109054 ⎘
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor; Recombinant DNA-technology; DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides against enzymes
ANTI-TUMOR THERAPY
#1802USE OF AGENTS FOR TREATING FAT-RELATED DISORDERS
#1803LATS AND BREAST CANCER
#1804Oligonucleotide targeted to the A20-3′ untranslated region
#1805RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#1806RNA interference agents for p21 gene modulation
#1807PLASMIDS COMPRISING INTERNAL RIBOSOMAL ENTRY SITES AND USES THEREOF
#1808Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
#1809ANTI-INFLUENZA VIRUS AGENT AND SCREENING METHOD FOR ANTI-INFLUENZA VIRUS AGENT
#1810Polypeptides having beta-xylosidase activity and polynucleotides encoding same
#1811Compositions and methods for diagnosis and treatment of prostate cancer
#1812KRAS nucleic acids and uses thereof
#1813Therapeutic compositions
#1814Methods and compositions for the treatment of cancer
#1815Antisense design
#1816Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting NOX-1
#1817Method and treatment of recurring endometrial cancer with an inhibitor of USP14
#1818DIAGNOSTIC AND THERAPEUTIC TARGETING OF DNMT-1 ASSOCIATED RNA IN HUMAN CANCER
#1819Approach for treatment of cancer via immunomodulation by using talabostat
#1820Compositions for modulating cancer stem cells and uses therefor
#1821Methods for sub-typing and treating cancer
#1822MUCOSAL HEALING PROMOTER
#1823Delivery of dsRNA to arthropods
#1824Bacterially derived intact minicells that encompass plasmid free DNA and methods of using the same
#1825COMPOSITIONS AND METHODS OF SELECTIVELY INHIBITING IRP1 AND TREATING INFLAMMATION
#1826Interfering RNA molecules
#1827CDC25A inhibitor for the treatment of drug resistant cancer or for the prevention of tumor relapse
#1828Methods and pharmaceutical compositions for the treatment of erythropoietic protoporphyria
#1829Antisense oligonucleotides useful in treatment of Pompe disease
#1830Interfering RNA molecules
#1831Interfering RNA molecules
#1832Interfering RNA molecules
#1833Polyol-based osmotic polydixylitol polymer gene transporter and use thereof
#1834Methods and Pharmaceutical Compositions for Treating Lymphoid Malignancy
#1835MAP3K8 AS A MARKER FOR SELECTING A PATIENT AFFECTED WITH AN OVARIAN CANCER FOR A TREATMENT WITH A MEK INHIBITOR
#1836PREDICTING AMD WITH SNPS WITHIN OR NEAR C2, FACTOR B, PLEKHA1, HTRA1, PRELP, OR LOC387715
#1837Modulation of breast cancer growth by modulation of XBP1 activity
#1838Method and composition for the treatment, prevention, and diagnosis of cancer containing or derived from cancer stem cells
#1839VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES
#1840Compositions and methods for enhancing cardiac function in the neonate
#1841BIOLOGICALLY ACTIVE NUCLEOTIDE MOLECULES FOR SELECTIVELY KILLING OFF CELLS, USE THEREOF, AND APPLICATION KIT
#1842Treatment of disease by modulation of SIRT6
#1843Compositions for controlling mites in bees
#1844Antisense oligonucleotide directed removal of proteolytic cleavage sites, the HCHWA-D mutation, and trinucleotide repeat expansions
#1845PME-1 as a biomarker to predict and diagnose an increased risk of endometrial cancer and gene silencing of PME-1 to inhibit epithelial to mesenchymal transition
#1846METHODS OF TREATING ISCHEMIA-REPERFUSION INJURY WITH siRNAS
#1847PREVENTION OF TUMOUR METASTASIS BY INHIBITION OF NECROPTOSIS
#1848Nucleic acid aptamers
#1849METHOD OF PRODUCING LEUKOCYTES USING PTPN2 INHIBITION FOR ADOPTIVE CELL TRANSFER
#1850Screening method
#1851PANCREATIC CANCER TARGETS AND USES THEREOF
#1852Methods for preparing pecific polypeptide-binding antibodies
#1853DELIVERY MOLECULES FOR THERAPEUTICS
#1854Methods and compositions for inhibiting growth and epithelial to mesenchymal transition (EMT) in cancer cells
#1855BARD1 isoforms in lung and colorectal cancer and use thereof
#1856Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof
#1857dsRNA for treating viral infection
#1858Method for controlling obesity using minimally invasive means
#1859Method for controlling obesity using minimally invasive means
#1860Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
#1861Aminoalcohol lipidoids and uses thereof
#1862LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
#1863Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
#1864COMPOSITIONS AND METHODS OF USING SAME FOR INCREASING RESISTANCE OF INFECTED MOSQUITOES
#1865Oligonucleotides for inducing paternal UBE3A expression
#1866Targeting the steroidogenic pathway for treating and/or preventing allergic diseases
#1867Bruton's tyrosine kinase as anti-cancer drug target
#1868Exosomal loading using hydrophobically modified oligonucleotides
#1869Compositions and methods for modulating PKK expression
#1870INHIBITING OR DOWNREGULATING GLYCOGEN SYNTHASE BY CREATING PREMATURE STOP CODONS USING ANTISENSE OLIGONUCLEOTIDES
#1871METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION
#1872Methods of treating cancer
#1873Exon skipping technology in VCP disease
#1874Inhibition of Bruton's tyrosine kinase (Btk) in the lung to treat severe lung inflammation and lung injury
#1875Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins
#1876Skin Permeating and Cell Entering (SPACE) Peptides and Methods of Use Thereof
#1877Method and kits for identifying of CDK9 inhibitors for the treatment of cancer
#1878Targeting peptides for directing adeno-associated viruses (AAVs)
#1879siRNA structures for high activity and reduced off target
#1880COMPOSITIONS AND METHODS FOR TARGETING O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE AND PROMOTING WOUND HEALING
#1881ANTISENSE OLIGONUCLEOTIDES AND METHODS OF USE THEREOF
#1882Compositions and methods for modulating complement factor B expression
#1883Method of reducing acetylation in plants to improve biofuel production
#1884Treatment of amyotrophic lateral sclerosis
#1885Ship inhibition to induce activation of natural killer cells
#1886Multicistronic expression constructs
#1887COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
#1888Double stranded RNA constructs for aphid control
#1889MIR-125A-5P AS A BIOMARKER FOR BREAST CANCER
#1890Pharmaceutical composition for preventing or treating neurodegenerative diseases
#1891LIPID FORMULATION
#1892Double strand RNA-mediated RNA interference through feeding detrimental to larval (gypsy moth)
#1893Compositions and methods for inhibiting expression of RRM2 genes
#1894Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
#1895Apoptosis inducer
#1896NEW TREATMENT AGAINST INFLUENZA VIRUS
#1897Inhibition of PCSK9 through RNAI
#1898Amine cationic lipids and uses thereof
#1899Methods for immortalization of epithelial cells
#1900Modified oligonucleotides for telomerase inhibition
#1901Human antibodies to the glucagon receptor and methods of use thereof for lowering blood glucose or ketone levels
#1902METHOD FOR PREPARING RECOMBINANT GLYCOPROTEIN HAVING HIGH SIALIC ACID CONTENT, THROUGH GLYCOSPHINGOLIPID SYNTHESIS CYCLE CONTROL
#1903SHIP INHIBITION TO INDUCE EXPRESSION OF GRANULOCYTE COLONY STIMULATING FACTOR IN A SUBJECT
#1904TRANSPOSABLE ELEMENTS, TDP-43, AND NEURODEGENERATIVE DISORDERS
#1905Algal mutants with increased lipid productivity
#1906Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
#1907RAAV-based compositions and methods for treating amyotrophic lateral sclerosis
#1908Ionizable cationic lipid for RNA delivery
#1909COMPOSITIONS, METHODS AND KITS FOR CHARACTERIZING AND SCREENING FOR SMALL CELL OVARIAN CARCINOMA
#1910Pharmaceutical composition for treating chronic kidney disease
#1911FUNGAL PROTEASES
#1912METHODS OF INHIBITING VIRAL REPLICATION COMPRISING THE SIGNAL PEPTIDASE COMPLEX
#1913Modulation of gene expression and screening for deregulated protein expression
#1914MicroRNA induction of cardiac regeneration
#1915INHIBITING GENE EXPRESSION WITH dsRNA
#1916Compositions and methods for inhibiting gene expression of LPA
#1917METHODS FOR TREATING AND PREVENTING ALLERGIES AND ACUTE ALLERGIC RESPONSES
#1918Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
#1919Methods for improving cognitive function via modulation of quinone reductase 2
#1920Polypeptides having peroxygenase activity
#1921Polypeptides Having Peroxygenase Activity
#1922Modulation of TMPRSS6 expression
#1923MELK Regulation for the Treatment of Breast Cancer
#1924SUGAR CHAIN-RELATED GENE AND USE THEREOF
#1925Compositions and methods for treating cancer, inhibiting cell proliferation, and inducing cell death
#1926Methods for Prediction of Clinical Response to Radiation Therapy in Cancer Patients
#1927RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of CAMP-related ocular disorders
#1928METHODS FOR TREATMENT OF DISORDERS IN THE FRONT OF THE EYE UTILIZING NUCLEIC ACID MOLECULES
#1929Composition for enhancing radiation sensitivity comprising PI4K isozyme inhibitor
#1930Compositions comprising a mitofusin inhibitor for promoting cell reprogramming and a use thereof
#1931P97-polynucleotide conjugates
#1932Targeting PARP1 for treatment of TSC and cancers
#1933PIK3CA FUSIONS
#1934Genetic alterations on chromosome 16 and methods of use thereof for the diagnosis and treatment of type 1 diabetes
#1935Polycomb-associated non-coding RNAs
#1936SiRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia
#1937Compositions and methods to promote erythropoiesis
#1938Methods for the treatment of Leber congenital amaurosis
#1939Linkage modified oligomeric compounds
#1940Methods for treating T-cell acute lymphoblastic leukemia
#1941USE OF CASEIN KINASE I INHIBITORS FOR DEPLETING STEM CELLS
#1942NOVEL LIPID FORMULATIONS FOR NUCLEIC ACID DELIVERY
#1943Modulation of pre-MRNA using splice modulating oligonucleotides as therapeutic agents in the treatment of disease
#1944Compositions for modulating SOD-1 expression
#1945Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
#1946Use of annexin A3 as a diagnostic and prognostic biomarker and therapeutic target for treating hepatocellular carcinoma
#1947MODULATION OF FACTOR 11 EXPRESSION
#1948Compositions and methods for controlling pests
#1949Method and compositions for controlling pest insects on plants by silencing genes of the chitin synthase and of the vitellogenin family, as well as alternatively by expressing the gene of a cry toxin
#1950Methods for eliminating or reducing the expression of genes in filamentous fungal strains by transitive RNA interference
#1951COMPOUNDS FOR TREATING, DELAYING AND/OR PREVENTING A HUMAN GENETIC DISORDER SUCH AS MYOTONIC DYSTROPHY TYPE I (DMI)
#1952MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer
#1953CaMKK-β as a target for treating cancer
#1954RNA complexes that inhibit melanin production
#1955Tools and Methods for Targeting Oligonucleotide Repeat RNA Toxicity
#1956Polycomb-associated non-coding RNAs
#1957Methods of modulating WARS2
#1958DDX5 AND ASSOCIATED NON-CODING RNAs AND MODULATION OF TH17 EFFECTOR FUNCTION
#1959Method of Treating Cancer by Inhibition of DNA Repair Proteins
#1960Induction of thyroid iodide-handling gene expression in human cancers
#1961SGK1 INHIBITORS FOR TREATMENT OF PROSTATE CANCER
#1962RNA interference in skin indications
#1963TREATMENT OF NEURODEGENERATIVE AND NEURODEVELOPMENTAL DISEASES BY INHIBITION OF THE a2-Na/K ATPase/a-ADDUCIN COMPLEX
#1964SiRNA targeting PRK2, which is hepatitis C virus therapeutic agent
#1965PROTEIN PHOSPHATASE INHIBITOR
#1966Modulation of prekallikrein (PKK) expression
#1967LIPID FORMULATED DSRNA TARGETING THE PCSK9 GENE
#1968Identification and use of target genes for control of plant parasitic nematodes
#1969Polycomb-associated non-coding RNAS
#1970Biocompatible flavonoid compounds for organelle and cell imaging
#1971METHODS AND COMPOSITIONS INVOLVING CHITOSAN NANOPARTICLES
#1972Polypeptides having peroxygenase activity
#1973COMPOSITIONS FOR BACTERIAL MEDIATED GENE SILENCING AND METHODS OF USING SAME
#1974Target point, preparation and method for treating human ADSL deficiency
#1975Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
#1976METHODS AND COMPOSITIONS FOR INHIBITING THE GROWTH AND/OR PROLIFERATION OF MYC-DRIVEN TUMOR CELLS
#1977COMPOSITIONS AND METHODS FOR THE TREATMENT AND MANAGEMENT OF STEATOSIS IN HUMAN LIVER
#1978Methods and compositions for neuroprotection
#1979REDUCTION OF TRAF1 LEVELS COMBINED WITH NUTRIENT STRESS FOR TREATING LYMPHOCYTE-RELATED CANCERS
#1980RNA POLYMERASE II33 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#1981Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
#1982Treatment of disease by modulation of SIRT6
#1983Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis
#1984Control of Varroa mite infestation
#1985Polycomb-associated non-coding RNAs
#1986Polycomb-associated non-coding RNAs
#1987Compositions and Methods for Inhibition of PCSK9 Genes
#1988Gamma-secretase inhibition reduce APOC3 levels and plasma triglycerides
#1989MUCOSAL HEALING PROMOTER
#1990Compositions and methods for inhibiting expression of the PCSK9 gene
#1991Antisense design
#1992NUCLEIC ACID CHEMICAL MODIFICATIONS
#1993POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA "CLICK" CHEMISTRY
#1994Treatment of neurological disorders
#1995Ketohexokinase (KHK) iRNA compositions and methods of use thereof
#1996MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer
#1997Imino compounds for amphoteric liposomes and uses thereof
#1998Method of diagnosis, prognostic or treatment of neurodegenerative disease
#1999METHODS FOR DELIVERY OF siRNA TO THE SPINAL CORD AND THERAPIES ARISING THEREFROM
#2000DOUBLE STRANDED RNA COMPOUNDS TO RHOA AND USE THEREOF
#2001Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
#2002Methods and compositions for weed control
#2003Methods and compositions for weed control
#2004Targeting WSB1 and pVHL to treat cancer
#2005Cationic lipid
#2006NOVEL FUSION GENES AS FACTORS RESPONSIBLE FOR GASTRIC CANCER
#2007Lipids and lipid compositions for the delivery of active agents
#2008Treating neurodegenerative disease
#2009Methods of polynucleotide preparation using multivalent cation salt compositions
#2010Reduction of lipase activity in product formulations
#2011SYSTEM FOR CO-DELIVERY OF POLYNUCLEOTIDES AND DRUGS INTO PROTEASE-EXPRESSING CELLS
#2012Dual Targeting siRNA Agents
#2013Double-stranded RNA compounds to CASP2 and uses thereof
#2014Nucleic acid inducing RNA interference modified for preventing off-target, and use thereof
#2015COMPOUNDS AND METHODS FOR MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
#2016METHODS FOR TREATMENT OF WOUND HEALING UTILIZING CHEMICALLY MODIFIED OLIGONUCLEOTIDES
#2017Immunotherapy of cancer
#2018Complement component iRNA compositions and methods of use thereof
#2019RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
#2020COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MYLIP/IDOL GENE
#2021Targeted augmentation of nuclear gene output
#2022Composition comprising a cell sample from a subject with scoliosis and a reagent for detecting PTPμ or PIPK1y
#2023Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related disease by inhibition of natural antisense transcript to PYCR1
#2024Small interference RNAs, uses thereof and method for inhibiting the expression of PLK1 gene
#2025Methods for identifying therapeutic targets and treating monitoring cancers
#2026Method of inhibiting macrophage activation using an inhibitor of PARP9
#2027Use of IKK epsilon inhibitors to activate NFAT and T cell response
#2028Breast cancer biomarkers and methods of using same
#2029Methods and compositions for interference with DNA polymerase and DNA synthesis
#2030MODULATION OF AXON DEGENERATION
#2031Compositions and methods for inhibiting gene expression of factor XII
#2032DNMT inhibitors
#2033PRODUCTS AND METHODS FOR TREATMENT OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS
#2034METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF ASSEMBLE IN CELLS AND PRODUCE RNAI ACTIVITY
#2035NTRK2 fusions
#2036Methods for treating hepatitis C virus infectious disease
#2037TYRP1, a natural miRNA sponge, and its use in managing human melanoma aggressiveness
#2038RNA POLYMERASE I1 NUCLEIC ACID MOLECULES TO CONTROL INSECT PESTS
#2039Dynamin 2 inhibitor for the treatment of centronuclear myopathies
#2040CELL DIFFERENTIATION MARKER AND ITS USES
#2041Compositions and Methods for Diagnosing and Treating Diseases and Disorders Associated With D-DT
#2042RNAi-MEDIATED INHIBITION OF SPLEEN TYROSINE KINASE-RELATED INFLAMMATORY CONDITIONS
#2043RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION
#2044POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS
#2045Interfering RNA delivery system and uses thereof
#2046TRANSGENIC TREES HAVING REDUCED XYLAN CONTENT
#2047COMPOSITIONS AND METHODS FOR TREATING CANCER AND MODULATING STRESS GRANULE FORMATION
#2048PIK3C2G fusions
#2049Antisense compounds targeting genes associated with cystic fibrosis
#2050Compositions and methods for inhibiting expression of the ALAS1 gene
#2051Reduced size self-delivering RNAI compounds
#2052RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#2053Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
#2054siRNA and their use in methods and compositions for inhibiting the expression of the PDK1 gene
#2055Modular RNA regulators and methods
#2056Compounds for inducing anti-tumor immunity and methods thereof
#2057Methods for Treating and Preventing Multiple Sclerosis
#2058Technology for the Preparation of Microparticles
#2059Methods for overcoming glucocorticoid resistance and for determining glucocorticoid resistance potential in cancer
#2060siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof
#2061MODULATORS OF COMPLEMENT FACTOR B
#2062Inhibition of ferrochelatase as an antiangiogenic therapy
#2063Anti-tumor therapy
#2064ATRX AS A COMPANION DIAGNOSTIC FOR CDK4 INHIBITORS
#2065Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis
#2066Cell-specific targeting using nanostructured delivery systems
#2067Translocation and mutant ROS kinase in human non-small cell lung carcinoma
#2068Nucleic acids and methods for the treatment of Pompe disease
#2069RNAi for the control of phytopathogenic fungi and oomycetes by inhibiting the expression of CYP51 genes
#2070Use of RHOA in cancer diagnosis and inhibitor screening
#2071Antisense Oligonucleotides Against Neutral Sphingomyelinase and Neutral Sphingomyelinase Inhibitor GW4869 for Degenerative Neurological Disorders
#2072Methods and means for treatment of osteoarthritis
#2073RNA interference agents for GST-PI gene modulation
#2074Antisense-induced exon2 inclusion in acid alpha-glucosidase
#2075Liposome for topical administration and application thereof
#2076RNA interference agents for P21 gene modulation
#2077RNA agents for P21 gene modulation
#2078RNA agents for GST-Pi gene modulation
#2079METHODS AND COMPOSITIONS FOR ENHANCING DELIVERY OF DOUBLE-STRANDED RNA OR A DOUBLE-STRANDED HYBRID NUCLEIC ACID TO REGULATE GENE EXPRESSION IN MAMMALIAN CELLS
#2080Conjugated lipomers and uses thereof
#2081Bruton's Tyrosine Kinase as Anti-Cancer Drug Target
#2082Methods and compositions for selecting siRNA of improved functionality
#2083COMPOSITIONS AND METHODS FOR MODULATING EXPRESSION OF FRATAXIN
#2084EPIGENETIC REGULATORS OF FRATAXIN
#2085Methods and compositions for selecting siRNA of improved functionality
#2086HDAC2 DEFENDS VASCULAR ENDOTHELIUM FROM INJURY
#2087Methods and Compositions for Inducing Deregulation of EPHA7 and ERK Phosphorylation in Human Acute Leukemias
#2088Methods for treating ischemia-reperfusion injury
#2089Methods of treating thyroid eye disease
#2090Methods and compositions for selecting siRNA of improved functionality
#2091Ligase E3 RNF185 inhibitors and uses thereof
#2092Method of enhancing miR-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell
#2093Compositions and methods for inhibiting gene expressions
#2094Novel linker, preparation method, and application thereof
#2095Methods and compositions for selecting siRNA of improved functionality
#2096Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
#2097Methods and Compositions for the Treatment of Prostate Related Disorders using miR-1
#2098Methods and compositions for treating malignant tumors associated with KRAS mutation
#2099RNA interference compositions and methods for malignant tumors
#2100Composition for reducing senescence of cell or subject comprising smurf2 inhibitor and use thereof