108937 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses
Dystrophin Gene Exon Deletion Using Engineered Nucleases
#6302Method for increasing the resistance of a plant to a plant RNA virus
#6303TRANSGENIC NUCLEASE SYSTEMS AND METHODS
#6304ADIPOSE-DERIVED STEM CELL PRODUCT
#6305COMPOSITIONS AND METHODS FOR TREATMENT OF LATENT VIRAL INFECTIONS
#6306ANTIVIRAL FUSION PROTEINS AND GENES
#6307Genetic engineering of macrophages for immunotherapy
#6308Modifying messenger RNA stability in plant transformations
#6309Engineered CRISPR-Cas9 nucleases
#6310Use of polypeptide
#6311CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6312Compositions and methods for high efficiency in vivo genome editing
#6313Binding-induced DNA nanomachines
#6314CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
#6315Genomic sequence modification method for specifically converting nucleic acid bases of targeted DNA sequence, and molecular complex for use in same
#6316Targeted remodeling of prokaryotic genomes using CRISPR-nickases
#6317Methods and compositions for the targeted modification of a mouse embryonic stem cell genome
#6318Modified cells and methods of therapy
#6319Stitched polypeptides
#6320Modified cells and methods of therapy
#6321Immobilized transposase complexes for DNA fragmentation and tagging
#6322Compounds and methods for CRISPR/Cas-based genome editing by homologous recombination
#6323METHODS AND COMPOSITIONS FOR PRODUCING MALE STERILE PLANTS
#6324N-terminal derivatisation of proteins with polysaccharides
#6325DIRECTED NUCLEIC ACID REPAIR
#6326Engineered CRISPR-Cas9 nucleases
#6327Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6328Methods and compositions for targeted gene modification
#6329Compositions and methods of nucleic acid-targeting nucleic acids
#6330Method for fragmenting genomic DNA using CAS9
#6331Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#6332Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
#6333MODIFIED RNASE H ENZYMES AND THEIR USES
#6334Detergent Composition
#6335CCR5 disruption of cells expressing anti-HIV chimeric antigen receptor (CAR) derived from broadly neutralizing antibodies
#6336CHROMOSOMAL MODIFICATION INVOLVING THE INDUCTION OF DOUBLE-STRANDED DNA CLEAVAGE AND HOMOLOGOUS RECOMBINATION AT THE CLEAVAGE SITE
#6337Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
#6338COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROGENERATIVE DISEASES
#6339Compositions and methods for the production and delivery of double stranded RNA
#6340CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING PRIMARY OPEN ANGLE GLAUCOMA
#6341TAL EFFECTOR MEANS USEFUL FOR PARTIAL OR FULL DELETION OF DNA TANDEM REPEATS
#6342Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes
#6343Nanoparticle mediated delivery of sequence specific nucleases
#6344CRISPR/CAS-related methods and compositions for treating cystic fibrosis
#6345METHODS AND COMPOSITIONS FOR THE PRODUCTION OF GUIDE RNA
#6346Compositions and methods comprising sequences having meganuclease activity
#6347Materials and methods for the treatment of latent viral infection
#6348GENE EDITING FOR IMMUNOLOGICAL DESTRUCTION OF NEOPLASIA
#6349DNA-binding proteins and uses thereof
#6350Hybrid polymers, pharmaceutical compositions and methods of synthesizing the same
#6351Methods and products for expressing proteins in cells
#6352BIOCONTROL
#6353CRISPR-Mediated Genome Engineering for Protein Depletion
#6354CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION AND AIDS
#6355Methods and compositions for sequence guiding Cas9 targeting
#6356PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
#6357NON-NATURAL RIBONUCLEASE CONJUGATES AS CYTOTOXIC AGENTS
#6358CELL CYCLE DEPENDENT GENOME REGULATION AND MODIFICATION
#6359Nuclease-mediated regulation of gene expression
#6360RNA preparations comprising purified modified RNA for reprogramming cells
#6361CRISPR hybrid DNA/RNA polynucleotides and methods of use
#6362CRISPR-Cas Compositions and Methods
#6363Endonucleases
#6364Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems
#6365Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
#6366ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS WITH NEW ARCHITECTURES FOR SEQUENCE MANIPULATION
#6367COMPOSITIONS AND METHODS OF USE OF CRISPR-CAS SYSTEMS IN NUCLEOTIDE REPEAT DISORDERS
#6368Caution chelator hot start
#6369ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
#6370Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for genome editing
#6371CRISPR-Cas systems, crystal structure and uses thereof
#6372ACTIN BINDING PEPTIDES AND COMPOSITIONS COMPRISING SAME FOR INHIBITING ANGIOGENESIS AND TREATING MEDICAL CONDITIONS ASSOCIATED WITH SAME
#6373Multimeric Complexes with Improved in Vivo Stability, Pharmacokinetics and Efficacy
#6374Polypeptide tagging fusions and methods
#6375Nuclease profiling system
#6376RNA-guided gene drives
#6377DNA vector production system
#6378Zinc finger nuclease-mediated homologous recombination
#6379METHODS AND COMPOSITIONS FOR GENE INACTIVATION
#6380SECRETION AND FUNCTIONAL DISPLAY OF CHIMERIC POLYPEPTIDES
#6381Sequence specific antimicrobials
#6382Compositions and methods of nucleic acid-targeting nucleic acids
#6383ATYPICAL INTEINS
#6384Multiplex guide RNAs
#6385Cas9 crystals and methods of use thereof
#6386Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#6387Engineered CRISPR-Cas9 nucleases with altered PAM specificity
#6388Gene editing in the oocyte by Cas9 nucleases
#6389Methods of transcription activator like effector assembly
#6390Compositions and methods of nucleic acid-targeting nucleic acids
#6391NEW METHOD OF SELECTION OF ALGAL-TRANSFORMED CELLS USING NUCLEASE
#6392Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6393Engineered CRISPR-CAS9 nucleases with altered PAM specificity
#6394Engineered CRISPR-CAS9 nucleases with altered PAM specificity
#6395Compositions for linking DNA-binding domains and cleavage domains
#6396Humanized monoclonal antibodies from a transgenic rat
#6397RNA-guided human genome engineering
#6398CAS9 NUCLEASE PLATFORM FOR MICROALGAE GENOME ENGINEERING
#6399Coexpression of CAS9 and TREX2 for targeted mutagenesis
#6400Cas variants for gene editing
#6401DNA cleavage enzyme
#64025T4-TARGETED IMMUNOFUSION MOLECULE AND METHODS
#6403CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6404CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6405CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6406CRISPR-based genome modification and regulation
#6407CRISPR-based genome modification and regulation
#6408CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6409CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6410CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6411PERMANENT GENE CORRECTION BY MEANS OF NUCLEOTIDE-MODIFIED MESSENGER RNA
#6412Method for the generation of compact tale-nucleases and uses thereof
#6413Mutant Cas9 proteins
#6414CRISPR-CAS SYSTEM MATERIALS AND METHODS
#6415Plurality of transposase adapters for DNA manipulations
#6416Methods and compositions for repair of DNA ends by multiple enzymatic activities
#6417Compositions and methods related to a type-II CRISPR-Cas system in
#6418Targeted integration into the PPP1R12C locus
#6419Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
#6420Guide RNA with chemical modifications
#6421Optimized small guide RNAs and methods of use
#6422High fidelity restriction endonucleases
#6423Methods and compositions for modifying a single stranded target nucleic acid
#6424CRISPR/CAS-MEDIATED GENE CONVERSION
#6425CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#6426Methods for structural determination of selenium derivatized nucleic acid complexes
#6427Solid medium for the storage of biological material
#6428USE OF MEGANUCELASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6429Rare-cutting endonucleases for efficient and specific targeting DNA sequences comprising highly repetitive motives
#6430Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
#6431METHOD FOR TARGETED MODIFICATION OF ALGAE GENOMES
#6432Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof
#6433Engineered cleavage half-domains for generating nuclease-mediated genomic modifications in a cell
#6434Nucleic acid silencing sequences
#6435Nucleic acids encoding SB10 variants
#6436Methods for increasing CAS9-mediated engineering efficiency
#6437Stabilized RNA solutions
#6438POLLEN PREFERRED PROMOTERS AND METHODS OF USE
#6439Methods and products for expressing proteins in cells
#6440Compositions and methods of nucleic acid-targeting nucleic acids
#6441Methods and products for expressing proteins in cells
#6442Therapeutic nuclease-albumin fusions and methods
#6443Compositions for increasing polypeptide stability and activity, and related methods
#6444Methods and compositions for RNA-guided treatment of HIV infection
#6445RNA-guided transcriptional regulation
#6446CRISPR-RELATED METHODS AND COMPOSITIONS
#6447CONFERRING RESISTANCE TO GEMINIVIRUSES IN PLANTS USING CRISPR/CAS SYSTEMS
#6448Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
#6449RECOMBINANT FUSION PROTEIN POSSESSING NUCLEASE AND PHOSPHATASE ACTIVITY
#6450Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
#6451Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#6452Modified zinc finger binding proteins
#6453Methods and compositions for modulating PD1
#6454CRISPR hybrid DNA/RNA polynucleotides and methods of use
#6455Mammalian gene modification method using electroporation
#6456Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
#6457CAS9 variants and uses thereof
#6458Switchable Cas9 nucleases and uses thereof
#6459CRISPR enzymes and systems
#6460Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
#6461RNA-guided gene editing and gene regulation
#6462Engineered transcription activator-like effector (TALE) domains and uses thereof
#6463Delivery system for functional nucleases
#6464Restriction endonucleases and their uses
#6465Modified cascade ribonucleoproteins and uses thereof
#6466Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
#6467MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
#6468Polypeptide containing DNA-binding domain
#6469Compositions of and methods for in vitro viral genome engineering
#6470Use of thermophilic nucleases for degrading nucleic acids
#6471Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
#6472Methods and compositions for targeted genetic modification through single-step multiple targeting
#6473Cas9-DNA targeting unit chimeras
#6474Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
#6475ONCOGENIC MODELS BASED ON DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS
#6476RNA-guided human genome engineering
#6477Mutant endonuclease V enzymes and applications thereof
#6478Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
#6479Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
#6480DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETING AND MODELING DISEASES AND DISORDERS OF POST MITOTIC CELLS
#6481Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
#6482Polypeptide containing DNA-binding domain
#6483Methods and compositions for targeted genetic modification using paired guide RNAs
#6484Targeted genomic modification with partially single-stranded donor molecules
#6485METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS
#6486Compositions and methods for the improved production and delivery of RNA by efficient transcription termination
#6487Cytolethal distending toxin subunit B conjugated or fused to toxin lethal factor
#6488Mapping cytosine modifications
#6489IMPROVED POLYNUCLEOTIDE SEQUENCES ENCODING TALE REPEATS
#6490Compositions and methods directed to CRISPR/Cas genomic engineering systems
#6491Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6492Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6493Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6494Method for treating oncological diseases
#6495LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
#6496Methods for engineering highly active T cell for immunotherapy
#6497CRISPR-Cas component systems, methods and compositions for sequence manipulation
#6498Compositions and methods of nucleic acid-targeting nucleic acids
#6499Compounds and methods for trans-membrane delivery of molecules
#6500Ribotoxin molecules derived from sarcin and other related fungal ribotoxins
#6501Compact scaffold of Cas9 in the type II CRISPR system
#6502Laglidadg homing endonuclease cleaving the C-C chemokine receptor type-5 (CCR5) gene and uses thereof
#6503Methods for identifying a target site of a CAS9 nuclease
#6504Methods and compositions for treatment of a genetic condition
#6505Target detection and signal amplification
#6506BORONATE-MEDIATED DELIVERY OF MOLECULES INTO CELLS
#6507Enzyme-pore constructs
#6508Isolated human cell with an inactivated glucocorticoid receptor gene
#6509DNA-binding protein using PPR motif, and use thereof
#6510Method of treating mucopolysaccharidosis type I or II
#6511COMPOSITIONS AND METHODS TO TREAT LATENT VIRAL INFECTIONS
#6512METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
#6513Site-specific enzymes and methods of use
#6514THERMOSTABLE NUCLEASE
#6515Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use
#6516Compostions and methods of nucleic acid-targeting nucleic acids
#6517COMPOSITIONS AND METHODS OF NUCLEIC ACID-TARGETING NUCLEIC ACIDS
#6518Methods and compositions for targeted single-stranded cleavage and targeted integration
#6519Methods and compositions for gene correction
#6520CIS-blocked guide RNA
#6521Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
#6522RNA-guided human genome engineering
#6523Compositions and Methods for Treatment of Stroke
#6524Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
#6525Methods of in vivo engineering of large sequences using multiple CRISPR/cas selections of recombineering events
#6526Increasing specificity for RNA-guided genome editing
#6527Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#6528Sequence specific antimicrobials
#6529Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
#6530Bioreversible boronates for delivery of molecules into cells
#6531Sensation-improving agent
#6532Directed endonucleases for repeatable nucleic acid cleavage
#6533Methods and products for producing engineered mammalian cell lines with amplified transgenes
#6534CRISPR-BASED GENOME MODIFICATION AND REGULATION
#6535Methods and compositions for RNA-guided treatment of HIV infection
#6536Method for using heat-resistant mismatch endonuclease
#6537OBLIGATE HETERODIMER VARIANTS OF FOKI CLEAVAGE DOMAIN
#6538RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#6539Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
#6540RNA-guided human genome engineering
#6541Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
#6542Adeno-associated-virus Rep sequences, vectors and viruses
#6543Gene editing in the oocyte by CAS9 nucleases
#6544RNA Modification to Engineer Cas9 Activity
#6545RNA Modification to Engineer Cas9 Activity
#6546TEVI CHIMERIC ENDONUCLEASE AND THEIR PREFERENTIAL CLEAVAGE SITES
#6547Methods of treating and prophylactically protecting mammalian patients infected by viruses classified in Baltimore group V
#6548Compositions and methods to treat latent viral infections
#6549Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses
#6550Compositions and methods of delivering treatments for latent viral infections
#6551Method of producing dicer
#6552Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results thereof
#6553Methods and compositions for nuclease design
#6554Method for removing genetic linkage in a plant
#6555Regulated genetic suicide mechanism compositions and methods
#6556Methods and compositions for regulation of transgene expression
#6557Methods and compositions to modulate RNA processing
#6558PLANT CENTROMERE COMPOSITIONS
#6559Methods and compositions for prevention or treatment of a disease
#6560Methods for cleaving a target DNA using a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein
#6561HBV RNASE H PURIFICATION AND ENZYME INHIBITORS
#6562MEGANUCLEASE VARIANTS CLEAVING THE GENOME OF A PATHOGENIC NON-INTEGRATING VIRUS AND USES THEREOF
#6563Fusion Molecules of Rationally-Designed DNA-Binding Proteins and Effector Domains
#6564Genetically edited pigs comprising a modification in the RELA gene
#6565RNase H-based assays utilizing modified RNA monomers
#6566Targeting BCL11A distal regulatory elements for fetal hemoglobin reinduction
#6567Engineered transcription activator like effector (TALE) proteins
#6568Factor VIII mutation repair and tolerance induction
#6569Chimeric VSV-G proteins as nucleic acid transfer vehicles
#6570Improved Methods for Inducing Apomixis in Plants
#6571ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
#6572Modified transposases for improved insertion sequence bias and increased DNA input tolerance
#6573CHIMERA COMPRISING BACTERIAL CYTOTOXIN AND METHODS OF USING THE SAME
#6574Chimeric polypeptides having targeted binding specificity
#6575Endoribonuclease compositions and methods of use thereof
#6576Methods and products for expressing proteins in cells
#6577Method for making nicotiana plants with mutations in XylT and FucT alleles using rare-cutting endonucleases
#6578Methods and products for expressing proteins in cells
#6579Double knockout (GT/CMAH-KO) pigs, organs and tissues
#6580Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
#6581Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
#6582CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
#6583ANTIMICROBIAL ACTIVITY ENHANCING AGENT
#6584RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
#6585CRISPR-related methods and compositions with governing gRNAS
#6586PROCESS FOR PURIFYING GROWTH FACTORS FROM MILK AND PRODUCTS THEREOF
#6587Modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins
#6588Compositions and Methods for Improvement of Ligation Yields
#6589Compositions and methods for oxygenation of nucleic acids containing 5-methylpyrimidine
#6590Genetic test and genetic basis for SCID in pigs
#6591Compositions and methods for modifying a predetermined target nucleic acid sequence
#6592Therapeutic ribonucleases
#6593CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#6594Transcription activator-like effector (TALE) fusion protein
#6595Methods for genomic integration
#6596Targeted genome engineering in plants
#6597CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS
#6598Enzyme Preparation for Modifying Food Material
#6599Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
#6600Methods for targeted transgene-integration using custom site-specific DNA recombinases