109048 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
PLANT TRANSFORMATION METHOD PERFORMED VIA GRAFTING OF ROOTSTOCK AND SCION
#10502Compositions and methods for xylem-specific expression in plant cells
#10503ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10504Modified single-stranded polynucleotides
#10505Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#105062′-arabino-fluorooligonucleotide N3′→P5′ phosphoramidates: their synthesis and use
#10507ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10508Transcription factor decoys
#10509MICRORNA-INDUCED ES-LIKE CELLS AND USES THEREOF
#10510COMPOSITION AND METHOD FOR IN VIVO AND IN VITRO ATTENUATION OF GENE EXPRESSION USING DOUBLE STRANDED RNA
#10511COMPOSITIONS, ORGANISMS, SYSTEMS, AND METHODS FOR EXPRESSING A GENE PRODUCT IN PLANTS
#10512Antagonat compositions and methods of use
#10513RNAi-mediated inhibition of HIF1A for treatment of ocular angiogenesis
#10514Methods targeting miR-33 microRNAs for regulating lipid metabolism
#10515Micro-RNAS that control myosin expression and myofiber identity
#10516Identification of novel genes coding for small temporal RNAs
#10517RNAi sequence-independent modification formats, and stabilized forms thereof
#10518MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells
#10519Regulation of translation of expressed genes
#10520MULTIFUNCTIONAL COPOLYMERS FOR NUCLEIC ACID DELIVERY
#10521Modifications for antisense compounds
#10522Nucleic acid fragments from a ribosomal protein promoter for enhancing gene expression
#10523Nanotopography-mediated reverse uptake platform for nucleic acid delivery and applications thereof
#10524Compositions, kits and methods for treatment of cardiovascular, immunological and inflammatory diseases
#10525Phased small RNAs
#10526METHODS AND COMPOSITIONS REDUCING TARGET GENE EXPRESSION USING COCKTAILS OF siRNAS OR CONSTRUCTS EXPRESSING siRNAS
#10527Down-regulating gene expression in insect pests
#10528Short interfering ribonucleic acid (siRNA) for oral administration
#10529METHODS AND COMPOSITIONS RELATING TO POLYPEPTIDES WITH RNASE III DOMAINS THAT MEDIATE RNA INTERFERENCE
#10530Synthetic nucleic acids for polymerization reactions
#10531Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation
#10532Myomegalin variant 8
#10533Genetic inhibition by double-stranded RNA
#10534UBIQUITIN REGULATORY ELEMENTS
#10535MicroRNAs that regulate muscle cell proliferation and differentiation
#10536Inhibitors of SP140 and their use in therapy
#10537COMPOSITIONS AND METHODS FOR SPECIFIC CLEAVAGE OF EXOGENOUS RNA IN A CELL
#10538MODULATION OF NUCLEAR-RETAINED RNA
#10539SiRNA targeting ETS1 and ELK1 and method of using same in the inhibition of CIP2A gene in cancer treatment
#10540Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application
#10541Segmented micro RNA mimetics
#10542SiRNA compositions and methods for potently inhibiting viral infection
#10543siRNA Targeting Apolipoprotein B (APOB)
#10544METHOD OF EXAMINING POLYCYSTIC KIDNEY DISEASE AND METHOD OF SCREENING FOR THERAPEUTIC AGENT OF THE DISEASE
#10545Regulatory element for heterologous protein production in the fruiting body of filamentous fungi
#10546ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10547Preventive or therapeutic agent for fibrosis
#10548Method of deriving mature hepatocytes from human embryonic stem cells
#10549Cell growth inhibitor and screening method thereof
#10550Culture method
#10551Modified cell lines for increasing lentiviral titers
#10552Methods for producing enteroendocrine cells that make and secrete insulin
#10553Laticiferous tissue-specific SRPP promoter from and uses thereof
#10554Tetrahydropyran nucleic acid analogs
#10555Modified iRNA agents
#10556Antisense nucleic acids
#10557Modified human U1snRNA molecule, a gene encoding for the modified human U1snRNA molecule, an expression vector including the gene, and the use thereof in gene therapy
#10558Pharmaceutical composition for transcolonic absorption
#10559siRNA targeting myeloid differentiation primary response gene (88) (MYD88)
#10560High-expression promoter derived from
#10561Microvesicles carrying small interfering RNAs, preparation methods and uses thereof
#10562Oligonucleotides comprising alternating segments and uses thereof
#105632′ and 5′ modified monomers and oligonucleotides
#10564Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof
#10565Targeted particles comprising landscape phage fusion proteins and heterologous nucleic acid
#10566Puf-A and related compounds for treatment of retinopathies and sight-threatening ophthalmologic disorders
#10567Nucleic acid construct for increasing abiotic stress tolerance in plants
#10568Compositions and methods for modulating expression of gene products
#10569Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins
#10570RNA sequence-specific mediators of RNA interference
#10571Method of inhibiting Alu RNA and therapeutic uses thereof
#10572METHOD AND COMPOSITION FOR ALVEOLAR EPITHELIAL CELL-SPECIFIC NUCLEIC ACID NUCLEAR IMPORT
#10573Use of a growth-stimulating protein
#10574Agent for suppressing expression of dominant mutant gene
#10575Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas
#10576BNIP3 ISOFORMS AND METHODS OF USE
#10577Biologically active molecules for influencing virus-, bacteria-, parasite-infected cells and/or tumor cells and method for the use thereof
#10578Micro-RNA family that modulates fibrosis and uses thereof
#10579MCPIP PROTECTION AGAINST OSTEOCLAST PRODUCTION
#10580In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
#10581Multiple exon skipping compositions for DMD
#10582Method for producing novel hiPSC by means of miRNA introduction
#10583Method for modulating double-strand break-induced homologous recombination
#10584NUCLEIC ACID COMPOUNDS WITH CONFORMATIONALLY RESTRICTED MONOMERS AND USES THEREOF
#10585Methods for inhibiting expression of connective tissue growth factor
#10586Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#10587SMALL RNA MOLECULES, PRECURSORS THEREOF, MEANS AND METHODS FOR DETECTING THEM, AND USES THEREOF IN TYPING SAMPLES
#10588Compositions and their uses directed to huntingtin
#10589Method to trigger RNA interference
#10590Method for producing novel hipsc by means of siRNA introduction
#10591Ligand-conjugated monomers
#10592Cell growth inhibitor and screening method thereof
#10593TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO HGF
#10594Dual targeting siRNA agents
#10595Inhibitor of HMGB protein-mediated immune response activation, and screening method
#10596FGFR4 antibodies
#10597Methods and compositions for the inhibition of Stat5 in prostate cancer cells
#10598Structurally designed shRNAs
#10599SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA
#10600Nucleic acid molecules and collections thereof, their application and modification
#10601Potentiator of activity of anti-cancer agent and use thereof, and biomarker for prediction of prognosis in cancer patient and use thereof
#10602Method and medicament for inhibiting the expression of a given gene
#10603MIRNA EXPRESSION IN ALLERGIC DISEASE
#10604Compositions and methods to control insect pests
#10605In vivo gene silencing by chemically modified and stable siRNA
#10606Cancer cell identification marker and cancer cell proliferation inhibitor
#10607Selective inhibition of polyglutamine protein expression
#10608PROTEINS RELATED TO THE SUPPRESSION OF PHYTOPHTHORA INFECTIONS IN MEMBERS OF THE SOLANACEAE FAMILY
#10609Single-stranded RNAi agents containing an internal, non-nucleic acid spacer
#10610PROCESSES USING VLPS WITH CAPSIDS RESISTANT TO HYDROLASES
#10611Invertebrate microRNAs
#10612RNA MOLECULES AND USES THEREOF
#10613Method and medicament for inhibiting the expression of a given gene
#10614Method and medicament for inhibiting the expression of a given gene
#10615METHOD FOR DOWN-REGULATING GENE EXPRESSION IN FUNGI
#10616Compositions and methods directed to treating liver fibrosis
#10617miRNAs involved in the blood brain barrier function
#10618Insulin-resistance-improving drug
#10619Compositions and methods for treating cancer and modulating stress granule formation
#10620Nuclease resistant double-stranded ribonucleic acid
#10621MIR-33 INHIBITORS AND USES THEREOF
#10622NOVEL MICRORNAS FOR THE DETECTION AND ISOLATION OF HUMAN EMBRYONIC STEM CELL-DERIVED CARDIAC CELL TYPES
#10623Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein
#10624Regulatory proteins and inhibitors
#10625ROLE OF FRAGILE X MENTAL RETARDATION GENE AND PROTEIN IN CANCER METASTASIS
#10626Methods of generating oligodendrocytes and cell populations comprising same
#10627Therapeutic compositions
#10628THERAPEUTIC USES OF MICROVESICLES AND RELATED MICRORNAS
#10629Methods and compositions for treating prostate cancer
#10630HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
#10631METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER
#10632RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
#10633TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF
#10634LONG NON-CODING RNA SPRY4-IT1 AS A DIAGNOSTIC AND THERAPEUTIC AGENT
#10635Peptide conjugated, inosine-substituted antisense oligomer compound and method
#10636Antisense Formulation
#10637Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
#10638Compositions and methods for altering RNAi
#10639Reduced size self-delivering RNAi compounds
#10640Method for inhibiting HIV replication in mammal and human cells
#10641SiRNA structure for minimizing off-target effects caused by antisense strands, and use thereof
#10642Prevention and treatment of cast nephropathy
#10643Modulation of BCL11A for treatment of hemoglobinopathies
#10644RNA interference mediating small RNA molecules
#10645Compositions and methods for silencing apolipoprotein B
#10646RNAi Inhibition of Serum Amyloid A For Treatment of Glaucoma
#10647Nucleic acid functionalized nanoparticles for therapeutic applications
#10648Compositions and methods for inhibiting expression of Mylip/Idol gene
#10649MicroRNA compositions and methods
#10650Combined use of PRAME inhibitors and HDAC inhibitors
#10651Use of DNAzymes for analysis of an RNA sample
#10652Regulatory polynucleotides and uses thereof
#10653ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
#10654Oligomeric compounds for the modulation of HIF-1A expression
#10655Antagonists of miRNA-29 expression and their use in the prevention and treatment of aneurysm
#10656Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
#10657Method for transfecting nucleic acid to cell and nucleic acid complex
#10658Method of producing lipid nanoparticles for drug delivery
#10659Reducer of immunosuppression by tumor cell and antitumor agent using the same
#10660Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
#10661Prophylactic or therapeutic agent for diabetes
#10662MiRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway
#10663Methods and compositions for the specific inhibition of beta-catenin by double-stranded RNA
#10664MicroRNA compositions and methods related thereto
#10665Compositions and methods for modulation of SMN2 splicing
#10666Baculovirus-mediated transgene expression in both mammalian and insect cells
#10667MicroRNA as a cancer progression predictor and its use for treating cancer
#10668Cationic lipid
#10669Construct and method for expressing transgenes using a bidirectional constitutive promoter
#10670Interfering RNA molecules
#10671Nuclear reprogramming factor comprising miRNA and a protein factor
#10672General composition framework for ligand-controlled RNA regulatory systems
#10673Nucleic acid molecules that target RPS6 and confer resistance to coleopteran pests
#10674UNA oligomers for therapeutics
#10675NKX3-1 saRNA and KLF4 saRNA and uses thereof
#10676Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA
#10677Bispecific antisense oligonucleotides that inhibit IGFBP-2 and IGFBP-5 and methods of using same
#10678Hyaluronic acid decomposition-promoting factor and inhibitor thereof
#10679BIOMARKER SPECIFIC TO BRAIN/NERVE OR SPECIFIC TO NEURONAL DIFFERENTIATION
#10680Nucleic acid molecules that target RPA70 and confer resistance to coleopteran pests
#10681Nucleic acid molecules that target PP1-87B and confer resistance to coleopteran pests
#10682ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors
#10683Agent for suppressing expression of dominant allele
#10684MicroRNA-130a,b as a tumor suppressor and sensitizing agent for chemotherapy
#10685METHOD AND COMPOSITIONS TO INDUCE APOPTOSIS OF TUMORAL CELLS EXPRESSING SHH
#10686Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
#10687Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
#10688BIVALENT ANTISENSE OLIGONUCLEOTIDES
#10689Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
#10690Anti-microRNA oligonucleotide molecules
#10691METHODS FOR DETECTING AND REGULATING ALOPECIA AREATA AND GENE COHORTS THEREOF
#10692Embedded chimeric peptide nucleic acids and uses thereof
#10693Double Stranded RNA Constructs to Control Ants
#10694CANCER-SPECIFIC GENETIC REARRANGEMENTS
#10695Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#10696Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
#10697MiRNA molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with EMT
#10698Treatment of sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a sirtuin (SIRT)
#10699Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin
#10700Mammalian Genes Involved in Tularemia and Other Infections
#10701COLON CANCER TARGETS AND USES THEREOF
#10702MODULATING PRODUCTION TRAITS IN AVIANS
#10703Use of Antisense Oligonucleotides or siRNA to Suppress Expression of eIF-5A1
#10704COMPOSITIONS AND METHODS RELATED TO MIRNA MODULATION OF NEOVASCULARIZATION OR ANGIOGENESIS
#10705Modified oligonucleotides for telomerase inhibition
#10706MICRORNA MIRNA-31 AS A THERAPEUTIC APPROACH FOR THE TREATMENT OF CANCER
#10707Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4
#10708Materials and Methods Related to Modulation of Mismatch Repair and Genomic Stability by miR-155
#10709Reverse micelle system comprising nucleic acids and use thereof
#10710Nucleic acid-lipopolymer compositions
#10711Compositions and methods for silencing genes expressed in cancer
#10712Mutator activity induced by microRNA-155 () links inflammation and cancer
#10713MODULATORS OF PROTEASOME ACTIVITY
#10714SiRNA-mediated gene silencing
#10715METHODS OF INCREASING MACROPINOCYTOSIS IN CANCER CELLS
#10716NOTCH inhibition in the treatment and prevention of a metabolic disease or disorder and cardiovascular complications thereof
#10717ANTAGONISTS OF PRODUCTS OF THE HS.459642 UNIGENE CLUSTER FOR THE INHIBITION OF PROLIFERATION, DEVELOPMENT OR DIFFERENTIATION OF STEM CELLS INCLUDING CANCER STEM CELLS
#10718Methods and compositions for the detection and treatment of cancer involving miRNAs and miRNA inhibitors and targets
#10719METHODS AND COMPOSITIONS FOR MAINTENANCE OF A FUNCTIONAL WOUND
#10720METHODS AND COMPOSITIONS FOR INFLUENCING TUMORS USING MICRORNA-185 AS A TUMOR SUPPRESSOR
#10721METHODS AND COMPOSITIONS USEFUL IN TREATMENT OF DISEASES OR CONDITIONS RELATED TO REPEAT EXPANSION
#10722Nucleic acid complexes
#10723siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1)
#10724METHODS AND COMPOSITIONS FOR TREATMENT OF ANGELMAN SYNDROME AND AUTISM SPECTRUM DISORDERS
#10725Cationic lipids for oligonucleotide delivery
#10726MODULATION OF CETP EXPRESSION
#10727Treatment of fibrosis using microRNA 19b
#10728Natural antisense and non-coding RNA transcripts as drug targets
#10729Conjugate constructs, delivery, and use for treatment of disease
#10730Composition For Delivery Of Genetic Material
#10731Monomers and oligonucleotides comprising cycloaddition adduct(s)
#10732Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3
#10733COMPOSITIONS AND METHODS FOR TREATMENT OF PARKINSON'S DISEASE
#10734Methods of increasing bone mass in a subject comprising inhibiting DKK1
#10735POLYNUCLEOTIDE MOLECULES FOR GENE REGULATION IN PLANTS
#10736SUMO as a marker of cancer development and target for cancer therapy
#10737Selective reduction of allelic variants
#10738Selective reduction of allelic variants
#10739Double-stranded oligonucleotides
#10740AGENT FOR TREATING MYELOFIBROSIS
#10741P53 MODULATOR AND CANCER TARGET
#10742Treatment of metastatic tumors
#10743Method of increasing expression of nucleic acid molecules in plants using multiple transcription units
#10744Isoform of bruton's tyrosine kinase (BTK) protein
#10745ISOFORM OF BRUTON'S TYROSINE KINASE (BTK) PROTEIN
#10746NEW ISOFORM OF BRUTON'S TYROSINE KINASE (BTK) PROTEIN
#10747Recurrent gene fusions in prostate cancer
#10748BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS
#10749Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics
#10750STING (STIMULATOR OF INTERFERON GENES), A REGULATOR OF INNATE IMMUNE RESPONSES
#10751miR-150 for the treatment of blood disorders
#10752Compositions and methods for the control of root lesion nematode
#10753Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
#10754Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3
#10755Compositions and methods for modulation of LMNA expression
#10756DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#10757Oligonucleotide compounds comprising non-nucleotide overhangs
#10758Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
#10759Anti-sense oligonucleotides targeted against exon 9 of IL-23Rα gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases
#10760KLF6 ALTERNATIVE SPLICE FORMS AND A GERMLINE KLF6 DNA POLYMORPHISM ASSOCIATED WITH INCREASED CANCER RISK
#10761Plant regulatory elements and uses thereof
#10762Regulatory region having increased expression and method of using same
#10763Dermatological, pharmaceutical composition suitable for oligonucleotides
#10764Modulation of forkhead box O1A expression
#10765Identification of micro-RNAs involved in neuromuscular synapse maintenance and regeneration
#10766MODULATION OF TIMP1 AND TIMP2 EXPRESSION
#10767Genetic Inhibition by Double-Stranded RNA
#10768Pharmaceutical composition for treating cancer
#10769METHOD FOR PREVENTING OR TREATING MEMORY IMPAIRMENT AND PHARMACEUTICAL COMPOSITIONS USEFUL THEREFORE
#10770Semaphorin 3C (Sema3C) inhibitor therapeutics, methods, and uses
#10771DOSING REGIMENS FOR TREATING AND PREVENTING OCULAR DISORDERS USING C-RAF ANTISENSE
#10772Methods to predict and prevent resistance to taxoid compounds
#10773Compositions and methods for inhibiting expression of XBP-1 gene
#10774Modulation of angiopoietin-like 3 expression
#10775Compositions and methods for inhibiting expression of Eg5 and VEGF genes
#10776siRNA Targeting Beta Secretase (BACE)
#10777Fidgetin-like 2 as a target to enhance wound healing
#10778Cationic lipids for therapeutic agent delivery formulations
#10779IMMUNE MODULATORS RELATING TO FOXO3A
#10780Methods and compositions to modulate antiviral and immune activity responses
#10781MicroRNA (miRNA) and downstream targets for diagnostic and therapeutic purposes
#10782RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#10783OSTEOARTHRITIS BIOMARKERS AND USES THEREOF
#10784METHOD FOR TREATING NON-SMALL CELL LUNG CANCER
#10785Compounds for targeting drug delivery and enhancing siRNA activity
#10786Genes of an otitis media isolate of nontypeable
#10787Compositions and methods for inhibiting expression of GSK-3 genes
#10788GNAQ targeted dsRNA compositions and methods for inhibiting expression
#10789Compositions and methods for transport across the blood brain barrier
#10790ANTI-VIRAL THERAPY
#10791Protein arginine N-methyltransferase-5 method of cancer treatment
#10792Antisense antiviral compounds and methods for treating a filovirus infection
#10793METHOD FOR PROLIFERATING CARDIOMYOCYTES USING MICRO-RNA
#10794Methods and sequences to suppress primate Huntington gene expression
#10795MICRO-RNA REGULATION IN ISCHEMIA AND ISCHEMIA-REPERFUSION INJURY
#10796Ovary tumor markers and methods of use thereof
#10797SMOCI, TENASCIN-C AND BRAIN CANCERS
#10798COMPOSITION COMPRISING INHIBITORS OF IRS-1 AND OF VEGF
#10799Inhibition of P21 and Use Thereof for Inducing Tissue Regeneration
#10800TRANSGENIC PLANT MALE STERILITY