ClassID:

108937

C12N9/22 - page 17 - CPC Classification

Classification description:

Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses

Recent Application in this class:
#4801
20200255861
2020-08-13

CRISPR CPF1 direct repeat variants

#4802
20200255860
2020-08-13

Strong insulator and uses thereof in gene delivery

#4803
20200255858
2020-08-13

CasY compositions and methods of use

#4804
20200255857
2020-08-13

CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING BETA HEMOGLOBINOPATHIES

#4805
20200255852
2020-08-13

Abiotic stress tolerant plants and polynucleotides to improve abiotic stress and methods

#4806
20200255838
2020-08-13

Selenium Cancer Therapy

#4807
20200255836
2020-08-13

NUCLEIC ACID APTAMER FOR INHIBITING ACTIVITY OF GENOME-EDITING ENZYME

#4808
20200255830
2020-08-13

NOVEL CRISPR-ASSOCIATED TRANSPOSON SYSTEMS AND COMPONENTS

#4809
20200255829
2020-08-13

NOVEL CRISPR-ASSOCIATED TRANSPOSON SYSTEMS AND COMPONENTS

#4810
20200255828
2020-08-13

METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS

#4811
20200255813
2020-08-13

PROSS OPTIMIZED ENZYMES

#4812
20200255483
2020-08-13

Delivery of structurally diverse polypeptide cargo into mammalian cells by a bacterial toxin

#4813
20200254025
2020-08-13

Methods of treating an ischemic disease

#4814
20200253174
2020-08-13

NANOS knock-out that ablates germline cells

#4815
20200252359
2020-08-06

RNA targeting methods and compositions

#4816
20200250546
2020-08-06

NUCLEIC ACID-BASED DATA STORAGE

#4817
20200248196
2020-08-06

Modifying the specificity of plant non-coding RNA molecules for silencing gene expression

#4818
20200248180
2020-08-06

Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis

#4819
20200248174
2020-08-06

GENOMIC SEQUENCE MODIFICATION METHOD FOR SPECIFICALLY CONVERTING NUCLEIC ACID BASES OF TARGETED DNA SEQUENCE, AND MOLECULAR COMPLEX FOR USE IN SAME

#4820
20200248173
2020-08-06

Enhanced selection of efficient targeted genome manipulating agents

#4821
20200248169
2020-08-06

CRISPR/CAS-CYTIDINE DEAMINASE BASED COMPOSITIONS, SYSTEMS, AND METHODS FOR TARGETED NUCLEIC ACID EDITING

#4822
20200248168
2020-08-06

COMPOSITIONS AND METHODS FOR TREATMENT OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)-RELATED DISORDERS

#4823
20200248156
2020-08-06

Targetable 3`-Overhang Nuclease Fusion Proteins

#4824
20200248155
2020-08-06

RNA-guided endonuclease fusion polypeptides and methods of use thereof

#4825
20200248106
2020-08-06

Detergent composition

#4826
20200246488
2020-08-06

COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES

#4827
20200246179
2020-08-06

Cancer treatment methods using thermotherapy and/or enhanced immunotherapy

#4828
20200244609
2020-07-30

RNA targeting methods and compositions

#4829
20200239969
2020-07-30

METHODS AND COMPOSITIONS FOR USE OF TREX2 AS DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER

#4830
20200239939
2020-07-30

Bioinformatics methods of in silico validation and selection of circRNAs

#4831
20200239879
2020-07-30

Compositions and methods for regulating proteins and nucleic acids activities

#4832
20200239871
2020-07-30

METHOD, LYSIS SOLUTION AND KIT FOR SELECTIVELY DEPLETING ANIMAL NUCLEIC ACIDS IN A SAMPLE

#4833
20200239864
2020-07-30

Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome

#4834
20200239863
2020-07-30

Tracking and manipulating cellular RNA via nuclear delivery of CRISPR/CAS9

#4835
20200239600
2020-07-30

Dynamic control of colocalization of proteins

#4836
20200239596
2020-07-30

Extracellular matrix-producing composition using MAST4 gene and preparation method therefor

#4837
20200231989
2020-07-23

Methods and compositions for the treatment of lysosomal storage diseases

#4838
20200231988
2020-07-23

Artifical nucleases comprising engineered cleavage half-domains

#4839
20200231987
2020-07-23

NUCLEIC ACID-GUIDED NUCLEASES

#4840
20200231979
2020-07-23

TARGETED CHROMOSOMAL MUTAGENESIS USING ZINC FINGER NUCLEASES

#4841
20200231975
2020-07-23

NOVEL TYPE VI CRISPR ORTHOLOGS AND SYSTEMS

#4842
20200231965
2020-07-23

Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors

#4843
20200231953
2020-07-23

Compositions and methods for transient delivery of nucleases

#4844
20200231952
2020-07-23

Materials and methods for increasing gene editing frequency

#4845
20200231699
2020-07-23

T-cells expressing anti-LIV1 chimeric antigen receptor

#4846
20200231649
2020-07-23

TCRS SPECIFIC FOR MINOR HISTOCOMPATIBILITY (H) ANTIGEN HA-1 AND USES THEREOF

#4847
20200230259
2020-07-23

ISOLATION OF EXTRACELLULAR VESICLES (EVS) FROM RED BLOOD CELLS FOR GENE THERAPY

#4848
20200224222
2020-07-16

Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing

#4849
20200224221
2020-07-16

GENOME EDITING METHOD

#4850
20200224163
2020-07-16

Targeted gene insertion for improved immune cells therapy

#4851
20200224160
2020-07-16

PROCESS FOR DNA INTEGRATION USING RNA-GUIDED ENDONUCLEASES

#4852
20200216977
2020-07-09

Automated instrumentation for production of T-cell receptor peptide libraries

#4853
20200216860
2020-07-09

DELIVERY OF A GENE-EDITING SYSTEM WITH A SINGLE RETROVIRAL PARTICLE AND METHODS OF GENERATION AND USE

#4854
20200216857
2020-07-09

MATERIALS AND METHODS FOR TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 2 (SCA2) AND OTHER SPINOCEREBELLAR ATAXIA TYPE 2 PROTEIN (ATXN2) GENE RELATED CONDITIONS OR DISORDERS

#4855
20200216843
2020-07-09

Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency

#4856
20200216826
2020-07-09

Transposase polypeptides and uses thereof

#4857
20200216825
2020-07-09

CAS12a MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME

#4858
20200216805
2020-07-09

GENE EDITING T CELL AND USE THEREOF

#4859
20200216551
2020-07-09

Methods and compositions for overcoming immunosuppression

#4860
20200216543
2020-07-09

Nucleic acid, chimeric antigen receptor expression plasmid, chimeric antigen receptor expressing cell, use thereof, and pharmaceutical composition for treating cancer

#4861
20200215114
2020-07-09

COMPOSITIONS AND METHODS FOR PRODUCING EXOSOME LOADED THERAPEUTICS FOR THE TREATMENT OF MULTIPLE ONCOLOGICAL DISORDERS

#4862
20200208174
2020-07-02

Sequential gene editing in primary immune cells

#4863
20200208172
2020-07-02

Scarless genome editing through two-step homology directed repair

#4864
20200208171
2020-07-02

Universal self-regulating mammalian cell line platform for the production of biologics

#4865
20200208166
2020-07-02

Oleic Acid-Enriched Plant Body Having Genetically Modified FAD2 And Production Method Thereof

#4866
20200208155
2020-07-02

Engineered nucleic acid-targeting nucleic acids

#4867
20200208146
2020-07-02

Materials and methods for efficient targeted knock in or gene replacement

#4868
20200208144
2020-07-02

Methods and compositions using one-sided transposition

#4869
20200208138
2020-07-02

Genomic sequence modification method for specifically converting nucleic acid bases of targeted DNA sequence, and molecular complex for use in same

#4870
20200208135
2020-07-02

Using nucleosome interacting protein domains to enhance targeted genome modification

#4871
20200208129
2020-07-02

Engineered CAS9 variants

#4872
20200208114
2020-07-02

TAXONOMY AND USE OF BONE MARROW STROMAL CELL

#4873
20200208111
2020-07-02

GENOME-EDITED NK CELL AND METHODS OF MAKING AND USING

#4874
20200207829
2020-07-02

CHIMERIC RECEPTORS

#4875
20200206361
2020-07-02

Methods of treating mitochondrial disorders

#4876
20200199781
2020-06-25

Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells

#4877
20200199630
2020-06-25

Biosynthesis of curcuminoids in mammalian cells

#4878
20200199617
2020-06-25

Artificial genome manipulation for gene expression regulation

#4879
20200199616
2020-06-25

Methods of treating rheumatoid arthritis using RNA-guided genome editing of HLA gene

#4880
20200199605
2020-06-25

Compositions and methods for genome editing

#4881
20200199599
2020-06-25

A GUIDE-RNA EXPRESSION SYSTEM FOR A HOST CELL

#4882
20200199570
2020-06-25

Compositions and methods for non-antibiotic treating of bacterial infections by blocking or disrupting bacterial genes involved in virulence or viability

#4883
20200199556
2020-06-25

RNA targeting methods and compositions

#4884
20200199555
2020-06-25

Cas proteins with reduced immunogenicity and methods of screening thereof

#4885
20200199554
2020-06-25

NOVEL DNASE

#4886
20200199553
2020-06-25

Site-specific enzymes and methods of use

#4887
20200199552
2020-06-25

Variant Cas9 polypeptides comprising internal insertions

#4888
20200199239
2020-06-25

Compositions and methods for treating alzheimer's disease

#4889
20200197536
2020-06-25

POROUS NANOPARTICLE-SUPPORTED LIPID BILAYER DELIVERY OF TRANSCRIPTIONAL GENE MODULATORS

#4890
20200197432
2020-06-25

Methods And Compositions For Controlling Cardiac Fibrosis And Remodeling

#4891
20200196581
2020-06-25

Nuclease-mediated repeat expansion

#4892
20200190699
2020-06-18

Assessing nuclease cleavage

#4893
20200190542
2020-06-18

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#4894
20200190541
2020-06-18

METHODS FOR REDUCING DNA-INDUCED CYTOTOXICITY AND ENHANCING GENE EDITING IN PRIMARY CELLS

#4895
20200190539
2020-06-18

In vitro recombination method

#4896
20200190536
2020-06-18

Recombinant lentiviral vector for stem cell- based gene therapy of sickle cell disorder

#4897
20200190534
2020-06-18

Method of Off-Target Recording of Spacer Sequences within a Cell In Vivo

#4898
20200190527
2020-06-18

Methods of targeted genetic alteration in plant cells

#4899
20200190509
2020-06-18

METHODS FOR IDENTIFYING ACTIVATORS AND SUPPRESSORS

#4900
20200190508
2020-06-18

CREATION AND USE OF GUIDE NUCLEIC ACIDS

#4901
20200190494
2020-06-18

CRISPR-CAS systems for genome editing

#4902
20200190493
2020-06-18

High efficiency base editors comprising Gam

#4903
20200190492
2020-06-18

Anti-CRISPR polynucleotides and polypeptides and methods of use

#4904
20200190487
2020-06-18

CRISPR-associated transposase systems and methods of use thereof

#4905
20200190147
2020-06-18

Chimeric receptor binding proteins for use in bacterial delivery vehicles

#4906
20200181686
2020-06-11

Methods and compositions for cluster generation by bridge amplification

#4907
20200181683
2020-06-11

In vitro isolation and enrichment of nucleic acids using site-specific nucleases

#4908
20200181651
2020-06-11

Repairing compound heterozygous recessive mutations by allele exchange

#4909
20200181643
2020-06-11

Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system

#4910
20200181642
2020-06-11

NANOPARTICLE-MEDIATED GENE DELIVERY, GENOMIC EDITING AND LIGAND-TARGETED MODIFICATION IN VARIOUS CELL POPULATIONS

#4911
20200181626
2020-06-11

Compositions of self-reporting transposon (SRT) constructs and methods for mapping transposon insertions

#4912
20200181623
2020-06-11

Systems, methods, and compositions for targeted nucleic acid editing

#4913
20200181619
2020-06-11

Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation

#4914
20200181610
2020-06-11

Gene-regulating compositions and methods for improved immunotherapy

#4915
20200181609
2020-06-11

Needle-based devices and methods for in vivo diagnostics of disease conditions

#4916
20200181608
2020-06-11

METHOD FOR KNOCKING OUT TARGET GENE IN T CELL IN VITRO AND crRNA USED IN THE METHOD

#4917
20200181592
2020-06-11

Engineered enzymes

#4918
20200181591
2020-06-11

COMPOSITIONS AND METHODS FOR SITE-DIRECTED DNA NICKING AND CLEAVING

#4919
20200181205
2020-06-11

ENGINEERING OF MONOMERIC, RED-SHIFTED, AND BRIGHTER VARIANTS OF iRFP USING STRUCTURE-GUIDED MULTI-SITE MUTAGENESIS

#4920
20200179534
2020-06-11

Compositions and methods for treatment of peroxisome proliferator-activated receptor gamma (PPARG) activated cancer

#4921
20200179495
2020-06-11

Treatment of retinitis pigmentosa using engineered meganucleases

#4922
20200174016
2020-06-04

MYB-RELATED TRANSCRIPTION FACTOR (MYPOP) AS DIAGNOSTIC MARKER AND THERAPEUTIC TARGET FOR TUMOR THERAPY

#4923
20200172959
2020-06-04

Method for Fragmenting Genomic DNA Using CAS9

#4924
20200172935
2020-06-04

Modified Cpf1 MRNA, modified guide RNA, and uses thereof

#4925
20200172934
2020-06-04

CRISPR-CAS system for a yeast host cell

#4926
20200172931
2020-06-04

Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)

#4927
20200172927
2020-06-04

REPROGRAMMING METABOLISM BY INHIBITING VHL FOR TREATMENT OF NEURODEGENERATION

#4928
20200172899
2020-06-04

Epigenetically Regulated Site-Specific Nucleases

#4929
20200172895
2020-06-04

USING SPLIT DEAMINASES TO LIMIT UNWANTED OFF-TARGET BASE EDITOR DEAMINATION

#4930
20200172886
2020-06-04

CasZ compositions and methods of use

#4931
20200172885
2020-06-04

Base editors with improved precision and specificity

#4932
20200172883
2020-06-04

Compositions for increasing polypeptide stability and activity, and related methods

#4933
20200172564
2020-06-04

Stabilized nucleic acids encoding messenger ribonucleic acid (mRNA)

#4934
20200171171
2020-06-04

GENE THERAPY FOR TREATMENT OF INFERTILITY

#4935
20200171132
2020-06-04

METHODS OF INHIBITING FUNGAL CERAMIDE SYNTHASE FOR TREATMENT OF CRYPTOCOCCUS NEOFORMANS INFECTION

#4936
20200170229
2020-06-04

Multiplexed genome editing

#4937
20200165637
2020-05-28

CRISPR-CAS system for a lipolytic yeast host cell

#4938
20200165636
2020-05-28

Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites

#4939
20200165605
2020-05-28

Mammalian cells for producing a secreted protein

#4940
20200165594
2020-05-28

CRISPR SYSTEM BASED ANTIVIRAL THERAPY

#4941
20200165587
2020-05-28

Multiplex Guide RNAS

#4942
20200164008
2020-05-28

APHERESIS METHODS AND USES

#4943
20200157611
2020-05-21

RIBONUCLEOPROTEIN-BASED IMAGING AND DETECTION

#4944
20200157599
2020-05-21

NEGATIVE-POSITIVE ENRICHMENT FOR NUCLEIC ACID DETECTION

#4945
20200157576
2020-05-21

Compositions and methods related to a type-II CRISPR-Cas system in

#4946
20200157575
2020-05-21

CRISPR enabled multiplexed genome engineering

#4947
20200157574
2020-05-21

CRISPR enabled multiplexed genome engineering

#4948
20200157570
2020-05-21

ENHANCED MODIFIED VIRAL CAPSID PROTEINS

#4949
20200157565
2020-05-21

Compositions and methods for gene editing

#4950
20200157563
2020-05-21

METHODS OF PRODUCING HUMAN CANCER CELL MODELS AND METHODS OF USE

#4951
20200157559
2020-05-21

METHODS TO IMPROVE PLANT AGRONOMIC TRAIT USING BCS1L GENE AND GUIDE RNA/CAS ENDONUCLEASE SYSTEMS

#4952
20200157552
2020-05-21

Programmable transcription factors and methods

#4953
20200157534
2020-05-21

METHODS AND SYSTEMS FOR CONDITIONALLY REGULATING GENE EXPRESSION

#4954
20200157532
2020-05-21

Automated cell processing methods, modules, instruments, and systems

#4955
20200157531
2020-05-21

METHOD TO ENHANCE SCREENING FOR HOMOLOGOUS RECOMBINATION IN GENOME EDITED CELLS USING RECOMBINATION-ACTIVATED FLUORESCENT DONOR DELIVERY VECTOR

#4956
20200157516
2020-05-21

PEPTIDE-MEDIATED DELIVERY OF RNA-GUIDED ENDONUCLEASE INTO CELLS

#4957
20200157515
2020-05-21

Systems and methods for the treatment of hemoglobinopathies

#4958
20200157504
2020-05-21

Methods and products for transfecting cells

#4959
20200155703
2020-05-21

Therapeutic Membrane Vesicles

#4960
20200155606
2020-05-21

CRISPR/RNA-guided nuclease systems and methods

#4961
20200155597
2020-05-21

Genetic engineering of macrophages for immunotherapy

#4962
20200149071
2020-05-14

Yeast strain with glucose and xylose co-utilization capacity

#4963
20200149070
2020-05-14

METHODS AND COMPOSITIONS FOR GENOME EDITING

#4964
20200149064
2020-05-14

Self-inactivating endonuclease-encoding nucleic acids and methods of using the same

#4965
20200149041
2020-05-14

Gene Therapy Drug for Granular Corneal Degeneration

#4966
20200149039
2020-05-14

REGULATION OF TRANSCRIPTION THROUGH CTCF LOOP ANCHORS

#4967
20200149038
2020-05-14

METHODS AND COMPOSITIONS RELATING TO HOMOLOGY-DIRECTED REPAIR

#4968
20200149024
2020-05-14

Engineered CRISPR-Cas9 nucleases

#4969
20200149023
2020-05-14

Engineered CRISPR-Cas9 nucleases with altered PAM specificity

#4970
20200149022
2020-05-14

Target-specific CRISPR mutant

#4971
20200149021
2020-05-14

System and method for genome editing

#4972
20200149020
2020-05-14

High-fidelity CAS9 variants and applications thereof

#4973
20200147423
2020-05-14

Special fire protection system for runaway grass and forest fires and method for use

#4974
20200147239
2020-05-14

NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF

#4975
20200146988
2020-05-14

Nano-liposome carrier composition containing hybrid of Cas9 protein and guide RNA

#4976
20200146269
2020-05-14

METHODS AND COMPOSITIONS FOR MODULATING INNATE LYMPHOID CELL PATHOGENIC EFFECTORS

#4977
20200140897
2020-05-07

CRISPR-BASED GENOME MODIFICATION AND REGULATION

#4978
20200140893
2020-05-07

METHODS FOR ALTERING GENE EXPRESSION FOR GENETIC DISORDERS

#4979
20200140887
2020-05-07

Viral delivery of RNA utilizing self-cleaving ribozymes and CRISPR-based applications thereof

#4980
20200140885
2020-05-07

DNA sequence modification-based gene drive

#4981
20200140875
2020-05-07

GENOME EDITING METHODS FOR PRODUCING LOW-NICOTINE TOBACCO PRODUCTS

#4982
20200140867
2020-05-07

Compositions and methods for the treatment of myotonic dystrophy

#4983
20200140858
2020-05-07

Gene correction of Pompe disease and other autosomal recessive disorders via RNA-guided nucleases

#4984
20200140856
2020-05-07

Cell model for in vitro evaluation of compound-induced skin sensitization and a constructing method therefor

#4985
20200140847
2020-05-07

Enhancement of CRISPR gene editing or target destruction by co-expression of heterologous DNA repair protein

#4986
20200140844
2020-05-07

CRISPR nanocomplex for nonviral genome editing and method for preparing the same

#4987
20200140842
2020-05-07

BIPARTITE BASE EDITOR (BBE) ARCHITECTURES AND TYPE-II-C-CAS9 ZINC FINGER EDITING

#4988
20200140838
2020-05-07

Enzyme products

#4989
20200140835
2020-05-07

Engineered CRISPR-Cas9 Nucleases

#4990
20200138869
2020-05-07

Genetically engineered hematopoietic stem cells and uses thereof

#4991
20200131539
2020-04-30

CRISPR/Cas 9-mediated integration of polynucleotides by sequential homologous recombination of AAV donor vectors

#4992
20200131536
2020-04-30

Method for identifying DNA base editing by means of cytosine deaminase

#4993
20200131511
2020-04-30

CRISPR-Cas system for an algal host cell

#4994
20200131501
2020-04-30

METHOD AND COMPOSITION FOR PRODUCING TARGET NUCLEIC ACID MOLECULE

#4995
20200131496
2020-04-30

APOBEC ENZYMES WITH INCREASED DNA EDITING ACTIVITY, AND METHODS FOR THEIR USE

#4996
20200131490
2020-04-30

Regulation of gene expression using engineered nucleases

#4997
20200131489
2020-04-30

Engineered meganucleases specific for recognition sequences in the PCSK9 gene

#4998
20200131488
2020-04-30

Cas13b orthologues CRISPR enzymes and systems

#4999
20200131487
2020-04-30

COMPOSITION CONTAINING C2CL ENDONUCLEASE FOR DIELECTRIC CALIBRATION AND METHOD FOR DIELECTRIC CALIBRATION USING SAME

#5000
20200131474
2020-04-30

METHODS AND COMPOSITIONS FOR OCULAR CELL THERAPY

#5001
20200128802
2020-04-30

Recombinant vector comprising ERT2 fused to CAS9

#5002
20200123575
2020-04-23

Molecular system for cancer biology

#5003
20200123570
2020-04-23

MATERIALS AND METHODS FOR TREATMENT OF APOLIPOPROTEIN C3 (APOCIII)-RELATED DISORDERS

#5004
20200123569
2020-04-23

RNA-targeting fusion protein compositions and methods for use

#5005
20200123567
2020-04-23

A UNIVERSAL PLATFORM TO ENHANCE CRISPR-BASED GENE EDITING FOR IN VIVO THERAPIES

#5006
20200123544
2020-04-23

GENE THERAPY TARGETING THE NEONATAL FORM OF NAV1.5 FOR TREATING CANCER

#5007
20200123542
2020-04-23

RNA COMPOSITIONS FOR GENOME EDITING

#5008
20200123535
2020-04-23

HTP genomic engineering platform for improving fungal strains

#5009
20200123533
2020-04-23

HIGH-THROUGHPUT STRATEGY FOR DISSECTING MAMMALIAN GENETIC INTERACTIONS

#5010
20200123517
2020-04-23

Engineered enzymes

#5011
20200123516
2020-04-23

Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene

#5012
20200123515
2020-04-23

TGFBetaR2 endonuclease variants, compositions, and methods of use

#5013
20200123503
2020-04-23

GENETICALLY MODIFIED NK-92 CELLS WITH DECREASED CD96/TIGIT EXPRESSION

#5014
20200123476
2020-04-23

Polypeptides

#5015
20200121768
2020-04-23

Sequence-specific antimicrobials by blocking DNA repair

#5016
20200121746
2020-04-23

ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSIDS AND METHODS OF USE THEREOF

#5017
20200115716
2020-04-16

Single-vector type I vectors

#5018
20200115706
2020-04-16

Method of Recording Multiplexed Biological Information into a CRISPR Array Using a Retron

#5019
20200115690
2020-04-16

Manufacturing and engineering of DNASE enzymes for therapy

#5020
20200115689
2020-04-16

Recombinant nucleoside-specific ribonuclease and method of producing and using same

#5021
20200115688
2020-04-16

COMPOSITIONS AND METHODS FOR ENHANCING GENOME EDITING

#5022
20200115687
2020-04-16

Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems

#5023
20200109421
2020-04-09

METHODS FOR INTEGRATION OF TRANSGENE DNA

#5024
20200109408
2020-04-09

METHODS OF SELECTING CELLS COMPRISING GENOME EDITING EVENTS

#5025
20200109406
2020-04-09

ENGINEERED GENETIC MODULATORS

#5026
20200109398
2020-04-09

Methods and compositions for modulating a genome

#5027
20200109385
2020-04-09

CBLB endonuclease variants, compositions, and methods of use

#5028
20200109384
2020-04-09

FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS

#5029
20200109383
2020-04-09

RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY

#5030
20200109382
2020-04-09

Protein mutants that enhance the DNA cleavage activity of sp. CPF1

#5031
20200109381
2020-04-09

Polypeptides having DNase activity

#5032
20200109364
2020-04-09

METHODS FOR GENOME-EDITING AND ACTIVATION OF CELLS

#5033
20200108157
2020-04-09

NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF

#5034
20200103399
2020-04-02

METHODS FOR RARE EVENT DETECTION

#5035
20200102580
2020-04-02

Method for producing DNA-edited eukaryotic cell, and kit used in the same

#5036
20200102570
2020-04-02

COMPOSITIONS AND METHODS FOR INCREASING SHELF-LIFE OF BANANA

#5037
20200102563
2020-04-02

EXOSOME LOADED THERAPEUTICS FOR TREATING SICKLE CELL DISEASE

#5038
20200102561
2020-04-02

Compositions and methods for the treatment of hemoglobinopathies

#5039
20200102551
2020-04-02

Recombinant type I CRISPR-Cas system

#5040
20200102550
2020-04-02

TAL effector-mediated DNA modification

#5041
20200101173
2020-04-02

Genome Editing System For Repeat Expansion Mutation

#5042
20200095605
2020-03-26

COMPOSITIONS AND METHODS FOR NUCLEIC ACID AND/OR PROTEIN PAYLOAD DELIVERY

#5043
20200095604
2020-03-26

Genomic engineering of pluripotent cells

#5044
20200095589
2020-03-26

ENGINEERED DCAS9 WITH REDUCED TOXICITY AND ITS USE IN GENETIC CIRCUITS

#5045
20200095586
2020-03-26

COMPOSITIONS AND METHODS OF TREATMENT FOR LYTIC AND LYSOGENIC VIRUSES

#5046
20200095582
2020-03-26

BCL11A guide delivery

#5047
20200095579
2020-03-26

MATERIALS AND METHODS FOR TREATMENT OF MEROSIN-DEFICIENT COGENITAL MUSCULAR DYSTROPHY (MDCMD) AND OTHER LAMININ, ALPHA 2 (LAMA2) GENE RELATED CONDITIONS OR DISORDERS

#5048
20200095576
2020-03-26

Methods and systems for modulating intracellular gene expression

#5049
20200093865
2020-03-26

Genetically engineered hematopoietic stem cells and uses thereof

#5050
20200087681
2020-03-19

THERAPEUTIC CELLS

#5051
20200087671
2020-03-19

FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks

#5052
20200087652
2020-03-19

CAPTURE OF NUCLEIC ACIDS USING A NUCLEIC ACID-GUIDED NUCLEASE-BASED SYSTEM

#5053
20200087651
2020-03-19

Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction

#5054
20200087642
2020-03-19

METHODS AND COMPOSITIONS FOR MODIFYING A SINGLE STRANDED TARGET NUCLEIC ACID

#5055
20200087641
2020-03-19

CRISPR enzyme mutations reducing off-target effects

#5056
20200087640
2020-03-19

CASZ COMPOSITIONS AND METHODS OF USE

#5057
20200087639
2020-03-19

Variant CAS9 proteins with improved DNA cleavage selectivity

#5058
20200087635
2020-03-19

Hyperactive piggybac transposases

#5059
20200087376
2020-03-19

BIOMARKERS AND CAR T CELL THERAPIES WITH ENHANCED EFFICACY

#5060
20200085872
2020-03-19

Immune cells expressing engineered antigen receptors

#5061
20200080140
2020-03-12

Vesicular adaptor and uses thereof in nucleic acid library construction and sequencing

#5062
20200080126
2020-03-12

Method for selective translation of desired proteins in the presence of a specified nucleic acid ligand

#5063
20200080114
2020-03-12

Universal donor cells

#5064
20200080113
2020-03-12

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

#5065
20200080110
2020-03-12

METHOD FOR TARGETED ALTERATION OF DUPLEX DNA

#5066
20200080108
2020-03-12

CRISPR/CAS9-BASED COMPOSITIONS AND METHODS FOR TREATING RETINAL DEGENERATIONS

#5067
20200080107
2020-03-12

UNIVERSAL DONOR CELLS

#5068
20200080094
2020-03-12

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

#5069
20200080082
2020-03-12

Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders

#5070
20200080078
2020-03-12

Automated cell processing methods, modules, instruments, and systems

#5071
20200080068
2020-03-12

CRISPR-associated (Cas) protein

#5072
20200080067
2020-03-12

CRISPR-CAS SYSTEMS, CRYSTAL STRUCTURE AND USES THEREOF

#5073
20200080056
2020-03-12

CRISPR-Cas9 Knock-out of SHP-1/2 to Reduce T cell Exhaustion in Adoptive Cell Therapy

#5074
20200079826
2020-03-12

Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene

#5075
20200078402
2020-03-12

Compositions and methods for selective elimination and replacement of hematopoietic stem cells

#5076
20200071753
2020-03-05

Thermolabile exonucleases

#5077
20200071730
2020-03-05

Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing

#5078
20200071729
2020-03-05

CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION

#5079
20200071728
2020-03-05

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

#5080
20200071718
2020-03-05

RNA-TARGETING FUSION PROTEIN COMPOSITIONS AND METHODS FOR USE

#5081
20200071693
2020-03-05

HTP genomic engineering platform for improving fungal strains

#5082
20200071689
2020-03-05

RNA affinity purification

#5083
20200071684
2020-03-05

Engineered nucleic-acid targeting nucleic acids

#5084
20200071660
2020-03-05

Detection of nuclease edited sequences in automated modules and instruments

#5085
20200071369
2020-03-05

Targeted DNA demethylation and methylation

#5086
20200069735
2020-03-05

Targeted disruption of the MHC cell receptor

#5087
20200063288
2020-02-27

Automated instrumentation for production of T-cell receptor peptide libraries

#5088
20200063165
2020-02-27

Mutants of the bacteriophage lambda integrase

#5089
20200063164
2020-02-27

Genome editing

#5090
20200063160
2020-02-27

METHOD FOR THE TREATMENT OF MUCOPOLYSACCHARIDOSIS TYPE II

#5091
20200063157
2020-02-27

TRANSPOSON SYSTEM AND METHODS OF USE

#5092
20200063147
2020-02-27

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

#5093
20200063127
2020-02-27

DNA WRITERS, MOLECULAR RECORDERS AND USES THEREOF

#5094
20200063126
2020-02-27

CRISPR DNA targeting enzymes and systems

#5095
20200063123
2020-02-27

Automated cell processing methods, modules, instruments, and systems

#5096
20200063121
2020-02-27

High Fidelity Restriction Endonucleases

#5097
20200063120
2020-02-27

Automated instrumentation for production of peptide libraries

#5098
20200063114
2020-02-27

Engineered target specific base editors

#5099
20200063100
2020-02-27

METHODS AND COMPOSITIONS FOR TREATING CANCER

#5100
20200061211
2020-02-27

METHODS FOR DELIVERING GENE EDITING REAGENTS TO CELLS WITHIN ORGANS