109227 ⎘
Applications; Uses Methods for regulating/modulating their activity
Sub-classes:Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing
#2PLANT REGULATORY ELEMENTS AND USES THEREOF
#3Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof
#4METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION
#517ß-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
#6SEQUENCE DETERMINANTS OF DSRNA PROCESSING BY DICER
#7STEREOSPECIFIC LINKAGES IN RNA EDITING OLIGONUCLEOTIDES
#8SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION
#9TOEHOLD EXCHANGE RIBOREGULATOR GATE AND REGULATING PROTEIN TRANSLATION WITH TOEHOLD EXCHANGE RIBOREGULATOR
#10METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#11Compositions and Methods for Modulating Single Stranded DNA Regions that Catalyze Enzymatic Reactions
#12METHODS OF EDITING WITH ENGINEERED CLASS 2 TYPE V CRISPR SYSTEMS
#13COMPOSITIONS CONTAINING NUCLEIC ACID NANOPARTICLES AND PROCESSES RELATED TO ALTERATION OF THEIR PHYSIOCHEMICAL CHARACTERISTICS
#14ENGINEERED CLASS 2 TYPE V CRISPR SYSTEMS
#15Riboswitch modulated gene therapy for retinal diseases
#16PLANT REGULATORY ELEMENTS AND USES THEREOF
#17miRNA Switches for RNA-Triggered Control of RNA Interference
#18RIBOSWITCH MODULATED GENE THERAPY FOR RETINAL DISEASES
#19METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION
#20ENGINEERED CLASS 2 TYPE V CRISPR SYSTEMS
#21COMPOSITION CONTAINING NUCLEIC ACID MOLECULE STABLY
#22MODIFIED OLIGONUCLEOTIDES FOR USE IN TREATMENT OF TAUOPATHIES
#23Modified DAAO enzyme and application thereof
#24CONDITIONAL-SIRNAS AND USES THEREOF IN TREATING ACUTE MYELOID LEUKEMIA
#25RNA-Editing Compositions and Methods of Use
#26lncRNA-REGULATED GENE EXPRESSION SYSTEM
#27Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing
#28Selectively altering microbiota for immune modulation
#29MODULATING NUCLEOTIDE EXPRESSION USING EXPRESSION MODULATING ELEMENTS AND MODIFIED TATA AND USE THEREOF
#30Synthetic ethylene-responsive binding element and uses thereof
#31USE OF AN ORPHAN MOTIF TO INCREASE EXPRESSION OF A HETEROLOGOUS TRANSGENE
#32METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#33Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof
#34Engineered class 2 type V CRISPR systems
#35BIOACTIVE GLASS AS NUCLEIC ACID CARRIERS WITH PH SWITCH CONTROL-RELEASING
#36APTAMER NANOFIBERS AND KILL-SWITCHES AND USES THEREOF
#37Modified DAAO enzyme and application thereof
#38METHOD FOR STABILIZING INTRACELLULAR RNA
#39NUCLEIC ACIDS, PROTEINS AND PROCESSES FOR PRODUCING AMIDES
#40CIRCULARLY PERMUTATED HALOALKANE TRANSFERASE FUSION MOLECULES
#41COMPOSITIONS AND METHODS FOR RAPID AND DYNAMIC FLUX CONTROL USING SYNTHETIC METABOLIC VALVES
#42SYSTEMS AND METHODS FOR POLYNUCLEOTIDE SPATIAL ORGANIZATION
#4317ß-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13) iRNA Compositions And Methods Of Use Thereof
#44Genetic toolbox for metabolic engineering of non-conventional yeast
#45IMMUNOTHERAPY OF CANCER
#46Plant regulatory elements and uses thereof
#47Nitrogen responsive transcription factors in plants
#48Methods of genetic mediated engineering of RNAi models
#49Stereospecific linkages in RNA editing oligonucleotides
#50METHODS OF MODULATING ANTISENSE ACTIVITY
#51RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
#52Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof
#53Increasing RNAi efficiency through single nucleotide mismatches
#54Conditional-siRNAS and uses thereof in treating acute myeloid leukemia
#55Selectively altering microbiota for immune modulation
#56Simultaneous gene silencing and suppressing gene silencing in ihe same cell
#57Modified oligonucleotides for use in treatment of tauopathies
#58RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
#59Antisense oligonucleotide compositions
#60Inhibitors of micro-RNA 22
#61Micro-RNA and obesity
#62Methods and compositions for modulating apolipoprotein (a) expression
#63Method for inhibiting the expression of inflammation promoting factors
#64METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#65Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
#66High Specificity Genome Editing Using Chemically Modified Guide RNAs
#67Anti-HERV-K envelope protein antibodies and methods for detecting HERV-K envelope protein in patients with sporadic amyotrophic lateral sclerosis
#68Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
#69Methods and Compositions for Engineering Synthetic Bioswitches for Remote Control of Biological Activity
#70Riboswitch modulated gene therapy for retinal diseases
#71Methods and compositions for controlling efficacy of RNA silencing
#72Antisense antibacterial compounds and methods
#73Lin28-mediated control of let-7 biogenesis
#74METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
#75Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#76Methods for alleviating symptoms of sporadic amyotrophic lateral sclerosis by neutralizing a HERV-K envelope protein using an anti-HERV-K envelope protein antibody
#77Selectively altering microbiota for immune modulation
#78Oligonucleotide compositions with enhanced efficiency
#79Anti-Fibrinogen Aptamers and Uses Thereof
#80ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
#81METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
#82Expression Inhibitor of Inflammation Promoting Factor, Screening Method for Active Ingredient Thereof, Expression Cassette Useful for Said Method, Diagnostic Agent and Diagnosis Method
#83Selectively altering microbiota for immune modulation
#84Method of releasing the suppression of egg maturation in economically-important prawn/shrimp species
#85OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
#86Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#87Oligonucleotide compositions with enhanced efficiency
#88DOUBLE-STRANDED OLIGONUCLEOTIDES
#89THERAPEUTIC AND DIAGNOSTIC MOLECULES
#90System and method for reversible photo-controlled gene silencing
#91Enhanced protein expression and methods thereof
#92LIN28- MEDIATED CONTROL OF LET-7 BIOGENESIS
#93Small molecule biosensors
#94Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
#95Compounds and methods for increasing antisense activity
#96Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#97SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF
#98Cyanobacterial strains capable of utilizing phosphite
#99Oligonucleotide compositions with enhanced efficiency
#100Catalytic strands of minimal hammerhead ribozymes and methods of using the same
#101NOVEL EXPRESSION REGULATING RNA-MOLECULES AND USES THEREOF
#102COMPOSITION CONTAINING NUCLEIC ACID MOLECULE STABLY
#103Disulfide-containing alkyne linking agents
#104DOUBLE STRAND RNA DELIVERY SYSTEM FOR PLANT-SAP-FEEDING INSECTS
#105Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#106Compositions and methods thereof for down-regulation of genes following oral delivery of an RNAi molecule bioencapsulated within plant cells
#107COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#108Factor V/Va-targeting aptamer compositions and methods of using the same
#109High specificity genome editing using chemically modified guide RNAs
#110Oligonucleotide compositions with enhanced efficiency
#111Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#112Delivery of dsRNA to arthropods
#113Antibacterial antisense oligonucleotide and method
#114Antisense oligonucleotide compositions
#115Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#116Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
#117Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#118THERAPEUTIC AND DIAGNOSTIC MOLECULES
#119Double stranded oligonucleotide compounds comprising positional modifications
#120Alternative export pathways for vector expressed RNA interference
#121Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#122Bi-Functional Short-Hairpin RNA (Bi-shRNA) Specific for Single-Nucleotide KRAS Mutations
#123Sequence-specific inhibition of small RNA function
#124Immunotherapy of cancer
#125Disulfide-containing alkyne linking agents
#126Method of modulating the activity of a nucleic acid molecule
#127Modular RNA regulators and methods
#128Method for the inhibition of angiogenesis
#129Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#130INHIBITING CANCER METASTASIS
#131RNA with a combination of unmodified and modified nucleotides for protein expression
#132Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#133Hydrazinyl lipidoids and uses thereof
#134Site-specific induction of bimolecular quadruplex-duplex hybrids and methods of using the same
#135Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#136Bridged bicyclic nucleosides
#137Vectors and methods for genetic immunization
#138Oligonucleotide
#139Antisense antibacterial compounds and methods
#140Compositions and methods for inhibiting expression of a target gene
#141Methods and compositions involving miRNA and miRNA inhibitor molecules
#142Vectors and methods for genetic immunization
#143METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#144Methods and compositions involving miRNA and miRNA inhibitor molecules
#145Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#146Methods and compositions of improved modified siRNA
#147COMPOUNDS AND METHODS FOR IMPROVED CELLULAR UPTAKE OF ANTISENSE COMPOUNDS
#148Signal activatable constructs and related components compositions methods and systems
#149Delivery of dsRNA to arthropods
#150Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#151Gene silencing methods
#152MUTAGENESIS METHODS
#153Plant microRNAs and methods of use thereof
#154Double-stranded oligonucleotides
#155Delivery of dsRNA to arthropods
#156Trans-acting RNA switches
#157Promoter and use thereof
#158Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis
#159Methods and compositions for reducing viral genome amounts in a target cell
#160Small conditional RNAs
#161Methods and compositions involving miRNA and miRNA inhibitor molecules
#162Simultaneous gene silencing and suppressing gene silencing in the same cell
#163OLIGONUCLEOTIDE N3'-->P5' THIOPHOSPHORAMIDATES: THEIR SYNTHESIS AND USE
#164Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#165Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#166Lin28-mediated control of let-7 biogenesis
#167Double-stranded nucleic acid molecule for gene expression control
#168Immune tolerance inducer
#169Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
#170Antibacterial antisense oligonucleotide and method
#171Sequence-specific inhibition of small RNA function
#172Alternative export pathways for vector expressed RNA interference
#173Methods and compositions for controlling efficacy of RNA silencing
#174Nucleic acid/polysaccharide complex
#175Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#176Compositions and methods for inhibiting expression of a target gene
#177Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#178Oligonucleotide compositions with enhanced efficiency
#179Bi-functional short-hairpin RNA (bi-shRNA) specific for single-nucleotide mutations
#180Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA
#181Aptazyme capable of selective silencing of target miRNA by releasing an antisense sequence in hepatitis C virus-infected cells and use thereof
#182Biologically active molecules for influencing virus-, bacteria-, parasite-infected cells and/or tumor cells and method for the use thereof
#183Photocleavable morpholino oligos with integral photolinkers for modulating the activity of any selected gene transcript by exposure to light
#184In vivo gene sensors
#185Modified U7 snRNAs for treatment of neuromuscular diseases
#186Double-stranded oligonucleotides
#187Methods and compositions for reducing viral genome amounts in a target cell
#188Compositions and Methods for Inhibiting Expression of a Mutant Gene
#189Method for treating myocardial infarct
#190METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF SINGLE AND DOUBLE BLUNT-ENDED siRNA
#191Delivery of dsRNA to arthropods
#192AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL
#193Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts
#194Method of inhibiting miR-33 using a modified oligonucleotide
#195Methods and reagents for analyzing riboswitches using FRET
#196Alternative export pathways for vector expressed RNA interference
#197Trans-acting RNA switches
#198NOVEL SIRNA STRUCTURE FOR MINIMIZING OFF-TARGET EFFECTS AND RELAXING SATURATION OF RNAI MACHINERY AND THE USE THEREOF
#199Therapeutic and diagnostic molecules
#200RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
#201Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#202NUCLEIC ACID DELIVERY COMPOSITIONS AND METHODS OF USE THEREOF
#203Aptamer that recognizes peptide
#204Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#205DOUBLE-STRANDED OLIGONUCLEOTIDES
#206Methods for producing microRNAs
#207Vector
#208Methods and compositions involving miRNA and miRNA inhibitor molecules
#209Reengineering mRNA primary structure for enhanced protein production
#210Delivery of dsRNA to arthropods
#211Method for inhibiting the activity of mir-155
#212Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders
#213MULTIPLE RNA POLYMERASE III PROMOTER EXPRESSION CONSTRUCTS
#214Signal activated molecular delivery
#215Compositions And Methods For Increasing Cellular Uptake Of RNAi Via SID-1
#216METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES
#217Method and materials for the cooperative hybridization of oligonucleotides
#218Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#219METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#220Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#221Triggered covalent probes for imaging and silencing genetic expression
#222Compositions and methods for inhibiting expression of a mutant gene
#223Construction of protein-responsive shRNA/RNAi control system using RNP motif
#224Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
#225Oligomeric compounds and compositions for use in modulation of small non-coding RNAS
#226ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND
#227ENHANCED ANTISENSE OLIGONUCLEOTIDES
#228Modulation of gene expression by oligomers targeted to chromosomal DNA
#229ANTIDOTE OLIGOMERS
#230Compositions and Systems for the Regulation of Genes
#231SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION
#232Methods and compositions for controlling efficacy of RNA silencing
#233IMPROVED GENE SILENCING METHODS
#234Methods and compositions for reducing viral genome amounts in a target cell
#235Compositions and methods for inhibiting expression of a target gene
#236Methods of altering an immune response induced by CpG oligodeoxynucleotides
#237In vivo gene sensors
#238Methods and compositions for increasing the activity of inhibitory RNA
#239METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#240Immunostimulatory siRNA molecules
#241Antidotes to antisense compounds
#242METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#243Method for promoting angiogenesis, vascularization or vessel repair
#244Methods and compositions for controlling efficacy of RNA silencing
#245Nucleic acid modulators of glycoprotein VI
#246Conditionally Active Ribozymes And Uses Thereof
#247METHODS FOR MEDIATING GENE SUPPRESSION
#248Vectors and method for genetic immunization
#249MEANS AND METHODS FOR shRNA MEDIATED CONDITIONAL KNOCKDOWN OF GENES
#250Oligonucleotide Compositions with Enhanced Efficiency
#251Nucleotide Motifs Providing Localization Elements and Methods of Use
#252Alternative export pathways for vector expressed RNA interference
#253Compositions and methods for inhibiting expression of a mutant gene
#254Method for inhibiting the activity of mir-155
#255Treatment of cancer using TLR3 agonists
#256INERT DNA SEQUENCES FOR EFFICIENT VIRAL PACKAGING AND METHODS OF USE
#257Integrated—ligand-responsive microRNAs
#258Oligomeric compounds and compositions for use in modulation of pri-miRNAs
#259Antibacterial antisense oligonucleotide and method
#260ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND
#261Genetic control of mammalian cells with synthetic RNA regulatory systems
#262High potency siRNAS for reducing the expression of target genes
#263Methods to regulate miRNA processing by targeting Lin-28
#264AGENTS, COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIES IN WHICH REGULATING AN ACHE-ASSOCIATED BIOLOGICAL PATHWAY IS BENEFICIAL
#265Method of producing recombinant biological products
#266PRIMARY MICRO RNA EXPRESSION CASSETTE
#267Method of modulating the activity of a nucleic acid molecule
#268COMPOSITIONS AND METHODS FOR INHIBITING GENE SILENCING BY RNA INTERFERENCE
#269siRNA Kinase and Methods of Use
#270DOUBLE-STRANDED OLIGONUCLEOTIDES
#271SMALL INTERFERING RNA (SIRNA) TARGET SITE BLOCKING OLIGOS AND USES THEREOF
#272RNA interference tags
#273Inhibitor Nucleic Acids
#274METHODS OF MODULATING EPITHELIAL-MESENCHYMAL TRANSITION AND MESENCHYMAL-EPITHELIAL TRANSITION IN CELLS AND AGENTS USEFUL FOR THE SAME
#275COMPOSITIONS AND METHODS FOR THE EXPRESSION OF NUCLEIC ACIDS
#276METHODS AND COMPOSITIONS RELATING TO POLYPEPTIDES WITH RNASE III DOMAINS THAT MEDIATE RNA INTERFERENCE
#277METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#278METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#279METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#280METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#281METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#282METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#283METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#284Modulation of gene expression through endogenous small RNA targeting of gene promoters
#285METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#286METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#287METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#288METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
#289Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#290Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification
#291Multiple RNA polymerase III promoter expression constructs
#292Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#293Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#294Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#295Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs
#296Small interfering RNAS as non-specific drugs
#297Multitargeting Interfering RNAs And Methods Of Their Use And Design
#298Cell-based RNA interference and related methods and compositions
#299RNA interference induction element and use thereof
#300SHRNA AND SIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE