109162 ⎘
Structure or type of the nucleic acid; Chemical structure of the backbone Phosphorothioates
MicroRNA compounds and methods for modulating miR-21 activity
#2702Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
#2703Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
#2704Compositions and methods for treatment of prostate and other cancers
#2705Oligonucleotide-based inhibitors comprising locked nucleic acid motif
#2706Methods for treatment of alport syndrome
#2707FULLY STABILIZED ASYMMETRIC SIRNA
#2708Cell penetrating conjugates and methods of use thereof
#2709Modulation of huntingtin expression
#2710Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide
#2711SiRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene
#2712COMPOUNDS AND METHODS FOR MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION
#2713Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#2714METHODS FOR TREATMENT OF WOUND HEALING UTILIZING CHEMICALLY MODIFIED OLIGONUCLEOTIDES
#2715Compositions for modulating C9ORF72 expression
#2716Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
#2717Compositions of asymmetric interfering RNA and uses thereof
#2718MEANS AND METHODS FOR COUNTERACTING MUSCLE DISORDERS
#2719Complement component iRNA compositions and methods of use thereof
#2720RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
#2721Targeted augmentation of nuclear gene output
#2722Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions
#2723Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related disease by inhibition of natural antisense transcript to PYCR1
#2724APOB Antisense Conjugate Compounds
#2725Guide RNA with chemical modifications
#2726METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF MYC BY DOUBLE-STRANDED RNA
#2727PREVENTION OF VIRAL INFECTIVITY
#2728Modulation of T cell signaling threshold and T cell sensitivity to antigens
#2729Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisene transcript to CSF3
#2730Organic compositions to treat beta-ENaC-related diseases
#2731Compositions and methods for inhibiting gene expression of factor XII
#2732Compositions and methods for inhibiting JC virus (JCV)
#2733Disulfide-containing alkyne linking agents
#2734Targeting microRNA-26a/b for the treatment of neurodegenerative disease
#2735Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
#2736MODIFIED iRNA AGENTS
#2737OLIGONUCLEOTIDE COMPRISING AN INOSINE FOR TREATING DMD
#2738Compositions and methods for inhibiting expression of the LECT2 gene
#2739RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
#2740Compositions and Methods for Inhibiting Expression of Transthyretin
#2741Suicide contrast agents targeting HIV reservoirs for theranostic eradication
#2742RNA INTERFERENCE MEDIATED INHIBITION OF ISOCITRATE DEHYDROGENASE (IDH1) GENE EXPRESSION
#2743SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#2744MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#2745MicroRNA compounds and methods for modulating miR-122
#2746MicroRNAs modulating the effect of glucocorticoid signaling
#2747Compositions for modulating C9ORF72 expression
#2748Method for reducing circulating leukocytes in a human subject
#2749Antisense compounds targeting genes associated with cystic fibrosis
#2750Compositions and methods for inhibiting expression of the ALAS1 gene
#2751Reduced size self-delivering RNAI compounds
#2752Complement component C5 iRNA compositions and methods of use thereof
#2753Reducing intron retention
#2754RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#2755Compositions and methods for modulating neuronal excitability and motor behavior
#2756MicroRNA compounds and methods for modulating miR-21 activity
#2757Modular RNA regulators and methods
#2758Modulation of apolipoprotein C-III expression
#2759METHODS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#2760Tau antisense oligomers and uses thereof
#2761TOLEROGENIC DENDRITIC CELLS TO TREAT INFLAMMATORY BOWEL DISEASE
#2762COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT
#2763MODULATORS OF COMPLEMENT FACTOR B
#2764Antisense compositions and methods of making and using same
#2765Notch 1 specific siRNA molecule
#2766Nucleic acids and methods for the treatment of Pompe disease
#2767Antisense-induced exon2 inclusion in acid alpha-glucosidase
#2768Complex containing oligonucleotide having immunopotentiating activity and use thereof
#2769Targeting microRNAs for metabolic disorders
#2770miR-92 inhibitors and uses thereof
#2771Compositions and methods for inhibiting expression of mutant EGFR gene
#2772SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOREGULATORY AGENTS
#2773Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#2774Compounds and methods for modulating target nuclear and sub-nuclear nucleic acid molecules in cells and animals
#2775MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#2776Compositions and methods for modulating angiopoietin-like 3 expression
#2777Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
#2778Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
#2779Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
#2780SUBSTITUTED MORPHOLINO COMPOUNDS ANALOGS THEREOF AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
#2781C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
#2782Compositions and methods for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
#2783Compositions and methods for increasing erythropoietin (EPO) production
#2784PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
#2785Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#2786CRISPR-based compositions and methods of use
#2787MicroRNA (miRNA) and downstream targets for diagnostic and therapeutic purposes
#2788MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#2789Treatment of Adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an Adiponectin (ADIPOQ)
#2790COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING MUSCULAR DYSTROPHY
#2791RIG-I ligands and methods for producing them
#2792Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
#2793TMPRSS6 iRNA compositions and methods of use thereof
#2794Compositions and methods for inhibiting expression of TMPRSS6 gene
#2795Dnazyme for silencing the expression of EGFR
#2796Dengue virus-specific siRNA, double helix oligo-RNA structure comprising siRNA, and composition for suppressing proliferation of dengue virus comprising RNA structure
#2797Oligomers with improved off-target profile
#2798Compositions for modulating Tau expression
#2799Double-stranded agents for delivering therapeutic oligonucleotides
#2800Micro-RNA family that modulates fibrosis and uses thereof
#2801Micro-RNA family that modulates fibrosis and uses thereof
#2802Micro-RNA family that modulates fibrosis and uses thereof
#2803Antisense-oligonucleotides as inhibitors of TGF-R signaling
#2804Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF
#2805ANTISENSE COMPOUNDS AND USES THEREOF
#2806Use of HMGA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells
#2807Preventive or therapeutic agent for fibrosis
#2808Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#2809Double-stranded antisense nucleic acid with exon-skipping effect
#2810OLIGONUCLEOTIDE MODULATORS OF B-CELL CLL/LYMPHOMA 11A (BCL11A) AND USES THEREOF
#2811Reduced size self-delivering RNAi compounds
#2812COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS
#2813COMPOSITIONS AND METHODS FOR MODULATING FOXP3 EXPRESSION
#2814Dosages and methods for delivering lipid formulated nucleic acid molecules
#2815Compositions and methods for inhibiting expression of the ALAS1 gene
#2816Anti-sense oligonucleotides targeted against exon 9 of IL-23R-alpha gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases
#2817Complement component C5 iRNA compositions and methods of use thereof
#2818Modulation of HSP47 expression
#2819Hydrophobically modified antisense oligonucleotides comprising a ketal group
#2820Targeting microRNAs for the treatment of fibrosis
#2821CHIMERIC SINGLE-STRANDED ANTISENSE POLYNUCLEOTIDES AND DOUBLE-STRANDED ANTISENSE AGENT
#2822Compositions and methods for inhibiting expression of the HAMP gene
#2823Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1
#2824Antisense compounds and uses thereof
#2825Compositions and methods for modulating apolipoprotein (a) expression
#2826Compositions and methods for modulating apolipoprotein C-III expression
#2827Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same
#2828Therapeutic compositions
#2829RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
#2830Compositions and methods
#2831Phosphorous-linked oligomeric compounds and their use in gene modulation
#2832Compositions and methods for modulating HBV expression
#2833Modulation of androgen receptor expression
#2834Modulation of dystrophia myotonica-protein kinase (DMPK) expression
#2835miR-29 mimics and uses thereof
#2836RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF
#2837Composition for delivery of genetic material
#2838MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
#2839MODULATION OF APOLIPOPROTEIN CIII (APOCIII) EXPRESSION
#2840RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#2841Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means
#2842COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
#2843Treatment of genetic disorders associated with DNA repeat instability
#2844Modulation of hepatitis B virus (HBV) expression
#2845Aptamer to IL-17 and use thereof
#2846Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
#2847Targeting microRNAs for the treatment of liver cancer
#2848Targeting microRNAs for metabolic disorders
#2849Methods for enhancing utrophin production via inhibition of microRNA
#2850Oral delivery of therapeutically effective LNA oligonucleotides
#2851Inhibitors of MYH7B and uses thereof
#2852Compositions and methods for modulating Tau expression
#2853Method for identifying biologically active oligonucleotides capable of modulating the immune system
#2854Treatment of LCAT gene related diseases by inhibition of a natural antisense transcript to LCAT
#2855Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
#2856Compositions and methods for inhibition of expression of protein C (PROC) genes
#2857Methods for monitoring C9ORF72 expression
#2858LNA antisense oligonucleotides for the modulation of Myc expression
#2859COMPOSITIONS AND METHODS FOR ENHANCED SENSITIVITY AND SPECIFICITY OF NUCLEIC ACID SYNTHESIS
#2860Compositions and Methods for Inhibiting Expression of Eg5 Gene
#2861PCSK9 iRNA compositions and methods of use thereof
#2862Serpinc1 iRNA compositions and methods of use thereof
#2863Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#2864DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#2865Reducing intron retention
#2866Oligomers and oligomer conjugates
#2867Treatment of tristetraproline (TTP) related diseases by inhibition of natural antisense transcript to TTP
#2868Locked nucleic acid inhibitor of miR-145 and uses thereof
#2869Bridged bicyclic nucleosides
#2870Organic compositions to treat EPAS1-related diseases
#2871Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1
#2872Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#2873Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#2874METHODS AND COMPOSITIONS FOR MANAGING VASCULAR CONDITIONS
#2875Compositions and methods for modulation of SMN2 splicing in a subject
#2876Cancer treatment
#2877Selective antisense compounds and uses thereof
#2878Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
#2879Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#2880Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#2881Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
#2882CCCTC-Binding Factor (CTCF) RNA Interactome
#2883TREATMENT OF INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (IFRD1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IFRD1
#2884LNA OLIGONUCLEOTIDE CARBOHYDRATE CONJUGATES
#2885Inhibitors of miRNAs 221 and 222 for anti-tumor activity in multiple myeloma
#2886Compositions and methods for inhibiting gene expression of alpha-1 AntiTrypsin
#2887Antisense oligonucleotides for inducing exon skipping and methods of use thereof
#2888Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
#2889Compounds and methods for modulating gene expression
#2890RNA TARGETED TO C-MET
#2891dsRNA For Treating Viral Infection
#2892Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#2893Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
#2894Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#2895Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#2896Methods and compositions for modulating apolipoprotein (a) expression
#2897Methods of treating ischemia-reperfusion injury with siRNAs
#2898DESIGN OF OLIGONUCLEOTIDE ANALOGS AS THERAPEUTIC AGENTS
#2899SELECTIVE REDUCTION OF ALLELIC VARIANTS
#2900Oligomeric compounds and compositions for the use in modulation of micrornas
#2901SNPs OF APOLIPOPROTEIN B AND MODULATION OF THEIR EXPRESSION
#2902COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#2903Synthetic Nucleic Acids for Polymerization Reactions
#2904Antisense modulation of PTP1B expression
#2905Compositions and methods for modulating angiopoietin-like 3 expression
#2906NICKED OR GAPPED NUCLEIC ACID MOLECULES AND USES THEREOF
#2907Methods of delivering multiple targeting oligonucleotides to a cell using cleavable linkers
#2908Multimeric oligonucleotides compounds having cleavable linkers
#2909METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS
#2910Multimeric oligonucleotide compounds having non-nucleotide based cleavable linkers
#2911Deep intronic target for splicing correction on spinal muscular atrophy gene
#2912COMPOUNDS AND METHODS FOR IMPROVING CELLULAR UPTAKE OF OLIGOMERIC COMPOUNDS
#2913DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#2914Compositions and methods for selective delivery of oligonucleotide molecules to cell types
#2915Compositions and their uses directed to huntingtin
#2916Inhibitory oligonucleotide and use thereof
#2917Methods for treatment of alport syndrome
#2918In vivo gene silencing by chemically modified and stable siRNA
#2919Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
#2920MICROMIRs
#2921Multimeric oligonucleotides compounds
#2922MODULATION OF RENIN-ANGIOTENSIN SYSTEM (RAS) RELATED DISEASES BY ANGIOTENSINOGEN
#2923MODULATION OF CD40 EXPRESSION
#2924RNA TARGETED TO BETA CATENIN
#2925Antisense compounds targeting genes associated with fibronectin
#2926Method of promoting wound healing
#2927RNAi inhibition of alpha-ENaC expression
#2928Methods of treating kennedy's disease
#2929Oligonucleotide complex compositions and methods of use as gene alteration tools
#2930Modified cytosine polynucleotide oligomers and methods
#2931Organic compositions to treat beta-ENaC-related diseases
#2932RIG-I ligands and methods for producing them
#2933Methods and compositions for inhibition of immune responses and autoimmunity
#2934Oligonucleotide conjugates
#2935Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
#2936Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a Sirtuin (SIRT)
#2937RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#2938Methods for modulating C9ORF72 expression
#2939Oligomeric compounds comprising bicyclic nucleosides and uses thereof
#2940Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2
#2941Nucleic acid functionalized nonoparticles for therapeutic applications
#2942Compositions for modulating C9ORF72 expression
#2943Short interfering ribonucleic acid (siRNA) for oral administration
#2944Splice Switching Oligomers for TNF Superfamily Receptors and Their Use in Treatment of Disease
#2945Modulation of transthyretin expression
#2946Compositions and methods for modulating SMN gene family expression
#2947Piggy back delivery of nucleic acids into organisms
#2948Complement component C5 iRNA compositions and methods of use thereof
#2949ANTISENSE COMPOUNDS HAVING ENHANCED ANTI-MICRORNA ACTIVITY
#2950Treatment of insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to IRS2 and transcription factor E3 (TFE3)
#2951Methods targeting miR-128 for regulating cholesterol/lipid metabolism
#2952Treatment of fibrotic conditions
#2953Methods for use in modulating miR-122A
#2954Methods and compositions for treating neurological disease
#2955COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION
#2956Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
#2957Treatment of adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an adiponectin (ADIPOQ)
#2958Selective reactivation of genes on the inactive X chromosome
#2959Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#2960MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
#2961Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
#2962Restoration of the CFTR function by splicing modulation
#2963Chiral control
#2964Methods of treatment using TLR7 and/or TLR9 inhibitors
#2965Oligonucleotide comprising an inosine for treating DMD
#2966Method for Generating Aptamers with Improved Off-Rates
#2967Treatment of ‘IQ motif containing gtpase activating protein’ (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
#2968Sense oligonucleotide capable of controlling the expression of INOS and composition comprising the same
#2969Modulation of UBE3A-ATS expression
#2970COMPOSITIONS AND METHODS FOR MODULATING APOA1 AND ABCA1 EXPRESSION
#2971Toll-like receptors
#2972ANTISENSE MODULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR 4 EXPRESSION
#2973MODULATION OF TRANSTHYRETIN EXPRESSION
#2974MODULATION OF APOLIPOPROTEIN (a) EXPRESSION
#2975METHODS FOR PREVENTING AND TREATING CHRONIC KIDNEY DISEASE (CKD)
#2976Compositions and methods for modulating HBV expression
#2977Modulation of enhancer RNA mediated gene expression
#2978Antisense modulation of superoxide dismutase 1, soluble expression
#2979TREATMENT OF SIALIDASE 4 (NEU4) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO NEU4
#2980Oligomeric compounds and methods
#2981Chiral nucleic acid adjuvant
#2982Methods and means for efficient skipping of at least one of the exons 51-53, 55, 57 and 59 of the human duchenne muscular dystrophy gene
#2983Antisense nucleic acids
#2984Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
#2985Lipid formulations
#2986Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
#2987Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
#2988Modulation of huntingtin expression
#2989Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4
#2990Treatment of Methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA
#2991Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
#2992Compounds and methods for altering RSV replication rate
#2993Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3
#2994Treatment of filaggrin (FLG) related diseases by modulation of FLG expression and activity
#2995Chemical modification of short small hairpin RNAs for inhibition of gene expression
#2996METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION
#2997COMPOSITIONS AND METHODS FOR MODULATING MECP2 EXPRESSION
#2998RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
#2999Antisense modulation of GCCR expression
#3000Methods of treating and diagnosing diseases using agents that regulate the alternative splicing pathway