109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Nucleic acid nanoparticles for analyte detection
#6602METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6603Methods and compositions for the activation of gamma-delta T-cells
#6604Modulation of angiopoietin-like 3 expression
#6605Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo
#6606Polypeptide inhibitors of SMAD3 polypeptide activities
#6607RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#6608MicroRNA composition for the treatment of neuroblastoma
#6609Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#6610Multimeric oligonucleotide compounds
#6611Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#6612Methods and compositions for inhibiting PMP22 expression
#6613Compositions and methods of using piRNAS in cancer diagnostics and therapeutics
#6614Mitochondrial genome editing and regulation
#6615Method and System for the Diagnosis, Prevention or Treatment of Alzheimer s and Related Disease by Measuring, Inhibiting or Arresting Amyloid Plaque Development
#6616GATA-3 inhibitors for use in the treatment of Th2-driven asthma
#6617IN SITU AND IN VIVO ANALYSIS OF CHROMATIN INTERACTIONS BY BIOTINYLATED DCAS9 PROTEIN
#6618CRISPR-CPF1-RELATED METHODS, COMPOSITIONS AND COMPONENTS FOR CANCER IMMUNOTHERAPY
#6619Improved Promoters And Compositions
#6620Cancer treatment through RLIP76 partial depletion
#6621RNA targeting methods and compositions
#6622Nucleic acid-polypeptide compositions and uses thereof
#6623Nucleic acid-polypeptide compositions and uses thereof
#6624GENETICALLY ALTERED PLANTS HAVING WEEPING PHENOTYPE
#6625Adeno-associated virus vector delivery of microRNA-29 and micro-dystrophin to treat muscular dystrophy
#6626Intracellular genomic transplant and methods of therapy
#6627Intracellular genomic transplant and methods of therapy
#6628TLX and MIR-219 as potential therapeutic targets for neurodevelopmental disorders
#6629POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
#6630Technology for the Preparation of Microparticles
#6631RNAi FOR CONTROL OF PHLOEM SAP-FEEDING INSECTS IN CROP PLANTS
#6632Adeno-associated virus vector delivery of micro-dystrophin to treat muscular dystrophy
#6633Prevention, diagnosis and treatment of cancer overexpressing GPR160
#6634Micro-RNAS and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions
#6635FATS AS A TARGET FOR TREATING TUMORS AND USES THEREOF
#6636Methods of treating intestinal fibrosis using SMAD7 inhibition
#6637Nucleic acid conjugate
#6638Compositions and Methods For Treating Cachexia
#6639Targeting pleiotrophin signaling to limit high-grade glioma invasion
#6640Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
#6641COMPOSITIONS AND METHODS FOR MODULATING HBV EXPRESSION
#6642METHODS FOR IDENTIFYING AND TARGETING NON-CODING RNA SCAFFOLDS
#6643Compositions and methods for treating Huntington's disease and related disorders
#6644LNA-G Process
#6645Eliminating MHC restriction from the T cell receptor as a strategy for immunotherapy
#6646Compositions and methods for treating cancer with anti-ROR1 immunotherapy
#6647Methods and products for genetic engineering
#6648Stabilized thrombin
#6649Cell membrane-permeating peptide
#6650Molecular marker for cancer stem cell
#6651Intracellular genomic transplant and methods of therapy
#6652POLYNUCLEOTIDE FORMULATIONS FOR USE IN THE TREATMENT OF RENAL DISEASES
#6653Method of evaluating quality of miRNA derived from body fluid
#6654Double strand RNA-mediated RNA interference through feeding detrimental to larval (gypsy moth)
#6655COMPOSITIONS AND METHODS FOR DELIVERING MICRORNA
#6656Post-transcriptionally chemically modified double strand RNAs
#6657CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION
#6658Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization
#6659CROSS-REGULATION OF TYPE I INTERFERON SIGNALING PATHWAYS
#6660Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
#6661NOVEL FAMILY OF RNA-PROGRAMMABLE ENDONUCLEASES AND THEIR USES IN GENOME EDITING AND OTHER APPLICATIONS
#6662Methods for reactivating genes on the inactive X chromosome
#6663Structure-guided chemical modification of guide RNA and its applications
#6664Compositions and methods for regulating gene expression for targeted mutagenesis
#6665Method for promoting differentiation of pluripotent stem cells by reducing undifferentiated state thereof
#6666Method for producing highly functional platelets
#6667Biodegradable cationic polymers and uses thereof
#6668CONJUGATED ANTISENSE COMPOUNDS FOR USE IN THERAPY
#6669Materials and methods for the treatment of vascular disease
#6670Pharmaceutical composition for treating and/or preventing cancer
#6671Liposomes for modulating Wiskott-Aldrich syndrome protein
#6672MICRO-RNA PROFILING, COMPOSITIONS, AND METHODS OF TREATING DISEASES
#6673Decreasing lactate level and increasing polypeptide production by down regulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
#6674Methods and compositions for plant pest control
#6675PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE
#6676CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#6677Managing Intercellular Communications
#6678Post-transcriptionally chemically modified double strand RNAs
#6679HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL
#6680Antisense nucleic acids
#6681MODULATION OF ENHANCER RNA MEDIATED GENE EXPRESSION
#6682Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof
#6683COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT
#6684Targeted RNA editing
#6685Engineered nucleic-acid targeting nucleic acids
#6686TRACKING AND MANIPULATING CELLULAR RNA VIA NUCLEAR DELIVERY OF CRISPR/CAS9
#6687BIOLOGICAL MATERIALS AND USES THEREOF
#6688VECTORS AND SYSTEM FOR MODULATING GENE EXPRESSION
#6689Methods and compositions for modifying a mutant dystrophin gene in a cell's genome
#6690Modified RNAi agents
#6691Synthetic promoters and uses thereof
#6692High density lipoprotein binding protein (Hdlbp/Vigilin) iRNA compositions and methods of use thereof
#6693RNA interference for control of insect pests
#6694Methods for performing antisense oligonucleotide-mediated exon skipping in the retina of a subject in need thereof
#6695Fusions and method for detecting same
#6696High performance multi-input microRNA sensors and uses thereof
#6697Method for decoding base sequence of nucleic acid corresponding to end region of RNA and method for analyzing DNA element
#6698Nuclease-mediated genome editing of primary cells and enrichment thereof
#6699NUCLEIC ACID-CONTAINING LIPID PARTICLES AND RELATED METHODS
#6700Targeting glioblastoma stem cells through the TLX-TET3 axis
#6701RNA cleavage-induced transcript stabilizer and uses thereof
#6702SYNTHETIC GUIDE RNA FOR CRISPR/CAS ACTIVATOR SYSTEMS
#6703METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF
#6704NON-LIPOSOMAL SYSTEMS FOR NUCLEIC ACID DELIVERY
#6705RNA nanoparticle for treatment of gastric cancer
#6706Permanent epigenetic gene silencing
#6707Parallel functional testing of synthetic DNA parts, pathways, and genomes
#6708TIFA antagonists and their use for treating diseases
#6709COMPOSITIONS AND METHODS FOR MODULATION OF SMN2 SPLICING IN A SUBJECT
#6710Detection of nucleic acids
#6711Tissue selective transgene expression
#6712PARENTAL RNAI SUPPRESSION OF KRUPPEL GENE TO CONTROL HEMIPTERAN PESTS
#6713Interfering RNA molecules
#6714Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof
#6715Methods and compositions for modulating gene expression
#6716RNA ligand-displaying exosomes for specific delivery of therapeutics to cell by RNA nanotechnology
#6717Treatment of filaggrin (FLG) related diseases by modulation of FLG expression and activity
#6718Recombinant virus products and methods for inducing DUX4 exon skipping
#6719Two-tailed self-delivering siRNA
#6720Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of the nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG repeats
#6721Methods and compositions for inhibiting detoxification response
#6722PRIMARY HEMATOPOIETIC CELLS GENETICALLY ENGINEERED BY SLOW RELEASE OF NUCLEIC ACIDS USING NANOPARTICLES
#6723ANTI-NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE ANTIBODY GENES AND METHODS OF USE THEREOF
#6724Monoclonal antibody FnAb8 and application thereof
#6725PROTOCOL FOR INCREASING LIFE EXPECTANCY IN A TEST SUBJECT
#6726Antiviral drugs
#6727MOLECULAR TARGETS FOR THE TREATMENT OF WOUNDS, IN PARTICULAR CHRONIC WOUNDS
#6728COMPOSITIONS AND METHODS FOR DELIVERING NUCLEIC ACID TO A CELL
#6729CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#6730Oligonucleotide compositions with enhanced efficiency
#6731Engineered immunostimulatory bacterial strains and uses thereof
#6732Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing
#6733Antisense oligonucleotides for the treatment of Usher syndrome type 2
#6734Methods for modulating Ataxin 2 expression
#6735Using nucleosome interacting protein domains to enhance targeted genome modification
#6736Protein prostheses for mitochondrial diseases or conditions
#6737Endothelin-1 receptor based endothelin-1 sponge
#6738Compositions and methods directed to treating liver fibrosis
#6739Dual molecular delivery of oligonucleotides and peptide containing conjugates
#6740METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6741PREVENTIVE OR THERAPEUTIC AGENT FOR FIBROSIS
#6742RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
#6743Genome editing for treating glioblastoma
#6744COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
#6745RNAi agents for inhibiting expression of alpha-ENaC and methods of use
#6746Treatment of heart disease by inhibtion of the action of muscle A-kinase anchoring protein (mAKAP)
#6747Monocarboxylate transporter 4 (MCT) antisense oligonucleotide (ASO) inhibitors for use as therapeutics in the treatment of cancer
#6748Micrornas and uses thereof
#6749Ubiquitin variants and uses therof as 53BP1 inhibitors
#6750Oligonucleotide compositions and methods thereof
#6751Compounds and methods for trans-membrane delivery of molecules
#6752Compound as cationic lipid
#6753Tumor infiltrating lymphocytes and methods of therapy
#6754α-synuclein expression inhibitor
#6755MiRNA biomarkers for cartilage degeneration
#6756Method for diagnosing and treating ovarian cancer
#6757METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6758Drought-Tolerance in Plants
#6759CRISPR RNA targeting enzymes and systems and uses thereof
#6760Methods of treating cancer by inhibition of DNA repair proteins using antisense based therapies
#6761Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
#6762RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
#6763DOUBLE-STRANDED OLIGONUCLEOTIDES
#6764Methods and compositions for the specific inhibition of β-catenin by double-stranded RNA
#6765Isolated dsRNA Molecules And Methods Of Using Same For Silencing Target Molecules Of Interest
#6766SELECTIVE REDUCTION OF ALLELIC VARIANTS
#6767COMPOSITIONS AND METHODS FOR TREATMENT OF FRIEDREICH'S ATAXIA
#6768CRISPR RNA targeting enzymes and systems and uses thereof
#6769In vitro cleavage of DNA using argonaute
#6770Peptides and nanoparticles for intracellular delivery of molecules
#6771Oligo-guanidines based cellular transporter comprising heterocyclic rings with hydrophobic and/or lipophilic groups at N-terminal for effective delivery of nonpenetrable cargos in-vitro and in-vivo
#6772TREATMENT OF DEVELOPMENTAL SYNDROMES
#6773Gene therapy for AADC deficiency
#6774Carrier nanoparticles and related compositions, methods and systems
#6775Nucleic acid-polypeptide compositions and uses thereof
#6776Nucleic acid-polypeptide compositions and methods of inducing exon skipping
#6777Compositions and methods for treating allergic inflammatory conditions
#6778Method for producing natural rubber by using recombinant microorganism
#6779Nucleic acid-guided nucleases
#6780PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE
#6781RNA interference in dermal and fibrotic indications
#6782Compositions and methods for controlling arthropod parasite and pest infestations
#6783Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#6784Compositions and methods for modulation of IKBKAP splicing
#6785ATP-binding cassette family coding polyribonucleotides and formulations thereof
#6786Enhanced fermentation
#6787Formulation comprising extracellular vesicles, method for producing the same, and uses thereof
#6788Methods and compositions for delivery of CRISPR based antimicrobials
#6789Identification and use of new tumor-promoting gene in hematological malignancies
#6790Nucleic acid-polypeptide compositions and uses thereof
#6791Lentiviral vector expressing membrane-anchored or secreted antibody
#6792Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
#6793Nucleic acid-polypeptide compositions and methods of inducing exon skipping
#6794Lipids and lipid compositions for the delivery of active agents
#6795AMPHIPHILIC POLYMER MICELLES AND USES THEREOF
#6796Methods and compositions of insect control
#6797Method for determining decrease in functions of hippocampus by using correlation between micro RNA and NMDA receptor, method for inhibiting decrease in functions, and method for screening for inhibitors of decrease in functions
#6798Reporter system for detecting and targeting activated cells
#6799Recombinant expression vector and lipid membrane structure having said vector encapsulated therein
#6800Promoters from
#6801Targeted augmentation of nuclear gene output
#6802UNA oligomers having reduced off-target effects in gene silencing
#6803Methods and compositions for managing vascular conditions
#6804Methods and compositions for reprogramming cells
#6805Antisense antibacterial compounds and methods
#6806Pharmaceutical composition for treating and/or preventing cancer
#6807Effective gene therapy tools for dystrophin exon 53 skipping
#6808THERAPEUTIC AND DIAGNOSTIC MOLECULES
#6809Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
#6810RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
#6811ANTISENSE MOLECULES FOR TREATMENT OF STAPHYLOCOCCUS AUREUS INFECTION
#6812Compositions and methods for immunooncology
#6813EDIBLE PLANT-DERIVED MICROVESICLE COMPOSITIONS FOR DELIVERY OF miRNA AND METHODS FOR TREATMENT OF CANCER
#6814RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy
#6815REGULATION OF CYTOKINE PRODUCTION
#6816POLYPEPTIDES WITH TYPE V CRISPR ACTIVITY AND USES THEREOF
#6817ANTI-TUMOR COMPOSITION COMPRISING GM-CSF GENE, Flt3L-TRAIL FUSION GENE, shRNA INHIBITING TGF-BETA EXPRESSION, AND shRNA INHIBITING HSP EXPRESSION
#6818PHARMACEUTICAL COMPOSITION AND A METHOD FOR PRODUCING THEREOF
#6819Repairing a mutant human titin gene using CRISPR technology
#6820Compositions and methods for modulating stem cells and uses thereof
#6821MicroRNA (miRNA) and downstream targets for diagnostic and therapeutic purposes
#6822Methods and compositions for delivery of polynucleotides
#6823Metastasis and Adaptive Resistance Inhibiting Immunotherapy Combined Online Chemotherapy with Radiotherapy's tumor Seeking Extracellular Vesicles with siRNA and Chemotherapeutics
#6824Modulation of pre-MRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#6825Peptide, Complex of Peptide and siRNA, and Methods of Use Thereof
#6826Micro-RNAs as biomarkers for subconcussive and concussive injury and therapeutic applications
#6827MicroRNA Compounds and Methods for Modulating MIR-21 Activity
#6828Promoters and uses thereof
#6829TRANSCRIPTION TERMINATOR AND USE THEREOF
#6830INHIBITING GENE EXPRESSION WITH dsRNA
#6831Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
#6832LIPIDS FOR DELIVERY OF THERAPEUTICS
#6833Methods and compositions for treating disorders and diseases using Survival Motor Neuron (SMN) protein
#6834Double-stranded nucleic acid molecule, DNA, vector, cancer cell growth inhibitor, cancer cell migration inhibitor, and drug
#6835Nucleic acid-containing lipid nanoparticles
#6836ApoCIII and the Treatment and Diagnosis of Diabetes
#6837TENASCIN-W AND BILIARY TRACT CANCERS
#6838CD318 as a marker for, and CD318 inhibition as a treatment for, autoimmune disease
#6839METHODS OF DIAGNOSING AND TREATING BREAST CANCER
#6840COMPOSITIONS AND METHODS FOR THE PRODUCTION OF HYDROCARBONS, HYDROGEN AND CARBON MONOXIDE USING ENGINEERED AZOTOBACTER STRAINS
#6841Methods and compositions for reprogramming cells
#6842RNA-guided nucleic acid modifying enzymes and methods of use thereof
#6843MICRORNA-198 AS A TUMOR SUPPRESSOR IN OVARIAN CANCER
#6844Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
#6845Method for improving memory using CCNY inhibitor
#6846Serpina1 iRNA compositions and methods of use thereof
#6847System and method for reversible photo-controlled gene silencing
#6848POLYNUCLEOTIDES FOR MULTIVALENT RNA INTERFERENCE, COMPOSITIONS AND METHODS OF USE THEREOF
#6849Cancer treatment
#6850Methods of reducing expression of X-inactivation escapee genes and autosomal genes
#6851Phage engineering: protection by circularized intermediate
#6852Engineered nucleic-acid targeting nucleic acids
#6853Neuroprotective peptides derived from activity-dependent neuroprotective protein for treatment of neurological diseases
#6854Direct reprogramming of cells to cardiac myocyte fate
#6855Use of microRNA-146A and nanoceria conjugate to improve wound healing and promote tissue regeneration
#6856Use of antisense oligonucleotides for producing truncated Ig by exon skipping for the treatment of diseases involving B cells
#6857METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING CHRONIC INFLAMMATORY DISEASES
#6858Delivery method of target material into extracellular vesicles using extracorporeal shockwave
#6859Supplementation of milk formulas with microvesicles isolated from milk
#6860TREATMENT OF INFLAMMATORY DISEASES
#6861Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein
#6862CRISPR effector system based diagnostics
#6863CRISPR effector system based diagnostics
#6864Compositions and their uses directed to huntingtin
#6865siRNA and their use in methods and compositions for inhibiting the expression of the NRARP gene
#6866Production of viruses in avian eggs
#6867Composition stably containing single-stranded nucleic acid molecule that suppresses expression of TGF-β1 gene
#6868Oncolytic viral vectors and uses thereof
#6869THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#6870INHIBITORS FOR METHYLATION-RELATED ENZYMES HAT1 AND KAT8
#6871Directed editing of cellular RNA via nuclear delivery of CRISPR/CAS9
#6872STRUCTURE SPECIFIC RECOGNITION PROTEIN 1 (SSRP1) NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#6873Treatment of C9FTD/ALS by targeting RNA expanded repeat sequences
#6874SPLICE MODULATING OLIGONUCLEOTIDES THAT INHIBIT CANCER
#6875Culicinae Mosquito TRA-2 RNA Interference Technique to Genetically Produce Maleness Population
#6876Antitumor drug delivery formulation
#6877CELL PENETRATING MOLECULE
#6878Methods and compositions for producing double allele knock outs
#6879USE OF COMPLEMENT PATHWAY INHIBITORS TO TREAT OCULAR DISEASES
#6880Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging
#6881PEPTIDE-MEDIATED INTRAVESICAL DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS
#6882lincRNA for the detection of esophageal cancer
#6883CRISPR enzymes and systems
#6884CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#6885Treatment of age-related macular degeneration using RNA complexes that target MyD88 or TLR3
#6886Modulation of CCR10 signals for treatment of skin and intestinal inflammatory diseases and infection
#6887Methods and compositions for modulating AAV infection
#6888Methods and compositions for reducing immunosupression by tumor cells
#6889RNA interference in skin indications
#6890METHODS OF CONTROLLING CELL FATE AND CONSEQUENCES FOR DISEASE
#6891iRNA agents with biocleavable tethers
#6892Antisense Polynucleotides to Induce Exon Skipping and Method of Treating Dystrophies
#6893Targeted self-assembly of functionalized carbon nanotubes on tumors
#6894Nucleic acid nanostructures with core motifs
#6895High-throughput CRISPR-based library screening
#6896Composition for preventing or treating keloid or hypertrophic scars
#6897Argonaute protein-double stranded RNA complexes and uses related thereto
#6898Natural type miRNA for controlling gene expression, and use of same
#6899Fatty acids and their use in conjugation to biomolecules
#6900COMPOUNDS FOR USE IN THE TREATMENT OF TELOMERE RELATED DISEASES AND/OR TELOMERE RELATED MEDICAL CONDITIONS