109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
SEPTIN PROTEINS AS NOVEL BIOMARKERS FOR DETECTION AND TREATMENT OF MÜLLERIAN CANCERS
#7202Methods and pharmaceutical compositions for expressing a polynucleotide of interest in the peripheral nervous system of a subject
#7203Fertility gene and use thereof
#7204Fertility gene and use thereof
#7205MULTI-TARGET MODULATION FOR TREATING FIBROSIS AND INFLAMMATORY CONDITIONS
#7206RNA-directed DNA cleavage by the Cas9-crRNA complex
#7207Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
#7208MicroRNA inhibition for the treatment of inflammation and myeloproliferative disorders
#7209Synthetic hammerhead ribozymes with ligand-responsive tertiary interactions
#7210Targeted-Delivery of Small Interference RNA Against Anthrax
#7211NEW CRISPR ASSAYS
#7212Nucleic acid functionalized nanoparticles for therapeutic applications
#7213Cancer specific-splicing ribozyme and use thereof
#7214CRISPR/CPF1 systems and methods
#7215Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
#7216Methods for treating inflammatory bowel disease
#7217Device and method to treat esophageal disorders
#7218ANTISENSE NUCLEIC ACIDS
#7219MODULATION OF TRANSTHYRETIN EXPRESSION
#7220MODULATION OF TRANSTHYRETIN EXPRESSION
#7221MODULATION OF TRANSTHYRETIN EXPRESSION
#7222MODULATION OF TRANSTHYRETIN EXPRESSION
#7223MODULATION OF TRANSTHYRETIN EXPRESSION
#7224MODULATION OF TRANSTHYRETIN EXPRESSION
#7225MODULATION OF TRANSTHYRETIN EXPRESSION
#7226MODULATION OF TRANSTHYRETIN EXPRESSION
#7227MODULATION OF TRANSTHYRETIN EXPRESSION
#7228MODULATION OF TRANSTHYRETIN EXPRESSION
#7229Modulation of BCL11A for treatment of hemoglobinopathies
#7230Method and Medicament For Inhibiting The Expression of A Given Gene
#7231Methods and compositions for modulating gene expression
#7232COMPOSITIONS AND METHODS FOR INHIBITING CELL PROLIFERATION
#7233Methods to accelerate antibody diversification
#7234COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
#7235Methods of making and using live attenuated viruses
#7236miRNAs as novel therapeutic adjuvants and biomarkers for the prognosis and treatment of drug resistant breast cancers
#7237Exon skipping oligomer conjugates for muscular dystrophy
#7238Composition
#7239Vectors
#7240Citrus derived transcription and translation regulatory elements for tissue specific expression
#7241Recombinant for producing acetylglucosamine and construction method thereof
#7242Compositions and methods for enhancing gene expression
#7243Selective reduction of the deleterious activity of extended tri-nucleotide repeat containing genes
#7244Antisense oligonucleotides for treatment of cancer stem cells
#7245Targeting microRNAs for metabolic disorders
#7246Antisense molecules and methods for treating pathologies
#7247siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis
#7248DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS
#7249Anti-human transferrin receptor antibody permeating blood-brain barrier
#7250CRISPR-based methods and products for increasing frataxin levels and uses thereof
#7251Ionizable cationic lipid for RNA delivery
#7252Self-assembled ribonucleoprotein nanoparticles
#7253Methods of delivery of transgenes for treating brain diseases
#7254Carrier nanoparticles and related compositions, methods and systems
#7255Combined therapy for duchenne muscular dystrophy
#7256Dual assembly nanoparticles
#7257Methods for treatment of metastatic thyroid cancer using a PDGFR-α inhibitor
#7258Compositions and methods for controlling vasculature
#7259MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
#7260Method for treatment of subjects with TUG1 gene expressing brain tumor
#7261In vivo production of small interfering RNAs that mediate gene silencing
#7262ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#7263Micro-RNA family that modulates extracellular matrix genes and uses thereof
#7264Compositions and methods for delivery of a polynucleotide into a plant
#7265TRIM11 for degradation of protein aggregates
#7266NON-INTEGRATING VIRAL DELIVERY SYSTEM AND METHODS OF USE THEROF
#7267Compositions and methods for transport across the blood brain barrier
#7268P-ethoxy nucleic acids for liposomal formulation
#7269Methods and compounds for treatment of lymphocyte-related diseases and conditions
#7270Tau antisense oligomers and uses thereof
#7271CITRIN INHIBITORS FOR THE TREATMENT OF CANCER
#7272COMPOSITIONS AND METHODS FOR MODULATING ONCOGENIC MIRNA
#7273Compositions and methods to control insect pests
#7274Use of an miRNA to reduce proliferation of a cancer cell
#7275Materials and methods for modulation of tendon healing
#7276Restoration of the CFTR function by splicing modulation
#7277β-actin promoters and uses thereof
#7278Synthetic bacteriophages and bacteriophage compositions
#7279Engineered nucleic acid-targeting nucleic acids
#7280MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
#7281CRISPR enzymes and systems
#7282CANCER TARGETS AND USES THEREOF
#7283Targeting Apolipoprotein E (APOE) in Neurologic Disease
#7284INHIBITION OF EXPANSION AND FUNCTION OF PATHOGENIC AGE-ASSOCIATED B CELLS AND USE FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASE
#7285ORGANIC COMPOSITIONS TO TREAT KRAS-RELATED DISEASES
#7286METHODS FOR TREATING AND ASSESSING TUMOR INVASION AND METASTASIS
#7287Down-regulating gene expression in insect plants
#7288UNA oligomers and compositions for treating amyloidosis
#7289SMN2 element 1 antisense compositions and methods and uses thereof
#7290Chemical modification of short small hairpin RNAs for inhibition of gene expression
#7291Dual Targeting siRNA Agents
#7292Natural antisense and non-coding RNA transcripts as drug targets
#7293Inhibition of lncRNA HOTAIR and related materials and methods
#7294Delivering CRISPR therapeutics with lipid nanoparticles
#7295Compounds and methods for increasing antisense activity
#7296GENOME EDITING VECTORS
#7297CARBON MATERIAL DELIVERY SYSTEMS AND METHODS
#7298Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions
#7299ALTERING MICROBIAL POPULATIONS & MODIFYING MICROBIOTA
#7300REGULATOR TARGETING FATTY ACID SYNTHASE AND METHOD OF USING THE SAME FOR IMPROVING MEAT QUALITY
#7301Immobilized poly(n)polymerase
#7302Methods and compositions for the activation of gamma-delta T-cells
#7303Methods and compositions for the activation of gamma-delta T-cells
#7304Controlling fungal pathogens by disabling their small RNA pathways using RNAi-based strategy
#7305METHODS FOR THE IN PLANTA TRANSFORMATION OF PLANTS AND MANUFACTURING PROCESSES AND PRODUCTS BASED AND OBTAINABLE THEREFORM
#7306Antisense nucleic acids
#7307MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#7308Method of regulating gene expression
#7309Methods and compositions for enhancing the therapeutic effect of anti-tumor T cells
#7310Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#7311Methods for modulating expression of C9ORF72 antisense transcript
#7312Methods and compositions for the treatment of cancer or other diseases
#7313Oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and application thereof
#7314METHODS FOR CONTROLLING PESTS USING RNAi
#7315Generation of neural stem cells and motor neurons
#7316Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
#7317Oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and application thereof
#7318Production of stable non-polyadenylated RNAs
#7319Reducing levels of nicotinic alkaloids in plants
#7320Reducing levels of nicotinic alkaloids in plants
#7321Therapeutic oligomers for treating amyloidosis
#7322Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#7323RNAi inhibitors of glucose-6-phosphate dehydrogenase for treating cardiovascular and pulmonary conditions
#7324COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
#7325Oligodeoxy nucleotide for preparing drugs for inhibiting tumor growth and application thereof
#7326Small-interfering RNA expression systems for production of small-interfering RNAs and their use
#7327Stabilized STAT3 decoy oligonucleotides and uses therefor
#7328MicroRNA initiated DNAzyme motor operating in living cells
#7329Targeting macula densa cells as a new therapeutic approach for kidney disease
#7330Site-Specific DNA-Doxorubicin Conjugates Display Enhanced Cytotoxicity to Breast Cancer Cells
#7331Cytomegalovirus vectors eliciting T cells restricted by major histocompatibility complex E molecules
#7332Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
#7333Modulation of nuclear-retained RNA
#7334METHODS FOR CONTROLLING OBESITY USING MINIMALLY INVASIVE MEANS
#7335Targeting microRNAs for the treatment of liver cancer
#7336BIVALENT ANTISENSE OLIGONUCLEOTIDES
#7337Post-transcriptionally chemically modified double strand RNAs
#7338Therapeutics targeting IGFBP7 for the treatment or prevention of heart failure and metabolic diseases
#7339ANTISENSE COMPOUNDS TARGETING GENES ASSOCIATED WITH FIBRONECTIN
#7340MIR-155 INHIBITORS FOR TREATING CUTANEOUS T CELL LYMPHOMA (CTCL)
#7341Compositions and methods for inhibiting expression of factor V
#7342METHODS RELATING TO THE PREVENTION AND TREATMENT OF DRUG RESISTANCE
#73432′-arabino-fluorooligonucleotide N3′˜P5′ phosphoramidates: their synthesis and use
#7344ANTI-INFLAMMATORY DRUG AND USES THEREOF
#7345Lipids and compositions for the delivery of therapeutics
#7346Topical Compositions And Methods For Stimulating MIR-146A In Skin Cells
#7347Exonic splicing enhancers and exonic splicing silencers
#7348Cell engineering using MICRORNAs
#7349ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS
#7350Engineered nucleic acid-targeting nucleic acids
#7351Synthetic promoter and methods of use thereof
#7352Modified CPMV enhancer elements
#7353Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability
#7354Methods for treating acute myeloid leukemia and nanoparticle complexes of miR-22 utilized therein
#7355REGULATION OF MIR-33 MICRORNAS IN THE TREATMENT OF CHOLESTEROL-RELATED DISORDERS
#7356RNA amidates and thioamidates for RNAi
#7357METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
#7358Compounds and methods for reducing Tau expression
#7359Methods and compositions for selecting siRNA of improved functionality
#7360Therapeutic methods, products and compositions inhibiting ZNF555
#7361Compositions for modulating expression of C9ORF72 antisense transcript
#7362CRISPR/CAS GLOBAL REGULATOR SCREENING PLATFORM
#7363Cells comprising engineered nucleic-acid targeting nucleic acids
#7364siRNA Inhibition Of Human Antigen R Expression For Treatment of Cancer
#7365Fungal immunogens and related materials and methods
#7366MiRNA compositions for the treatment of mature B-cell neoplasms
#7367LncRNA serves as a biomarker and therapeutic target
#7368Methods of inducing insulin production
#7369Targeting hepatitis B virus (HBV) host factors
#7370Segmented micro RNA mimetics
#7371Therapy
#7372Treatment of genetic disorders associated with DNA repeat instability
#7373Poly(β-amino ester)-co-polyethylene glycol (PEG-PBAE-PEG) polymers for gene and drug delivery
#7374Delivery of hydrophobic active agent particles
#7375DUAL AAV VECTOR SYSTEM FOR CRISPR/Cas9 MEDIATED CORRECTION OF HUMAN DISEASE
#7376Compositions and methods for making selenocysteine containing polypeptides
#7377Targeted RNA knockdown and knockout by type III-A Csm complexes
#7378NOVEL AFLATOXIN AND FUNGAL INFECTION CONTROL METHODS
#7379Plant regulatory elements and uses thereof
#7380Plant regulatory elements and uses thereof
#7381Compounds and methods for modulating TMPRSS6 expression
#7382Therapeutic UNA oligomers and uses thereof
#7383Bivalent siRNA chimeras and methods of use thereof
#7384A METHOD OF REGULATING GENE EXPRESSION
#7385Treatment of Cancers with Micro-RNA Inhibitors
#7386Short interfering nucleic acid (siNA) compositions
#7387Compositions for treating muscular dystrophy
#7388Lipid compositions
#7389Cells for producing influenza virus and method for producing influenza virus
#7390Multiple sclerosis treatment
#7391Method for sorting tissue cells
#7392Modulation of pre-mRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#7393Organic compositions to treat EPAS1-related diseases
#7394Factor XII (Hageman Factor) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), and Kininogen 1 (KNG1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#7395Exosomes and micro-ribonucleic acids for tissue regeneration
#7396CAS9 mutant genes and polypeptides encoded by same
#7397Methods and compositions for generating CRISPR guide RNA libraries
#7398Click nucleic acid polymers and methods of use
#7399COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
#7400Method for diagnosing and treating ovarian cancer
#7401Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus
#7402Down-regulating gene expression in insect pests
#7403AAV treatment of Huntington's disease
#7404Oligonucleotide compounds for targeting huntingtin mRNA
#7405Inhibitors of MYH7B and uses thereof
#7406Compositions for modulating Tau expression
#7407EFFECTS OF APOLIPOPROTEIN B INHIBITION ON GENE EXPRESSION PROFILES IN ANIMALS
#7408Methods to detect motor neuron disease comprising micro-RNAs
#7409METHOD FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS
#7410RNA nanoparticles and method of use thereof
#7411METHOD OF TREATMENT
#7412Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, HAO1) and methods of use thereof
#7413Lipids and compositions for the delivery of therapeutics
#7414Oligonucleotide analogues targeting human LMNA
#7415NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY
#7416Genetically modified cells, tissues, and organs for treating disease
#7417COMPETITIVE MODULATION OF MICRORNAS
#7418BACTERIAL MEDIATED THF ALPHA GENE SILENCING
#7419Oligonucleotide compositions with enhanced efficiency
#7420Modulation of huntingtin expression
#7421POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
#7422NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY
#7423Altering microbial populations and modifying microbiota
#7424Altering microbial populations and modifying microbiota
#7425Highly specific delivery of polynucleotides to the cell nucleus via compression
#7426Compositions and methods for correcting limb girdle muscular dystrophy type 2C using exon skipping
#7427Composition for preventing or treating atopic dermatitis comprising X-shape DNA structure as active ingredient
#7428MULTI-CONJUGATE OF SIRNA AND PREPARING METHOD THEREOF
#7429Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
#7430MIRNA MIMETICS AND THEIR USE IN TREATING SENSORY CONDITIONS
#7431Catalytic strands of minimal hammerhead ribozymes and methods of using the same
#7432RNA-guided gene editing system and uses thereof
#7433Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
#7434Amphiphilic nanoparticles for delivery of CRISPR based therapy
#7435Compositions and methods for delivery of biomacromolecule agents
#7436INTRACELLULAR DELIVERY SYSTEM AND METHODS
#7437Biomarkers for diagnosis and prognosis of lung cancer
#7438Homologous recombination factors
#7439Micro-RNA inhibitors and their uses in disease
#7440Chimeric double-stranded nucleic acid
#7441CIRCULAR SINGLE-STRANDED NUCLEIC ACID, METHOD FOR PREPARING THE SAME, AND METHOD FOR USING THE SAME
#7442Modulation of alpha synuclein expression
#7443Recombinant protein-based method for the delivery of silencer RNA to target the brain
#7444Ionizable cationic lipid for RNA delivery
#7445RNA guided endonuclease targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same
#7446Altering microbial populations and modifying microbiota
#7447Plasmonic nanoparticle immunoassay method
#7448NUCLEAR TARGETING SEQUENCES
#7449RECOMBINANT AAV VECTORS USEFUL FOR REDUCING IMMUNITY AGAINST TRANSGENE PRODUCTS
#7450Compositions and methods for controlling
#7451Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants
#7452Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and triple negative breast cancer
#7453Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
#7454MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
#7455Specific synthetic chimeric Xenonucleic acid guide RNA; s(XNA-gRNA) for enhancing CRISPR mediated genome editing efficiency
#7456Pharmaceutical composition for treating Charcot Marie Tooth disease
#7457RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Neuromuscular Disorders
#7458Compositions and methods for inhibition of expression of protein C (PROC) genes
#7459RNA interference mediated therapy for neurodegenerative diseases
#7460METHODS AND COMPOSITIONS FOR MODIFYING ENDOTHELIAL CELLS
#7461p63 inactivation for the treatment of heart failure
#7462RNA products and uses thereof
#7463Pharmaceutical composition for preventing and teating endocrine disrupting chemicals-induced diseases and treating method using the same
#7464Biodegradable lipids for the delivery of active agents
#7465Targeting ligands
#7466NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
#7467METHODS OF TREATING MOTOR NEURON DISEASES
#7468Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes
#7469Cardiac glycosides to reduce pulmonary exacerbations and other adverse events in cystic fibrosis and other related disorders
#7470Altering microbial populations and modifying microbiota
#7471Altering microbial populations and modifying microbiota
#7472Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
#7473Plant regulatory elements and uses thereof
#7474MOLECULAR TARGETS FOR THE PREVENTION AND/OR TREATMENT OF FIBROSIS, HYPERTROPHIC SCARS OR KELOIDS
#7475miRNA modulators of thermogenesis
#7476Particle-nucleic acid conjugates and therapeutic uses related thereto
#7477Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing
#7478siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof
#7479Compositions and methods for inhibition of nucleic acids function
#7480Compositions and methods for nucleic acid transfer
#7481Hepcidin antagonists for use in the treatment of inflammation
#7482Functional screening with optimized functional CRISPR-Cas systems
#7483Talen targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same
#7484CANCER THERAPEUTICS
#7485Prevention and/or treatment of hearing loss or impairment
#7486COMPOSITIONS AND METHODS FOR ENHANCING THE THERAPEUTIC POTENTIAL OF STEM CELLS
#7487COMPOSITIONS AND METHODS FOR MODULATING RNA
#7488Therapeutic nanoparticles and methods of use thereof
#7489STERILE MALE INSECTS THAT SIGNIFICANTLY REDUCE LIFESPAN AND EGG-PRODUCTION OF MATED WILD-TYPE FEMALE INSECTS
#7490METHODS AND USES FOR DIAGNOSIS AND TREATMENT OF PROSTATE CANCER
#7491Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
#7492Cationic lipid
#7493INHIBITORS OF MIR-17-92 CLUSTER FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA AND OTHER MALIGNANCIES
#7494Compositions and methods for modulating Tau expression
#7495ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#7496Guide RNA with chemical modifications
#7497METHODS TO ENHANCE CELL-MEDIATED IMMUNITY
#7498Cholesteryl ester transfer protein (CETP) inhibition in the treatment of cancer
#7499Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
#7500Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases