108937 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses
Automated instrumentation for production of T-cell receptor peptide libraries
#4502METHOD AND VECTORS FOR INTRODUCING A GENETIC MUTATION INTO A NON-HUMAN ANIMAL USING A HUMANIZED GENETIC CONSTRUCT
#4503Homology dependent repair genome editing
#4504MODULAR SYSTEM FOR GENE AND PROTEIN DELIVERY BASED ON AAV
#4505Materials and methods for controlling gene editing
#4506NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
#4507NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
#4508TRANSFORMED HUMAN CELL AND USE THEREOF
#4509Methods and compositions for assessing protein function
#4510CRISPR-NANOPARTICLES AND METHODS OF USE IN BRAIN DISORDERS
#4511Circular strained zymogen compositions and methods of use
#4512System for the biocontrol of white spot syndrome virus (WSSV) in aquaculture
#4513DNA ORIGAMI NANOPARTICLE DELIVERY OF PROGRAMMED CHROMOSOME BREAKAGE MACHINERY
#4514NOVEL DELIVERY OF LARGE PAYLOADS
#4515Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements
#4516MODELING TDP-43 PROTEINOPATHY
#4517Nucleic acid-based data storage
#4518Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs
#4519Uses of adenosine base editors
#4520DNase therapy for intravascular accumulation of extracellular DNA
#4521Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#4522Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#4523Editing of CCR2 receptor gene to protect against HIV infection
#4524THE VOLUME-REGULATED ANION CHANNEL PROTEIN LRRC8A FOR USE IN ALTERING EPIDERMAL KERATINOCYTE DIFFERENTIATION
#4525Inhibition of nucleic acid polymerases by endonuclease v-cleavable oligonucleotide ligands
#4526Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy
#4527CRISPR enabled multiplexed genome engineering
#4528ITERATIVE GENOME ASSEMBLY
#4529Modified orthopoxvirus vectors
#4530IN VIVO GENE EDITING OF BLOOD PROGENITORS
#4531High-efficiency transfection of biological cells using sonoporation
#4532METHODS AND COMPOSITIONS FOR DETECTING AND PROMOTING CARDIOLIPIN REMODELING AND CARDIOMYOCYTE MATURATION AND RELATED METHODS OF TREATING MITOCHONDRIAL DYSFUNCTION
#4533EXCISION OF RETROVIRAL NUCLEIC ACID SEQUENCES
#4534NOVEL CRISPR ENZYMES AND SYSTEMS
#4535Thermostable RNA-guided endonucleases and methods of use thereof
#4536Sequence specific reagents targeting CCR5 in primary hematopoietic cells
#4537Microorganisms with increased photosynthetic capacity
#4538Subject-specific tumor inhibiting cells and the use thereof
#4539MANIPULATION OF THE RETINOIC ACID SIGNALING PATHWAY
#4540IDENTIFYING AND CHARACTERIZING GENOMIC SAFE HARBORS (GSH) IN HUMANS AND MURINE GENOMES, AND VIRAL AND NON-VIRAL VECTOR COMPOSITIONS FOR TARGETED INTEGRATION AT AN IDENTIFIED GSH LOCI
#4541Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
#4542Curing for recursive nucleic acid-guided cell editing
#4543DELIVERING CRISPR THERAPEUTICS WITH LIPID NANOPARTICLES
#4544RNA-programmable endonuclease systems and their use in genome editing and other applications
#4545COMPOSITIONS AND METHODS FOR ALTERING BACTERIA FITNESS
#4546Recombinant type I CRISPR-CAS system
#4547Thermostable Cas9 nucleases
#4548Materials and methods for treatment of autosomal dominant cone-rod dystrophy
#4549Compositions and methods for epigenome editing
#4550CRISPR-CAS9 modified CD34+ human hematopoietic stem and progenitor cells and uses thereof
#4551METHOD FOR INCREASING FETAL HEMOGLOBIN EXPRESSION LEVEL
#4552Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
#4553METHOD FOR INCREASING MUTATION INTRODUCTION EFFICIENCY IN GENOME SEQUENCE MODIFICATION TECHNIQUE, AND MOLECULAR COMPLEX TO BE USED THEREFOR
#4554DIRECTED GENOME ENGINEERING USING ENHANCED TARGETED EDITING TECHNOLOGIES
#4555Regulating lignin biosynthesis and sugar release in plants
#4556CRISPR fluorescent guide RNA (fgRNA) to understanding gRNAs expressed from pol II promotors
#4557Methods of Genome Engineering by Nuclease-Transposase Fusion Proteins
#4558MODIFIED T CELLS AND USES THEREOF
#4559Production of unnatural nucleotides using a CRISPR/Cas9 system
#4560Modulating human Cas9-specific host immune response
#4561Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
#4562Genetically engineered hematopoietic stem cell as a platform for systemic protein expression
#4563PCSK9 endonuclease variants, compositions, and methods of use
#4564CONSTRUCTION METHOD FOR ANIMAL MODEL FOR RETINITIS PIGMENTOSA DISEASES AND APPLICATION
#4565Construction and methods of use of a barcoded and gene edited DNA library
#4566METHOD TO IDENTIFY AND VALIDATE GENOMIC SAFE HARBOR SITES FOR TARGETED GENOME ENGINEERING
#4567NON-HUMAN ANIMALS HAVING A HEXANUCLEOTIDE REPEAT EXPANSION IN A C9ORF72 LOCUS
#4568Gene knockout of NRF2 for treatment of cancer
#4569METHOD OF TREATING TYPE II DIABETES AND OBESITY AND METHOD OF SCREENING A MEDICAMENT FOR THE SAME
#4570COMPOSITIONS AND METHODS FOR CORRECTING DYSTROPHIN MUTATIONS IN HUMAN CARDIOMYOCYTES
#4571Gene knockout of variant for treatment of cancer
#4572TREATMENT FOR PARKINSONIAN PATIENTS WITH MUTATIONS IN THE LRRK2 GENE
#4573METHODS FOR IN VITRO SITE-DIRECTED MUTAGENESIS USING GENE EDITING TECHNOLOGIES
#4574CasZ compositions and methods of use
#4575ENDONUCLEASE SEXING AND STERILIZATION IN INSECTS
#4576Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4577Protected guide RNAS (pgRNAS)
#4578TARGETED NON-VIRAL DNA INSERTIONS
#4579GENOME EDITING USING CRISPR IN CORYNEBACTERIUM
#4580HIGH-THROUGHPUT METHODS FOR IDENTIFYING GENE INTERACTIONS AND NETWORKS
#4581Full replacement technique for T cell receptor using platinum TALEN
#4582Polypeptide variants
#4583ANTIBODY-MEDIATED DELIVERY OF CAS9 TO MAMMALIAN CELLS
#4584Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
#4585Gene editing to improve joint function
#4586Engineered chimeric guide RNA and uses thereof
#4587Modified biotin-binding proteins for immobilization
#4588Cation chelator hot start
#4589Engineered CAS9 systems for eukaryotic genome modification
#4590GENOME EDITING USING CAS9 NICKASES
#4591Method of target cleaving using CRISPR hybrid DNA/RNA polynucleotides
#4592Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4593Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4594Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4595CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
#4596GENE-EDITING SYSTEMS FOR MODIFYING A SCN9A OR SCN10A GENE AND METHODS OF USE THEREOF
#4597Fusion proteins for improved precision in base editing
#4598Materials and methods for treatment of usher syndrome type 2A
#4599Methods of treating amyotrophic lateral sclerosis (ALS)
#4600RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
#4601Engineered enzymes
#4602Polynucleotides, compositions, and methods for genome editing
#4603CRISPR protein inhibitors
#4604CAS9-nucleic acid complexes and uses related thereto
#4605HSD17B13 variants and uses thereof
#4606METHODS AND COMPOSITIONS FOR KILLING A TARGET BACTERIUM
#4607Modified pluripotent cells
#4608Mutant algal strain and methods thereof
#4609Intracellular genomic transplant and methods of therapy
#4610Method to Implement a CRISPR Gene Drive in Mammals
#4611RNA targeting methods and compositions
#4612RNA targeting methods and compositions
#4613Universal donor cells
#4614SPLIT SINGLE-BASE GENE EDITING SYSTEMS AND APPLICATION THEREOF
#4615Universal donor cells
#4616GENES AND GENE COMBINATIONS FOR ENHANCED CROPS
#4617COMPOSITIONS AND METHODS FOR GENERATING DIVERSITY AT TARGETED NUCLEIC ACID SEQUENCES
#4618COMPOSITIONS AND METHODS FOR TARGET NUCLEIC ACID MODIFICATION
#4619COMBINATION GENE TARGETS FOR IMPROVED IMMUNOTHERAPY
#4620Engineered DNase enzymes and use in therapy
#4621Methods and compositions for in vivo gene editing based cell-type-specific cellular engineering
#4622GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYOTES
#4623METHODS AND COMPOSITIONS FOR TREATING CANCER USING EXOSOMES-ASSOCIATED GENE EDITING
#4624Genetically modified non-human animals and methods for producing heavy chain-only antibodies
#4625COMPOSITIONS AND METHODS FOR ENHANCING CELL TRANSPLANTATION EFFICACY
#4626Engineered target specific nucleases
#4627DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING PARTICLE DELIVERY COMPONENTS
#4628CRISPR-CAS GENOME ENGINEERING VIA A MODULAR AAV DELIVERY SYSTEM
#4629CENH3 DELETION MUTANTS
#4630Method for base editing in plants
#4631METHOD FOR IMPROVING FETAL HEMOGLOBIN EXPRESSION
#4632CAS12C COMPOSITIONS AND METHODS OF USE
#4633Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
#4634Generation of induced pluripotent cells by CRISPR activation
#4635Systems and methods for treating hyper-igm syndrome
#4636Genetically engineered hematopoietic stem cells and uses thereof
#4637Large animal model for developing therapeutic agents to treat impaired ophthalmic function in usher syndrome
#4638THERMOLABILE EXONUCLEASES
#4639Polynucleotide based movement, kits and methods related thereto
#4640TYPE I-E CRISPR-CAS SYSTEMS FOR EUKARYOTIC GENOME EDITING
#4641USE OF CPFI ENDONUCLEASE FOR PLANT GENOME MODIFICATIONS
#4642Translation control tool for plants
#4643Materials and methods for treatment of autosomal dominant retinitis pigmentosa
#4644DIFFERENTIAL KNOCKOUT OF AN ALLELE OF A HETEROZYGOUS FIBRINOGEN ALPHA CHAIN (FGA) GENE
#4645Materials and methods for the synthesis of error-minimized nucleic acid molecules
#4646Automated cell processing methods, modules, instruments, and systems
#4647Variant CAS12 proteins with improved dna cleavage selectivity and methods of use
#4648Enzymes with RuvC domains
#4649Enzymes with RuvC domains
#4650SYSTEMS, METHODS, AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING
#4651Applications of engineered Cas9 variants on single-base PAM targets
#4652METHOD TO BIOENGINEER DESIGNER RED BLOOD CELLS USING GENE EDITING AND STEM CELL METHODOLOGIES
#4653MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES
#4654Materials and methods for engineering cells and uses thereof in immuno-oncology
#4655TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
#4656TRANSGENIC EUKARYOTIC ORGANISMS AND METHODS FOR GENDER SELECTION
#4657Pig genome-wide specific sgRNA library, preparation method therefor and application thereof
#4658Methods and products for expressing proteins in cells
#4659METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#4660Therapeutic genome editing in Wiskott-Aldrich syndrome and X-linked thrombocytopenia
#4661RNA-GUIDED DNA INTEGRATION USING TN7-LIKE TRANSPOSONS
#4662Mammalian cell line for protein production and library generation
#4663Modified cascade ribonucleoproteins and uses thereof
#4664DNase variants
#4665Methods and products for transfecting cells
#4666DELIVERY SYSTEM FOR FUNCTIONAL NUCLEASES
#4667Methods of using DNASE1-like 3 in therapy
#4668Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
#4669Method for preparing porcine fibroblasts with both CD163 gene and CD13 gene being knocked-out
#4670RNA targeting methods and compositions
#4671Automated instrumentation for production of T-cell receptor peptide libraries
#4672CRISPR enzymes and systems
#4673NOVEL CRISPR ENZYMES AND SYSTEMS
#4674Genome engineering with type I CRISPR systems in eukaryotic cells
#4675METHODS AND COMPOSITIONS FOR INSERTION OF ANTIBODY CODING SEQUENCES INTO A SAFE HARBOR LOCUS
#4676Methods for scarless introduction of targeted modifications into targeting vectors
#4677Method for introducing protein into plant cell
#4678CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#4679Unnatural base pair compositions and methods of use
#4680Materials and methods for treatment of Usher syndrome type 2A and/or non-syndromic autosomal recessive retinitis pigmentosa (ARRP)
#4681CONTROLLING PHENOTYPE OF ORGANISMS WITH CRISPR/CAS GENE TARGETING
#4682Engineered nucleic-acid targeting nucleic acids
#4683Compositions for linking DNA-binding domains and cleavage domains
#4684TEMPERATURE-SENSITIVE CAS9 PROTEIN
#4685Genetically engineered hematopoietic stem cells and uses thereof
#4686Non-human animals comprising a humanized coagulation factor 12 locus
#4687METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#4688METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#4689METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#4690CRISPR-related methods and compositions with governing gRNAS
#4691SELF-LIMITING VIRAL VECTORS ENCODING NUCLEASES
#4692RNA-Guided Human Genome Engineering
#4693Engineered nucleases in plant generation
#4694Composition for genome editing using CRISPR/CPF1 system and use thereof
#4695CRISPR/Cas system and method for genome editing and modulating transcription
#4696DNA-RESPONSIVE HYDROGELS, METHODS OF ALTERING A PROPERTY OF A HYDROGEL, AND APPLICATIONS THEREOF
#4697Simultaneous multiplex genome editing in yeast
#4698Cas9 variants and methods of use
#4699NOVEL TYPE VI CRISPR ORTHOLOGS AND SYSTEMS
#4700Methods and products for transfecting cells
#4701Polypeptides having RNase activity
#4702Intracellular genomic transplant and methods of therapy
#4703INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
#4704Compositions and methods for treating rheumatoid arthritis
#4705Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs
#4706Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4707Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#4708RNA-Guided Transcriptional Regulation
#4709TARGETING PEPTIDE TO DELIVER A COMPOUND TO OOCYTES
#4710METHODS FOR IMPROVED HOMOLOGOUS RECOMBINATION AND COMPOSITIONS THEREOF
#4711Methods of treating Danon disease
#4712Methods for genetic modification of plants
#4713MUTATIONS IN MADS-BOX GENES AND USES THEREOF
#4714Florigen pathway toolkit
#4715CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation
#4716CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
#4717CPF1-RELATED METHODS AND COMPOSITIONS FOR GENE EDITING
#4718CASZ compositions and methods of use
#4719CRISPR-associated systems and components
#4720ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A
#4721Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector
#4722Methods and compositions for targeted cleavage and recombination
#4723Treatment of increased lipid levels with sterol regulatory element binding protein cleavage-activating protein (SCAP) inhibitors
#4724Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors
#4725METHODS OF DETECTING MINIMAL RESIDUAL DISEASE
#4726Globin gene therapy for treating hemoglobinopathies
#4727CRISPR-BASED THERAPEUTICS FOR TARGETING HTRA1 AND METHODS OF USE
#4728Methods and compositions for the targeted modification of a genome
#4729TARGETED DELETION OF CELLULAR DNA SEQUENCES
#4730CRISPR-associated transposon systems and components
#4731Systems, methods, and compositions for targeted nucleic acid editing
#4732Mutant Cas Proteins
#4733Improved CRISPR-Cas9 Genome Editing Tool
#4734Improved CRISPR-Cpf1 Genome Editing Tool
#4735Transcriptional control in prokaryotic cells using DNA-binding repressors
#4736Methods and products for transfecting cells
#4737RNA-guided systems for in vivo gene editing
#4738TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY
#4739Tumor infiltrating lymphocytes and methods of therapy
#4740METHODS FOR GENDER DETERMINATION OF AVIAN EMBRYOS IN UNHATCHED EGGS AND MEANS THEREOF
#4741Mutant cell-free DNA isolation kit and mutant cell-free DNA isolation method using the same
#4742Methods and compositions for preparing polynucleotides
#4743Plant virus movement proteins and methods of using same
#4744Method for improving rice yield by jointly knocking out ABA receptor PYL family genes and use thereof
#4745Iterative genome editing in microbes
#4746RNA-guided DNA integration using Tn7-like transposons
#4747Direct cloning
#4748Systems, methods, and compositions for targeted nucleic acid editing
#4749Mutant Cas9 proteins
#4750CRISPR-cas system for genome engineering and recombinant strains produced thereof
#4751NUCLEAR-TARGETED DNA REPAIR ENZYMES AND METHODS OF USE
#4752APPLICATION OF CRISPR/CAS12A GENE EDITING SYSTEM IN GENE EDITING OF PHYSCOMITRELLA PATENS
#4753NOVEL CRISPR ENZYMES AND SYSTEMS
#4754SEQUENCE SPECIFIC ANTIMICROBIALS
#4755Sequence specific antimicrobials
#4756Methods and compositions for RNA-guided treatment of HIV infection
#4757Methods and compositions for targeted single-stranded cleavage and targeted integration
#4758METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#4759Gene manipulation for treatment of retinal dysfunction disorder
#4760Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system
#4761Multi-effector CRISPR based diagnostic systems
#4762Engineered cascade components and cascade complexes
#4763Evolution of TALENs
#4764Modified Cas9 protein and use thereof
#4765Detergent Composition
#4766Nucleoside triphosphate transporter and uses thereof
#4767Chimeric receptor binding proteins for use in bacterial delivery vehicles
#4768Synthetic system for tunable thresholding of protein signals
#4769GENERATION AND CORRECTION OF A HUMANIZED MOUSE MODEL WITH A DELETION OF DYSTROPHIN EXON 44
#4770Methods for analyzing nucleic acid sequences
#4771USE OF MEDEA ELEMENTS FOR BIOCONTROL OF D. SUZUKII POPULATIONS
#4772MULTIPLEX PRODUCTION AND BARCODING OF GENETICALLY ENGINEERED CELLS
#4773Method for modifying target site in double-stranded DNA in cell
#4774Balanced indels
#4775COMPOSITIONS AND METHODS FOR TRANSGENE EXPRESSION FROM AN ALBUMIN LOCUS
#4776MODIFYING THE SPECIFICITY OF NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION IN EUKARYOTIC CELLS
#4777USE OF ANTI-CRISPR POLYPEPTIDES FOR SPECIFIC ACTIVATION OF CAS NUCLEASES
#4778Automated cell processing methods, modules, instruments, and systems
#4779CD1d and TCR-NKT Cells
#4780Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
#4781NUCLEIC ACID CONSTRUCTS AND METHODS OF USE
#4782Live attenuated cholera vaccine with probiotic properties
#4783Cell-based assay for quantifying the potency and efficacy of cannabinoids and/or terpenoids, and methods of use thereof
#4784Polypeptides
#4785TARGETED INTEGRATION SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES
#4786Methods for genomic integration for host cells
#4787COMPOSITION FOR TREATING HEMOPHILIA A BY CRISPR/CAS SYSTEM OF REVERTING FVIII GENE INVERSION
#4788Methods and compositions for in situ germline genome engineering
#4789NOVEL CRISPR ENZYMES AND SYSTEMS
#4790Systems and methods for cellular reprogramming of a plant cell
#4791Methods for genetic engineering host cells
#4792ALTERED GUIDE RNAS FOR MODULATING CAS9 ACTIVITY AND METHODS OF USE
#4793Cpf1 complexes with reduced indel activity
#4794METHODS AND COMPOSITIONS FOR POLYMERASE II (POL-II) BASED GUIDE RNA EXPRESSION
#4795CRISPR/Cas fusion proteins and systems
#4796Regulated multiplex reactions in a single tube
#4797GENETICALLY ENGINEERED T CELL AND APPLICATION THEREOF
#4798Compositions, methods, and kits for one-step digestion of nucleic acid for analysis by liquid chromatography tandem mass spectrometry
#4799Switchable CAS9 nucleases and uses thereof
#4800Gene knockout method