108937 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses
Compositions for facilitating membrane fusion and uses thereof
#5102BARCODED TRANSPOSASES TO INCREASE EFFICIENCY OF HIGH-ACCURACY GENETIC SEQUENCING
#5103CRISPR hybrid DNA/RNA polynucleotides and methods of use
#5104Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA
#5105Methods and products for expressing proteins in cells
#5106CRISPR-BASED TREATMENT OF FRIEDREICH ATAXIA
#5107Applications of CRISPRi in high throughput metabolic engineering
#5108Modified nucleic acids, hybrid guide RNAs, and uses thereof
#5109Engineered Cas9 nucleases
#5110Compositions and methods for gene editing in T cells using CRISPR/Cpf1
#5111THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
#5112RNA-guided human genome engineering
#5113GENE EDITING AND TRANSGENE FREE MUTANT PLANTS
#5114Engineered cascade components and cascade complexes
#5115SHP INHIBITOR COMPOSITIONS AND USES FOR CHIMERIC ANTIGEN RECEPTOR THERAPY
#5116PREVENTION OF MUSCULAR DYSTROPHY BY CRISPR/CPF1-MEDIATED GENE EDITING
#5117COMPOSITIONS AND METHODS SPECIFICALLY TARGETING THE APOLIPOPROTEIN E4 (APOE4) AND USES THEREOF IN APOE4 ASSOCIATED CONDITIONS
#5118Methods and products for expressing proteins in cells
#5119Methods and products for expressing proteins in cells
#5120Methods and products for expressing proteins in cells
#5121Compositions and methods for genomic editing by insertion of donor polynucleotides
#5122RNA-based regulatory technologies for miRNA sensors
#5123Method for editing filamentous fungal genome through direct introduction of genome-editing protein
#5124SYSTEMS AND METHODS FOR PREDICTING REPAIR OUTCOMES IN GENETIC ENGINEERING
#5125Modified cascade ribonucleoproteins and uses thereof
#5126Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids
#5127MATERIALS AND METHODS FOR TREATMENT OF EARLY ONSET PARKINSON'S DISEASE (PARK1) AND OTHER SYNUCLEIN, ALPHA (SNCA) GENE RELATED CONDITIONS OR DISORDERS
#5128Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
#5129Specific detection of deoxyribonucleic acid sequences using novel CRISPR enzyme-mediated detection strategies
#5130SPECIFIC DETECTION OF RIBONUCLEIC ACID SEQUENCES USING NOVEL CRISPR ENZYME-MEDIATED DETECTION STRATEGIES
#5131Methods and products for expressing proteins in cells
#5132Methods and products for expressing proteins in cells
#5133Methods and products for expressing proteins in cells
#5134Methods and products for expressing proteins in cells
#5135Methods and products for expressing proteins in cells
#5136CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#5137CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#5138SELF-GUIDING INTEGRATION CONSTRUCT (SGIC)
#5139Stem loop RNA mediated transport of mitochondria genome editing molecules (endonucleases) into the mitochondria
#5140Compositions and Methods for Enhancing Homologous Recombination
#5141Laundry Method, Use of Polypeptide and Detergent Composition
#5142Polypeptides having DNase activity
#5143TARGETED DISRUPTION OF A CSF1-DAP12 PATHWAY MEMBER GENE FOR THE TREATMENT OF NEUROPATHIC PAIN
#5144Inhibition of stress granule formation through manipulation of UBAP2L
#5145System and method for targeted depletion of nucleic acids
#5146RNA-guided transcriptional regulation
#5147Methods and compositions for treating Leber congenital amaurosis
#5148Engineered DNase enzymes and use in therapy
#5149Polypeptides having DNase activity
#5150Mapping a Functional Cancer Genome Atlas of Tumor Suppressors Using AAV-CRISPR Mediated Direct In Vivo Screening
#5151METHOD FOR RAPID IDENTIFICATION OF MICROORGANISMS PRODUCING NUCLEASE ENZYMES
#5152RNA-guided nucleic acid modifying enzymes and methods of use thereof
#5153Methods of rapid ligation-independent cloning of DNA and uses thereof
#5154SYSTEMS AND METHODS FOR SINGLE-STRAND BREAK SIGNALING AND REPAIR IN A CELL-FREE SYSTEM
#5155COMPOSITIONS AND METHODS FOR TARGET NUCLEIC ACID MODIFICATION
#5156CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10)
#5157Silencing of DUX4 by recombinant gene editing complexes
#5158Methods and Reagents for Purification of Proteins
#5159METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES
#5160AAV-Mediated Direct In vivo CRISPR Screen in Glioblastoma
#5161METHOD OF HOMOLOGOUS RECOMBINATION OF DNA
#5162Method for converting nucleic acid sequence of cell specifically converting nucleic acid base of targeted DNA using cell endogenous DNA modifying enzyme, and molecular complex used therein
#5163Incorporation of unnatural amino acids into proteins using base editing
#5164Evaluation and improvement of nuclease cleavage specificity
#5165Nuclease-mediated genome editing
#5166NUCLEASE FUSIONS FOR ENHANCING GENOME EDITING BY HOMOLOGY-DIRECTED TRANSGENE INTEGRATION
#5167Systems and methods of assisted reproduction and prevention of genetic defects in offspring using induced pluripotent stem cells
#5168Methods and compositions for targeted genetic modification using paired guide RNAs
#5169CRISPR-BASED GENOME MODIFICATION AND REGULATION
#5170DNASE VARIANTS
#5171Targeted replacement of endogenous T cell receptors
#5172Method for normalizing a nucleic acid sample
#5173VIRAL RESISTANT CELLS AND CULTURE SYSTEMS
#5174GENE EDITING REAGENTS WITH REDUCED TOXICITY
#5175CRISPR enabled multiplexed genome engineering
#5176Nucleic acid-guided nucleases
#5177Cas9 proteins and guiding features for DNA targeting and genome editing
#5178Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof
#5179PLASMID VECTORS FOR EXPRESSION OF LARGE NUCLEIC ACID TRANSGENES
#5180Incorporation of internal polya-encoded poly-lysine sequence tags and their variations for the tunable control of protein synthesis in bacterial and eukaryotic cells
#5181Reversible method for sustainable human cognitive enhancement
#5182Donor repair templates multiplex genome editing
#5183Synthetic reverse transcriptases and uses thereof
#5184NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS WITH ENHANCED HUMAN SKELETAL MUSCLE TROPISM
#5185Pharmaceutical compositions comprising bacterial delivery vehicles and uses thereof
#5186Methods and products for transfecting cells
#5187PROTEIN DELIVERY IN PRIMARY HEMATOPOIETIC CELLS
#5188Genetically modified mice expressing humanized PD-1
#5189NEGATIVE-POSITIVE ENRICHMENT FOR NUCLEIC ACID DETECTION
#5190NOVEL CRISPR ENZYMES AND SYSTEMS
#5191NOVEL CRISPR ENZYMES AND SYSTEMS
#5192VIRAL METHODS OF MAKING GENETICALLY MODIFIED CELLS
#5193Materials and methods for treatment of glycogen storage disease type 1A
#5194Methods and systems for guide RNA design and use
#5195Adenoviral vectors
#5196Truncated CRISPR-Cas proteins for DNA targeting
#5197Artificial single guide RNA and use thereof
#5198Method for re-expression of different hypermethylated genes involved in fibrosis, like hypermethylated RASAL1 and use thereof in treatment of fibrosis as well as kit of parts for re-expression of hypermethylated genes including RASAL1 in a subject
#5199Anti-CRISPR compounds and methods of use
#5200Chemical-inducible genome engineering technology
#5201COMPOSITIONS AND METHODS RELATING TO MYOMIXER-PROMOTED MUSCLE CELL FUSION
#5202Pharmaceutical composition or food composition, and method for assessing effect of active ingredient in vivo
#5203Compositions and methods for the improved production and delivery of RNA by efficient transcription termination
#5204Methods for in vitro joining and combinatorial assembly of nucleic acid molecules
#5205RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#5206Type I-B CRISPR-Cas system gene Cas3-based gene editing method
#5207Method of treating diseases associated with elevated KRAS expression using CRISPR-GNDM system
#5208CRISPR enabled multiplexed genome engineering
#5209SIMULTANEOUS GENE EDITING AND HAPLOID INDUCTION
#5210Methods and compositions for generating complex trait loci
#5211Methods of modulating expression of target nucleic acid sequences in a cell
#5212Permanent gene correction by means of nucleotide-modified messenger RNA
#5213Engineered natural killer (NK) cells and compositions and methods thereof
#5214APPARATUS AND METHODS FOR IN VITRO PRECLINICAL HUMAN TRIALS
#5215Nucleoside triphosphate transporter and uses thereof
#5216Nucleoside triphosphate transporter and uses thereof
#5217Tunable endogenous protein degradation with heterobifunctional compounds
#5218Materials and methods for treatment of Duchenne Muscular Dystrophy
#5219RNA-guided nucleases and active fragments and variants thereof and methods of use
#5220Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#5221METHODS FOR THE IDENTIFICATION OF VARIANT RECOGNITION SITES FOR RARE-CUTTING ENGINEERED DOUBLE-STRAND-BREAK-INDUCING AGENTS AND COMPOSITIONS AND USES THEREOF
#5222Method for targeted DNA alteration in plant cells
#5223METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
#5224Thermostable Cas9 nucleases
#5225Mutant Cas9 proteins
#5226Programmable CAS9-recombinase fusion proteins and uses thereof
#5227EMBRYONIC STEM CELL MEDIA AND CULTURE
#5228Delivery of target specific nucleases
#5229Nucleic acid products and methods of administration thereof
#5230DYSTROPHIN GENE EXON DELETION USING ENGINEERED NUCLEASES
#5231GENETICALLY-TAGGED STEM CELL LINES AND METHODS OF USE
#5232IMMUNOLOGICALLY DISCERNIBLE CELL SURFACE VARIANTS FOR USE IN CELL THERAPY
#5233Inhibitors of nucleotidyl transferases and uses in herpes and hepatitis viral infections therefor
#5234DMD REPORTER MODELS CONTAINING HUMANIZED DUCHENNE MUSCULAR DYSTROPHY MUTATIONS
#5235Genetically modified non-human animal with human or chimeric LAG-3
#5236Systems for nucleic acid-based data storage
#5237Thermostable Cas9 nucleases
#5238Nucleic acid-guided nucleases
#5239Method for Producing Mutant Filamentous Fungi
#5240Methods and Platform of Designing Genetic Editing Tools
#5241METHODS FOR IN VITRO SITE-DIRECTED MUTAGENESIS USING GENE EDITING TECHNOLOGIES
#5242Compositions and methods for scarless genome editing
#5243Type VI CRISPR orthologs and systems
#5244Angiogenin expression in plants
#5245Methods of editing DNA methylation
#5246Modified transposases for improved insertion sequence bias and increased DNA input tolerance
#5247Transcription activator-like effector (tale) - lysine-specific demethylase 1 (LSD1) fusion proteins
#5248Methods and compositions for efficient gene deletion
#5249SYSTEM, METHOD, COMPUTER-ACCESSIBLE MEDIUM AND APPARATUS FOR DNA MAPPING
#5250Methods for Increasing Efficiency of Gene Editing in Cells
#5251PLANTS RESISTANT TO HUANGLONGBING
#5252CRISPR-SYSTEMS FOR MODIFYING A TRAIT OF INTEREST IN A PLANT
#5253Genome editing reagents and their use
#5254Engineered transcription activator-like effector (TALE) domains and uses thereof
#5255REPAIR TEMPLATE LINKAGE TO ENDONUCLEASES FOR GENOME ENGINEERING
#5256Gene therapy for haploinsufficiency
#5257Factor VIII mutation repair and tolerance induction
#5258Multiplexed genome editing
#5259Method and apparatus for a tissue engineering system
#5260Methods and products for expressing proteins in cells
#5261NOVEL CRISPR ENZYMES AND SYSTEMS
#5262GENOME EDITING KIT
#5263METHODS AND COMPOSITIONS FOR RNA-GUIDED GENETIC CIRCUITS
#5264Modified immune cells having enhanced function and methods for screening for same
#5265Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
#5266AAV Split Cas9 Genome Editing and Transcriptional Regulation
#5267Compositions and methods for improved gene editing
#5268Cas9 variants and methods of use thereof
#5269COMPOSITIONS AND METHODS FOR MODULATING TH-17 AND TH-1 CELL BALANCE
#5270Chimeric proteins and methods of immunotherapy
#5271Methods and compositions for treating hemophilia
#5272CLOAKED CRISPRs
#5273Exosome delivery system
#5274OPTIMIZED STRATEGY FOR EXON SKIPPING MODIFICATIONS USING CRISPR/CAS9 WITH TRIPLE GUIDE SEQUENCES
#5275Controllable transcription
#5276TRANSCRIPTION REPRESSOR GENE FAMILY AND USES THEREOF
#5277Method for producing genome-modified plants from plant protoplasts at high efficiency
#5278Compositions and methods for modifying genomes
#5279Method to overcome DNA chemical modifications sensitivity of engineered TALE DNA binding domains
#5280Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
#5281MODULAR EXTRACELLULAR SENSOR ARCHITECTURE FOR REGULATING GENES
#5282POLYPEPTIDES FOR ENGINEERING INTEGRASE CHIMERIC PROTEINS AND THEIR USE IN GENE THERAPY
#5283Genetically modified rabbit expressing an exogenous protein in milk
#5284Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5285Efficient genetic screening method
#5286Targeted gene editing platform independent of DNA double strand break and uses thereof
#5287ENGINEERING OF BACTERIOPHAGES BY GENOME EDITING USING THE CRISPR-CAS9 SYSTEM
#5288RNA COMPOSITIONS FOR GENOME EDITING
#5289High-throughput precision genome editing
#5290Compositions and methods using Cas9 with enhanced spacer acquisition function
#5291CRISPR-Cas systems and methods for altering expression of gene products, structural information and inducible modular Cas enzymes
#5292Materials and methods for treatment of Amyotrophic Lateral Sclerosis (ALS) and other related disorders
#5293CRISPR-CAS SYSTEM, MATERIALS AND METHODS
#5294Compositions and methods for suppressing MSUT2
#5295Automated instrumentation for production of T-cell receptor peptide libraries
#5296BIDIRECTIONAL TARGETING FOR GENOME EDITING
#5297ANALYSIS SYSTEM FOR ORTHOGONAL ACCESS TO AND TAGGING OF BIOMOLECULES IN CELLULAR COMPARTMENTS
#5298Methods for identifying selective binding pairs
#5299Thermostable CAS9 nucleases
#5300Cas variants for gene editing
#5301Compositions of and methods for in vitro viral genome engineering
#5302Complexes for gene deletion and editing
#5303Compositions for linking DNA-binding domains and cleavage domains
#5304FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#5305Modified guide RNAs
#5306Automated cell processing methods, modules, instruments, and systems
#5307MODIFICATION OF IMMUNE-RELATED GENOMIC LOCI USING PAIRED CRISPR NICKASE RIBONUCLEOPROTEINS
#5308METHODS AND COMPOSITIONS FOR GENETICALLY MANIPULATING GENES AND CELLS
#5309Tale-protein scaffolds and uses thereof
#5310Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
#5311System and products for improved quantification of ADCC activity
#5312CRISPR effector system based diagnostics
#5313Cell-free expression system having novel inorganic polyphosphate-based energy regeneration
#5314BACTERIAL CELLS WITH IMPROVED TOLERANCE TO POLYOLS
#5315TARGETED MUTAGENESIS
#5316METHODS AND KITS FOR DYNAMIC TARGETED HYPERMUTATION
#5317Modified nucleic acid editing systems for tethering donor DNA
#5318IL-10 RECEPTOR ALPHA HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
#5319Artificial antigen-presenting cell prepared from HLA-null cell line by using multiplex CRISPR-CAS9 system and use thereof
#5320Nucleic acid products and methods of administration thereof
#5321Method for finding low abundance sequences by hybridization (FLASH)
#5322RNA-guided nucleic acid modifying enzymes and methods of use thereof
#5323METHODS AND COMPOSITIONS FOR T-RNA BASED GUIDE RNA EXPRESSION
#5324COMPOSITIONS AND METHODS FOR CRISPR-BASED SCREENING
#5325BYPASSING THE PAM REQUIREMENT OF THE CRISPR-CAS SYSTEM
#5326Proteome Editing System
#5327GENOMIC EDITING IN AUTOMATED SYSTEMS
#5328Constructs and methods to improve abiotic stress tolerance in plants
#5329Method for base editing in plants
#5330CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
#5331Prokaryotic Argonaute Proteins and Uses Thereof
#5332Automated cell processing methods, modules, instruments, and systems
#5333Adeno-associated-virus Rep sequences, vectors and viruses
#5334Compositions and methods for mitochondrial genome editing
#5335PLURALITY OF TRANSPOSASE ADAPTERS FOR DNA MANIPULATIONS
#5336System and method for targeted depletion of nucleic acids
#5337Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5338PREPARATION METHOD FOR ANTI-PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME CLONED PIG
#5339Transcription modulation in animals using CRISPR/Cas systems
#5340WHEAT
#5341ENHANCED PROCESSES AND REAGENTS FOR HOST ENGINEERING
#5342GENE-REGULATING COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY
#5343METHODS OF DEPLETING OR ISOLATING TARGET RNA FROM A NUCLEIC ACID SAMPLE
#5344NgAgo-based gene-editing method and the uses thereof
#5345Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome
#5346Materials and methods for treatment of hemoglobinopathies
#5347Gene-regulating compositions and methods for improved immunotherapy
#5348GENE-REGULATING COMPOSITIONS AND METHODS FOR IMPROVED IMMUNOTHERAPY
#5349Methods of treating cells containing fusion genes by genomic targeting
#5350RNA-guided nucleic acid modifying enzymes and methods of use thereof
#5351High fidelity restriction endonucleases
#5352CAS9-CAS9 fusion proteins
#5353Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5354Genomic engineering of pluripotent cells
#5355Nanoparticles comprising protein-polynucleotide complexes and for delivering protein based complexes
#5356Automated cell processing methods, modules, instruments, and systems
#5357Methods and compositions for the making and using of guide nucleic acids
#5358Methods and products for transfecting cells
#5359DYSTROPHIN GENE EXON DELETION USING ENGINEERED NUCLEASES
#5360REGULATABLE CELL LINES AND METHODS OF USE THEREOF
#5361Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5362Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5363Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5364Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5365Cas9 orthologs
#5366CRISPR enabled multiplexed genome engineering
#5367Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
#5368Engineered guide RNA sequences for in situ detection and sequencing
#5369CRYSTAL STRUCTURE OF CRISPR CPF1
#5370Inhibitors of RNA guided nucleases and uses thereof
#5371Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
#5372Genetically modified non-human animals and methods for producing heavy chain-only antibodies
#5373Crispr enzymes and systems
#5374Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5375Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5376Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#5377COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOTONIC DYSTROPHY
#5378RNA GUIDED COMPOSITIONS FOR PREVENTING AND TREATING HEPATITIS B VIRUS INFECTIONS
#5379Rewiring aberrant cancer signaling to a therapeutic effector response with a synthetic two-component system
#5380Polypeptide variants
#5381METHOD FOR CELL-SPECIFICALLY CONTROLLING NUCLEASE
#5382Materials and methods for treatment of hemoglobinopathies
#5383EPIGENOME EDITING SYSTEMS AND METHODS
#5384METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION
#5385Modified biotin-binding proteins for immobilization
#5386Detection of gene loci with CRISPR arrayed repeats and/or polychromatic single guide ribonucleic acids
#5387Reporter construct and biosensor for interferon second messenger 2-5A
#5388Engineered CAS9 systems for eukaryotic genome modification
#5389METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES
#5390RNA-guided human genome engineering
#5391RNA-guided human genome engineering
#5392MULTIPLEX GENE TARGETING IN PLANTS
#5393METHODS AND COMPOSITIONS FOR GENE EDITING IN STEM CELLS
#5394CRISPR/cas-related methods and compositions for treating herpes simplex virus
#5395METHODS OF MODIFYING THE DYSTROPHIN GENE AND RESTORING DYSTROPHIN EXPRESSION AND USES THEREOF
#5396COMPOSITIONS AND METHODS FOR GENE EDITING FOR HEMOPHILIA A
#5397TYPE V CRISPR/CAS EFFECTOR PROTEINS FOR CLEAVING SSDNAS AND DETECTING TARGET DNAS
#5398Methods for in vitro joining and combinatorial assembly of nucleic acid molecules
#5399Engineered guide RNA and uses thereof
#5400Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity