Compositions and methods for the production and delivery of double stranded RNA

CRISPR enabled multiplexed genome engineering

Nucleic acid-guided nucleases

Nucleic acid-guided nucleases

Methods and compositions for delivery of CRISPR based antimicrobials

Bacterial colicin-immunity protein protein purification system

Thermolabile exonucleases

Modified site-directed modifying polypeptides and methods of use thereof

Method for inducing CCR5Δ32 deletion by using CRISPR-Cas9 genome editing technique

Methods and compositions for reprogramming cells

Modified guide RNAs, CRISPR-ribonucleotprotein complexes and methods of use

Method for performing multiple enzyme reactions in a single tube

CONDITIONAL GUIDE RNAs

RNA-guided DNA nucleases and uses thereof

Targeted disruption of T cell and/or HLA receptors

Methods and compositions for genome engineering

POLYPEPTIDES WITH TYPE V CRISPR ACTIVITY AND USES THEREOF

Repairing a mutant human titin gene using CRISPR technology

Methods for rare event detection

RARE NUCLEIC ACID DETECTION

TUMOR MUTATION BURDEN BY QUANTIFICATION OF MUTATIONS IN NUCLEIC ACID

SELECTIVE PROTECTION OF NUCLEIC ACIDS

LARGE GENOMIC DNA KNOCK-IN AND USES THEREOF

METHODS AND KITS FOR QUALITY CONTROL

CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes

Manipulation of nuclear architecture

Engineered Cas9 nucleases

DNase H activity of Neisseria meningitidis Cas9

Fusion polymerase and method for using the same

Site-specific serine recombinases and methods of their use

Methods and compositions for reprogramming cells

RNA-guided nucleic acid modifying enzymes and methods of use thereof

Phage engineering: protection by circularized intermediate

NOVEL GUIDE RNA/CAS ENDONUCLEASE SYSTEMS

Engineered nucleic-acid targeting nucleic acids

Chimeric proteins and methods of immunotherapy

PRECISE DELETION OF CHROMOSOMAL SEQUENCES IN VIVO AND TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS USING ENGINEERED NUCLEASES

Methods and reagents for molecular proximity detection using RNA-guided nucleic acid binding proteins

CRISPR effector system based diagnostics

CRISPR effector system based diagnostics

Multiplex Quantitative Polymerase Chain Reaction In One Reaction

Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing

CRISPR-CAS SGRNA LIBRARY

RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES

Artificial nucleases including engineered FokI cleavage half-domains

Genome engineering with Type I CRISPR systems in eukaryotic cells

Directed editing of cellular RNA via nuclear delivery of CRISPR/CAS9

SELECTIVE INSERTION OF SUICIDE GENES INTO CANCER CELLS

CRISPR enzymes and systems

CAS PROTEINS AND GUIDE RNA SYSTEMS FOR GENOME EDITING

Nuclease-independent targeted gene editing platform and uses thereof

Transduction buffer

Biocontainment/biocontrol system and methods

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

High-throughput CRISPR-based library screening

STABILIZED REAGENTS FOR GENOME MODIFICATION

Recombinogenic nucleic acid strands in situ

Methods and compositions for modulating PD1

RNA-Guided Systems For Probing And Mapping Of Nucleic Acids

Compositions and methods for modifying a target nucleic acid

Cas9 mutant genes and polypeptides encoded by same

RNA-guided gene editing and gene regulation

Transposon system, kit comprising the same, and uses thereof

Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair

Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption

CRISPR enzymes and systems

Recombinant nucleoside-specific ribonuclease and method of producing and using same

DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL INJECTION OF TALEN PROTEINS

CRISPR-associated (Cas) proteins with reduced immunogenicity

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

Method for producing whole plants from protoplasts

crRNA for detecting RSPO2 gene in body fluid with CRISPR-Cas13a specificity and applications thereof

Capture of nucleic acids using a nucleic acid-guided nuclease-based system

Nucleobase editors comprising nucleic acid programmable DNA binding proteins

Engineered nucleic-acid targeting nucleic acids

Methods and compositions for gene inactivation

Nucleobase editors and uses thereof

Engineering and optimization of systems, methods, enzymes and guide scaffolds of CAS9 orthologs and variants for sequence manipulation

Model animal for fibrosis

CRISPR effector system based diagnostics for malaria detection

Vectors For Integration Of DNA Into Genomes And Methods For Altering Gene Expression And Interrogating Gene Function

Methods for producing a complex transgenic trait locus

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

Compositions and methods for enhancing CRISPR activity by POLQ inhibition

Genetic tool for the transformation of bacteria

Recombinant attenuated Mopeia virus comprising a modified nucleoprotein with reduced exonuclease activity

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

CRISPR effector system based diagnostics

Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using CRISPR/Cas system proteins

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Cas9 variants and methods of use thereof

Modified transposases for improved insertion sequence bias and increased DNA input tolerance

Cell lines for screening odorant and aroma receptors

Cleaning of water filtration membranes

Compositions and methods for treating fragile X syndrome and related syndromes

Methods and compositions for RNA-guided treatment of HIV infection

CRISPR/Cas-related methods and compositions for improving transplantation

Genetically modified rat models for severe combined immunodeficiency (SCID)

Methods for Autocatalytic Genome Editing and Neutralizing Autocatalytic Genome Editing

SELF-TARGETING GENOME EDITING SYSTEM

High-throughput screening of regulatory element function with epigenome editing technologies

Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients

N-Terminal Polysialylation

Engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene

Multiplexed genome editing

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

RESTORING FUNCTION TO A NON-FUNCTIONAL GENE PRODUCT VIA GUIDED CAS SYSTEMS AND METHODS OF USE

Optimized CRISPR/cas9 systems and methods for gene editing in stem cells

SYSTEM FOR OVER-EXPRESSING TARGET PROTEIN AND METHOD FOR OVER-EXPRESSING TARGET PROTEIN

Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing

CRISPR-associated (Cas) protein

Engineered CRISPR-Cas9 nucleases with altered PAM specificity

Vector systems for nuclease-mediated genome editing

Engraftable cell-based immunotherapy for long-term delivery of therapeutic proteins

CRISPR effector system based diagnostics

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Chimeric proteins and methods of regulating gene expression

PROTECTED DNA TEMPLATES FOR GENE MODIFICATION AND INCREASED HOMOLOGOUS RECOMBINATION IN CELLS AND METHODS OF USE

Activation of taste receptor genes in mammalian cells using CRISPR-Cas-9

METHODS OF INCREASING VIRUS RESISTANCE IN CUCUMBER USING GENOME EDITING AND PLANTS GENERATED THEREBY

METHODS AND COMPOSITIONS FOR MARKER-FREE GENOME MODIFICATION

RNA and method for specifically activating human RSPO2 gene with CRISPR-Cas9 and application thereof

Genome editing enhancement

Methods and compositions for generating CRISPR/Cas guide RNAs

Use of exonucleases to improve CRISPR/CAS-mediated genome editing

TAL effector means useful for partial or full deletion of DNA tandem repeats

Methods and compositions for modifying a single stranded target nucleic acid

Polypeptide containing DNA-binding domain

Materials and methods for treatment of hemoglobinopathies

Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44

MODIFIED 3' REGION EXTRACTION AND DEEP SEQUENCING OF POLYDENYLATION SITES AND POLY(A) TAIL LENGTH ANALYSIS

Modified CAS9 compositions and methods of use

Genome engineering methods using a cytosine-specific Cas9

MODIFICATION OF THE DYSTROPHIN GENE AND USES THEREOF

RNA preparations comprising purified modified RNA for reprogramming cells

Small molecule biosensors

ANALYTE DETECTION

GENERATION OF COMPLEX TRAIT LOCI IN SOYBEAN AND METHODS OF USE

CRISPR COMPOSITIONS AND METHODS OF USING THE SAME FOR GENE THERAPY

METHOD OF IDENTIFYING GENOME-WIDE OFF-TARGET SITES OF BASE EDITORS BY DETECTING SINGLE STRAND BREAKS IN GENOMIC DNA

Rapid characterization of Cas endonuclease systems, PAM sequences and guide RNA elements

COMPOSITIONS AND METHODS FOR GENOME EDITING

Delivery, use and therapeutic applications of the CRISPR-cas systems and compositions for modeling mutations in leukocytes

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Method for cell line development

MULTILAYER GENETIC SAFETY KILL CIRCUITS BASED ON SINGLE CAS9 PROTEIN AND MULTIPLE ENGINEERED GRNA IN MAMMALIAN CELLS

Engineered nucleic acid-targeting nucleic acids

Crispr-CAS10 systems and methods for phage genome editing

CRISPR/Cas-related methods and compositions for treating herpes simplex virus

Methods for screening and using CRISPR/Cas9 guidance RNA sequence from HIV provirus genome

COMPOSITIONS AND METHODS FOR PROMOTING HOMOLOGY DIRECTED REPAIR

Treatment of retinitis pigmentosa using engineered meganucleases

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides

Haploid inducer line for accelerated genome editing

Integrated system for programmable DNA methylation

TREATING HEPATITIS B VIRUS INFECTION USING CRISPR

REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)

sgRNA and knockout method of human RSPO2 gene targeted with CRISPR-Cas9 specificity and application thereof

METHODS AND COMPOSITIONS FOR ENHANCING GENE EDITING

Compositions for linking DNA-binding domains and cleavage domains

SYSTEMS AND METHODS FOR SELECTION OF GRNA TARGETING STRANDS FOR CAS9 LOCALIZATION

COMPOSITIONS FOR INCREASING POLYPEPTIDE STABILITY AND ACTIVITY, AND RELATED METHODS

METHOD AND COMPOSITIONS FOR REMOVING DUPLICATED COPY NUMBER VARIAIONS (CNVS) FOR GENETIC DISORDERS AND RELATED USES

Protein having nuclease activity, fusion proteins and uses thereof

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

COMPOSITIONS AND METHODS FOR TARGET NUCLEIC ACID MODIFICATION

Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system

GENE EDITING OF PCSK9

Artificially-Manipulated Neovascularization Regulatory System

Compositions and Methods of Nucleic Acid-Targeting Nucleic Acids

Nuclease-mediated regulation of gene expression

Evolution of TALENs

CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS

Delivery of negatively charged proteins using cationic lipids

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Methods and compositions for RNA-guided treatment of HIV infection

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Dynamically-adaptive live therapeutic agents and methods of use thereof

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION

Methods for increasing efficiency of nuclease-induced homology-directed repair

CRISPR enabled multiplexed genome engineering

CRISPR enabled multiplexed genome engineering

REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)

Chimeric polypeptides having targeted binding specificity

Reverse transcriptases and uses thereof

Cas9 Genome Editing and Transcriptional Regulation

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS AND COMPOSITIONS FOR RNRA-GUIDED TREATMENT OF HIV INFECTION

System and method for targeted depletion of nucleic acids

Lentiviral protein delivery system for RNA-guided genome editing

Methods and compositions for treatment of a genetic condition

FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks

Bacteriophage recombination followed by blockage of non-recombinant bacteriophage replication

Recombinant K1-5 bacteriophages and uses thereof

Antimicrobial peptide for nosocomial infections

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Nuclease with enhanced efficiency of genome editing

HSD17B13 variants and uses thereof

Engineered CRISPR-Cas9 nucleases

Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems and methods

HSD17B13 variants and uses thereof

TRANSGENIC EXPRESSION OF DNASEI IN VIVO DELIVERED BY AN ADENO-ASSOCIATED VIRUS VECTOR

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

METHODS OF TREATING LYSOSOMAL STORAGE DISEASES

GENOME EDITING SYSTEMS AND METHODS OF USE

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

Increasing specificity for RNA-guided genome editing

LENTIVIRUS AND NON-INTEGRATING LENTIVIRUS AS VIRAL VECTOR TO DELIVER CRISPR THERAPEUTIC

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA

Targeted integration into the PPP1R12C locus

DNA-FREE GENOME EDITING AND SELECTION METHODS IN PLANTS

Methods and compositions using one-sided transposition

CRISPRs

Engineered nucleic-acid targeting nucleic acids

MODIFIED FNCAS9 PROTEIN AND USE THEREOF

APOA-1 FUSION POLYPEPTIDES AND RELATED COMPOSITIONS AND METHODS

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

CRISPR/CAS-related methods and compositions for treating Leber's Congenital Amaurosis 10 (LCA10)

Nano-liposome carrier composition containing hybrid of Cas9 protein and guide RNA

Selective degradation of wild-type DNA and enrichment of mutant alleles using nuclease

DNA editing using relatively long single-stranded DNA and CRISPR/Cas9 to increase success rate in methods for preparing transgenic embryos and animals

RNA-directed DNA cleavage by the Cas9-crRNA complex

Cancer specific-splicing ribozyme and use thereof

SELF-ASSEMBLING MOLECULAR NANOSYSTEM FOR TARGETED DNA AND GENE DELIVERY

Compositions comprising nucleic acids and methods of using the same

Compositions and methods for directing proteins to specific loci in the genome

CRISPR/CPF1 systems and methods

Polypeptides

Therapeutic nuclease compositions and methods

Genetically modified human cell with a corrected mutant sickle cell mutation

REGULATED GENE EXPRESSION FROM VIRAL VECTORS

Productivity and bioproduct formation in phototropin knock/out mutants in microalgae

DELIVERY OF TARGET SPECIFIC NUCLEASES

Method of inducing genetic recombination, and use therefor

COMPOSITIONS AND METHODS FOR NUCLEIC ACID AND/OR PROTEIN PAYLOAD DELIVERY

Methods for Inducing Apomixis in Plants

CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION

Methods and compositions for modulating gene expression

Modified CRISPR RNA and modified single CRISPR RNA and uses thereof

Method of breeding eukaryote using protein having double-stranded DNA cleavage activity

Editing of CCR5 receptor gene to protect against HIV infection

Nucleic Acid Analogue-Guided Chemical Nuclease System, Methods and Compositions

Compositions and methods for transient delivery of nucleases

Nucleic acid products and methods of administration thereof

Multiplexed genome editing

METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY

Self-limiting viral vectors encoding nucleases

Vectors

High fidelity restriction endonucleases

Thermostable Cas9 nucleases

Modified transposases for improved insertion sequence bias and increased DNA input tolerance

METHODS FOR IMPROVING FUNCTIONALITY IN NK CELL BY GENE INACTIVATION USING SPECIFIC ENDONUCLEASE

Targeting BCL11A enhancer functional regions for fetal hemoglobin reinduction

Laundry method, use of polypeptide and detergent composition

Afucosylated protein, cell expressing said protein and associated methods

CRISPR-based methods and products for increasing frataxin levels and uses thereof

Site-specific DNA base editing using modified APOBEC enzymes

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Methods and compositions for RNA-guided treatment of HIV infection

METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

Compositions and methods for treating platelet storage pool deficiency, gray platelet syndrome and quebec platelet disorder

INHIBITORS OF NUCLEOTIDYL TRANSFERASES AND USE IN HERPES AND HEPATITIS VIRAL INFECTIONS THEREFOR

Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing

Methods for assembling DNA molecules

METHODS AND PRODUCTS FOR PRODUCING ENGINEERED MAMMALIAN CELL LINES WITH AMPLIFIED TRANSGENES

Method for making site-directed modification to plant genomes by using non-inheritable materials

Reconstruction of site specific nuclease binding sites

FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks

Gene expression in Bacteroides

Cas9 mRNAs

Compositions and methods for delivery of a polynucleotide into a plant

CRISPR/CAS9 BASED ENGINEERING OF ACTINOMYCETAL GENOMES

DNase variants

Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA

Methods and compositions for nucleic acid and protein payload delivery

Compositions and methods for treating CEP290-associated disease

Gene detection device including gold nanoparticles and gene detection method using gold nanoparticles

Methods and compositions for efficient delivery of nucleic acids and RNA-based antimicrobials

Engineered nucleic acid-targeting nucleic acids

Genomic engineering of pluripotent cells

CRISPR enzymes and systems

RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain

Surface-based tagmentation

Split Cas9 Proteins