109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Modulators of vault RNAs for use in the treatment of diseases
#6302Antisense-induced exon exclusion in type VII collagen
#6303Anti-aging transgenic Caenorhabditis elegans
#6304PAPD5 and PAPD7 inhibitors for treating a hepatitis B infection
#6305Eukaryotic cells for protein manufacturing and methods of making them
#6306CRISPR-CAS system for a filamentous fungal host cell
#6307Vector-free delivery of gene editing proteins and compositions to cells and tissues
#6308HOST CELLS WITH ENHANCED PROTEIN EXPRESSION EFFICIENCY AND USES THEREOF
#6309Modulation of GYS1 expression
#6310Use of Rad18 inhibitors in the treatment of tumors
#6311MicroRNA-198 as a tumor suppressor in ovarian cancer
#6312MIR-92 INHIBITORS AND USES THEREOF
#6313Natural cryptic exon removal by pairs of antisense oligonucleotides
#6314Inhibitors of SRSF1 to treat neurodegenerative disorders
#6315ANTISENSE POLYNUCLEOTIDES TO INDUCE EXON SKIPPING AND METHOD OF TREATING DYSTROPHIES
#6316RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
#6317Anti-connexin compounds targeted to connexins and methods of use thereof
#6318RNA modulating oligonucleotides with improved characteristics for the treatment of Duchenne and Becker muscular dystrophy
#6319POLYNUCLEOTIDE CONSTRUCTS HAVING AN AUXILIARY MOIETY NON-BIOREVERSIBLY LINKED TO AN INTERNUCLEOSIDE PHOSPHATE OR PHOSPHOROTHIOATE
#6320COMBINATION
#6321Generation of cancer stem cells and use thereof
#6322GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE
#6323RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
#6324Nucleic acid-polypeptide compositions and uses thereof
#6325Nucleic acid conjugate
#6326Adipose derived stem cell exosomes and uses thereof
#6327Pharmaceutical composition containing mTOR inhibitor for treating macular degeneration
#6328Multi-functional particles and methods of using the same
#6329Expression from transposon-based vectors and uses
#6330Multi-conjugate of SiRNA and preparing method thereof
#6331Promoter and use thereof
#6332Synthetic near-threshold translational repressors
#6333Conjugated oligonucleotides
#6334Micro-RNA Delivery Compositions, Devices, and Methods
#6335AAV-based treatment of cholesterol-related disorders
#6336THERAPEUTICALLY MODULATING APOB AND APOAI
#6337EXOSOME SECRETION INHIBITOR
#6338Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions
#6339GENE THERAPY VECTORS AND CYTOSINE DEAMINASES
#6340Use of regulatory T cell-specific surface protein LRIG-1
#6341SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES
#6342Peptide nucleic acid complex having improved cell permeability and pharmaceutical composition comprising same
#6343Locked nucleic acid cyclic dinucleotide compounds and uses thereof
#6344METHODS AND COMPOSITIONS FOR THE PRESERVATIONOF ORGANS
#6345Algal lipid productivity via genetic modification of a TPR domain containing protein
#6346Nucleic acid molecules inducing RNA interference, and uses thereof
#63474'-phosphate analogs and oligonucleotides comprising the same
#6348MiR-127 agents for use in the treatment of renal fibrosis
#6349Methods for diagnosing and treating metastatic cancer
#6350METHOD OF REGULATING GENE EXPRESSION
#6351METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#6352Exon skipping compositions for treating muscular dystrophy
#6353COMPOSITIONS AND METHODS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY AND RELATED DISORDERS
#6354Site-specific crosslinking of antibodies
#6355Compositions comprising reversibly modified oligonucleotides and uses thereof
#6356Methods and systems for noninvasive control of brain cells and related vectors and compositions
#6357In vivo methods for selecting peptides that cross the blood brain barrier, related compositions and methods of use
#6358Compositions of Ascorbic Acid and Bone Morphogenetic Protein 4 (BMP-4) for Cell Growth and Uses Related Thereto
#6359Compositions and methods for treating viral infections in shrimps
#6360Loading of Extracellular Vesicles through Imparting of Mechanical Shear
#6361STK32C gene relevant to breast cancer and use thereof
#6362Compositions and methods for treating CEP290 associated disease
#6363Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6364METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6365METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6366METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6367METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6368Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6369Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6370Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6371Methods and compositions or RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6372Use of MIR101 or MIR128 in the treatment of seizure disorders
#6373Pharmaceutical composition for treating and/or preventing cancer
#6374Modulatory polynucleotides
#6375Modulation of BCL11A for treatment of hemoglobinopathies
#6376Methods and compositions for diagnosis and treatment of cancer
#6377MODULATION OF TRANSTHYRETIN EXPRESSION
#6378Methods of Manipulating the Fate of Cells
#6379DsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
#6380OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
#6381Antisense antibacterial compounds and methods
#6382Modified RNAi polynucleotides and uses thereof
#6383RNA targeting methods and compositions
#6384REELIN COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
#6385Treating metastatic cancer and model systems for metastatic disease
#6386Nucleic acid condensing peptide, nucleic acid condensing peptide set, nucleic acid delivery carrier, nucleic acid delivery method, cell production method, cell detection method and kit
#6387TLR9 TARGETED CYTOTOXIC AGENTS
#6388Lipids and compositions for the delivery of therapeutics
#6389THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#6390MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS
#6391Methods of treating conditions involving elevated inflammatory response
#6392Methods of treating transthyretin (TTR) mediated amyloidosis
#6393Method for modifying target site in genome of eukaryotic cell, and method for detecting presence or absence of nucleic acid sequence to be detected at target site
#6394CACTUS NUCLEIC ACID MOLECULES TO CONTROL COLEOPTERAN PESTS
#6395TRANSGENIC PLANT HAVING INCREASED EXPRESSION OF WAX SYNTHASE
#6396Hybrid nucleic acid sequences for genome engineering
#6397Reduced size self-delivering RNAI compounds
#6398FLUORESCENT BIOSENSOR FOR 2', 3'-CGAMP
#6399Methods for cleaving DNA and RNA molecules
#6400Materials and methods for treatment of friedreich ataxia and other related disorders
#6401Targeted nucleic acid conjugate compositions
#6402Rotavirus vaccines
#6403Exosome-based therapeutics against neurodegenerative disorders
#6404Compositions and methods for treating Huntington's disease
#6405Compounds and methods for modulating angiotensinogen expression
#6406Integrated nano system for liver-targeting co-delivery of genes/drugs and preparation method
#6407Inhibitory RNA-based therapeutics targeting ANLN for cancer treatment
#6408Method of fixing and expressing physiologically active substance
#6409MIR-149-3P AND METHOD FOR TREATING METABOLIC DISEASE USING THE SAME
#6410Composition for delivery of genetic material
#6411Targeting MicroRNAs for Metabolic Disorders
#6412METHODS FOR INCREASING EFFICACY OF LIPID FORMULATED siRNA
#6413Methods for treatment of polycystic kidney disease
#6414Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
#6415Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
#6416Method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
#6417Therapeutic applications of CPF1-based genome editing
#6418Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide
#6419COMBINATIONS THERAPIES FOR THE TREATMENT OF CANCER
#6420Minimal UTR sequences
#6421RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS
#6422MicroRNA Compounds and Methods for Modulating MIR-122
#6423Modulating the cellular stress response
#6424Using microRNAs to control activation status of hepatic stellate cells and to prevent fibrosis in progressive liver diseases
#6425Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#6426RNAi induced huntingtin gene suppression
#6427Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
#6428Compositions and methods for modulating neuronal excitability and motor behavior
#6429T cell differentiation and function regulation by decreasing let7 expression
#6430Methods to prevent or treat periodontitis or peri-implantitis
#6431Combinatorial Metabolic Engineering Using a CRISPR System
#6432ANTI-IL-23 ANTIBODIES
#6433METHODS FOR TREATING GLIOBLASTOMA OR RECURRENT GLIOBLASTOMA UTILIZING A WIRELESS SIGNAL ALONE OR IN COMBINATION WITH ONE OR MORE CANCER DRUGS, AND ASSOCIATED SYSTEMS, APPARATUSES, AND DEVICES
#6434Therapy specific, pre-programmed auto injection device
#6435Therapy specific, pre-programmed auto injection device
#6436METHODS AND COMPOSITIONS FOR ATTENUATING ANTI-VIRAL TRANSFER VECTOR IGM RESPONSES
#6437Compositions and methods for selective inhibition of grainyhead-like protein expression
#6438NUCLEIC ACID BASED TIA-1 INHIBITORS
#6439Methods involving Menain screening for inhibitors of cancer invasion and metastasis
#6440Particles coated with catalysts useful for splicing nucleic acids
#6441Application of gene in improving photosynthesis of rice
#6442Simultaneous gene editing and haploid induction
#6443ORGANELLE GENOME MODIFICATION USING POLYNUCLEOTIDE GUIDED ENDONUCLEASE
#6444Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
#6445Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
#6446LNCRNA MEG3 for therapy and diagnosis of cardiac remodelling
#6447Modified U6 promoter system for tissue specific expression
#6448Oligomer-conjugate complexes and their use
#6449Modulating apolipoprotein (a) expression
#6450Compositions and methods for manipulation of adipocyte energy consumption regulatory pathway
#6451Engineered mammalian cells for production of recombinant proteins
#6452System and Method for Managing All Cancers by Disabling the Cancer Cells Ability to Reproduce
#6453CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING DUCHENNE MUSCULAR DYSTROPHY
#6454CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
#6455Altering microbial populations and modifying microbiota
#6456Defective calcium signaling as a tool in autism spectrum disorders
#6457METHOD FOR PROGNOSING AND REDUCING CARDIOVASCULAR DISEASE IN PATIENTS WITH KIDNEY DISEASES
#6458RNA CONSTRUCTS
#6459Seed- and funiculus-preferential promoters and uses thereof
#6460BACTERIAL LEADER SEQUENCES FOR PERlPLASMIC PROTEIN EXPRESSION
#6461Self-assembled 3D RNA cage nanoparticles
#6462MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#6463SINGLE-STRANDED RNAI OLIGONUCLEOTIDES TARGETING APOC-III
#6464INHIBITION OF MIR-22 MIRNA BY APT-110
#6465Oligonucleotide analogues targeting human LMNA
#6466MIR-29 MIMICS AND USES THEREOF
#6467OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
#6468COMPOSITIONS AND METHODS FOR INSECT CONTROL
#6469Lysosomal degradation of lipids and proteins and method of use thereof
#6470Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases
#6471Microbial oil containing fatty acids obtained from stramenopile and method of producing the same
#6472Single-stranded oligonucleotide
#6473miRNA for treatment of breast cancer
#6474NOVEL NON-CODING RNA, CANCER TARGET AND COMPOUNDS FOR CANCER TREATMENT
#6475METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#6476MEANS AND METHODS FOR INACTIVATING THERAPEUTIC DNA IN A CELL
#6477MicroRNA-143 derivative
#6478Nucleic acid linked to a trivalent glycoconjugate
#6479Read through of truncated proteins in premature termination codon diseases by suppressor tRNAs
#6480COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE
#6481METHODS FOR ENGINEERING NON-NEURONAL CELLS INTO NEURONS AND USING NEWLY ENGINEERED NEURONS TO TREAT NEURODEGENERATIVE DISEASES
#6482SMALL INTERFERENCE RNA COMPLEX WITH INCREASED INTRACELLULAR TRANSMISSION CAPACITY
#6483Inhibitors of metastasis
#6484Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
#6485Methods for the treatment of cardiac hypertrophy
#6486TUMOR ANTIGEN PEPTIDE
#6487Methods for treating renal disease
#6488MICROFLUIDIC-FORMULATED LEUKOSOME COMPOSITIONS AND FABRICATION METHODS THEREFOR
#6489Use of exosomes for the treatment of disease
#6490KIT OR DEVICE FOR DETECTING MALIGNANT BRAIN TUMOR AND METHOD FOR DETECTING SAME
#6491METHODS FOR CREATING BOTH MALE AND FEMALE STERILE PLANTS AND RESTORATION OF FERTILITY
#6492METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA
#6493Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors
#6494Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#6495Oligomers
#6496Methods and Compositions for the Single Tube Preparation of Sequencing Libraries Using Cas9
#6497Engineered nucleic-acid targeting nucleic acids
#6498Construction of MicroRNA gene-mediated novel tissue engineered nerve and applications thereof in repairing nerve defect
#6499Exosome transfer of nucleic acids to cells
#6500NOVEL CANCER ANTIGEN EEF2
#6501Polypeptide compositions comprising spacers
#6502TREATMENT OF PRIMARY CILIARY DYSKINESIA WITH SYNTHETIC MESSENGER RNA
#6503Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
#6504Trans-splicing RNA (tsRNA)
#6505Method for promoting muscle regeneration
#6506TEST KIT AND TEST METHOD FOR ATROPHIC AGE-RELATED MACULAR DEGENERATION
#6507Molecular programming tools
#6508Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6509Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6510Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6511Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6512Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6513Compositions and methods for inducing resistance to soybean cyst nematode via RNAi
#6514Inhibition Of Lactate Transporters For Use In The Treatment Of Inflammatory Diseases
#6515Chiral design
#6516Oligonucleotide compositions and uses thereof
#6517GNAQ targeted dsRNA compositions and methods for inhibiting expression
#6518Regulation of the RAS/cAMP/PKA signaling pathway in yeasts for obtaining a fermentation product during fermentation
#6519RNA nanoparticles for brain tumor treatment
#6520CYTOCOMPATIBLE HYDROGELS FOR ENCAPSULATION OF CELLS
#6521Use of PLA2G5-deficient suppressive macrophages in suppression of inflammation
#6522Compositions and Methods for Treating Alzheimer's Disease and Other Tauopathies
#6523THIN-SHELL POLYMERIC NANOPARTICLES AND USES THEREOF
#6524Nanoparticle-induced fusogenicity between liposome and endosome membranes for targeted delivery through endosomal escape
#6525METHOD OF PRODUCING INFERTILE FISH AND EGG-PRODUCING AQUATIC ANIMALS AND OF DELIVERING COMPOUNDS INTO EGGS AND EMBRYOS
#6526Engineered nucleic acid-targeting nucleic acids
#6527NOVEL CAS9 SYSTEMS AND METHODS OF USE
#6528Methods and compositions for treating atherosclerosis
#6529Oligonucleotides for treating expanded repeat diseases
#6530Methods and means for efficient skipping of at least one of the following exons of the human Duchenne muscular dystrophy gene: 43, 46, 50-53
#6531NOVEL CAS SYSTEMS AND METHODS OF USE
#6532ASSAY FOR THE REMOVAL OF METHYL-CYTOSINE RESIDUES FROM DNA
#6533Method for producing monomer for single-stranded nucleic acid molecule
#6534Nanocapsule delivery system for ribonucleoproteins
#6535Screening method of anticancer agent focused on function of HP1 and evaluation system
#6536Mutant genes related to drug resistance and relapse of acute lymphoblastic leukaemia and a use thereof
#6537BIOMARKERS AND TREATMENTS FOR HEART FAILURE
#6538Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6539Methods and compositions for increasing expression of genes of interest in a plant by co-expression with p21
#6540AAV vectors for treatment of dominant retinitis pigmentosa
#6541Compositions and methods to promote bone formation and their uses including for the treatment of cancer
#6542Methods and compositions for increased double stranded RNA production
#6543Crispr enzymes and systems
#6544Compositions and methods for treating diabetic retinopathy
#6545Exosome packaging of nucleic acids
#6546METHODS AND SUBSTANCES FOR DIRECTED RNA EDITING
#6547Methods and compositions for ex vivo expansion of very small embryonic-like stem cells (VSELs)
#6548Method for diagnosis of polycystic ovary syndrome (PCOS) by measuring levels of DENN/MADD domain containing 1A variant 2 (DENND1A variant 2)
#6549Compositions and methods for the delivery of nucleic acids
#6550Amphipathic peptide
#6551Treatment of cancer by systemic administration of Dbait molecules
#6552TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS
#6553Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
#6554Seed-specific and endosperm-preferental promoters and uses thereof
#6555Treatment and diagnosis of inflammatory disorders
#6556In-vitro induction of adult stem cell expansion and derivation
#6557Defined multi-conjugate oligonucleotides
#6558miRNAs USEFUL FOR IDENTIFYING TARGETS ASSOCIATED WITH CANCER
#6559RNA-directed DNA cleavage by the Cas9-crRNA complex
#6560In vivo gene silencing by chemically modified and stable siRNA
#6561Bacteria-Mediated Gene Modulation Via microRNA Machinery
#6562Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
#6563Recombinant AAVS having useful transcytosis properties
#6564Methods for the treatment of corneal dystrophies
#6565Composition for regulating cell division comprising FCHO1 modulator, and method for regulating cell division using same
#65665′-cyclo-phosphonate modified nucleotides
#6567Using DREADD for neuronal modulation in treating neuronal diseases
#6568BIOSYNTHETIC MODULES
#6569Compositions and methods for detecting N-methyladenine in the mammalian genome
#6570Antisense antibacterial compounds and methods
#6571Preventing tumor development and metastasis
#6572Antisense oligonucleotides for the treatment of Leber congenital amaurosis
#6573DOWNREGULATING MIR-132 FOR THE TREATMENT OF LIPID RELATED DISORDERS
#6574RNAi agents and compositions for inhibiting expression of angiopoietin-like 3 (ANGPTL3), and methods of use
#6575RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3)
#6576Polynucleotides containing a morpholino linker
#6577Methods and compositions to treat drug-induced diseases and conditions
#6578Methods and compositions to increase the rate of ligation reactions catalyzed by a sortase
#6579Methods of modulating KEAP1
#6580Method of treating cancer by using siRNA nanocomplexes
#6581Enhancing plasmin activity to prevent soft tissue calcification
#6582Synthetic translation-sensing riboswitches and uses thereof
#6583CRISPR enzymes and systems
#6584COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS
#65853′-UTR sequences for stabilization of RNA
#6586ANTI-TUMOR THERAPY
#6587RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS
#6588CRISPRs WITH IMPROVED SPECIFICITY
#6589Pharmaceutical Composition
#6590Therapeutic for treatment of diseases including the central nervous system
#6591Methods Of Treatment For Alpha-1 Antitrypsin Deficiency
#6592LIPID ENCAPSULATING INTERFERING RNA
#6593COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF CANCER USING SLNCR ISOFORMS
#6594Transposon-based transfection system for primary cells
#6595Nano/micromotors for active and dynamic intracellular payload delivery
#6596Gene therapy for treating mucopolysaccharidosis type II
#6597Factor IX gene therapy
#6598Niacinamide (NAM) in ischemic tissue injury
#6599Compositions and methods for the treatment of a beta-catenin-associated disease or disorder
#6600Cancer examination method and examination kit