ClassID:

109162

C12N2310/315 - page 4 - CPC Classification

Classification description:

Structure or type of the nucleic acid; Chemical structure of the backbone Phosphorothioates

Recent Application in this class:
#901
20230323368
2023-10-12

NOVEL TLR9 AGONISTS

#902
20230323362
2023-10-12

COMPLEMENT COMPONENT C1R INHIBITORS FOR TREATING A NEUROLOGICAL DISEASE, AND RELATED COMPOSITIONS, SYSTEMS AND METHODS OF USING SAME

#903
20230323357
2023-10-12

TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6 (TRAF6) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#904
20230323355
2023-10-12

ANTIVIRAL SILENCING RNA MOLECULES, CHEMICALLY MODIFIED ANTIVIRAL SILENCING RNA MOLECULES WITH ENHANCED CELL PENETRATING ABILITIES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND USES THEREOF FOR TREATMENT OF VIRAL INFECTIONS

#905
20230323351
2023-10-12

Compositions for modulating tau expression

#906
20230323350
2023-10-12

RNAi Agents And Compositions for Inhibiting Expression of Apolipoprotein C-III (APOC3)

#907
20230323345
2023-10-12

UNA OLIGOMERS FOR THE TREATMENT OF POLYGLUTAMINE DISEASES

#908
20230321255
2023-10-12

Modulators of PCSK9 Expression

#909
20230313195
2023-10-05

NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE

#910
20230313189
2023-10-05

COMPLEMENT COMPONENT 4 INHIBITORS FOR TREATING NEUROLOGICAL DISEASES, AND RELATED COMPOSITONS, SYSTEMS AND METHODS OF USING SAME

#911
20230310506
2023-10-05

METHOD FOR ACTIVATING EXPRESSION OF GAMMA-GLOBIN GENE, AND COMPOSITION

#912
20230310485
2023-10-05

POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF

#913
20230304008
2023-09-28

Modified oligonucleotides

#914
20230304002
2023-09-28

TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES

#915
20230296587
2023-09-21

Oligonucleotides for inducing paternal UBE3A expression

#916
20230295631
2023-09-21

MICRORNAS AND METHODS OF THEIR USE

#917
20230295630
2023-09-21

GalNAc compositions for improving siRNA bioavailability

#918
20230295629
2023-09-21

ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS

#919
20230295619
2023-09-21

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

#920
20230295617
2023-09-21

METHODS AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS

#921
20230295614
2023-09-21

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE LYASE (ASL)

#922
20230287432
2023-09-14

G PROTEIN-COUPLED RECEPTOR 146 (GPR146) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#923
20230287425
2023-09-14

COMPOSITIONS AND METHODS FOR INHIBITING ANGPTL3 EXPRESSION

#924
20230287424
2023-09-14

RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION

#925
20230287423
2023-09-14

Tuning cascade assay kinetics via molecular design

#926
20230287412
2023-09-14

Oligonucleotide Agonists Targeting Progranulin

#927
20230287410
2023-09-14

OPA1 ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASES

#928
20230287400
2023-09-14

Modified guide RNAs

#929
20230287370
2023-09-14

NOVEL CAS ENZYMES AND METHODS OF PROFILING SPECIFICITY AND ACTIVITY

#930
20230279399
2023-09-07

RNAI CONSTRUCTS FOR INHIBITING HSD17B13 EXPRESSION AND METHODS OF USE THEREOF

#931
20230272401
2023-08-31

COMPOSITIONS FOR FLCN GENE MODULATION AND METHODS THEREOF

#932
20230272393
2023-08-31

Compositions and methods for modulating APOC3 expression

#933
20230272391
2023-08-31

ADAR DEPENDENT EDITING COMPOSITIONS AND METHODS OF USE THEREOF

#934
20230272387
2023-08-31

COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH LOSS-OF-FUNCTION MUTATIONS IN SCN2A

#935
20230272385
2023-08-31

siRNAs WITH VINYLPHOSPHONATE AT THE 5' END OF THE ANTISENSE STRAND

#936
20230272384
2023-08-31

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF RETINOCHISIN 1 (RS1)

#937
20230272382
2023-08-31

COMPLEMENT COMPONENT C3 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING COMPLEMENT COMPONENT C3-ASSOCIATED DISEASES

#938
20230272377
2023-08-31

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 (TMC1)

#939
20230272376
2023-08-31

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF METHYL-CPG BINDING PROTEIN 2 (MECP2)

#940
20230270873
2023-08-31

Muscle targeting complexes and uses thereof for treating dystrophinopathies

#941
20230265461
2023-08-24

Compositions and methods for targeting, editing, or modifying genes

#942
20230265436
2023-08-24

THERAPEUTICS FOR SYNGAP HAPLOINSUFFICIENCY

#943
20230265428
2023-08-24

Modulators of APOL1 expression

#944
20230263828
2023-08-24

Genetically engineered T cells with Regnase-1 and/or TGFBRII disruption have improved functionality and persistence

#945
20230263822
2023-08-24

MODULATION OF FACTOR 11 EXPRESSION

#946
20230257753
2023-08-17

PRODUCTS AND COMPOSITIONS

#947
20230257752
2023-08-17

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE SYNTHETASE (ASS1)

#948
20230257750
2023-08-17

SIRNA OF ANGPTL3 AND USE THEREOF

#949
20230257745
2023-08-17

Circular siRNAs

#950
20230257740
2023-08-17

Compositions and methods for inhibiting expression of transthyretin

#951
20230257731
2023-08-17

COMPOSITIONS AND METHODS FOR ENHANCING REVERSE TRANSCRIPTASE ACTIVITY AND/OR REDUCING THE INHIBITION OF REVERSE TRANSCRIPTASE

#952
20230256000
2023-08-17

Nucleic acid oligomers and uses therefor

#953
20230250435
2023-08-10

PCSK9 TARGETING OLIGONUCLEOTIDES FOR TREATING HYPERCHOLESTEROLEMIA AND RELATED CONDITIONS

#954
20230250429
2023-08-10

OPA1 antisense oligomers for treatment of conditions and diseases

#955
20230250423
2023-08-10

GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES

#956
20230250196
2023-08-10

CELL PENETRATING PROTEIN-ANTIBODY CONJUGATES AND METHODS OF USE

#957
20230242916
2023-08-03

METHOD AND DRUG FOR TREATING HURLER SYNDROME

#958
20230242913
2023-08-03

STING-DEPENDENT ACTIVATORS FOR TREATMENT OF DISEASE

#959
20230242909
2023-08-03

METHODS AND COMPOSITIONS FOR NEUROPROTECTION

#960
20230235381
2023-07-27

Compositions of matter for detection assays

#961
20230235362
2023-07-27

Compositions and methods for targeting, editing, or modifying genes

#962
20230235332
2023-07-27

TREATMENT OF NEUROLOGICAL DISEASES USING MODULATORS OF GENE TRANSCRIPTS

#963
20230235331
2023-07-27

COMPOUNDS AND METHODS FOR REDUCING MSH3 EXPRESSION

#964
20230235330
2023-07-27

CONJUGATE OF DOUBLE-STRANDED SIRNA ANALOGUE

#965
20230235329
2023-07-27

ANTISENSE OLIGONUCLEOTIDES (ASO) FOR EFFICIENT AND PRECISE RNA EDITING WITH ENDOGENOUS ADENOSINE DEAMINASE ACTING ON RNA (ADAR)

#966
20230235323
2023-07-27

Compounds and Methods for Reducing ATXN3 Expression

#967
20230235322
2023-07-27

RNA EDITING INHIBITORS AND METHODS OF USE

#968
20230220396
2023-07-13

Transmembrane protease, serine 6 (TMPRSS6) iRNA compositions and methods of use thereof

#969
20230220393
2023-07-13

METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT

#970
20230220390
2023-07-13

NUCLEIC ACID MOLECULE HAVING IMPROVED STABILITY, AND USE THEREOF

#971
20230220384
2023-07-13

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF

#972
20230212582
2023-07-06

COMPOSITIONS OF SMAD7 ANTISENSE OLIGONUCLEOTIDES (ASO) AND METHODS OF USING THE SAME

#973
20230212580
2023-07-06

INHIBITION OF POLYOMAVIRUS REPLICATION

#974
20230212576
2023-07-06

MAPT RNA INTERFERENCE AGENTS

#975
20230212572
2023-07-06

Guanosine Analogues for Use in Therapeutics Polynucleotides

#976
20230212569
2023-07-06

METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF OTOFERLIN (OTOF)

#977
20230212567
2023-07-06

THERAPEUTICS FOR HAPLOINSUFFICIENCY CONDITIONS

#978
20230212564
2023-07-06

METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION

#979
20230203498
2023-06-29

SINGLE-STRANDED OLIGONUCLEOTIDE

#980
20230203496
2023-06-29

SIRNA COMPOSITIONS AND METHODS FOR SILENCING GPAM (GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL) EXPRESSION

#981
20230203491
2023-06-29

DOUBLE-STRANDED OLIGONUCLEOTIDE AND COMPOSITION FOR TREATING COVID-19 CONTAINING SAME

#982
20230203486
2023-06-29

MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#983
20230203484
2023-06-29

DOUBLE STRANDED OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO

#984
20230203180
2023-06-29

MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR MODULATION OF GENES ASSOCIATED WITH MUSCLE HEALTH

#985
20230201363
2023-06-29

Compositions and methods of treating muscle atrophy and myotonic dystrophy

#986
20230201362
2023-06-29

Compositions and methods of treating muscle atrophy and myotonic dystrophy

#987
20230201243
2023-06-29

MODULATORS OF FOXP3 EXPRESSION

#988
20230193286
2023-06-22

CYTOTOXIC T-LYMPHOCYTE BINDING APTAMERS

#989
20230193285
2023-06-22

BISPECIFIC PERSONALIZED APTAMERS

#990
20230193284
2023-06-22

TRANSMEMBRANE SERINE PROTEASE 2 (TMPRSS2) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#991
20230193281
2023-06-22

OLIGONUCLEOTIDES FOR SOD1 MODULATION

#992
20230193277
2023-06-22

NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, PREPARATION METHOD, AND USE

#993
20230193272
2023-06-22

Tuning cascade assay kinetics via molecular design

#994
20230193268
2023-06-22

APOLIPOPROTEIN E (APOE) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#995
20230193263
2023-06-22

USE OF SBDS INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#996
20230193260
2023-06-22

Antisense oligonucleotides targeting alpha-synuclein and uses thereof

#997
20230183708
2023-06-15

PD-1-specific antisense oligonucleotide and its use in therapy

#998
20230183706
2023-06-15

COMPOSITIONS AND METHODS FOR TREATING SUBJECTS HAVING A HETEROZYGOUS ALANINE-GLYOXYLATE AMINOTRANSFERASE GENE (AGXT) VARIANT

#999
20230183696
2023-06-15

Compositions and Methods for Modulation of SMN2 Splicing in a Subject

#1000
20230183693
2023-06-15

Reducing intron retention

#1001
20230183692
2023-06-15

USE OF SEPT9 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#1002
20230183689
2023-06-15

Compositions and Methods for Genome Editing

#1003
20230174990
2023-06-08

Immunostimulatory compositions

#1004
20230174989
2023-06-08

Methods and Compositions for the ADAR-Mediated Editing of ABCA4

#1005
20230174987
2023-06-08

Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression

#1006
20230174984
2023-06-08

COMPOSITIONS AND METHODS FOR TREATING DISORDERS ASSOCIATED WITH LOSS-OF-FUNCTION MUTATIONS IN SYNGAP1

#1007
20230174979
2023-06-08

METHODS AND COMPOSITIONS FOR TREATING ATAXIA TELANGIECTASIA

#1008
20230167452
2023-06-01

COMPOSITIONS AND METHODS FOR CORRECTING LIMB GIRDLE MUSCULAR DYSTROPHY TYPE 2C USING EXON SKIPPING

#1009
20230167447
2023-06-01

Compositions for FNIP1/FNIP2 Gene Modulation and Methods Thereof

#1010
20230167446
2023-06-01

COMPOUNDS AND METHODS FOR REDUCING PSD3 EXPRESSION

#1011
20230159936
2023-05-25

CPG ODN HAVING IMMUNOREGULARTORY FUNCTION AND USE THEREOF

#1012
20230159933
2023-05-25

COMPOSITIONS AND METHODS FOR SILENCING SCN9A EXPRESSION

#1013
20230159929
2023-05-25

MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES AND USES THEREOF

#1014
20230159926
2023-05-25

Base editing of PCSK9 and methods of using same for treatment of disease

#1015
20230159925
2023-05-25

ANTISENSE OLIGONUCLEOTIDE OF CALM2

#1016
20230159924
2023-05-25

PREVENTION OR TREATMENT OF ANEURYSMS USING MIR-33B INHIBITOR

#1017
20230158174
2023-05-25

CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS9

#1018
20230158059
2023-05-25

Prekallikrein-modulating compositions and methods of use thereof

#1019
20230151369
2023-05-18

COMPOSITIONS AND METHODS FOR INHIBITING TDP-43 AND FUS AGGREGATION

#1020
20230151366
2023-05-18

COMPOSITIONS AND METHODS OF INHIBITING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)

#1021
20230151365
2023-05-18

COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION

#1022
20230151360
2023-05-18

NUCLEIC ACID COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

#1023
20230151050
2023-05-18

ANTISENSE NUCLEIC ACIDS

#1024
20230149438
2023-05-18

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PREKALLIKREIN-ASSOCIATED CONDITIONS

#1025
20230147979
2023-05-11

DESIGN METHOD FOR OPTIMIZED RIG-I LIGANDS

#1026
20230147811
2023-05-11

MODULATORS OF GROWTH HORMONE RECEPTOR

#1027
20230147733
2023-05-11

OXIDIZED TUMOR CELL LYSATES ENCAPSULATED IN LIPOSOMAL SPHERICAL NUCLEIC ACIDS AS POTENT CANCER IMMUNOTHERAPEUTICS

#1028
20230145795
2023-05-11

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF

#1029
20230140670
2023-05-04

FORMULATIONS

#1030
20230139322
2023-05-04

SiRNA molecule inhibiting the expression of the PCSK9 gene and use thereof

#1031
20230138507
2023-05-04

ALPHA-2A ADRENERGIC RECEPTOR (ADRA2A) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1032
20230136787
2023-05-04

COMPOSITIONS AND METHODS FOR SILENCING VEGF-A EXPRESSION

#1033
20230136552
2023-05-04

COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)

#1034
20230135763
2023-05-04

PRODUCTS AND COMPOSITIONS

#1035
20230134677
2023-05-04

ANTISENSE OLIGONUCLEOTIDES FOR USE IN THE TREATMENT OF USHER SYNDROME

#1036
20230134582
2023-05-04

CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS12B

#1037
20230133637
2023-05-04

ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1038
20230133147
2023-05-04

ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1039
20230132756
2023-05-04

DOUBLE-STRANDED OLIGONUCLEOTIDE, COMPOSITION AND CONJUGATE COMPRISING DOUBLE-STRANDED OLIGONUCLEOTIDE, PREPARATION METHOD THEREOF AND USE THEREOF

#1040
20230132377
2023-04-27

OLIGONUCLEOTIDES CONJUGATES COMPRISING 7'-5'-ALPHA-ANOMERIC-BICYCLIC SUGAR NUCLEOSIDES

#1041
20230132093
2023-04-27

EXTRACELLULAR VESICLE-NLRP3 ANTAGONIST

#1042
20230126881
2023-04-27

Fc FRAGMENT OF IgG RECEPTOR AND TRANSPORTER (FCGRT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1043
20230126233
2023-04-27

LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1044
20230125933
2023-04-27

MANNAN BINDING LECTIN SERINE PEPTIDASE 2 (MASP2) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1045
20230125671
2023-04-27

RNAi Agents for Inhibiting Expression of Xanthine Dehydrogenase (XDH), Pharmaceutical Compositions Thereof, and Methods of Use

#1046
20230125137
2023-04-27

UNC13A antisense oligonucleotides

#1047
20230124616
2023-04-20

COMPOUNDS AND METHODS FOR MODULATING KCNQ2

#1048
20230122801
2023-04-20

USP10 TARGETED SELF-DELIVERABLE SIRNA COMPOSITIONS AND METHODS FOR PREVENTING OR INHIBITING FIBROSIS AND/OR SCARRING

#1049
20230122751
2023-04-20

USE OF COPS3 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#1050
20230122244
2023-04-20

CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTS

#1051
20230121967
2023-04-20

Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

#1052
20230121944
2023-04-20

COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION

#1053
20230120063
2023-04-20

USE OF SARAF INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#1054
20230118177
2023-04-20

COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION

#1055
20230118138
2023-04-20

USE OF SCAMP3 INHIBITORS FOR TREATING HEPATITIS B VIRUS INFECTION

#1056
20230117883
2023-04-20

MUSCLE-TARGETING COMPLEXES AND USES THEREOF IN TREATING MUSCLE ATROPHY

#1057
20230117089
2023-04-20

COMPOUNDS AND METHODS FOR MODULATING SPLICING OF PRE-MRNA

#1058
20230116704
2023-04-13

ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASES

#1059
20230114930
2023-04-13

Compounds and methods for reducing LRRK2 expression

#1060
20230114649
2023-04-13

HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1061
20230114429
2023-04-13

Oligomeric compounds for reducing DMPK expression

#1062
20230113863
2023-04-13

Selective Antisense Compounds and Uses Thereof

#1063
20230113497
2023-04-13

Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection

#1064
20230112920
2023-04-13

Compositions for Modulating C9ORF72 Expression

#1065
20230111813
2023-04-13

Transthyretin (TTR) iRNA compositions and methods of use thereof

#1066
20230109466
2023-04-06

Compositions for treatment of polycystic kidney disease

#1067
20230108340
2023-04-06

METHODS FOR REDUCING HTT EXPRESSION

#1068
20230107967
2023-04-06

COMPOSITIONS AND METHODS FOR INHIBITING ALPHA-1 ANTITRYPSIN EXPRESSION

#1069
20230107651
2023-04-06

METHODS OF TREATING SPINAL MUSCULAR ATROPHY

#1070
20230107117
2023-04-06

CONDITIONAL-siRNAS AND USES THEREOF IN TREATING CARDIAC HYPERTROPHY

#1071
20230105319
2023-04-06

PRODRUG INCORPORATED sgRNA SYNTHESIS

#1072
20230104978
2023-04-06

RNA-Editing Oligonucleotides and Uses Thereof

#1073
20230104125
2023-04-06

METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER

#1074
20230101828
2023-03-30

KISSPEPTIN 1 (KISS1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1075
20230099372
2023-03-30

USE OF MIRNA-485 INHIBITORS FOR TREATING TAUOPATHY

#1076
20230098714
2023-03-30

MICRORNA COMPOSITIONS AND METHODS OF USE

#1077
20230098111
2023-03-30

COMPOSITIONS AND METHODS TO TREAT NEUROLOGICAL DISEASES

#1078
20230095566
2023-03-30

ANTI-ADAM33 OLIGONUCLEOTIDES AND RELATED METHODS

#1079
20230095192
2023-03-30

SYNTHETIC AGONISTS OF DNA-PK AND THEIR USE

#1080
20230093948
2023-03-30

STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1081
20230092615
2023-03-23

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSING OF METHYLATION-CONTROLLED J-PROTEIN (MCJ)

#1082
20230092393
2023-03-23

Guide RNAs with chemical modification for prime editing

#1083
20230091801
2023-03-23

Compositions and methods of treating facioscapulohumeral muscular dystrophy

#1084
20230090531
2023-03-23

Compositions of matter for detection assays

#1085
20230089915
2023-03-23

PRODUCTS AND COMPOSITIONS

#1086
20230089478
2023-03-23

CHEMICALLY MODIFIED OLIGONUCLEOTIDES WITH IMPROVED SYSTEMIC DELIVERY

#1087
20230086936
2023-03-23

COMPOUNDS AND METHODS FOR REDUCING APOE EXPRESSION

#1088
20230080198
2023-03-16

MODIFIED IMMUNE CELLS HAVING ADENOSINE DEAMINASE BASE EDITORS FOR MODIFYING A NUCLEOBASE IN A TARGET SEQUENCE

#1089
20230078622
2023-03-16

Optimized anti-FLT1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders

#1090
20230078200
2023-03-16

RNAi CONSTRUCTS AND METHODS FOR INHIBITING LPA EXPRESSION

#1091
20230074280
2023-03-09

TREATMENT OF THYMIC STROMAL LYMPHOPOIETIN (TSLP) RELATED DISEASES BY INHIBITION OF LONG-FORM TSLP TRANSCRIPTS

#1092
20230073999
2023-03-09

POLYNUCLEOTIDE AND PHARMACEUTICAL COMPOSITION

#1093
20230072079
2023-03-09

Nucleic acid vaccination using neo-epitope encoding constructs

#1094
20230068672
2023-03-02

Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity

#1095
20230068339
2023-03-02

APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1096
20230068063
2023-03-02

Modified compounds and uses thereof

#1097
20230066380
2023-03-02

ANTAGONISM AS A THERAPY FOR TDP-43 PROTEINOPATHIES

#1098
20230063394
2023-03-02

ANTISENSE MOLECULES AND METHODS FOR TREATING PATHOLOGIES

#1099
20230061751
2023-03-02

UNIVERSAL DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORS

#1100
20230061732
2023-03-02

STABLE TARGET-EDITING GUIDE RNA HAVING CHEMICALLY MODIFIED NUCLEIC ACID INTRODUCED THEREINTO

#1101
20230060517
2023-03-02

NEW METHOD FOR TARGETED EDITING OF RNA

#1102
20230058834
2023-02-23

Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA

#1103
20230057718
2023-02-23

Compositions and methods for modulating complement factor B expression

#1104
20230056788
2023-02-23

METHODS AND COMPOSITIONS FOR THE INHIBITION OF HEPATITIS B AND HEPATITIS D VIRUS INFECTIONS

#1105
20230056569
2023-02-23

ATAXIN3 (ATXN3) RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1106
20230055405
2023-02-23

COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION

#1107
20230054720
2023-02-23

Antisense Oligonucleotides Targeting ATXN3

#1108
20230053332
2023-02-23

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE

#1109
20230049529
2023-02-16

MODIFIED DOUBLE STRANDED OLIGONUCLEOTIDE

#1110
20230047776
2023-02-16

Polynucleotide compositions and methods for gene expression regulations

#1111
20230047452
2023-02-16

Modulators of diacyglycerol acyltransferase 2 (DGAT2)

#1112
20230044994
2023-02-09

Compositions and Methods Comprising a TTR Guide RNA and a Polynucleotide Encoding an RNA-Guided DNA Binding Agent

#1113
20230043648
2023-02-09

COMPOUNDS AND METHODS FOR MODULATING SCN1A EXPRESSION

#1114
20230042451
2023-02-09

Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (MARC1) expression

#1115
20230041178
2023-02-09

METHODS FOR THE TREATMENT OF TRINUCLEOTIDE REPEAT EXAPNSION DISORDERS ASSOCIATED WITH OGG1 ACTIVITY

#1116
20230041016
2023-02-09

ANTI-SLC6A1 OLIGONUCLEOTIDES AND RELATED METHODS

#1117
20230040920
2023-02-09

COMPOSITIONS AND METHODS FOR SILENCING DNAJB1-PRKACA FUSION GENE EXPRESSION

#1118
20230039928
2023-02-09

Antisense oligonucleotides for nucleotide deamination in the treatment of Stargardt disease

#1119
20230035774
2023-02-02

Compositions and methods for treating cancer

#1120
20230035659
2023-02-02

Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis Comprising a Corticosteroid or Use Thereof

#1121
20230032846
2023-02-02

SYSTEMS AND METHODS FOR LIPID NANOPARTICLE DELIVERY OF GENE EDITING MACHINERY

#1122
20230030119
2023-02-02

RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)

#1123
20230029227
2023-01-26

Tunable Reversir™ compounds

#1124
20230028937
2023-01-26

MicroRNA (miRNA) and Downstream Targets for Diagnostic and Therapeutic Purposes

#1125
20230027209
2023-01-26

Implantable Medical Device for the Delivery of a Nucleic Acid

#1126
20230026968
2023-01-26

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#1127
20230025910
2023-01-26

Compounds and methods for reducing IFNAR1 expression

#1128
20230024926
2023-01-26

Nucleic acids for inhibiting expression of C3 in a cell

#1129
20230023015
2023-01-26

Modulation of huntingtin expression

#1130
20230022489
2023-01-26

IDENTIFYING NON-PRODUCTIVE SPLICE SITES

#1131
20230022185
2023-01-26

Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases

#1132
20230021431
2023-01-26

Oligonucleotides for SARS-CoV-2 modulation

#1133
20230020092
2023-01-19

COMPOSITIONS FOR DELIVERY OF ANTISENSE COMPOUNDS

#1134
20230019513
2023-01-19

Nucleic acids for inhibiting expression of PROS1 in a cell

#1135
20230018254
2023-01-19

EXTRACELLULAR VESICLES WITH ANTISENSE OLIGONUCLEOTIDES TARGETING KRAS

#1136
20230015481
2023-01-19

Modulators and modulation of the receptor for advanced glycation end-products RNA

#1137
20230013224
2023-01-19

RNAi agents for inhibiting expression of xanthine dehydrogenase (XDH), pharmaceutical compositions thereof, and methods of use

#1138
20230010288
2023-01-12

RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES

#1139
20230002772
2023-01-05

PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1140
20230002771
2023-01-05

Compounds and methods for modulating factor XII

#1141
20230002770
2023-01-05

IL-34 ANTISENSE AGENTS AND METHODS OF USING SAME

#1142
20230002768
2023-01-05

Compositions and methods for inhibiting gene expression of alpha-1 antitrypsin

#1143
20230002767
2023-01-05

RNAi Agents for Inhibiting Expression of Mucin 5AC (MUC5AC), Compositions Thereof, and Methods of Use

#1144
20230002766
2023-01-05

CHEMICALLY MODIFIED OLIGONUCLEOTIDES TARGETING BROMODOMAIN CONTAINING PROTEIN 4 (BRD4) FOR IMMUNOTHERAPY

#1145
20230002763
2023-01-05

Selective antisense compounds and uses thereof

#1146
20230002762
2023-01-05

OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE

#1147
20230001002
2023-01-05

Muscle targeting complexes and uses thereof for treating dystrophinopathies

#1148
20230000895
2023-01-05

METHODS FOR TREATING HEPATITIS B INFECTION

#1149
20220411804
2022-12-29

PIKFYVE antisense oligonucleotides

#1150
20220411801
2022-12-29

XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1151
20220411796
2022-12-29

COMPOSITIONS AND METHODS FOR DECREASING TAU EXPRESSION

#1152
20220411793
2022-12-29

Compounds and methods for modulating UBE3A-ATS

#1153
20220409735
2022-12-29

Compositions and methods of treating muscle dystrophy

#1154
20220403393
2022-12-22

Modulation of Angiopoietin-Like 3 Expression

#1155
20220403387
2022-12-22

MODULATING GENOMIC COMPLEXES

#1156
20220403386
2022-12-22

Selective reduction of allelic variants

#1157
20220403382
2022-12-22

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#1158
20220403381
2022-12-22

COMPLEMENT COMPONENT C5 IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1159
20220403377
2022-12-22

MODIFIED iRNA AGENTS

#1160
20220401563
2022-12-22

COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGODEOXYNUCLEOTIDE, AND METHODS OF USE THEREOF

#1161
20220401562
2022-12-22

REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF

#1162
20220401467
2022-12-22

OLIGONUCLEOTIDES, COMPOSITIONS AND METHODS THEREOF

#1163
20220396799
2022-12-15

THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR

#1164
20220395580
2022-12-15

NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF

#1165
20220395554
2022-12-15

LAG3 binding peptides

#1166
20220389429
2022-12-08

COMPOSITIONS AND METHODS FOR SILENCING UGT1A1 GENE EXPRESSION

#1167
20220389428
2022-12-08

Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof

#1168
20220389421
2022-12-08

RNA MODULATING OLIGONUCLEOTIDES WITH IMPROVED CHARACTERISTICS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS

#1169
20220380835
2022-12-01

CRISPR COMPLEX-BASED DETECTION SYSTEM AND METHOD

#1170
20220380775
2022-12-01

Organic compositions to treat HSF1-related diseases

#1171
20220380774
2022-12-01

ASYMMETRIC SIRNA INHIBITING EXPRESSION OF PD-1

#1172
20220380773
2022-12-01

COMPOUNDS AND METHODS FOR REDUCING APP EXPRESSION

#1173
20220380772
2022-12-01

RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA)

#1174
20220380771
2022-12-01

Xanthine dehydrogenase (XDH) iRNA compositions and methods of use thereof

#1175
20220380770
2022-12-01

SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES AND USES THEREOF FOR CORONAVIRUS DISEASES

#1176
20220380768
2022-12-01

Transglutaminase-mediated conjugation

#1177
20220380762
2022-12-01

HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1178
20220378818
2022-12-01

OLIGONUCLEOTIDE-BASED THERAPY FOR ULCERATIVE COLITIS

#1179
20220372489
2022-11-24

PPM1A INHIBITORS AND METHODS OF USING SAME

#1180
20220372488
2022-11-24

COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS

#1181
20220372483
2022-11-24

Modified Guide RNAs for Gene Editing

#1182
20220372482
2022-11-24

Modified antisense oligonucleotide for inhibition of FoxP3 expression

#1183
20220372476
2022-11-24

Dynamic pharmacokinetic-modifying anchors

#1184
20220370626
2022-11-24

FN3 domain-siRNA conjugates and uses thereof

#1185
20220364100
2022-11-17

OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS

#1186
20220364098
2022-11-17

Compositions and methods for modulating PNPLA3 expression

#1187
20220364096
2022-11-17

Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof

#1188
20220364094
2022-11-17

CD44 aptamer

#1189
20220364088
2022-11-17

COMPLEMENT COMPONENT C3 IRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1190
20220364086
2022-11-17

ANTISENSE OLIGONUCLEOTIDE CAPABLE OF ALTERING SPLICING OF DUX4 pre-mRNA

#1191
20220354888
2022-11-10

ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS

#1192
20220348926
2022-11-03

PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1193
20220348916
2022-11-03

COMPOSITION FOR DIAGNOSIS OR TREATMENT OF A CONDITION ASSOCIATED WITH INCREASED ACTIVITY OF EIF4E COMPRISING AN EIF4E INHIBITOR

#1194
20220348915
2022-11-03

GNAQ targeted dsRNA compositions and methods for inhibiting expression

#1195
20220340909
2022-10-27

COMPOSITIONS AND METHODS FOR INHIBITING KETOHEXOKINASE (KHK)

#1196
20220340907
2022-10-27

OLIGONUCLEOTIDES FOR TREATMENT OF ANGIOPOIETIN LIKE 4 (ANGPTL4) RELATED DISEASES

#1197
20220340903
2022-10-27

TARGETING RLIM TO MODULATE BODY WEIGHT AND OBESITY

#1198
20220340900
2022-10-27

CHEMICALLY MODIFIED OLIGONUCLEOTIDES FOR RNA EDITING

#1199
20220333116
2022-10-20

COMPOSITIONS AND METHODS FOR CD123 MODIFICATION

#1200
20220333105
2022-10-20

OLIGONUCLEOTIDES AND METHODS OF USE FOR TREATING NEUROLOGICAL DISEASES