108937 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses
Double knockout (GT/CMAH-KO) pigs, organs and tissues
#6002Proteome Editing System and A Biomarker of Veev Infection
#6003Methods and compositions for treatment of a genetic condition
#6004Compositions and methods for modifying genomes
#6005Delivering CRISPR therapeutics with lipid nanoparticles
#6006GENOME EDITING VECTORS
#6007High fidelity restriction endonucleases
#6008HUMAN CELL LINES MUTANT FOR ZIC2
#6009Cells containing CRISPR hybrid DNA/RNA polynucleotides
#6010SYNTHETIC SINGLE GUIDE RNA FOR CAS9-MEDIATED GENE EDITING
#6011Method, lysis solution and kit for selectively depleting animal nucleic acids in a sample
#6012Compositions and methods comprising sequences having meganuclease activity
#6013REPORTER CAS9 VARIANTS AND METHODS OF USE THEREOF
#6014Hyperactive piggybac transposases
#6015Cells lacking B2M surface expression and methods for allogeneic administration of such cells
#6016Nucleic acid-based data storage
#6017Evaluation of Cas9 molecule/guide RNA molecule complexes
#6018CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6019Transposon, gene transfer system and method of using the same
#6020Microorganisms with increased photosynthetic capacity
#6021Treatment methods using DNA editing with single-stranded DNA
#6022COMPOSITIONS AND METHODS FOR GENE EDITING
#6023Optimized gene editing utilizing a recombinant endonuclease system
#6024CRISPR-related methods and compositions with governing gRNAS
#6025AAV delivery of nucleobase editors
#6026Modified aminoacyl-tRNA synthetase and use thereof
#6027DYNAMIC GENOME ENGINEERING
#6028Cell sorting
#6029Fusion polymerases
#6030Methods and compositions for treatment of a genetic condition
#6031Engineered nucleic acid-targeting nucleic acids
#6032Negative regulator of plant immunity against nematodes
#6033Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation
#6034Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
#6035CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS
#6036METHODS AND COMPOSITIONS FOR CELLULAR REPROGRAMMING
#6037Modified cascade ribonucleoproteins and uses thereof
#6038Cells comprising engineered nucleic-acid targeting nucleic acids
#6039DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL INJECTION OF TALEN PROTEINS
#6040Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs)
#6041Sensor systems for target ligands and uses thereof
#6042Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer
#6043CRISPR mediated in vivo modeling and genetic screening of tumor growth and metastasis
#6044Methods for modifying genomic DNA
#6045METHODS AND COMPOSITIONS FOR GENE EDITING
#6046Compositions comprising TALENs and methods of treating HIV
#6047CRISPR/CAS-RELATED METHODS, COMPOSITIONS AND COMPONENTS
#6048Modified DNase and uses thereof
#6049COMPOSITIONS AND METHODS FOR GENERATING ANTIGENS, ANTIBODIES, AND IMMUNOTHERAPEUTIC COMPOSITIONS AND METHODS
#6050LAUNDRY METHOD, USE OF POLYPEPTIDE AND DETERGENT COMPOSITION
#6051Nuclease-mediated regulation of gene expression
#6052DUAL AAV VECTOR SYSTEM FOR CRISPR/Cas9 MEDIATED CORRECTION OF HUMAN DISEASE
#6053Methods and compositions for the treatment of lysosomal storage diseases
#6054Targeted RNA knockdown and knockout by type III-A Csm complexes
#6055METHOD FOR RNA-GUIDED ENDONUCLEASE-BASED DNA ASSEMBLY
#6056DETERGENT COMPOSITION
#6057Enhanced processes and reagents for host engineering
#6058CAS9 mutant genes and polypeptides encoded by same
#6059Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus
#6060Three-component CRISPR/Cas complex system and uses thereof
#6061Compositions and methods for the improved production and delivery of RNA by efficient transcription termination
#6062Method for Analysing Nuclease Hypersensitive Sites
#6063Engineered target specific nucleases
#6064Cell-free production of ribonucleic acid
#6065Mutant reverse transcriptase
#6066CAS 9 RETROVIRAL INTEGRASE AND CAS 9 RECOMBINASE SYSTEMS FOR TARGETED INCORPORATION OF A DNA SEQUENCE INTO A GENOME OF A CELL OR ORGANISM
#6067Delivery of structurally diverse polypeptide cargo into mammalian cells by a bacterial toxin
#6068SIMULTANEOUS SEQUENCING OF RNA AND DNA FROM THE SAME SAMPLE
#6069Methods and Compositions for Synthetic RNA Endonucleases
#6070RNA-guided gene editing system and uses thereof
#6071Method of treating or preventing eye disease using Cas9 protein and guide RNA
#6072Hybrid protein for the identification of neddylated substrates
#6073High-efficiency transfection of biological cells using sonoporation
#6074TAT-INDUCED CRISPR/ENDONUCLEASE-BASED GENE EDITING
#6075COMPOSITIONS AND METHODS FOR SPECIFIC REACTIVATION OF HIV LATENT RESERVOIR
#6076Adenosine nucleobase editors and uses thereof
#6077Activatable CRISPR/CAS9 for spatial and temporal control of genome editing
#6078Trichoplusia ni piggyBac transposases with reduced integration activity
#6079RNA guided endonuclease targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same
#6080METHODS AND COMPOSITIONS FOR MODIFYING ENDOTHELIAL CELLS
#6081CRISPR-CAS systems and methods for altering expression of gene products, structural information and inducible modular CAS enzymes
#6082Modulation of liver genes
#6083Gene editing of reproductive hormones to sterilize aquatic animals
#6084Functional screening with optimized functional CRISPR-Cas systems
#6085Talen targeting blood coagulation factor VIII intron 1 inversion gene and composition for treating hemophilia comprising same
#6086Guide RNA with chemical modifications
#6087Materials and methods for the synthesis of error-minimized nucleic acid molecules
#6088TAL effector-mediated DNA modification
#6089TAL effector-mediated DNA modification
#6090Transposase polypeptides and uses thereof
#6091Carriers for Plasmid and RNP Delivery in the Treatment of Cancer and Other Disease States
#6092Fluid delivery systems including hydraulic drive systems
#6093RNase H mutants in an emulsion
#6094Method for constructing nucleic acid single-stranded cyclic library and reagents thereof
#6095Use and production of CHD8+/− transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
#6096INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE
#6097PIV5-based amplifying virus-like particles
#6098Compositions and methods for transient delivery of nucleases
#6099CHIMERIC VSV-G PROTEINS AS NUCLEIC ACID TRANSFER VEHICLES
#6100Variants of CRISPR from and 1 (Cpf1)
#6101CRISPR-CAS system for a lipolytic yeast host cell
#6102Method for inducing targeted meiotic recombinations
#6103FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
#6104Compositions and methods for epigenome editing
#6105Nanoparticle-protein complex for intracellular protein delivery
#6106Endonuclease targeting blood coagulation factor VIII gene and composition for treating hemophilia comprising same
#6107Methods for Modulating Genome Editing
#6108Method for conducting site-specific modification on entire plant via gene transient expression
#6109DNA-binding proteins and uses thereof
#6110CRISPR-CAS system for a yeast host cell
#6111Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for modeling competition of multiple cancer mutations in vivo
#6112TARGETED TREATMENT OF LEBER CONGENITAL AMOUROSIS
#6113POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE
#6114Methods and compositions for labeling a single-stranded target nucleic acid
#6115COMPOSITION AND METHODS FOR REGULATED EXPRESSION OF A GUIDE RNA/CAS ENDONUCLEASE COMPLEX
#6116Fungal genome modification systems and methods of use
#6117Methods and materials for assembling nucleic acid constructs
#6118Heterodimeric Cas9 and methods of use thereof
#6119Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
#6120METHODS AND COMPOSITIONS FOR IDENTIFICATION OF HIGHLY SPECIFIC NUCLEASES
#6121HORMONE DEGRADABLE CRISPR-BASED TRANSCRIPTION FACTORS
#6122Fungal genome modification systems and methods of use
#6123COMPOSITIONS AND METHODS FOR EFFICIENT GENE EDITING IN E. COLI USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS IN COMBINATION WITH CIRCULAR POLYNUCLEOTIDE MODIFICATION TEMPLATES
#6124SYSTEMS AND METHODS FOR GENOME MODIFICATION AND REGULATION
#6125ENGINEERING MESENCHYMAL STEM CELLS USING HOMOLOGOUS RECOMBINATION
#6126MUSCLE-SPECIFIC CRISPR/CAS9 EDITING OF GENES
#6127Methods and products for expressing proteins in cells
#6128Site-directed CRISPR/recombinase compositions and methods of integrating transgenes
#6129METHODS AND COMPOSITIONS FOR SELECTIVELY ELIMINATING CELLS OF INTEREST
#6130Vesicular linker and uses thereof in nucleic acid library construction and sequencing
#6131Methods and compositions for regulation of transgene expression
#6132Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
#6133TARGETED DISRUPTION OF A CSF1-DAP12 PATHWAY MEMBER GENE FOR THE TREATMENT OF NEUROPATHIC PAIN
#6134Method of conveniently producing genetically modified non-human mammal with high efficiency
#6135Using programmable DNA binding proteins to enhance targeted genome modification
#6136Genome editing with split Cas9 expressed from two vectors
#6137Escorted and functionalized guides for CRISPR-Cas systems
#6138Methods and compositions for treating hemophilia
#6139Compounds and Methods for Biofilm Disruption and Prevention
#6140Efficient delivery of therapeutic molecules in vitro and in vivo
#6141ENZYME-PORE CONSTRUCTS
#6142Compositions and methods of engineered CRISPR-CAS9 systems using split-nexus CAS9-associated polynucleotides
#6143Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
#6144Peptide-mediated delivery of RNA-guided endonuclease into cells
#6145RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
#6146HBV RNAse H purification and enzyme inhibitors
#6147FUSION PROTEINS CONTAINING RECOMBINANT CYTOTOXIC RNASES
#6148Compounds and methods for biofilm disruption and prevention
#6149RNA GUIDED ERADICATION OF HUMAN JC VIRUS AND OTHER POLYOMAVIRUSES
#6150Artificial nucleases comprising engineered cleavage half-domains
#6151Mutants of the bacteriophage lambda integrase
#6152Compositions and methods of nucleic acid-targeting nucleic acids
#6153Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#6154Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#6155Engineered CRISPR-Cas9 nucleases with Altered PAM Specificity
#6156Efficient delivery of therapeutic molecules in vitro and in vivo
#6157Methods and compositions for targeted cleavage and recombination
#6158CRISPR enabled multiplexed genome engineering
#6159DEAD GUIDES FOR CRISPR TRANSCRIPTION FACTORS
#6160Method for modifying genome sequence to introduce specific mutation to targeted DNA sequence by base-removal reaction, and molecular complex used therein
#6161CRISPR enzymes and systems
#6162Compositions and methods for modifying a predetermined target nucleic acid sequence
#6163Method for RGEN RNP delivery using 5′-phosphate removed RNA
#6164CRISPR/CAS-related methods and compositions for treating sickle cell disease
#6165DIMERIC PROTEINS FOR SPECIFIC TARGETING OF NUCLEIC ACID SEQUENCES
#6166Extensible recombinase cascades
#6167RNA-targeting system
#6168CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS
#6169Compositions and Methods for Enhancing Homologous Recombination
#6170Non-fucosylated protein and methods thereof
#6171RECONSTRUCTION OF ANCESTRAL CELLS BY ENZYMATIC RECORDING
#6172Recognition sequences for I-CreI-derived meganucleases and uses thereof
#6173Recognition sequences for I-CreI-derived meganucleases and uses thereof
#6174CONDITIONAL RESCUE SYSTEM, CELLS, AND METHODS
#6175Targeted deletion of cellular DNA sequences
#6176FUNCTIONAL MUTANT ALLELES OF EIN5 FOR YIELD INCREASE
#6177GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
#6178Genetic correction of mutated genes
#6179Set of polypeptides exhibiting nuclease activity or nickase activity with dependence on light or in presence of drug or suppressing or activating expression of target gene
#6180Compositions and methods for the treatment of hemoglobinopathies
#6181Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
#6182Prophylactic protection against viral infections, particularly HIV
#6183Cell-free production of ribonucleic acid
#6184Detection of nucleic acid sequences using endonuclease
#6185Protected guide RNAS (PGRNAS)
#6186Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
#6187DIRECT CRISPR SPACER ACQUISITION FROM RNA BY A REVERSE-TRANSCRIPTASE-CAS1 FUSION PROTEIN
#6188Cas9 proteins and guiding features for DNA targeting and genome editing
#6189Methods and compositions for treating leber congenital amaurosis
#6190Compositions and methods for treating hemophilia
#6191CAS9 proteins including ligand-dependent inteins
#6192RNA-Guided Systems for In Vivo Gene Editing
#6193METHODS AND COMPOSITIONS FOR GENE EDITING
#6194Tevi chimeric endonuclease and their preferential cleavage sites
#6195Construct for the delivery of a molecule into the cytoplasm of a cell
#6196Methods of utilizing thermostable mismatch endonuclease
#6197Plant virus movement proteins and methods of using the same
#6198COMPOSITIONS, METHODS AND USE OF SYNTHETIC LETHAL SCREENING
#6199METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS
#6200ANTIVIRAL NUCLEASE METHODS
#6201Method for efficient delivery of therapeutic molecules in vitro and in vivo
#6202Methods and compositions for blocking off-target nucleic acids from cleavage by CRISPR proteins
#6203MODIFIED ANTIVIRAL NUCLEASE
#6204Methods for treating cells containing fusion genes
#6205CRISPR enabled multiplexed genome engineering
#6206Reduction of amyloid beta peptide production via modification of the APP gene using the CRISPR/Cas system
#6207Magnetic control of gene delivery in vivo
#6208Thermolabile exonucleases
#6209Method for the production of yeast
#6210In vitro recombination method
#6211Compositions and methods for modifying genomes
#6212Compositions and methods for modifying a predetermined target nucleic acid sequence
#6213Compositions and methods for transcription-based CRISPR-Cas DNA editing
#6214Production for recombinant human DNase I
#6215Genetic indicator and control system and method utilizing split Cas9/CRISPR domains for transcriptional control in eukaryotic cell lines
#6216Methods and compositions for targeted single-stranded cleavage and targeted integration
#6217Cas9 plasmid, genome editing system and method of
#6218METHOD OF PRODUCING LEUKOCYTES USING PTPN2 INHIBITION FOR ADOPTIVE CELL TRANSFER
#6219REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS
#6220A PROTEIN TAGGING SYSTEM FOR IN VIVO SINGLE MOLECULE IMAGING AND CONTROL OF GENE TRANSCRIPTION
#6221CLEAVABLE PRIMERS FOR ISOTHERMAL AMPLIFICATION
#6222Methods and products for expressing proteins in cells
#6223METHOD TO SELECTIVELY TARGET CANCEROUS CELLS FOR GENETIC MANIPULATION
#6224Compositions for linking DNA-binding domains and cleavage domains
#6225Crispr enzymes and systems
#6226Recombinases and target sequences
#6227SYNTHETIC YEAST AGGLUTINATION
#6228GENOMICALLY-ENCODED MEMORY IN LIVE CELLS
#6229Methods of using engineered nucleic-acid targeting nucleic acids
#6230Ribotoxin molecules derived from sarcin and other related fungal ribotoxins
#6231COMPOSITIONS AND METHODS FOR DETECTION OF SMALL MOLECULES
#6232Chimeric proteins and methods of regulating gene expression
#6233METHODS FOR TARGETED MODIFICATION OF GENOMIC DNA
#6234ENGINEERING MAMMALIAN GENOME USING DNA-GUIDED ARGONAUTE INTERFERENCE SYSTEMS (DAIS)
#6235Methods and systems for targeted gene manipulation
#6236Programmable RNA shredding by the type III-A CRISPR-Cas system of
#6237Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system
#6238ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
#6239Compositions and Methods for Site-Directed DNA Nicking and Cleaving
#6240Method for purification of a DNase or RNase protein from a sample
#6241CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6242CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
#6243ADENOSINE-SPECIFIC RNASE AND METHODS OF USE
#6244Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
#6245Compositions and methods for modifying a predetermined target nucleic acid sequence
#6246Ref nuclease for site specific Ref-mediated DNA cleavage
#6247GENOME EDITING USING CAS9 NICKASES
#6248METHOD FOR EDITING A GENETIC SEQUENCE
#6249CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#6250PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF
#6251CRISPR-CAS-RELATED METHODS, COMPOSITIONS AND COMPONENTS FOR CANCER IMMUNOTHERAPY
#6252Methods and compositions for using argonaute to modify a single stranded target nucleic acid
#6253Well-tolerated and highly specific tailored recombinase for recombining asymmetric target sites in a plurality of retrovirus strains
#6254Globin gene therapy for treating hemoglobinopathies
#6255Methods and Genetic Systems for Cell Engineering
#6256Targeted disruption of the MHC cell receptor
#6257Endoribonuclease compositions and methods of use thereof
#6258Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6259METHODS RELATING TO NUCLEIC ACID SEQUENCE EDITING
#6260Hyperactive PiggyBac transposases
#6261Engineered nucleic acid-targeting nucleic acids
#6262Recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
#6263DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTIC APPLICATIONS
#6264Compositions for linking DNA-binding domains and cleavage domains
#6265Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#6266Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6267Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6268Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6269Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6270TAL-EFFECTOR NUCLEASE FOR TARGETED KNOCKOUT OF THE HIV CO-RECEPTOR CCR5
#6271Fusion polymerase and method for using the same
#6272Fusion polymerase and method for using the same
#6273METHODS AND PRODUCTS FOR TRANSFECTING CELLS
#6274Detergent Composition
#6275Viral Vectors for Gene Editing
#6276CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
#6277TRACKING AND MANIPULATING CELLULAR RNA VIA NUCLEAR DELIVERY OF CRISPR/CAS9
#6278HBV polymerase mutants
#6279NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS
#6280Independently inducible system of gene expression
#6281METHODS AND COMPOSITIONS FOR SYNTHETIC RNA ENDONUCLEASES
#6282Tissue-specific genome engineering using CRISPR-Cas9
#6283Tailored recombinase for recombining asymmetric target sites in a plurality of retrovirus strains
#6284Intracellular genomic transplant and methods of therapy
#6285CRISPR hybrid DNA/RNA polynucleotides and methods of use
#6286Nucleobase editors and uses thereof
#6287Methods for Generating Stably Linked Complexes Composed of Homodimers, Homotetramers or Dimers of Dimers and Uses
#6288Methods and compositions for modulating immune tolerance
#6289MODIFIED CELLS AND METHODS OF THERAPY
#6290Compositions and methods for targeting cancer-specific sequence variations
#6291Polynucleotide based movement, kits and methods related thereto
#6292Site-specific serine recombinases and methods of their use
#6293Engineered nucleic-acid targeting nucleic acids
#6294Targeted viral-mediated plant genome editing using CRISPR /Cas9
#6295RNA Modification to Engineer Cas9 Activity
#6296NUCLEIC ACID ENRICHMENT USING CAS9
#6297Ribonucleoprotein transfection agents
#6298Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
#6299Deoxyribonuclease Enzymes
#6300Detergent composition