112225 ⎘
Nucleic acids vectors Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
GENETICALLY MODIFIED T CELL RECEPTOR MICE
#2GENE REPLACEMENT THERAPY FOR FOXG1 SYNDROME
#3DNA IMMORTALIZATION CONSTRUCT AND PERFORMING PRIMARY CELL IMMORTALIZATION
#4HUMANIZED LIGHT CHAIN MICE
#5GENETIC SWITCH
#6NON-HUMAN ANIMALS HAVING AN ENGINEERED IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS
#7PROCESS FOR THE MANIPULATION OF NUCLEIC ACIDS
#8MEANS FOR GENERATING ADENOVIRAL VECTORS FOR CLONING LARGE NUCLEIC ACIDS
#9ADENOVIRAL HELPER VECTORS
#10SYNAPSE SURGERY TOOLS AND ASSOCIATED METHODS FOR NEURAL CIRCUIT-SPECIFIC SYNAPSE ABLATION AND MODIFICATION
#11ANIMAL MODEL OF TDP-43 PROTEINOPATHY
#12INDUCIBLE RECOMBINASE SYSTEMS
#13A GENE-BASED APPROACH TO CONFER LONG-LASTING PROTECTION FROM OPIOID USE DISORDER
#14METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF
#15MULTIPLEX ASSAY
#16REPROGRAMMING OF SOMATIC CELLS
#17TARGETED INTEGRATION OF NUCLEIC ACIDS
#18Stable Cell Lines for Inducible Production of rAAV Virions
#19CYTOMEGALOVIRUS VECTORS AND METHODS OF USE
#20Co-Delivery of a Gene Editor Construct and a Donor Template
#21COMPOSITIONS AND METHODS FOR SCREENING CIS REGULATORY ELEMENTS
#22ENGINEERED DNA BINDING PROTEINS
#23NEURODEGENERATIVE AND AMYOTROPHIC MODEL ANIMAL
#24NON-MEIOTIC ALLELE INTROGRESSION
#25MAMMALIAN ARTIFICIAL CHROMOSOME VECTOR HAVING HUMAN IMMUNOGLOBULIN HEAVY CHAIN LOCUS COMPRISING MODIFIED D-REGION, AND CELL OR NON-HUMAN ANIMAL RETAINING THE VECTOR
#26Genetically Engineered Eukaryotic Cells and Cell Lines and Uses Thereof
#27COMPOSITIONS AND METHODS FOR THE PRODUCTION OF LIBRARIES
#28Novel Animal Model for Autoimmune Disease
#29Improved Expression Vectors and Uses Thereof
#30ADAM6 MICE
#31BACULOVIRUS EXPRESSION SYSTEM
#32Means and Methods for Improved Regeneration
#33PREPARATION OF LIBRARIES OF PROTEIN VARIANTS EXPRESSED IN EUKARYOTIC CELLS AND USE FOR SELECTING BINDING MOLECULES
#34PROCESS FOR THE MANIPULATION OF NUCLEIC ACIDS
#35METHOD FOR PREPARING TRANSGENIC NON-HUMAN ANIMAL HAVING GENOME INCLUDING HUMANIZED IMMUNOGLOBULIN GENE LOCUS
#36EXPRESSION VECTORS, BACTERIAL SEQUENCE-FREE VECTORS, AND METHODS OF MAKING AND USING THE SAME
#37BETA-2 MICROGLOBULIN-DEFICIENT CELLS
#38COMPOSITIONS AND METHODS FOR RAPID GENERATION OF MODIFIABLE STABLE CELL LINES
#39PLASMID SYSTEM WITHOUT SELECTABLE MARKERS AND PRODUCTION METHOD THEREOF
#40COMPOSITIONS AND METHODS FOR PRODUCING AND OPTIMIZING VIRAL VECTOR PRODUCER CELLS FOR CELL AND GENE THERAPY
#41Recombinant Cytomegalovirus Vectors As Vaccines For Tuberculosis
#42TUNABLE TRANSPOSON SYSTEMS
#43EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION IN LIVESTOCK
#44NOVEL CAS13B ORTHOLOGUES CRISPR ENZYMES AND SYSTEMS
#45Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1
#46Methods and compositions for transducing lymphocytes and regulating the activity thereof
#47HUMANIZED LIGHT CHAIN MICE
#48PLATFORM VECTOR FOR MODULAR AND SIMPLIFIED INSERTION OF TRANSGENES INTO ALPHAHERPESVIRINAE
#49SINGLE GENERATION TARGETED GENE INTEGRATION
#50RECOMBINANT ADENO-ASSOCIATED VIRAL VECTORS FOR MULTIPARTITE GENE DELIVERY
#51DISCOVERY AND ENGINEERING OF INTEGRASES FOR HIGH-EFFICIENCY GENE INTEGRATION
#52CELL LINES WITH MULTIPLE DOCKS FOR GENE INSERTION
#53Methods and compositions for rapid generation of single and multiplexed reporters in cells
#54METHODS FOR TARGETED INTEGRATION
#55GENE REPLACEMENT THERAPY FOR FOXG1 SYNDROME
#56TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS
#57METHODS FOR SCREENING VARIANT OF TARGET GENE
#58Compositions and Methods for Controlling Production of Polypeptides in Cells
#59DUAL-CONTROLLED DRUG AND PHOTOACTIVATABLE SYSTEM FOR SPATIOTEMPORAL CONTROL OF CELL THERAPY
#60ANTI-MUC16 ANTIBODIES AND USES THEREOF
#61IMPROVED IN VIVO REPROGRAMMING SYSTEM AND CELL CONVERSION METHOD USING SAME
#62GENETICALLY-DIRECTED SPARSE AND COMPLETE LABELING OF BRAIN CELLS
#63ADENOVIRAL ASSEMBLY METHOD
#64GENETICALLY MODIFIED T CELL RECEPTOR MICE
#65CAS 9 RETROVIRAL INTEGRASE AND CAS 9 RECOMBINASE SYSTEMS FOR TARGETED INCORPORATION OF A DNA SEQUENCE INTO A GENOME OF A CELL OR ORGANISM
#66SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF
#67ACOUSTIC REMOTE CONTROL OF MICROBIAL IMMUNOTHERAPY
#68CRISPR GENOME EDITING WITH CELL SURFACE DISPLAY TO PRODUCE HOMOZYGOUSLY EDITED EUKARYOTIC CELLS
#69AGENT THAT ENABLES SIRT7 GENE EXPRESSION AND THE USE THEREOF
#70METHODS FOR MODIFYING A GENOME
#71INDUCIBLE PLASMID-SELF-DESTRUCTION ASSITED RECOMBINATION
#72Compositions and methods for producing genetically modified animals
#73STABLE TARGETED INTEGRATION
#74Methods of Host Cell Modification
#75ADENO-ASSOCIATED VIRAL VECTOR PRODUCER CELL LINES
#76METHOD FOR THE GENERATION OF A PROTEIN EXPRESSING CELL BY TARGETED INTEGRATION USING CRE MRNA
#77IMPROVED PROCESS FOR DNA INTEGRATION USING RNA-GUIDED ENDONUCLEASES
#78NUCLEIC ACID CONSTRUCTS FOR SIMULTANEOUS GENE ACTIVATION
#79ARTIFICIAL RECOMBINANT CHROMOSOME AND USE THEREOF
#80Process for the manipulation of nucleic acids
#81ADENOVIRUS LIBRARY AND METHODS
#82ARTIFICIAL RECOMBINANT CHROMOSOME AND USE THEREOF
#83A METHOD FOR SCREENING A THERAPEUTIC AGENT FOR CANCER USING BINDING INHIBITOR OF CYCLIN-DEPENDENT KINASE 1 (CDK1)-CYCLIN B1 AND RETINOIC ACID RECEPTOR RESPONDER 1 (RARRES1) GENE KNOCKOUT ANIMAL MODEL
#84TARGETED INTEGRATION OF NUCLEIC ACIDS
#85Recombinant cytomegalovirus vectors as vaccines for tuberculosis
#86A CELL SURFACE TAG EXCHANGE (CSTE) SYSTEM FOR TRACING AND MANIPULATION OF CELLS DURING RECOMBINASE MEDIATED CASSETTE EXCHANGE INTEGRATION OF NUCLEIC ACID SEQUENCES TO ENGINEERED RECEIVER CELLS
#87HUMANIZED RODENTS THAT EXPRESS HEAVY CHAIN CONTAINING VL DOMAINS
#88Inducible, tunable, and multiplex human gene regulation using CRISPR-Cpf1
#89Non-human animals models of retinoschisis
#90Targeted modification of rat genome
#91Non-human animals having a humanized signal-regulatory protein gene
#92Expression vector and method
#93Minimal volume reprogramming of mononuclear cells
#94NON-MEIOTIC ALLELE INTROGRESSION
#95ADAM6 mice
#96ADAM6 mice
#97SMARTBAC BACULOVIRUS EXPRESSION SYSTEM AND APPLICATION THEREOF
#98GENETICALLY MODIFIED T CELL RECEPTOR MICE
#99Targeted delivery of glycine receptors to excitable cells
#100Transgenic animals and methods of use
#101NON-HUMAN ANIMALS HAVING AN ENGINEERED IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS
#102Methods for screening variant of target gene
#103NOVEL NUCLEIC ACID CONSTRUCT
#104Targeted integration of nucleic acids
#105Engineered DNA binding proteins
#106Methods and compositions for rapid generation of single and multiplexed reporters in cells
#107Methods for screening variant of target gene
#108NON-HUMAN ANIMALS HAVING A HEXANUCLEOTIDE REPEAT EXPANSION IN A C9ORF72 LOCUS
#109DNA LAUNCHED RNA REPLICON SYSTEM (DREP) AND USES THEREOF
#110HUMAN ARTIFICIAL CHROMOSOME CONTAINING HUMAN ANTIBODY LAMBDA LIGHT CHAIN GENE AND NON-HUMAN ANIMAL CONTAINING THE HUMAN ARTIFICIAL CHROMOSOME CAPABLE OF GENETIC TRANSMISSION
#111Rodents With Conditional ACVR1 Mutant Alleles
#112PROCESS FOR DNA INTEGRATION USING RNA-GUIDED ENDONUCLEASES
#113Humanized light chain mice
#114Humanized light chain mice
#115CONDITIONAL PROTEIN TRANSLATION SWITCHES, CONDITIONAL GENE EXPRESSION SYSTEMS AND USES THEREOF
#116Non-human animals having a humanized signal-regulatory protein gene
#117Optogenetic construct for allosteric control of protein activity
#118PREPARATION OF LIBRARIES OF PROTEIN VARIANTS EXPRESSED IN EUKARYOTIC CELLS AND USE FOR SELECTING BINDING MOLECULES
#119Preparation of libraries of protein variants expressed in eukaryotic cells and use for selecting binding molecules
#120Preparation of libraries of protein variants expressed in eukaryotic cells and use for selecting binding molecules
#121Polypeptide set to be used in light dependent gene recombination
#122ADENOVIRAL ASSEMBLY METHOD
#123Targeted gene therapies for pain and other neuro-related disorders
#124Compositions and Methods of Chromosomal Silencing
#125Cas13b orthologues CRISPR enzymes and systems
#126Ungulates with genetically modified immune systems
#127Method for preparing mutant strain having high producibility of phytoene and mutant strain prepared thereby
#128Particle for the encapsidation of a genome engineering system
#129Vector for targeting the human Rosa26 gene
#130Transcriptional terminators for gene expression in plants
#131REGENERATING FUNCTIONAL NEURONS FOR TREATMENT OF NEURAL INJURY CAUSED BY DISRUPTION OF BLOOD FLOW
#132Somatic haploid human cell line
#133Non-meiotic allele introgression
#134Non-meiotic allele introgression
#135MEANS FOR GENERATING ADENOVIRAL VECTORS FOR CLONING LARGE NUCLEIC ACIDS
#136Adenovirus library and methods
#137MULTI-SITE SPECIFIC INTEGRATION CELLS FOR DIFFICULT TO EXPRESS PROTEINS
#138Mammalian cells for producing adeno-associated viruses
#139EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
#140Multifunctional alleles
#141Beta-2 microglobulin-deficient cells
#142HLA Class II Deficient Cells, HLA Class I Deficient Cells Capable of Expressing HLA Class II Proteins, and Uses Thereof
#143GENETICALLY STERILE ANIMALS
#144Methods of introducing multiple expression constructs into a eukaryotic cell
#145Targeted modification of rat genome
#146Non-meiotic allele introgression
#147SCRaMbLE of heterozygous diploid yeast
#148Transcription modulation in animals using CRISPR/Cas systems
#149Means and methods for improved regeneration
#150METHODS OF HOST CELL MODIFICATION
#151EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION IN LIVESTOCK
#152Compositions and methods for treating and preventing metabolic disorders
#153GENETIC ERASERS
#154Oncolytic expression vector comprising a nucleic acid comprising a nucleotide sequence encoding GADD34
#155Generating targeted sequence diversity in fusion proteins
#156Phage-mediated manipulation of
#157Humanized universal light chain mice
#158PRODUCTION OF VIRAL VECTORS
#159Expression of neuropeptides
#160Non-human animals having a humanized signal-regulatory protein gene
#161Site-specific integration
#162EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
#163CONDITIONAL PROTEIN TRANSLATION SWITCHES, CONDITIONAL GENE EXPRESSION SYSTEMS AND USES THEREOF
#164Efficient non-meiotic allele introgression in livestock
#165Conditional CRISPR sgRNA expression
#166Lineage reporter synthetic chromosomes and methods of use
#167Conditional rodent Acvr1 mutant gene
#168Method for making a genetically modified mouse with an inducible ACVR1 mutation that causes ectopic bone formation
#169TRANSGENIC MICE
#170Methods and compositions for recombinase-based genetic diversification
#171Methods of modifying genes in eukaryotic cells
#172ADAM6 mice
#173Gene targeting method
#174Minimal volume reprogramming of mononuclear cells
#175ADAM6 mice
#176ADAM6 mice
#177ADAM6 mice
#178Tissue selective transgene expression
#179LENTIVIRAL VECTORS AND USES THEREOF
#180Enhanced expression and stability regions
#181Mice with a modified glucose-6-phosphate dehydrogenase gene
#182GENOMIC COMBINATORIAL SCREENING PLATFORM
#183Animal models and therapeutic molecules
#184High-throughput mouse model for optimizing antibody affinities
#185Recombinant Influenza Viruses for Vaccines and Gene Therapy
#186RECOMBINANT MAMMALIAN CELLS AND METHOD FOR PRODUCING SUBSTANCE OF INTEREST
#187Rodent embryonic stem cell with conditional ACVR1 mutant alleles
#188Non-human animal models of retinoschisis
#189Transgenic chicken for production of antibodies having a common light chain
#190Targeted integration into the PPP1R12C locus
#191Methods of cell renewal
#192Non-human animals having a humanized signal-regulatory protein gene
#193Non-human animals having an engineered immunoglobulin Λ light chain locus
#194Generating targeted sequence diversity in fusion proteins
#195Anti-MUC16 antibodies and uses thereof
#196A METHOD OF SITE-DIRECTED INSERTION TO H11 LOCUS IN PIGS BY USING SITE-DIRECTED CUTTING SYSTEM
#197Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus
#198CAS 9 RETROVIRAL INTEGRASE AND CAS 9 RECOMBINASE SYSTEMS FOR TARGETED INCORPORATION OF A DNA SEQUENCE INTO A GENOME OF A CELL OR ORGANISM
#199Efficient non-meiotic allele introgression
#200Methods of introducing multiple expression constructs into a eukaryotic cell
#201Recombinant cytomegalovirus vectors as vaccines for tuberculosis
#202Circular nucleic acid vectors, and methods for making and using the same
#203Site-specific DNA recombination
#204Methods and compositions for rapid generation of single and multiplexed reporters in cells
#205Methods and compositions for nucleic acid integration
#206Methods and compositions for transducing lymphocytes and regulating the activity thereof
#207Reprogramming of somatic cells
#208Humanized light chain mice
#209Cloning method
#210Extensible recombinase cascades
#211Non-human animals having a humanized signal-regulatory protein gene
#212Stable genomic integration of multiple polynucleotide copies
#213Recombinases and target sequences
#214Production of viral vectors
#215Targeted modification of rat genome
#216METHODS OF MAKING MINICIRCLES
#217Genetically modified non-human mammals and cells
#218Methods of host cell modification
#219Method of genetically altering and producing allergy free cats
#220Human artificial chromosome containing human antibody lambda light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission
#221Enhanced expression and stability regions
#222Biological state machines
#223FACULTATIVELY ATTENUATED BACTERIAL SPECIES AND METHODS OF PREPARATION AND USE THEREOF
#224Targeted delivery of glycine receptors to excitable cells
#225Fluorescent and colored proteins and methods for using them
#226Preparation of libraries of protein variants expressed in eukaryotic cells and use for selecting binding molecules
#227Compositions and methods for site specific recombination at asymmetric sites
#228Mouse λ light chain locus
#229Nucleic acid construct for making a genetically modified rodent with an inducible ACVR1 mutation that causes ectopic bone formation
#230Method for Gene Amplification
#231Activity-dependent expression of nucleic acids
#232Somatic haploid human cell line
#233PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
#234Non-human animals having a humanized signal-regulatory protein gene
#235High-throughput mouse model for optimizing antibody affinities
#236COMPOSITIONS AND METHODS FOR PRODUCING GENETICALLY MODIFIED ANIMALS
#237Non-human animals having a disruption in a C9ORF72 locus
#238DNA vector production system
#239Method of making adenovirus and corresponding plasmids
#240Method for positioning and integrating transgene and use thereof
#241Promoter-regulated differentiation-dependent self-deleting cassette
#242Animal model and method for studying gene-gene interactions
#243Targeted integration into the PPP1R12C locus
#244Synthetic regulation of gene expression
#245Animal models and therapeutic molecules
#246Alphaviral vectors and cell lines for producing recombinant proteins
#247Expression Tools for Multiprotein Applications
#248Mini-intronic plasmid DNA vaccines in combination with LAG3 blockade
#249Domain 5 of CD163 for use in antiviral compositions against PRRS, and transgenic animals
#250Transgenic non-human mammal for producing chimeric human immunoglobulin E antibodies
#251miRNA-regulated differentiation-dependent self-deleting cassette
#252Recombinant influenza viruses for vaccines and gene therapy
#253Enhanced expression and stability regions
#254Vectors
#255Polycistronic Vector for Human Induced Pluripotent Stem Cell Production
#256Adenoviral assembly method
#257Non-human animals having a humanized signal-regulatory protein gene
#258Genetically modified T cell receptor mice
#259Stem cell gene targeting
#260Minimal volume reprogramming of mononuclear cells
#261METHOD OF GENETICALLY ALTERING AND PRODUCING ALLERGY FREE CATS
#262MiRNA-regulated differentiation-dependent self-deleting cassette
#263METHODS OF HOST CELL MODIFICATION
#264Generating targeted sequence diversity in fusion proteins
#265CONDITIONAL EXPRESSION OF TRANSGENES IN VIVO
#266Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
#267Fluorescent and colored proteins and methods for using them
#268Minicircles with viral expression cassettes and their use in the transformation of cells for generating recombinant virus or viral gene vectors
#269Minicircle DNA vector preparations and methods of making and using the same
#270ADAM6 mice
#271CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#272ADAM6 mice
#273Site-specific integration
#274Chromosomal landing pads and related uses
#275EXPRESSION CONSTRUCT FOR YEAST AND A METHOD OF USING THE CONSTRUCT
#276Method of producing induced pluripotent stem cells using inhibitors of P53
#277Transgenic non-human vertebrate for the in vivo production of dual specificity immunoglobulins or hypermutated heavy chain only immunoglobulins
#278METHODS FOR CONTROLLING STEM CELL DIFFERENTIATION
#279Reprogramming of somatic cells
#280Promoter-regulated differentiation-dependent self-deleting cassette
#281Rodent comprising mouse artificial chromosome vector
#282Non-human animals having a humanized signal-regulatory protein gene
#283Non-human animals having a humanized signal-regulatory protein gene
#284Circular nucleic acid vectors, and methods for making and using the same
#285Efficient non-meiotic allele introgression
#286Cloning method
#287Recombination system
#288Rasamsonia transformants
#289Nucleic acids for cloning and expressing multiprotein complexes
#290Targeted integration into the PPP1R12C locus
#291Methods and compositions relating to restricted expression lentiviral vectors and their applications
#292Genetically modified mouse with an inducible gene with a mutant R206H exon 5 that has ectopic bone formation
#293ADAM6 mice
#294Reassortant influenza viruses for vaccines
#295Introduction of modular vector elements during production of a lentivirus
#296Production of viral vectors
#297miRNA-regulated differentiation-dependent self-deleting cassette
#298Use of integrase for targeted gene expression
#299Homozygous and heterozygous IDH1 gene-defective cell lines derived from human colorectal cells
#300Transgenic non-human animal model of neurodegenerative disease