ClassID:

109054

C12N15/1137 - page 5 - CPC Classification

Classification description:

Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides against enzymes

Recent Application in this class:
#1201
20200289437
2020-09-17

Compositions for Modulating Cancer Stem Cells and Uses Therefor

#1202
20200283801
2020-09-10

Exosomal loading using hydrophobically modified oligonucleotides

#1203
20200283775
2020-09-10

Methods and compositions for inhibiting expression of LDHA

#1204
20200281501
2020-09-10

METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS

#1205
20200277611
2020-09-03

PRESERVATION OF THE NEUROMUSCULAR JUNCTION AFTER TRAUMATIC NERVE INJURY

#1206
20200277610
2020-09-03

Compositions and methods for inhibiting expression of RRM2 genes

#1207
20200277609
2020-09-03

METHOD OF OPTIMIZING COMPOUND SYNTHESIS REACTION BASED ON METABOLIC REACTION

#1208
20200277607
2020-09-03

RNA targeting of mutations via suppressor tRNAs and deaminases

#1209
20200277404
2020-09-03

COMPOSITIONS AND METHODS FOR REGULATION OF IMMUNE CELL ACTIVATION AND PROLIFERATION

#1210
20200276263
2020-09-03

Treatments of oxidative stress conditions

#1211
20200276223
2020-09-03

Compositions and methods for treatment of sepsis-related disorders

#1212
20200270692
2020-08-27

PREDICTING AGE-RELATED MACULAR DEGENERATION WITH SINGLE NUCLEOTIDE POLYMORPHISMS WITHIN OR NEAR THE GENES FOR COMPLEMENT COMPONENT C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715

#1213
20200270615
2020-08-27

siRNA compositions that specifically down regulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease

#1214
20200270614
2020-08-27

RNAi-BASED THERAPEUTICS FOR TARGETING HTRA1 AND METHODS OF USE

#1215
20200270607
2020-08-27

Methods and compositions for selecting siRNA of improved functionality

#1216
20200270588
2020-08-27

GLUCOSYL TRANSFERASE POLYPEPTIDES AND METHODS OF USE

#1217
20200268785
2020-08-27

METHOD FOR PREVENTING ORAL CANCER

#1218
20200263185
2020-08-20

Combination therapy of lymphoma

#1219
20200263184
2020-08-20

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING CANCER, CONTAINING MALATE-ASPARTATE SHUTTLE INHIBITOR AND ANTICANCER DRUG AS ACTIVE INGREDIENTS

#1220
20200263183
2020-08-20

Complement component iRNA compositions and methods of use thereof

#1221
20200263180
2020-08-20

RNA targeting of mutations via suppressor tRNAs and deaminases

#1222
20200263179
2020-08-20

COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF LPA

#1223
20200263176
2020-08-20

Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes

#1224
20200255839
2020-08-13

Method for treating a neurological disorder comprising administering ASM inhibitors

#1225
20200255838
2020-08-13

Selenium Cancer Therapy

#1226
20200255833
2020-08-13

Therapeutic compositions

#1227
20200255527
2020-08-13

Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy

#1228
20200254070
2020-08-13

Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors

#1229
20200248188
2020-08-06

POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF

#1230
20200248187
2020-08-06

SOD1 dual expression vectors and uses thereof

#1231
20200248186
2020-08-06

Antisense oligomers targeting PCSK9

#1232
20200247896
2020-08-06

Human antibodies to the human glucagon receptor and methods of use thereof to lower blood glucose or ketone levels

#1233
20200246313
2020-08-06

METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER

#1234
20200239596
2020-07-30

Extracellular matrix-producing composition using MAST4 gene and preparation method therefor

#1235
20200237929
2020-07-30

Gene therapy treatment of atrial fibrillation

#1236
20200237762
2020-07-30

USE OF RNAI INHIBITING PARP ACTIVITY FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF CANCER

#1237
20200237663
2020-07-30

Method and composition for targeted delivery of therapeutic agents

#1238
20200231704
2020-07-23

Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities

#1239
20200225215
2020-07-16

SCREENING METHOD FOR SELECTED AMINO-LIPID-CONTAINING COMPOSITIONS

#1240
20200224203
2020-07-16

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES, THE HCHWA-D MUTATION, AND TRINUCLEOTIDE REPEAT EXPANSIONS

#1241
20200224202
2020-07-16

Immunosuppression-reverting oligonucleotides inhibiting the expression of CD39

#1242
20200224200
2020-07-16

MODULATION OF IMMUNE RESPONSE THROUGH STIMULATOR OF INTERFERON GENES

#1243
20200223895
2020-07-16

Therapeutic targeting of SET1B/compass pathway for treating cancers

#1244
20200222444
2020-07-16

Methods of inhibiting cell proliferation and METTL8 activity

#1245
20200216564
2020-07-09

Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities

#1246
20200215032
2020-07-09

Methods and compositions for improving exercise endurance, performance, or tolerance

#1247
20200209264
2020-07-02

PIP2 AS A MARKER FOR HDL FUNCTION AND CARDIOVASCULAR DISEASE RISK

#1248
20200208158
2020-07-02

Products and compositions

#1249
20200207872
2020-07-02

METHODS FOR TREATING INFLAMMATION AND RELATED DISEASES AND DISORDERS BY INHIBITING ALPHA PROTEIN KINASE 1

#1250
20200206304
2020-07-02

METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY THROUGH MULTIPLE BIO BARRIERS

#1251
20200206188
2020-07-02

COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO

#1252
20200199597
2020-06-25

Modulatory polynucleotides

#1253
20200197527
2020-06-25

Nucleic acid-loaded unit polyion complex

#1254
20200197525
2020-06-25

Modulators of PCSK9 expression

#1255
20200197415
2020-06-25

Methods and compositions for the treatment of obesity

#1256
20200190523
2020-06-18

PKLR inhibition in the treatment of NAFLD and HCC

#1257
20200190522
2020-06-18

COMPOUNDS AND METHODS FOR MODULATING TMPRSS6 EXPRESSION

#1258
20200188431
2020-06-18

GLUTAMINE DEHYDROGENASE INHIBITORS FOR USE IN MUSCLE REGENERATION

#1259
20200181614
2020-06-11

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#1260
20200172911
2020-06-04

USP30 INHIBITORS AND METHODS OF USE

#1261
20200172910
2020-06-04

Methods of treating neurodegenerative disease by inhibiting N-deacetylase N-sulfotransferase

#1262
20200172909
2020-06-04

Ketohexokinase (KHK) iRNA compositions and methods of use thereof

#1263
20200171132
2020-06-04

METHODS OF INHIBITING FUNGAL CERAMIDE SYNTHASE FOR TREATMENT OF CRYPTOCOCCUS NEOFORMANS INFECTION

#1264
20200165681
2020-05-28

GENES AND POLYMORPHISMS ASSOCIATED WITH AGE RELATED MACULAR DEGENERATION (AMD)

#1265
20200165618
2020-05-28

Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

#1266
20200165616
2020-05-28

Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression

#1267
20200165605
2020-05-28

Mammalian cells for producing a secreted protein

#1268
20200163988
2020-05-28

Immunosuppression-Reverting Oligonucleotides Inhibiting the Expression of IDO

#1269
20200157556
2020-05-21

Polypeptides having beta-xylosidase activity and polynucleotides encoding same

#1270
20200157549
2020-05-21

Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy

#1271
20200157548
2020-05-21

COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS

#1272
20200157547
2020-05-21

Compositions and methods of treating amyotrophic lateral sclerosis (ALS)

#1273
20200157546
2020-05-21

ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION

#1274
20200157545
2020-05-21

Oligonucleotide compositions and methods of use thereof

#1275
20200149049
2020-05-14

METHODS AND COMPOSITIONS RELATING TO ANTI-CALCIFICATION

#1276
20200149048
2020-05-14

Transbiotic Regulation of Bacterial Gene Expression

#1277
20200149047
2020-05-14

MODULATORS OF COMPLEMENT FACTOR B

#1278
20200147123
2020-05-14

Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

#1279
20200146988
2020-05-14

Nano-liposome carrier composition containing hybrid of Cas9 protein and guide RNA

#1280
20200140871
2020-05-07

Methods and compositions for treating a proprotein convertase subtilisin kexin (PCSK9) gene-associated disorder

#1281
20200140870
2020-05-07

Fidgetin-like 2 as a target to enhance wound healing

#1282
20200140869
2020-05-07

Modulators of PNPLA3 expression

#1283
20200140868
2020-05-07

COMPOSITIONS AND METHODS FOR TREATING CANCER

#1284
20200140867
2020-05-07

Compositions and methods for the treatment of myotonic dystrophy

#1285
20200138955
2020-05-07

Lipid compositions

#1286
20200138846
2020-05-07

Enzymatic replacement therapy and antisense therapy for Pompe disease

#1287
20200131517
2020-04-30

Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a Sirtuin (SIRT)

#1288
20200131513
2020-04-30

Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher factor) 1 (KLKB1), and kininogen 1 (KNG1) iRNA compositions and methods of use thereof

#1289
20200129596
2020-04-30

m6A mRNA MODIFICATION IN CANCER TREATMENT

#1290
20200129523
2020-04-30

SHIP INHIBITION TO INDUCE EXPRESSION OF GRANULOCYTE COLONY STIMULATING FACTOR IN A SUBJECT

#1291
20200123550
2020-04-23

siRNA Targeting LDHA

#1292
20200123549
2020-04-23

Enhanced organogenesis through manipulation of LIN28/LET-7/DIS3L2

#1293
20200121642
2020-04-23

Methods and pharmaceutical compositions for the treatment of diseases associated with reduced CFTR function

#1294
20200116726
2020-04-16

PANCREATIC CANCER TARGETS AND USES THEREOF

#1295
20200113832
2020-04-16

NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY

#1296
20200108089
2020-04-09

Gemcitabine Derivatives for Cancer Therapy

#1297
20200102565
2020-04-02

Methods for overcoming glucocorticoid resistance and for determining glucocorticoid resistance potential in cancer

#1298
20200094031
2020-03-26

TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A CHST15 INHIBITOR

#1299
20200093838
2020-03-26

METHODS FOR TREATING AND PREVENTING ALLERGIES AND ACUTE ALLERGIC RESPONSES

#1300
20200080159
2020-03-12

TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON-SMALL CELL LUNG CARCINOMA

#1301
20200080091
2020-03-12

Methods for Treating Obesity of a Subject Suffering from Obesity

#1302
20200080090
2020-03-12

SELF-LIMITING CAS9 CIRCUITRY FOR ENHANCED SAFETY (SLICES) PLASMID AND LENTIVIRAL SYSTEM THEREOF

#1303
20200071702
2020-03-05

Engineered immunostimulatory bacterial strains and uses thereof

#1304
20200063140
2020-02-27

Methods of treating cancer harboring hemizygous loss of TP53

#1305
20200063139
2020-02-27

Prevention and/or treatment of inflammatory skin disease

#1306
20200063130
2020-02-27

CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF

#1307
20200062862
2020-02-27

METHODS AND COMPOSITIONS FOR PROGNOSIS, DIAGNOSIS, AND TREATMENT OF ADAM8-EXPRESSING CANCER

#1308
20200061197
2020-02-27

Amine-containing transfection reagents and methods for making and using same

#1309
20200057052
2020-02-20

Oligonucleotides for inducing paternal UBE3A expression

#1310
20200056185
2020-02-20

COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION

#1311
20200056151
2020-02-20

Agents and methods for treating and preventing seborrheic keratosis

#1312
20200054640
2020-02-20

METHOD AND KITS FOR IDENTIFYING OF CDK9 INHIBITORS FOR THE TREATMENT OF CANCER

#1313
20200054638
2020-02-20

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitors for prevention and/or treatment of lung injury and/or inflammation

#1314
20200048638
2020-02-13

COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION

#1315
20200048615
2020-02-13

Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells

#1316
20200040342
2020-02-06

Compositions for modulating SOD-1 expression

#1317
20200040341
2020-02-06

Modulators of diacyglycerol acyltransferase 2 (DGAT2)

#1318
20200032351
2020-01-30

COMPOSITIONS, METHODS AND KITS FOR CHARACTERIZING AND SCREENING FOR SMALL CELL OVARIAN CARCINOMA

#1319
20200032346
2020-01-30

Methods of treating cancers containing fusion genes

#1320
20200032293
2020-01-30

NUCLEIC ACID DELIVERY CARRIER, NUCLEIC ACID DELIVERY KIT, AND NUCLEIC ACID DELIVERY METHOD

#1321
20200032270
2020-01-30

NUCLEIC ACID CAPABLE OF INHIBITING EXPRESSION OF MASP2

#1322
20200032269
2020-01-30

GENETICALLY MODIFIED CELL LINES FOR METABOLIC STUDIES

#1323
20200032268
2020-01-30

Treatment of CNS injury with RNAi therapeutics

#1324
20200032263
2020-01-30

Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene

#1325
20200032256
2020-01-30

RAAV-based compositions and methods for treating amyotrophic lateral sclerosis

#1326
20200032231
2020-01-30

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same

#1327
20200031950
2020-01-30

Lin28-mediated control of let-7 biogenesis

#1328
20200031906
2020-01-30

Methods of treating cancer by administering inhibitory RNA molecules targeting protease serine 2 (PRSS2) expression

#1329
20200022957
2020-01-23

KINASE AND UBIQUITIN LIGASE INHIBITORS AND USES THEREOF

#1330
20200009185
2020-01-09

METHOD FOR MAINTAINING INCREASED INTRACELLULAR p53 LEVEL, INDUCED BY PLATINUM-BASED ANTICANCER DRUG, AND APPLICATION THEREOF

#1331
20200009180
2020-01-09

METHODS OF TREATING ALZHEIMER'S DISEASE

#1332
20200002705
2020-01-02

Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA

#1333
20200000839
2020-01-02

Modulation of Factor 11 expression

#1334
20190390232
2019-12-26

Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control

#1335
20190390216
2019-12-26

P-coumaroyl-CoA:monolignol transferase

#1336
20190390203
2019-12-26

REDUCTION OF LIPASE ACTIVITY IN PRODUCT FORMULATIONS

#1337
20190390202
2019-12-26

Methods and compositions of short small hairpin RNAs and microRNAs for wound healing

#1338
20190390201
2019-12-26

Interfering RNA molecules

#1339
20190389969
2019-12-26

NTRK2 FUSIONS

#1340
20190388457
2019-12-26

Prognostic methods and systems of treatment for acute lymphoblastic leukemia

#1341
20190388456
2019-12-26

Methods and compositions for the activation of gamma-delta T-cells

#1342
20190388397
2019-12-26

Compositions and methods for the treatment and prevention of neurological disorders

#1343
20190382851
2019-12-19

Methods for sub-typing and treating cancer

#1344
20190382829
2019-12-19

Method for Identification of Sensitivity of a Patient to Telomerase Inhibition Therapy

#1345
20190382771
2019-12-19

Asymmetric siRNA for inhibiting expression of male pattern hair loss target gene

#1346
20190382770
2019-12-19

RNAi FOR THE CONTROL OF FUNGI AND OOMYCETES BY INHIBITING SACCHAROPINE DEHYDROGENASE GENE

#1347
20190382769
2019-12-19

K-RAS gene expression-suppressing siRNA, precursor of same, and applications thereof

#1348
20190382736
2019-12-19

Compositions and methods for treating and preventing pancreatitis, renal injury and cancer

#1349
20190381125
2019-12-19

Methods of Treating Angiogenesis-Related Disorders Using JNK3 Inhibitors

#1350
20190376064
2019-12-12

Genetic and pharmacological transcriptional upregulation of the repressed FXN gene as a therapeutic strategy for Friedreich ataxia

#1351
20190376063
2019-12-12

MUCOSAL HEALING PROMOTER

#1352
20190376062
2019-12-12

siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof

#1353
20190374578
2019-12-12

Car t-cells comprising inactivated CBL and CBL-B genes

#1354
20190367926
2019-12-05

Methods and compositions for treating malignant tumors associated with KRAS mutation

#1355
20190365754
2019-12-05

METHOD OF ELIMINATING STEM CELLS

#1356
20190365734
2019-12-05

Compositions and methods for hemoglobin production

#1357
20190365679
2019-12-05

Compositions and methods for regulating body weight and metabolic syndromes

#1358
20190359984
2019-11-28

Compositions and methods for inhibiting gene expression of factor XII

#1359
20190358170
2019-11-28

Lipids and lipid compositions for the delivery of active agents

#1360
20190352646
2019-11-21

STEAP2 inhibitors for the treatment of liver cancers

#1361
20190345573
2019-11-14

Methods and Compositions for Selecting siRNA of Improved Functionality

#1362
20190345500
2019-11-14

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR MODULATING STEM CELLS PROLIFERATION OR DIFFERENTIATION

#1363
20190338290
2019-11-07

TREATMENT OF SARCOMA

#1364
20190338289
2019-11-07

Compositions and methods for reactivating latent immunodeficiency virus

#1365
20190338288
2019-11-07

MODULATION OF TMPRSS6 EXPRESSION

#1366
20190336462
2019-11-07

USE OF HYDROGEN SULFIDE SYNTHESIS INHIBITORS FOR CANCER THERAPY

#1367
20190330638
2019-10-31

Methods and materials for treating cancer

#1368
20190330637
2019-10-31

SUGAR CHAIN-RELATED GENE AND USE THEREOF

#1369
20190330636
2019-10-31

RNAI THERAPIES FOR CEREBRAL ISCHEMIA

#1370
20190330625
2019-10-31

Consequences of a defective switch in cutaneous squamous cell carcinoma

#1371
20190328761
2019-10-31

METHODS FOR ENHANCING VASCULAR DENSITY

#1372
20190328758
2019-10-31

Methods of treating mitochondrial dysfunction

#1373
20190323015
2019-10-24

SiRNA structures for high activity and reduced off target

#1374
20190323014
2019-10-24

Therapeutic inhibition of lactate dehydrogenase and agents therefor

#1375
20190316139
2019-10-17

Methods and Compositions for Selecting siRNA of Improved Functionality

#1376
20190316138
2019-10-17

Oligonucleotide compositions with enhanced efficiency

#1377
20190316128
2019-10-17

DELIVERY OF dsRNA TO ARTHROPODS

#1378
20190316126
2019-10-17

RAAV-based compositions and methods for treating amyotrophic lateral sclerosis

#1379
20190310244
2019-10-10

Oligonucleotides for inducing paternal UBE3A expression

#1380
20190309305
2019-10-10

Allele-specific silencing therapy for Dynamin 2-related diseases

#1381
20190309304
2019-10-10

Antisense compounds targeting Leucine-Rich repeat kinase 2(LRRK2) for the treatment of Parkinsons disease

#1382
20190309303
2019-10-10

Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene

#1383
20190309302
2019-10-10

Antisense oligonucleotides

#1384
20190309301
2019-10-10

Compositions and methods for improving immune system function

#1385
20190309300
2019-10-10

Inhibitors of cytoplasmic histone deacetylase 4 complex for treating or preventing vascular or valve calcification

#1386
20190309297
2019-10-10

Methods and compositions for the treatment of cancer

#1387
20190309032
2019-10-10

Recombinant protein-based method for the delivery of silencer RNA to target the brain

#1388
20190307929
2019-10-10

Compositions and methods for reducing neointima formation

#1389
20190307809
2019-10-10

Methods and compositions for in vivo induction of pancreatic beta cell formation

#1390
20190300886
2019-10-03

Visceral adipose tissue macrophage-targeted gene/carrier complex for preventing or treating obesity-induced type II diabetes

#1391
20190300885
2019-10-03

A NOVEL ROLE FOR TERMINAL RNA URIDYLATION AND RNA TURNOVER IN ONCOGENESIS

#1392
20190298747
2019-10-03

Methods for treatment of cancer by targeting SIRT5

#1393
20190298715
2019-10-03

IMMUNE EFFECTOR CELL THERAPIES WITH ENHANCED EFFICACY

#1394
20190290780
2019-09-26

Compositions and methods for mitochondrial genome editing

#1395
20190290779
2019-09-26

Composition for gene therapy or transfection, and preparation method and use thereof

#1396
20190284563
2019-09-19

Fidgetin-like 2 as a target to enhance wound healing

#1397
20190284562
2019-09-19

TMPRSS6 iRNA compositions and methods of use thereof

#1398
20190284555
2019-09-19

Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene

#1399
20190282639
2019-09-19

Viral vectors for treating Parkinson's disease

#1400
20190282552
2019-09-19

Treatment of synucleinopathies

#1401
20190277844
2019-09-12

Disruption of EGFR-SAR1 interaction for cancer treatment

#1402
20190276849
2019-09-12

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#1403
20190276848
2019-09-12

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#1404
20190276833
2019-09-12

CANCER TREATMENT BY GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1 INHIBITION

#1405
20190276832
2019-09-12

Compounds and methods for modulation of dystrophia myotonica-protein kinase (DMPK) expression

#1406
20190276826
2019-09-12

RAAV-based compositions and methods for treating amyotrophic lateral sclerosis

#1407
20190275148
2019-09-12

CAMK2D antisense oligonucleotides and uses thereof

#1408
20190270997
2019-09-05

Inhibition of KMT2D for the treatment of cancer

#1409
20190270796
2019-09-05

THERAPEUTIC AGENT FOR PERIODONTITIS AND COMPOSTION FOR TREATING PERIODONTITIS

#1410
20190269670
2019-09-05

Compounds and methods of promoting myelination

#1411
20190264230
2019-08-29

Agents for improved delivery of nucleic acids to eukaryotic cells

#1412
20190264212
2019-08-29

Inhibiting microRNA to prevent development of essential hypertension

#1413
20190264211
2019-08-29

Modulation of gene expression and screening for deregulated protein expression

#1414
20190264210
2019-08-29

Compound and method for treating myotonic dystrophy

#1415
20190264207
2019-08-29

Therapeutic compositions

#1416
20190262377
2019-08-29

METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS

#1417
20190256858
2019-08-22

AAV delivery of shRNA for treatment of pancreatic cancer

#1418
20190256857
2019-08-22

Cancer-treating pharmaceutical composition inhibiting expression of CCND3 or PAK2 gene

#1419
20190256856
2019-08-22

Methods of modulating melanosome pH and melanin level in cells

#1420
20190256855
2019-08-22

COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES

#1421
20190249179
2019-08-15

Fibrotic treatment

#1422
20190249175
2019-08-15

Antisense compounds and uses thereof

#1423
20190249159
2019-08-15

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same

#1424
20190247420
2019-08-15

Compounds and methods for reducing ATXN3 expression

#1425
20190247413
2019-08-15

COMPOSITIONS AND METHODS FOR TREATING CANCER AND BIOMARKERS TO DETECT CANCER STEM CELL REPROGRAMMING AND PROGRESSION

#1426
20190241906
2019-08-08

IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES

#1427
20190241897
2019-08-08

Antisense oligonucleotides useful in treatment of Pompe disease

#1428
20190241896
2019-08-08

Modulators of DNM2 expression

#1429
20190240339
2019-08-08

Lipid formulations for delivery of therapeutic agents

#1430
20190233829
2019-08-01

Methods and compositions for selecting siRNA of improved functionality

#1431
20190233828
2019-08-01

Methods of treating a wound using epigenetic regulation

#1432
20190233827
2019-08-01

Modulation of prekallikrein (PKK) expression

#1433
20190233821
2019-08-01

RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)

#1434
20190231761
2019-08-01

COMPOSITIONS AND METHODS FOR TARGETING FRUCTOSE ENZYMES AND TRANSPORTERS FOR THE TREATMENT OF CANCER

#1435
20190225684
2019-07-25

REDUCING CUTANEOUS SCAR FORMATION AND TREATING SKIN CONDITIONS

#1436
20190218558
2019-07-18

Therapeutic compositions and methods of making and using the same

#1437
20190218557
2019-07-18

INHIBITION OF PCSK9 THROUGH RNAI

#1438
20190218549
2019-07-18

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#1439
20190216857
2019-07-18

DELIVERY OF NUCLEIC ACIDS, PROTEINS AND SMALL MOLECULES IN VITREOUS VESICULAR BODIES

#1440
20190216846
2019-07-18

Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

#1441
20190216845
2019-07-18

Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof

#1442
20190211341
2019-07-11

TMPRSS6 iRNA compositions and methods of use thereof

#1443
20190211340
2019-07-11

Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA

#1444
20190211339
2019-07-11

Modulators of telomere disease

#1445
20190211337
2019-07-11

Neutral nanotransporters

#1446
20190209618
2019-07-11

METHODS AND COMPOSITIONS FOR EXPANSION OF HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS EMPLOYING A CYTOCHROME P450 1B1 (CYP1B1) INHIBITOR OR A MUSASHI-2 (MSI2) ACTIVATOR

#1447
20190209603
2019-07-11

Modulation of PCSK9 and LDLR through DRP1 inhibition

#1448
20190209570
2019-07-11

Methods and Pharmaceutical Compositions for Treating Lymphoid Malignancy

#1449
20190203304
2019-07-04

METHOD FOR PREDICTING RESPONSIVENESS TO PHOSPHATIDYLSERINE SYNTHASE 1 INHIBITOR

#1450
20190203210
2019-07-04

Increasing ATOH1 life to drive sensorineural hair cell differentiation

#1451
20190203207
2019-07-04

Anabolic Enhancers for Ameliorating Neurodegeneration

#1452
20190194768
2019-06-27

PAPD5 and PAPD7 inhibitors for treating a hepatitis B infection

#1453
20190194689
2019-06-27

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#1454
20190194688
2019-06-27

CNS TARGETING AAV VECTORS AND METHODS OF USE THEREOF

#1455
20190194685
2019-06-27

Nucleus-encoded male sterility through mutation in cytochrome P450 oxidase

#1456
20190194666
2019-06-27

Modulation of GYS1 expression

#1457
20190194665
2019-06-27

Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA

#1458
20190194664
2019-06-27

Use of Rad18 inhibitors in the treatment of tumors

#1459
20190194661
2019-06-27

Natural cryptic exon removal by pairs of antisense oligonucleotides

#1460
20190194658
2019-06-27

RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)

#1461
20190192551
2019-06-27

Pharmaceutical composition containing mTOR inhibitor for treating macular degeneration

#1462
20190192533
2019-06-27

INHIBITION OF HISTONE METHYLTRANSFERASE FOR CARDIAC REPROGRAMMING

#1463
20190185942
2019-06-20

PIK3CA fusions

#1464
20190185851
2019-06-20

EXOSOME SECRETION INHIBITOR

#1465
20190185848
2019-06-20

Means and methods for modifying multiple alleles

#1466
20190185820
2019-06-20

Compositions and Methods for Inhibiting Stem Cell Aging

#1467
20190177751
2019-06-13

Production of itaconic acid

#1468
20190177433
2019-06-13

Method of screening a candidate compound for activity as an elastase 2A (ELA2A) inhibitor

#1469
20190177289
2019-06-13

Aminoalcohol lipidoids and uses thereof

#1470
20190169639
2019-06-06

CRISPR-related methods and compositions with governing gRNAs

#1471
20190169619
2019-06-06

Use of MIR101 or MIR128 in the treatment of seizure disorders

#1472
20190169618
2019-06-06

Nucleic acids and methods for the treatment of Pompe disease

#1473
20190169608
2019-06-06

Modified RNAi polynucleotides and uses thereof

#1474
20190167795
2019-06-06

Conjugated lipomers and uses thereof

#1475
20190161757
2019-05-30

Reduced size self-delivering RNAI compounds

#1476
20190160184
2019-05-30

Means and methods to treat dystonia

#1477
20190153452
2019-05-23

Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy

#1478
20190153450
2019-05-23

Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides

#1479
20190153443
2019-05-23

METHODS FOR INCREASING EFFICACY OF LIPID FORMULATED siRNA

#1480
20190153038
2019-05-23

Method for significantly increasing lentiviral production

#1481
20190151321
2019-05-23

Treatment and prevention of atherothrombosis by inhibition of bruton's tyrosine kinase (BTK)

#1482
20190144870
2019-05-16

Compositions and methods for inhibiting expression of the ALAS1 gene

#1483
20190144869
2019-05-16

Allele-specific gene suppression

#1484
20190144868
2019-05-16

Products and methods for treatment of familial amyotrophic lateral sclerosis

#1485
20190144867
2019-05-16

METHOD FOR MITIGATING METASTASIS

#1486
20190144552
2019-05-16

Nucleic acid molecules encoding antibodies to the human glucagon receptor

#1487
20190142868
2019-05-16

METHODS OF TREATING DISEASES ASSOCIATED WITH ILC3 CELLS

#1488
20190136243
2019-05-09

Method for preventing or treating obesity by using a composition including HOGA1-inhibiting substance and method of screening a preventive or therapeutic agent for obesity by using the composition

#1489
20190136238
2019-05-09

Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer

#1490
20190127740
2019-05-02

Targeting the Steroidogenic Pathway For Treating and/or Preventing Allergic Diseases

#1491
20190125829
2019-05-02

METHOD FOR PREVENTING OBESITY-INDUCED FATTY LIVER BY INHIBITING KCTD17

#1492
20190119685
2019-04-25

Compositions and methods for inhibiting expression of TMPRSS6 gene

#1493
20190119684
2019-04-25

Methods for improving cognitive function via modulation of quinone reductase 2

#1494
20190119683
2019-04-25

Single-stranded oligonucleotide

#1495
20190117794
2019-04-25

Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides

#1496
20190117642
2019-04-25

Targeting AMP deaminase 2 for ameliorating craving for sugar and other substances

#1497
20190112607
2019-04-18

Cancer therapy

#1498
20190112358
2019-04-18

DNA-binding domain of CRISPR system, non-fucosylated and partially fucosylated proteins, and methods thereof

#1499
20190111073
2019-04-18

Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

#1500
20190106755
2019-04-11

Methods for identifying polymorphisms linked to the PPO11 gene