109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#6002Piston arrangement
#6003ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES
#6004Identification of a JAK2 mutation in Polycythemia Vera
#6005COMPOUNDS AND METHODS FOR MODULATION OF SMN2
#6006Thermostable CAS9 nucleases
#6007Methods for promoting reinnervation of auditory hair cells
#6008Compositions and methods for transport across the blood brain barrier
#6009METHODS AND COMPOSITIONS RELATED TO CHITOSAN-DERIVED NANOPARTICLE-MEDIATED CRISPR/CAS9 DELIVERY
#6010Method of treating diabetic retinopathy or wet type adult macular degeneration
#6011Pharmaceutical compositions and methods for potentiating gene silencing
#6012COMPOUNDS AND METHODS FOR MODULATION OF TRANSCRIPT PROCESSING
#6013Method of Encapsulating a Nucleic Acid in a Lipid Nanoparticle Host
#6014MIR-320E AND COLORECTAL CANCER
#6015Complexes for gene deletion and editing
#6016Insecticidal proteins
#6017Methods and Compositions for Selecting siRNA of Improved Functionality
#6018Oligonucleotide compositions with enhanced efficiency
#6019Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
#6020Compositions and methods to treating hemoglobinopathies
#6021Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
#6022Compositions and methods for controlling insect pests
#6023Compositions and methods for treating alpha-1 antitrypsin deficiency
#6024DELIVERY OF dsRNA TO ARTHROPODS
#6025Serpina1 iRNA compositions and methods of use thereof
#6026RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#6027Double-stranded nucleic acid inhibitor molecules modified with Tm-increasing nucleotides
#6028SEMAPHORIN 3D AND PLEXIN D1 AS THERAPEUTIC TARGETS FOR PANCREATIC CANCER TREATMENT
#6029ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
#6030Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
#6031Antisense nucleic acids
#6032Compositions for in vivo Expression of Therapeutic Sequences in the Microbiome
#6033Carrier Nanoparticles And Related Compositions, Methods And Systems
#6034Cells for producing influenza virus and method for producing influenza virus
#6035MEANS FOR MODULATING GENE EXPRESSION
#6036HOMEOSTATIC REGULATION OF L-DOPA BIOSYNTHESIS
#6037Use of micro-ribonucleic acid (miRNA) to diagnose transplant rejection and tolerance of immunosuppression therapy
#6038Oligonucleotides for inducing paternal UBE3A expression
#6039CRISPR effector system based diagnostics
#6040Cell-free expression system having novel inorganic polyphosphate-based energy regeneration
#6041Inhibitors of cytoplasmic histone deacetylase 4 complex for treating or preventing vascular or valve calcification
#6042Methods and compositions for the treatment of cancer
#6043Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
#6044Process of delivering small RNAs to sperm
#6045Compositions and Methods for Inhibiting Expression of Transthyretin
#6046Compounds and methods for enhanced cellular uptake
#6047CCCTC-binding factor (CTCF) RNA interactome
#6048Soluble TNF Receptors and Their Use in Treatment of Disease
#6049Non-enzymatic, salt-mediated synthesis of polynucleic acids
#6050Adipocyte-targeting non-viral gene delivery complex comprising dual plasmid vector
#6051Compositions and methods for treating cancer
#6052MicroRNA in T cell activation
#6053Use of leucine-zipper protein for diagnosis or treatment of fatty liver
#6054RNA-guided nucleic acid modifying enzymes and methods of use thereof
#6055Recombinant virus products and methods for inhibition of expression of DUX4
#6056DEVELOPMENT OF FUNGAL RESISTANT CROPS BY HIGS (HOST-INDUCED GENE SILENCING) MEDIATED INHIBITION OF GPI-ANCHORED CELL WALL PROTEIN SYNTHESIS
#6057Modulators of human KAI1 metastasis suppressor gene, methods and uses thereof
#6058Method of treatment
#6059NOVEL BETA-ACTIN AND RPS21 PROMOTERS AND USES THEREOF
#6060Methods for enhancing utrophin production via inhibition of microRNA
#6061METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#6062METHODS AND COMPOSITIONS FOR T-RNA BASED GUIDE RNA EXPRESSION
#6063Metabolically competent cells, methods of making, and uses thereof
#6064POLYMER-BASED NANOPARTICLES, RELATED FORMULATIONS METHODS, AND APPARATUS
#6065Compositions and methods of treating muscle atrophy and myotonic dystrophy
#6066Angiotensinogen (AGT) iRNA compositions and methods of use thereof
#6067Nucleic Acid Complexes
#6068Small peptide compositions and uses thereof
#6069Combination immunotherapies for treatment of cancer
#6070Use of microRNA-188-5p for treating Alzheimer's disease
#6071Compositions and methods for treating pulmonary vascular disease
#6072RNAi insecticide materials and methods
#6073Repressors of viral infection
#6074ASSAYS AND METHODS FOR DETERMINING ACTIVITY OF A THERAPEUTIC AGENT IN A SUBJECT
#6075GENOMIC EDITING IN AUTOMATED SYSTEMS
#6076Compositions for transfecting resistant cell types
#6077IL6R block CAR-T transgenic vector for alleviating CRS, preparation method thereof
#6078CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#6079RNAi agents for Hepatitis B virus infection
#6080COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
#6081Plant regulatory elements and uses thereof
#6082METHOD FOR EFFICIENT EXON (44) SKIPPING IN DUCHENNE MUSCULAR DYSTROPHY AND ASSOCIATED MEANS
#6083SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES
#6084SYNTHESIS OF HIGH DENSITY MOLECULAR DNA BRUSHES VIA ORGANIC-PHASE RING-OPENING METATHESIS (CO)POLYMERIZATION
#60855′S-LNA nucleotides and oligonucleotides
#6086Processes for preparing phosphorodiamidate morpholino oligomers
#6087Cationic lipids for nucleic acid delivery and preparation thereof
#6088Compositions and methods for mitochondrial genome editing
#6089PHARMACEUTICAL ASSOCIATION OF GROWTH FACTOR RECEPTOR AGONIST AND ADHESION PROTEIN INHIBITOR FOR CONVERTING A NEOPLASTIC CELL INTO A NON-NEOPLASTIC CELL AND USES THEREOF
#6090Plants with useful traits and related methods
#6091Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6092Transcription modulation in animals using CRISPR/Cas systems
#6093Plasmid vector for expressing a PVT1 exon and method for constructing standard curve therefor
#6094Fidgetin-like 2 as a target to enhance wound healing
#6095E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS
#6096Compositions and methods for inhibiting gene expression of alpha-1 AntiTrypsin
#6097DOSAGES AND METHODS FOR DELIVERING LIPID FORMULATED NUCLEIC ACID MOLECULES
#6098MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#6099Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
#6100MicroRNAs and methods of their use
#6101Materials and methods for treatment of hemoglobinopathies
#6102Gene-regulating compositions and methods for improved immunotherapy
#6103BETA-CATENIN BARCODED PEPTIDES
#6104Isolation of novel AAV's and uses thereof
#6105METHODS OF USING ZSCAN4 FOR REJUVENATING HUMAN CELLS
#6106Methods of using ZSCAN4 for rejuvenating human cells
#6107Treatment methods for fibrosis targeting SMOC2
#6108MICRORNAS IN NEURODEGENERATIVE DISORDERS
#6109RNA-guided nucleic acid modifying enzymes and methods of use thereof
#6110Organic compositions to treat HSF1-related diseases
#6111RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#6112Oligonucleotide decoys for the treatment of pain
#6113Cancer Treatment and Immune System Regulation Through FAT10 Pathway Inhibition
#6114SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF
#6115Recombinant adeno-associated virus delivery of exon 2-targeted U7SNRNA polynucleotide constructs
#6116ARTIFICIALLY ENGINEERED SC FUNCTION CONTROL SYSTEM
#6117GENE THERAPY FOR AUTOSOMAL DOMINANT DISEASES
#6118Crosslinked micellar spherical nucleic acids
#6119CAMK2D antisense oligonucleotides and uses thereof
#6120Temperature-sensitive attenuated FMDV strains, construction method and application thereof
#6121PARTICLE-MEDIATED DELIVERY OF BIOLOGICS
#6122Microrna let-7 and transforming growth factor beta receptor III axis as target for cardiac injuries
#6123GENETICALLY MODIFIED MOUSE MODEL FOR HUMAN HEPATOCYTE XENOTRANSPLANTATION
#6124METHODS OF TREATEMENT OF CANCER DISEASE BY TARGETTING TUMOR ASSOCIATED MACROPHAGE
#6125Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6126COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA
#6127Chimeric double-stranded nucleic acid
#6128Methods and Compositions for Selecting siRNA of Improved Functionality
#6129Antisense molecules and methods for treating pathologies
#6130Therapeutic targeting of a microRNA to treat Duchenne muscular dystrophy
#6131METHODS OF CONTROLLING RED BLOOD CELL PRODUCTION
#6132Compositions for delivery of cargo to cells
#6133Antisense compounds and uses thereof
#6134Methods and compositions for the making and using of guide nucleic acids
#6135Integrin alpha 9 blockade suppresses lymphatic valve formation and promotes transplant survival
#6136Polymerizable compound, compound, and method for producing boranophosphate oligomer
#6137REGULATABLE CELL LINES AND METHODS OF USE THEREOF
#6138Methods and compositions for treating disorders associated with cortico-hippocampal hyperactivity
#6139USE OF H2A.Z.1 AS A HEPATOCELLULAR CARCINOMA BIOMARKER
#6140Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6141Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6142Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6143Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6144Cas9 orthologs
#6145Non-integrating viral delivery system and methods related thereto
#6146Inhibiting microRNA to prevent development of essential hypertension
#6147Modulation of gene expression and screening for deregulated protein expression
#6148Compound and method for treating myotonic dystrophy
#6149Therapeutic compositions
#6150MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
#6151Photoreversible acylation reagents
#6152Compositions for modulating C9ORF72 expression
#6153GLYCOCONJUGATES OF RNA INTERFERENCE AGENTS
#6154Engineered guide RNA sequences for in situ detection and sequencing
#6155Compositions, methods, and therapeutic uses related to fusogenic protein minion
#6156Treatments of non-alcoholic steatohepatitis (NASH)
#6157Compositions comprising antisense-encoded erythropoietin receptor and use thereof
#6158EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
#6159Genetically modified non-human animals and methods for producing heavy chain-only antibodies
#6160Biosensor for detecting the presence of bacteria
#6161Crispr enzymes and systems
#6162Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6163Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6164Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6165COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOTONIC DYSTROPHY
#6166Cancer-treating pharmaceutical composition inhibiting expression of CCND3 or PAK2 gene
#6167RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS
#6168DOWN-REGULATING GENE EXPRESSION IN INSECT PESTS
#6169MicroRNAs for cardiac regeneration through induction of cardiac myocyte proliferation
#6170Targeting ligands
#6171Antisense oligomers targeting HOXB-AS3 long non-coding RNA
#6172Antisense oligonucleotides for the treatment of eye disease
#6173Modulation of TJP1 expression to regulate regeneration of heart cells
#6174COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
#6175Materials and methods for treatment of hemoglobinopathies
#6176Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (NASH)
#6177SYNOVIOLIN EXPRESSION INHIBITOR CONTAINING MESENCHYMAL STEM CELL OR CULTURE SUPERNATANT THEREOF
#6178METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION
#6179Guide RNA complementary to KRAS gene, and use thereof
#6180Use of myostatin inhibitors and combination therapies
#6181RNAi AGENTS FOR HEPATITIS B VIRUS INFECTION
#6182EGFR gene expression-suppressing siRNA, precursor of same, and applications thereof
#6183Genetically modified cells, tissues, and organs for treating disease
#6184Engineered CAS9 systems for eukaryotic genome modification
#6185Digestibility of plant biomass
#6186Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping
#6187Compositions and methods for treatment of cardiac diseases
#6188Modulation of huntingtin expression
#6189C/EBPα short activating RNA compositions and methods of use
#6190Antisense compounds and uses thereof
#6191Recombinant virus products and methods for inhibition of expression of myotilin
#6192NOVEL IGFR-LIKE RECEPTOR AND USES THEREOF
#6193NUCLEIC ACIDS, PEPTIDES AND METHODS
#6194Neuronal enhancers
#6195Branched oligonucleotides
#6196Coordinating gene expression using RNA destabilizing elements
#6197RUNX inhibitor
#6198Compounds and methods for reducing ATXN3 expression
#6199Blood-brain barrier permeable heteroduplex nucleic acid
#6200COMPOSITIONS AND RELATED METHODS FOR MODULATING ENDOSYMBIONTS
#6201Expression Inhibitor of Inflammation Promoting Factor, Screening Method for Active Ingredient Thereof, Expression Cassette Useful for Said Method, Diagnostic Agent and Diagnosis Method
#6202Promoter of Hspa5 gene
#6203IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES
#6204CONTROL OF MEIOTIC CROSSOVER IN MAIZE
#6205Modulators of DNM2 expression
#6206MOLECULAR RE-ENGINEERING OF EXCITATION-INHIBITION BALANCE IN MEMORY CIRCUITS
#6207Modified double-stranded RNA agents
#6208MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#6209Modified double-stranded RNA agents
#6210METHODS AND COMPOSITIONS FOR MANIPULATING TRANSLATION OF PROTEIN ISOFORMS FROM ALTERNATIVE INITIATION START SITES
#6211Double-stranded nucleic acid complex having overhang
#6212Functionalized nucleic acid nanostructures for RNA delivery
#6213Therapeutic Compositions Comprising Mesenchymal Stem Cell Particles And Related Methods
#6214Variant RNA-guided polypeptides and methods of use
#6215Methods of enhancing chromosomal homologous recombination
#6216SPATIOTEMPORAL REGULATORS
#6217Modulation of prekallikrein (PKK) expression
#6218RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#6219NANOPARTICLES FUNCTIONALIZED WITH GENE EDITING TOOLS AND RELATED METHODS
#6220Method of releasing the suppression of egg maturation in economically-important prawn/shrimp species
#6221PNA probe
#6222Organic compositions to treat APOC3-related diseases
#6223STRUCTURE-GUIDED CHEMICAL MODIFICATION OF GUIDE RNA AND ITS APPLICATIONS
#6224METHODS AND COMPOSITIONS FOR TREATING INSECTS
#6225CONDITIONAL ACTIVATION OF NUCLEIC ACID-GUIDED ENDONUCLEASES
#6226THERAPEUTIC COMBINATION AND METHOD FOR TREATING CANCER
#6227KIDNEY DISEASE TARGETS AND USES THEREOF
#6228Modulation of micrornas against myotonic dystrophy type 1 and antagonists of micrornas therefor
#6229Compositions and methods for the treatment of expanded repeat-associated disorders
#6230Compositions and methods for nanoparticle lyophile forms
#6231ALTERING MICROBIAL POPULATIONS & MODIFYING MICROBIOTA
#6232METHOD AND KIT FOR DETERMINING PROGNOSIS, REMOTE RECURRENCE RISK AND INVASION OF GLIOMA, AND PHARMACEUTICAL COMPOSITION FOR TREATING GLIOMA
#6233OBESITY-RELATED DISEASE THERAPEUTIC AGENT BY HEPATIC SECRETORY METABOLIC REGULATOR INHIBITORY ACTION
#6234Methods and compositions for genome editing in non-dividing cells
#6235Enhancing Bacillus Thuringiensis CRY Insecticidal Activity With a Chaperone
#6236Means and methods for improved regeneration
#6237Intrathecal delivery of nucleic acid sequences encoding ABCD1 for treatment of adrenomyeloneuropathy
#6238Treatment for glaucoma and other eye diseases
#6239Oligonucleotide compounds for targeting huntingtin mRNA
#6240MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#6241MODULATION OF FUNCTION OF IMMUNE EFFECTOR CELLS
#6242ANTIGENIC PEPTIDES FOR THE DIAGNOSIS, THERAPY MONITORING AND/OR TREATMENT OF PSORIASIS VULGARIS
#6243COMPOSITIONS FOR THE TREATMENT OF DISEASE
#6244Nucleic acid conjugates and uses thereof
#6245Induce and enhance immune responses using recombinant replicon systems
#6246GENERATION OF NEURONS BY REPROGRAMMING OF OLIGODENDROCYTES AND OLIGODENDROCYTE PRECURSOR CELLS
#6247Exosomes and miRNA to treat glaucoma
#6248Let-7 microRNA and mimetics thereof as therapeutics for cancer
#6249Adeno-associated virus virions with variant capsid
#6250Loop-mediated synthetic riboregulators
#6251CRISPR enzymes and systems
#6252Therapeutic compositions and methods of making and using the same
#6253COMPOSITIONS AND METHODS OF INHIBITING GENE EXPRESSION IN A LUNG
#6254Pharmaceutical composition for treating cancer comprising microrna as active ingredient
#6255Mixed tricyclo-DNA, 2′-modified RNA oligonucleotide compositions and uses thereof
#6256Von Willebrand Factor (VWF)—targeting agents and methods of using the same
#6257Chemically modified single-stranded RNA-editing oligonucleotides
#6258Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
#6259Methods and compositions for the specific inhibition of complement component 5(C5) by double-stranded RNA
#6260COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
#6261Method for producing N-acetylglucosamine by co-utilizing glucose and xylose based on CRISPRi
#6262Platform for the induction and maintenance of ground state pluripotency
#6263TARGETED ENHANCED DNA DEMETHYLATION
#6264Antisense nucleic acids
#6265ANTIMICROBIAL PEPTIDE DERIVATIVE AND USE THEREOF
#6266Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection
#6267Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
#6268Pharmaceutical composition for treating and/or preventing cancer
#6269Trinucleotide mRNA cap analogs
#6270Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
#6271COMPOSITIONS COMPRISING CURONS AND USES THEREOF
#6272Neutral nanotransporters
#6273Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#6274Targeting Ligands For Therapeutic Compounds
#6275COMPOUNDS AND METHODS FOR REDUCING TAU EXPRESSION
#6276RNA PRODUCTS AND USES THEREOF
#6277COMPOSITIONS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY
#6278Short hairpin RNA compositions, methods of making and applications thereof
#6279Polycation-Functionalized Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Agents
#6280RAAV-based compositions and methods
#6281Antisense nucleic acids
#6282Antisense nucleic acids
#6283MiRNA pharmaceutical compositions and therapeutic uses thereof
#6284ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in alzheimer's disease
#6285RNA targeting methods and compositions
#6286Therapeutic targets for Alzheimer's disease
#6287CORTICAL NEURON CELL MODEL OF ALZHEIMER'S DISEASE BASED ON BMI1 DEFICIENCY, AND USES THEREOF
#6288Cell-specific expression of modRNA
#6289Compositions and methods for silencing gene expression
#6290TRANSCRIPTION FACTOR NtERF241 AND METHODS OF USING THE SAME
#6291Increasing ATOH1 life to drive sensorineural hair cell differentiation
#6292Carboxylated 2′-amino-LNA nucleotides and oligonucleotides comprising the same
#6293Anabolic Enhancers for Ameliorating Neurodegeneration
#6294Compositions and methods for controlling arthropod parasite and pest infestations
#6295Production of viruses in avian eggs
#6296Materials and methods for modifying the activity of T cells
#6297Polynucleotide constructs
#6298Aptamer compositions and methods of use thereof
#6299COMPOSITIONS AND METHODS FOR PREVENTING BONE LOSS AND/OR STIMULATING BONE HEALING
#6300COMPOSITIONS AND METHODS RELATING TO C5L2