ClassID:

108937

C12N9/22 - page 15 - CPC Classification

Classification description:

Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses

Recent Application in this class:
#4201
20210177899
2021-06-17

Genome editing of graft-derived T-cells for post-transplant immunotherapy

#4202
20210172934
2021-06-10

SINGLE CELL CLONING APPROACHES FOR BIOLOGICAL STUDIES

#4203
20210172008
2021-06-10

METHODS AND COMPOSITIONS TO IDENTIFY NOVEL CRISPR SYSTEMS

#4204
20210171985
2021-06-10

Compositions and methods for genomic editing by insertion of donor polynucleotides

#4205
20210171983
2021-06-10

Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies

#4206
20210171958
2021-06-10

METHODS OF TREATING CANCER

#4207
20210171944
2021-06-10

Compositions and methods for modulating gene expression

#4208
20210171943
2021-06-10

Compositions and methods for treating disorders of genomic imprinting

#4209
20210171935
2021-06-10

METHOD FOR MODIFYING GENOME SEQUENCE TO INTRODUCE SPECIFIC MUTATION TO TARGETED DNA SEQUENCE BY BASE-REMOVAL REACTION, AND MOLECULAR COMPLEX USED THEREIN

#4210
20210171929
2021-06-10

SINGLE BASE EDITING TOOLS WITH PRECISE ACCURACY

#4211
20210171926
2021-06-10

Modified cascade ribonucleoproteins and uses thereof

#4212
20210171925
2021-06-10

Using proteases to control restriction enzyme activity

#4213
20210171924
2021-06-10

Transposase polypeptides and uses thereof

#4214
20210171923
2021-06-10

MAD nucleases

#4215
20210166783
2021-06-03

METHODS FOR IDENTIFYING CLASS 2 CRISPR-CAS SYSTEMS

#4216
20210164030
2021-06-03

Method for removing and/or detecting nucleic acids having mismatched nucleotides

#4217
20210163968
2021-06-03

Optimized plant CRISPR/CPF1 systems

#4218
20210163960
2021-06-03

Single-vector type I vectors

#4219
20210163944
2021-06-03

NOVEL CAS12B ENZYMES AND SYSTEMS

#4220
20210163943
2021-06-03

Compositions and Methods for Hydroxyacid Oxidase 1 (HAO1) Gene Editing for Treating Primary Hyperoxaluria Type 1 (PH1)

#4221
20210163940
2021-06-03

COMPOSITIONS AND METHODS FOR NICKING TARGET DNA SEQUENCES

#4222
20210163939
2021-06-03

CRISPR therapy

#4223
20210163938
2021-06-03

MRNA driven expression of RNA editors for treatment of pathologies

#4224
20210163937
2021-06-03

ENRICHMENT OF GENOME-EDITED CELLS

#4225
20210163936
2021-06-03

METHOD FOR SCREENING AND IDENTIFYING FUNCTIONAL LNCRNAS

#4226
20210163935
2021-06-03

Targeted Critical Fluid Nanoparticles Platform for Delivery of Nucleic Acids for Treatment of HIV-1 and Other Diseases

#4227
20210163913
2021-06-03

Fusion proteins for base editing

#4228
20210163910
2021-06-03

CRISPR/Cas fusion proteins and systems

#4229
20210163909
2021-06-03

Polypeptides

#4230
20210163908
2021-06-03

CRISPR-cas systems for genome editing

#4231
20210163907
2021-06-03

Modified CAS9 protein, and use thereof

#4232
20210163895
2021-06-03

Enhanced immune effector cells and use thereof

#4233
20210163853
2021-06-03

Detergent composition

#4234
20210162022
2021-06-03

Sequence specific antimicrobials

#4235
20210161111
2021-06-03

FACTOR VIII OR FACTOR IX GENE KNOCKOUT RABBIT, METHOD FOR PREPARING SAME AND USE THEREOF

#4236
20210155954
2021-05-27

CRISPR logic circuits for safer and controllable gene therapies

#4237
20210155932
2021-05-27

Compositions and methods to treat cancer

#4238
20210155927
2021-05-27

METHODS FOR TREATING SICKLE CELL DISEASE

#4239
20210155925
2021-05-27

Compositions and methods for disrupting the molecular mechanisms associated with mitochondrial dysfunction and neurodegenerative disease

#4240
20210155924
2021-05-27

METHODS AND COMPOSITIONS FOR INDUCING TUMOR CELL DEATH

#4241
20210155912
2021-05-27

Engineered enzymes

#4242
20210155911
2021-05-27

NOVEL CRISPR ENZYMES AND SYSTEMS

#4243
20210154326
2021-05-27

CRISPR-Based Synthetic Gene Circuits as Next Generation Gene Therapy of Inner Ear

#4244
20210154236
2021-05-27

HAEMATOPOIETIC STEM CELL TREATMENT

#4245
20210147887
2021-05-20

Method for producing lysine by utilizing adsorption and immobilized fermentation of recombinant corynebacterium glutamicum

#4246
20210147878
2021-05-20

Methods and means for genetic alteration of genomes utilizing designer DNA recombining enzymes

#4247
20210147868
2021-05-20

Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system

#4248
20210147862
2021-05-20

COMPOSITIONS AND METHODS FOR RNA-TEMPLATED EDITING IN PLANTS

#4249
20210147861
2021-05-20

Optimized CRISPR-Cas nucleases and base editors and methods of use thereof

#4250
20210147858
2021-05-20

Methods for increasing observed editing in bacteria

#4251
20210147856
2021-05-20

Gene editing methods with increased knock-in efficiency

#4252
20210147854
2021-05-20

Chimeric polypeptides having targeted binding specificity

#4253
20210147844
2021-05-20

Method for Site-Specific Mutagenesis of Medicago Sativa Genes by Using CRISPR/Cas9 System

#4254
20210147841
2021-05-20

COMPOSITIONS AND METHODS FOR MODIFYING REGULATORY T CELLS

#4255
20210147831
2021-05-20

Sequencing-based proteomics

#4256
20210147828
2021-05-20

DNA damage response signature guided rational design of CRISPR-based systems and therapies

#4257
20210147818
2021-05-20

CBLB endonuclease variants, compositions, and methods of use

#4258
20210147798
2021-05-20

Artificially manipulated immune cell

#4259
20210145960
2021-05-20

PROPHYLACTIC PROTECTION AGAINST VIRAL INFECTIONS, PARTICULARLY HIV

#4260
20210145940
2021-05-20

DYSTROPHIN GENE EXON DELETION USING ENGINEERED NUCLEASES

#4261
20210139935
2021-05-13

METHODS OF MANUFACTURING CAR-T CELLS

#4262
20210139892
2021-05-13

COMPOSITIONS AND METHODS FOR DELIVERY OF RNA TO A CELL

#4263
20210139891
2021-05-13

MODIFIED GUIDE RNAS, CRISPR-RIBONUCLEOTPROTEIN COMPLEXES AND METHODS OF USE

#4264
20210139890
2021-05-13

NOVEL CRISPR RNA TARGETING ENZYMES AND SYSTEMS AND USES THEREOF

#4265
20210139889
2021-05-13

Compositions and Methods for Multiplexed Genome Editing and Screening

#4266
20210139874
2021-05-13

CRISPR-Cas systems for genome editing

#4267
20210139873
2021-05-13

RNA silencing nanozymes

#4268
20210139872
2021-05-13

CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS

#4269
20210139871
2021-05-13

Nucleases and methods for making and using them

#4270
20210139870
2021-05-13

ANTI-HBV COMBINATION THERAPIES INVOLVING SPECIFIC ENDONUCLEASES

#4271
20210139850
2021-05-13

MANUFACTURING PROCESS FOR MAKING T CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTORS

#4272
20210137839
2021-05-13

COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DELIVERY

#4273
20210130874
2021-05-06

RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF

#4274
20210130850
2021-05-06

Increasing specificity for RNA-guided genome editing

#4275
20210130838
2021-05-06

SYSTEMS AND METHODS FOR PLANT GENOME EDITING USING CAS 12a ORTHOLOGS

#4276
20210130835
2021-05-06

Compositions and methods for RNA-encoded DNA-replacement of alleles

#4277
20210130833
2021-05-06

BACTERIAL DEFENSE SYSTEMS AND METHODS OF IDENTIFYING THEREOF

#4278
20210130832
2021-05-06

METHODS OF GENE THERAPY

#4279
20210130827
2021-05-06

TYPE V CRISPR-CAS BASE EDITORS AND METHODS OF USE THEREOF

#4280
20210130824
2021-05-06

COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING FIBRINOGEN-ALPHA

#4281
20210130818
2021-05-06

Compositions and Methods for Enhancement of Homology-Directed Repair Mediated Precise Gene Editing by Programming DNA Repair with a Single RNA-Guided Endonuclease

#4282
20210130817
2021-05-06

Gene Editing System and Gene Editing Method

#4283
20210130805
2021-05-06

Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence

#4284
20210130804
2021-05-06

Method to inactivate a mutant allele of an gene

#4285
20210130800
2021-05-06

SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING

#4286
20210130799
2021-05-06

Regulation of CRISPR-associated rossman fold (CARF) domain containing proteins by oligoadenylates

#4287
20210130779
2021-05-06

CLOSED PROCESS FOR EXPANSION AND GENE EDITING OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY

#4288
20210130773
2021-05-06

METHOD AND COMPOSITION FOR GENERATING BASAL FOREBRAIN CHOLINERGIC NEURONS (BFCNs)

#4289
20210127649
2021-05-06

Transgenic mouse for aglycosylated antibody production and use of aglycosylated antibody produced therefrom

#4290
20210123075
2021-04-29

COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY

#4291
20210123068
2021-04-29

Method for removing genetic linkage in a plant

#4292
20210123053
2021-04-29

Mammalian cells for producing a secreted protein

#4293
20210123052
2021-04-29

METHODS FOR THE IN VIVO PRODUCTION OF SINGLE STRANDED DNA AND USES THEREOF

#4294
20210123047
2021-04-29

Crispr DNA targeting enzymes and systems

#4295
20210123046
2021-04-29

Optimized small guide RNAs and methods of use

#4296
20210123045
2021-04-29

A YEAST TWO-HYBRID RNA-PROTEIN INTERACTION SYSTEM BASED ON CATALYTICALLY INACTIVATED CRISPR-DCAS9

#4297
20210123035
2021-04-29

Modified double-stranded donor templates

#4298
20210123034
2021-04-29

Cas9-based transcription modulation systems

#4299
20210121581
2021-04-29

METHODS AND COMPOSITIONS FOR TREATING TUMOR CELLS

#4300
20210115475
2021-04-22

SYSTEMS AND METHODS FOR MODULATING CHROMOSOMAL REARRANGEMENTS

#4301
20210115471
2021-04-22

Universal donor cells

#4302
20210115470
2021-04-22

Method for creating new germplasm of male sterile crop by gene editing and application thereof

#4303
20210115449
2021-04-22

THERAPEUTIC MODULATION OF TUMOR SUPPRESSORS USING EXOSOMES

#4304
20210115437
2021-04-22

IN VITRO SYNTHESIS METHOD FOR SGRNA AND KIT THEREOF

#4305
20210115429
2021-04-22

Tyrosol-producing recombinant and construction method and application thereof

#4306
20210115428
2021-04-22

Suppression of pain by gene editing

#4307
20210115421
2021-04-22

Variants of CAS12A nucleases and methods of making and use thereof

#4308
20210115420
2021-04-22

ENHANCED BCL11A RNP / CRISPR DELIVERY & EDITING USING A 3XNLS-CAS9

#4309
20210115419
2021-04-22

CRISPR/Cas9-Mediated Exon-Skipping Approach for USH2A-Associated Usher Syndrome

#4310
20210115092
2021-04-22

Systems and methods for increasing efficiency of genome editing

#4311
20210113674
2021-04-22

COMPOSITIONS AND METHODS FOR MULTIPLEXED TUMOR VACCINATION WITH ENDOGENOUS GENE ACTIVATION

#4312
20210113616
2021-04-22

Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene

#4313
20210108267
2021-04-15

CRISPR EFFECTOR SYSTEM BASED MULTIPLEX DIAGNOSTICS

#4314
20210108231
2021-04-15

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4315
20210108230
2021-04-15

Carboxylated nanodiamond-mediated CRISPR-CAS9 delivery system

#4316
20210108229
2021-04-15

Systems, methods, and compositions for correction of frameshift mutations

#4317
20210108196
2021-04-15

FUNCTIONAL GENOMICS USING CRISPR-CAS SYSTEMS, COMPOSITIONS, METHODS, SCREENS AND APPLICATIONS THEREOF

#4318
20210108195
2021-04-15

Automated cell processing methods, modules, instruments, and systems

#4319
20210108188
2021-04-15

NON-COVALENT SYSTEMS AND METHODS FOR DNA EDITING

#4320
20210108174
2021-04-15

Materials and methods for engineering cells and uses thereof in immuno-oncology

#4321
20210108170
2021-04-15

PHENOTYPIC READOUT FOR EDITED SEQUENCES IN LIVE CELLS IN AUTOMATED INSTRUMENTATION

#4322
20210107948
2021-04-15

Hybrid recombinant adeno-associated virus serotype between AAV9 and AAVrh74 with reduced liver tropism

#4323
20210102244
2021-04-08

RNA-guided systems for probing and mapping of nucleic acids

#4324
20210102242
2021-04-08

Programmable nuclease compositions and methods of use thereof

#4325
20210102241
2021-04-08

Method for confirming introduction of foreign gene into cells and method for manufacturing introduction foreign gene into cells

#4326
20210102222
2021-04-08

Method of inactivating a glucocorticoid receptor gene in an isolated cell

#4327
20210102206
2021-04-08

TARGETED GENE ACTIVATION USING MODIFIED GUIDE RNA

#4328
20210102197
2021-04-08

DESIGNING SENSITIVE, SPECIFIC, AND OPTIMALLY ACTIVE BINDING MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS

#4329
20210102191
2021-04-08

METHOD FOR THE ISOLATION OF INTACT EXTRACELLULAR VESICLES

#4330
20210102183
2021-04-08

Engineered cascade components and cascade complexes

#4331
20210100225
2021-04-08

Multiplexed genome editing

#4332
20210095394
2021-04-01

Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells

#4333
20210095316
2021-04-01

Platform for expressing protein of interest in liver

#4334
20210095299
2021-04-01

REPEAT-MEDIATED PLANT SITE-SPECIFIC RECOMBINATION METHOD

#4335
20210095286
2021-04-01

Trans-activated functional RNA by strand displacement and uses thereof

#4336
20210095273
2021-04-01

MODULATION OF MICROBIOTA COMPOSITIONS USING TARGETED NUCLEASES

#4337
20210095271
2021-04-01

System and method for genome editing

#4338
20210095269
2021-04-01

Method For Isolating DNA By Using Cas Protein System

#4339
20210095267
2021-04-01

Dynamically-adaptive live therapeutic agents and methods of use thereof

#4340
20210093679
2021-04-01

ENGINEERED GUT MICROBES AND USES THEREOF

#4341
20210093667
2021-04-01

CRISPR/CAS-ADENINE DEAMINASE BASED COMPOSITIONS, SYSTEMS, AND METHODS FOR TARGETED NUCLEIC ACID EDITING

#4342
20210087607
2021-03-25

METHODS AND COMPOSITIONS FOR NUCLEIC ACID DETECTION

#4343
20210087604
2021-03-25

Programmable DNA-guided artificial restriction enzymes

#4344
20210087588
2021-03-25

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4345
20210087573
2021-03-25

METHODS AND COMPOSITIONS FOR HOMOLOGY-DIRECTED REPAIR OF CAS ENDONUCLEASE MEDIATED DOUBLE STRAND BREAKS

#4346
20210087572
2021-03-25

Modified aminoacyl-tRNA synthetase and use thereof

#4347
20210087568
2021-03-25

Modified Guide RNAs for Gene Editing

#4348
20210087557
2021-03-25

Methods and compositions for targeted genomic insertion

#4349
20210087555
2021-03-25

Method for inducing exon skipping by genome editing

#4350
20210087550
2021-03-25

His-MBP tagged DNA endonuclease for facilitated enzyme removal

#4351
20210087548
2021-03-25

Compositions and Methods for Inducing Protein Function

#4352
20210087540
2021-03-25

RECOMBINANT ORGANISMS AND METHODS FOR PRODUCING GLYCOMOLECULES WITH LOW SULFATION

#4353
20210087538
2021-03-25

Compositions of and methods for in vitro viral genome engineering

#4354
20210087537
2021-03-25

ENHANCED IMMUNE EFFECTOR CELLS AND USE THEREOF

#4355
20210085771
2021-03-25

Method for inducing a tolerogenic immune response

#4356
20210085721
2021-03-25

Compositions and methods for the treatment of cancer using a CD8 engineered T cell therapy

#4357
20210085720
2021-03-25

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TET2 ENGINEERED T CELL THERAPY

#4358
20210085718
2021-03-25

Materials and methods for engineering cells and uses thereof in immuno-oncology

#4359
20210079428
2021-03-18

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4360
20210079427
2021-03-18

CRISPR-BASED GENOME MODIFICATION AND REGULATION

#4361
20210079407
2021-03-18

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

#4362
20210079404
2021-03-18

ENGINEERED DCAS9 WITH REDUCED TOXICITY AND ITS USE IN GENETIC CIRCUITS

#4363
20210079394
2021-03-18

TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS DELIVERED BY LIPID NANOPARTICLES

#4364
20210079389
2021-03-18

GUIDE RNA WITH CHEMICAL MODIFICATIONS

#4365
20210079388
2021-03-18

SCREENING AND APPLICATION OF SGRNA FOR AHI1 GENE EDITING

#4366
20210079387
2021-03-18

CLEAVAGE-RESISTANT DONOR NUCLEIC ACIDS AND METHODS OF USE

#4367
20210079373
2021-03-18

Near-infrared photothermally activated CRISPR/CAS9 genome editing machine

#4368
20210079367
2021-03-18

CRISPR-associated (CAS) protein

#4369
20210079366
2021-03-18

CAS12A SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED RNA BASE EDITING

#4370
20210079360
2021-03-18

VIRAL VECTOR PRODUCTION SYSTEM

#4371
20210079347
2021-03-18

GENETICALLY ENGINEERED T CELLS HAVING IMPROVED PERSISTENCE IN CULTURE

#4372
20210077594
2021-03-18

Sequence-specific in vivo cell targeting

#4373
20210076647
2021-03-18

Double knockout (GT/CMAH-KO) pigs, organs and tissues

#4374
20210072248
2021-03-11

Biomarkers predictive of anti-immune checkpoint response

#4375
20210072228
2021-03-11

Methods for immunoregulation by modulating plasminogen-apple-nematode (PAN) domain-containing proteins

#4376
20210071255
2021-03-11

METHODS FOR IDENTIFICATION OF GENES AND GENETIC VARIANTS FOR COMPLEX PHENOTYPES USING SINGLE CELL ATLASES AND USES OF THE GENES AND VARIANTS THEREOF

#4377
20210071193
2021-03-11

PLANTS WITH ENHANCED RESISTANCE TO BACTERIAL PATHOGENS

#4378
20210071182
2021-03-11

Compositions and methods for immunooncology

#4379
20210071179
2021-03-11

Mobile-CRISPRi plasmids and related methods

#4380
20210071178
2021-03-11

Targeted trans-splicing using CRISPR/Cas13

#4381
20210071174
2021-03-11

CRISPR TRANSIENT EXPRESSION CONSTRUCT (CTEC)

#4382
20210071168
2021-03-11

Barcode-based nucleic acid sequence assembly

#4383
20210071163
2021-03-11

CAS12B SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED RNA BASE EDITING

#4384
20210071159
2021-03-11

TUNING MICROBIAL POPULATIONS WITH PROGRAMMABLE NUCLEASES

#4385
20210071158
2021-03-11

Type VI CRISPR orthologs and systems

#4386
20210071140
2021-03-11

Gene-regulating compositions and methods for improved immunotherapy

#4387
20210070830
2021-03-11

GENE REGULATION VIA CONDITIONAL NUCLEAR LOCALIZATION OF GENE MODULATING POLYPEPTIDES

#4388
20210069303
2021-03-11

Methods and compositions for RNA-guided treatment of HIV infection

#4389
20210062250
2021-03-04

EXTRACHROMOSOMAL DNA LABELING

#4390
20210062227
2021-03-04

Chimeric proteins and methods of regulating gene expression

#4391
20210062226
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4392
20210062225
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4393
20210062224
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4394
20210062223
2021-03-04

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4395
20210062201
2021-03-04

Methods for producing a complex transgenic trait locus

#4396
20210062187
2021-03-04

CAS9 mutant genes and polypeptides encoded by same

#4397
20210062170
2021-03-04

SITE-SPECIFIC ENZYMES AND METHODS OF USE

#4398
20210062169
2021-03-04

Modified protein and method for altering genome of cell

#4399
20210060180
2021-03-04

Recombinogenic nucleic acid strands in situ

#4400
20210060179
2021-03-04

MODULATION OF LIVER GENES

#4401
20210060141
2021-03-04

Sequence specific antimicrobials

#4402
20210060140
2021-03-04

Sequence specific antimicrobials

#4403
20210060072
2021-03-04

Methods and compositions for treating cancer

#4404
20210060028
2021-03-04

DNA-PK inhibitors

#4405
20210059142
2021-03-04

Mutant plant or cell with reduced XylT and FucT

#4406
20210054416
2021-02-25

CAS9 proteins including ligand-dependent inteins

#4407
20210054415
2021-02-25

RIBONUCLEOPROTEIN TRANSFECTION AGENTS

#4408
20210054390
2021-02-25

GENOME EDITING IN PLANTS

#4409
20210054389
2021-02-25

TRANSFORMATION OF DICOT PLANTS

#4410
20210054388
2021-02-25

Gene targeting in plants using DNA viruses

#4411
20210054387
2021-02-25

Recombinant cell and preparation process and use thereof

#4412
20210054376
2021-02-25

Expression of FOXP3 in edited CD34+ cells

#4413
20210054372
2021-02-25

METHODS OF INACTIVATING GENE EDITING MACHINERIES

#4414
20210054371
2021-02-25

Conjugates of Guide RNA-Cas Protein Complex

#4415
20210054370
2021-02-25

METHODS AND COMPOSITIONS FOR TREATING ANGELMAN SYNDROME

#4416
20210054362
2021-02-25

Chimeric genome engineering molecules and methods

#4417
20210054354
2021-02-25

RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES

#4418
20210054353
2021-02-25

RNA-programmable endonuclease systems and uses thereof

#4419
20210054030
2021-02-25

Tale RVD specifically recognizing DNA base modified by methylation and application thereof

#4420
20210052709
2021-02-25

Methods and compositions for RNA-guided treatment of HIV infection

#4421
20210052650
2021-02-25

Nucleic acids encoding engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene

#4422
20210052648
2021-02-25

METHOD OF PRODUCING LEUKOCYTES USING PTPN2 INHIBITION FOR ADOPTIVE CELL TRANSFER

#4423
20210047679
2021-02-18

Determination of base modifications of nucleic acids

#4424
20210047659
2021-02-18

SYSTEM AND METHOD FOR INDUCING CLUSTERS OF GENE REGULATORY PROTEINS TARGETED TO SPECIFIC GENOMIC LOCI

#4425
20210047654
2021-02-18

RNA-TARGETING FUSION PROTEIN COMPOSITIONS AND METHODS FOR USE

#4426
20210047653
2021-02-18

COMPOSITIONS AND METHODS FOR REGULATING A BIOLOGICAL PROCESS

#4427
20210047649
2021-02-18

CRISPR/CAS ALL-IN-TWO VECTOR SYSTEMS FOR TREATMENT OF DMD

#4428
20210047648
2021-02-18

COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF

#4429
20210047647
2021-02-18

COMPOSITION FOR CLEAVING A TARGET DNA COMPRISING A GUIDE RNA SPECIFIC FOR THE TARGET DNA AND CAS PROTEIN-ENCODING NUCLEIC ACID OR CAS PROTEIN, AND USE THEREOF

#4430
20210047639
2021-02-18

Method for genome editing using a self-inactivating CRISPR nuclease

#4431
20210047633
2021-02-18

SELECTION METHODS

#4432
20210047632
2021-02-18

Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction

#4433
20210047627
2021-02-18

CRISPR-BASED DOWNREGULATION OF ALPHA-SYNUCLEIN EXPRESSION AS A NOVEL PARKINSON'S DISEASE THERAPEUTIC

#4434
20210047623
2021-02-18

CRISPR KNOCK-OUT OF THE ALPHA-SYNUCLEIN TRIPLICATION MODEL OF PARKINSON'S DISEASE

#4435
20210047386
2021-02-18

Customized class switch of immunoglobulin genes in lymphoma and hybridoma by CRISPR/CAS9 technology

#4436
20210047375
2021-02-18

LENTIVIRAL-BASED VECTORS AND RELATED SYSTEMS AND METHODS FOR EUKARYOTIC GENE EDITING

#4437
20210040546
2021-02-11

NOVEL CRISPR ENZYMES AND SYSTEMS

#4438
20210040506
2021-02-11

CRISPR-RELATED METHODS AND COMPOSITIONS

#4439
20210040505
2021-02-11

Method for increasing efficiency of homologous recombination-based gene editing in plant

#4440
20210040489
2021-02-11

Curing for recursive nucleic acid-guided cell editing

#4441
20210040462
2021-02-11

Detergent composition

#4442
20210040461
2021-02-11

DNase therapy for intravascular accumulation of extracellular DNA

#4443
20210040460
2021-02-11

Genetic correction of mutated genes

#4444
20210033606
2021-02-04

DNA mapping and sequencing on linearized DNA molecules

#4445
20210032664
2021-02-04

ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN BETA-2 MICROGLOBULIN GENE

#4446
20210032654
2021-02-04

RNA-GUIDED GENE EDITING AND GENE REGULATION

#4447
20210032622
2021-02-04

SELF-INACTIVATING (SIN) CRISPR/CAS OR CRISPR/CPF1 SYSTEMS AND USES THEREOF

#4448
20210032621
2021-02-04

EXTENDED SINGLE GUIDE RNA AND USE THEREOF

#4449
20210032613
2021-02-04

Simultaneous multiplex genome editing in yeast

#4450
20210032612
2021-02-04

CRISPR/Cas9 Systems, and Methods of Use Thereof

#4451
20210032611
2021-02-04

Angiogenin expression in plants

#4452
20210024977
2021-01-28

Single cell chromatin immunoprecipitation sequencing assay

#4453
20210024958
2021-01-28

ENGINEERED TARGET SPECIFIC NUCLEASES

#4454
20210024957
2021-01-28

ENGINEERED TARGET SPECIFIC NUCLEASES

#4455
20210024945
2021-01-28

THE FATTY ACID DESATURASE 2 FAMILY IN TOMATO

#4456
20210024943
2021-01-28

Compositions and methods for modifying genomes

#4457
20210024931
2021-01-28

METHOD FOR INDUCING RNA SILENCING

#4458
20210024916
2021-01-28

Using nucleosome interacting protein domains to enhance targeted genome modification

#4459
20210024907
2021-01-28

NUCLEIC ACID-BASED THERAPEUTICS

#4460
20210024906
2021-01-28

Complex for genome editing having stability and few side-effects, and nucleic acid coding same

#4461
20210024895
2021-01-28

RNA preparations comprising purified modified RNA for reprogramming cells

#4462
20210024889
2021-01-28

ANTIBODY GENE EDITING IN B LYMPHOCYTES

#4463
20210024606
2021-01-28

NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION

#4464
20210017545
2021-01-21

TALE-NUCLEASES FOR ALLELE-SPECIFIC CODON MODIFICATION AND MULTIPLEXING

#4465
20210017530
2021-01-21

RNA-guided endonuclease expressing algal strain for high efficiency in vivo genome editing

#4466
20210017523
2021-01-21

Systems, methods and composition of using RNase III mutants to produce sRNA to control host pathogen infection

#4467
20210017518
2021-01-21

Modified tracrRNAs gRNAs, and uses thereof

#4468
20210017516
2021-01-21

METHODS OF MULTIPLEXING CRISPR

#4469
20210017509
2021-01-21

Gene Editing for Autosomal Dominant Diseases

#4470
20210017508
2021-01-21

CasZ compositions and methods of use

#4471
20210017507
2021-01-21

METHODS AND COMPOSITIONS FOR SEQUENCES GUIDING CAS9 TARGETING

#4472
20210017506
2021-01-21

Optimized protein linkers and methods of use

#4473
20210015869
2021-01-21

T CELLS EXPRESSING A RECOMBINANT RECEPTOR, RELATED POLYNUCLEOTIDES AND METHODS

#4474
20210010065
2021-01-14

METHODS AND REAGENTS FOR ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS

#4475
20210010064
2021-01-14

ENRICHMENT OF NUCLEIC ACIDS

#4476
20210010031
2021-01-14

LENTIVIRAL VECTORS FOR HIGH-TITER TRANSDUCTION OF PRIMARY HUMAN CELLS

#4477
20210010022
2021-01-14

NOVEL NUCLEIC ACID CONSTRUCT

#4478
20210009988
2021-01-14

Modulating lactogenic activity in mammalian cells

#4479
20210009986
2021-01-14

Systems, methods, and compositions for targeted nucleic acid editing

#4480
20210009974
2021-01-14

Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection

#4481
20210009973
2021-01-14

Compositions for linking DNA-binding domains and cleavage domains

#4482
20210009972
2021-01-14

Systems methods, and compositions for targeted nucleic acid editing

#4483
20210009955
2021-01-14

Methods and products for transfecting cells

#4484
20210009633
2021-01-14

Bacterial colicin-immunity protein protein purification system

#4485
20210008161
2021-01-14

METHODS AND COMPOSITIONS FOR IMPROVED HOMOLOGY DIRECTED REPAIR

#4486
20210007334
2021-01-14

Identification of white leghorns red plumage mutagenic mutant genotype and cultivation method for supporting system of red plumage pink shell layer chickens

#4487
20210002670
2021-01-07

GENETIC MODIFICATION OF MITOCHONDRIAL GENOMES

#4488
20210002665
2021-01-07

RNA-GUIDED GENE EDITING AND GENE REGULATION

#4489
20210002656
2021-01-07

METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS

#4490
20210002652
2021-01-07

CRISPR/Cas9 vector combination and application thereof in gene knockout

#4491
20210002646
2021-01-07

DNMT3B GENE-DEFICIENT CHO CELL LINE, PREPARATION AND APPLICATIONS THEREOF AND RECOMBINANT PROTEIN EXPRESSION SYSTEM USING THE SAME

#4492
20210002645
2021-01-07

Methods of treating cancer by inhibiting SETD2

#4493
20210002634
2021-01-07

Automated cell processing methods, modules, instruments, and systems

#4494
20210002628
2021-01-07

Methods for identifying selective binding pairs

#4495
20210002622
2021-01-07

Engineered cascade components and cascade complexes

#4496
20210002621
2021-01-07

CTLA4 HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE

#4497
20210002609
2021-01-07

MODIFIED LYMPHOCYTES

#4498
20210000974
2021-01-07

Nucleic acid products and methods of administration thereof

#4499
20210000928
2021-01-07

TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASES

#4500
20210000091
2021-01-07

Split Trans-Complementing Gene-Drive System for Suppressing Aedes Aegypti Mosquitos