-20

Compositions and methods for treating transposon associated diseases

#5335
20200263166
2020-08-20

Cpf1 complexes with reduced indel activity

#5336
20200263165
2020-08-20

METHODS AND COMPOSITIONS FOR POLYMERASE II (POL-II) BASED GUIDE RNA EXPRESSION

#5337
20200263155
2020-08-20

CRISPR/Cas fusion proteins and systems

#5338
20200261881
2020-08-20

Regulated multiplex reactions in a single tube

#5339
20200261491
2020-08-20

Regulation of nucleic acid molecule expression

#5340
20200260698
2020-08-20

EXON DELETION CORRECTION OF DUCHENNE MUSCULAR DYSTROPHY MUTATIONS IN THE DYSTROPHIN ACTIN BINDING DOMAIN 1 USING CRISPR GENOME EDITING

#5341
20200255868
2020-08-13

Switchable CAS9 nucleases and uses thereof

#5342
20200255860
2020-08-13

Strong insulator and uses thereof in gene delivery

#5343
20200255858
2020-08-13

CasY compositions and methods of use

#5344
20200255857
2020-08-13

CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING BETA HEMOGLOBINOPATHIES

#5345
20200255834
2020-08-13

Oligonucleotide sequences targeting transcription factor TSC22D4 for the treatment of insulin resistance

#5346
20200255833
2020-08-13

Therapeutic compositions

#5347
20200255832
2020-08-13

Antisense oligonucleotides for the treatment of leber congenital amaurosis

#5348
20200255831
2020-08-13

miRNA biogenesis in exosomes for diagnosis and therapy

#5349
20200255830
2020-08-13

NOVEL CRISPR-ASSOCIATED TRANSPOSON SYSTEMS AND COMPONENTS

#5350
20200255829
2020-08-13

NOVEL CRISPR-ASSOCIATED TRANSPOSON SYSTEMS AND COMPONENTS

#5351
20200255828
2020-08-13

METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS

#5352
20200255827
2020-08-13

Stabilized HNF4A saRNA compositions and methods of use

#5353
20200255826
2020-08-13

HNF4A saRNA compositions and methods of use

#5354
20200255825
2020-08-13

BIOLOGICAL MATERIALS AND THERAPEUTIC USES THEREOF

#5355
20200255813
2020-08-13

PROSS OPTIMIZED ENZYMES

#5356
20200255603
2020-08-13

Facile assembly of soft nanoarchitectures and co-loading of hydrophilic and hydrophobic molecules via flash nanoprecipitation

#5357
20200254103
2020-08-13

Method for treating neurological conditions and improving human cognition

#5358
20200254036
2020-08-13

Virus for treatment of tumor

#5359
20200254025
2020-08-13

Methods of treating an ischemic disease

#5360
20200254001
2020-08-13

Therapeutic pharmaceutical composition for cancer including miRNA

#5361
20200253913
2020-08-13

Compositions for inhibiting 3′ repair exonuclease 2 and methods of screening for such compositions

#5362
20200253506
2020-08-13

TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH AN INTEGRIN INHIBITOR

#5363
20200252359
2020-08-06

RNA targeting methods and compositions

#5364
20200248196
2020-08-06

Modifying the specificity of plant non-coding RNA molecules for silencing gene expression

#5365
20200248188
2020-08-06

POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF

#5366
20200248186
2020-08-06

Antisense oligomers targeting PCSK9

#5367
20200248180
2020-08-06

Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis

#5368
20200248179
2020-08-06

MiRNA Detargeting System for Tissue Specific Interference

#5369
20200248178
2020-08-06

COMBINATION THERAPIES FOR TREATING MUSCULAR DYSTROPHY

#5370
20200248177
2020-08-06

SMALL GUIDE ANTISENSE NUCLEIC ACID AND USE THEREOF

#5371
20200247882
2020-08-06

Agents that modulate TMEM230 as angiogenesis regulators and that detect TMEM230 as markers of metastasis

#5372
20200247799
2020-08-06

Methods and compositions for modulating splicing

#5373
20200246488
2020-08-06

COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES

#5374
20200246438
2020-08-06

TARGETING GDF6 AND BMP SIGNALING FOR ANTI-MELANOMA THERAPY

#5375
20200246372
2020-08-06

METHODS OF TREATING MOTOR NEURON DISEASES

#5376
20200246370
2020-08-06

Methods and Compositions for RNAi Mediated Inhibition of Gene Expression in Mammals

#5377
20200246369
2020-08-06

Antisense oligonucleotide and composition for prevention or treatment of glycogen storage disease type Ia

#5378
20200246273
2020-08-06

Drug delivery systems containing oxidized cholesterols

#5379
20200244609
2020-07-30

RNA targeting methods and compositions

#5380
20200241013
2020-07-30

METHODS FOR DIAGNOSING HUNTINGTON'S DISEASE

#5381
20200239939
2020-07-30

Bioinformatics methods of in silico validation and selection of circRNAs

#5382
20200239927
2020-07-30

Sensor for cyanuric acid detection

#5383
20200239912
2020-07-30

Treatment of amyotrophic lateral sclerosis (ALS)

#5384
20200239892
2020-07-30

MULTI-CONJUGATE OF SIRNA AND PREPARING METHOD THEREOF

#5385
20200239891
2020-07-30

Control of plant pests using RNA molecules

#5386
20200239890
2020-07-30

Compositions and methods for inhibition of expression of protein C (PROC) genes

#5387
20200239889
2020-07-30

Channel modulators

#5388
20200239888
2020-07-30

Compositions and methods for modulation of protein aggregation

#5389
20200239887
2020-07-30

Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene

#5390
20200239886
2020-07-30

Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-mRNA

#5391
20200239885
2020-07-30

Antisense oligonucleotides for treatment of cancer stem cells

#5392
20200239884
2020-07-30

METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION

#5393
20200239883
2020-07-30

Compositions for modulating expression of C9ORF72 antisense transcript

#5394
20200239882
2020-07-30

COMPOSITIONS FOR MODULATING C9ORF72 EXPRESSION

#5395
20200239881
2020-07-30

Morpholino modified oligomeric compounds

#5396
20200239879
2020-07-30

Compositions and methods for regulating proteins and nucleic acids activities

#5397
20200239863
2020-07-30

Tracking and manipulating cellular RNA via nuclear delivery of CRISPR/CAS9

#5398
20200237971
2020-07-30

Delivery of hydrophobic active agent particles

#5399
20200237931
2020-07-30

MOLECULES TARGETING SURVIVAL MOTOR NEURON 2

#5400
20200237928
2020-07-30

Nanoparticle conjugates and uses thereof