108937 ⎘
Enzymes; Proenzymes; Compositions thereof ; Processes for preparing, activating, inhibiting, separating or purifying enzymes; Hydrolases (3) acting on ester bonds (3.1) Ribonucleases RNAses, DNAses
METHODS FOR CORRECTING VON WILLEBRAND FACTOR POINT MUTATIONS
#6602METHODS FOR CORRECTING ALPHA-ANTITRYPSIN POINT MUTATIONS
#6603Methods for correcting presenilin point mutations
#6604METHODS FOR CORRECTING PI3K POINT MUTATIONS
#6605Methods for nucleic acid editing
#6606Fusions of Cas9 domains and nucleic acid-editing domains
#6607Fusion polymerases
#6608Methods and compositions for treating hemophilia
#6609Colicins for Treating Bacterial Infections
#6610Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
#6611Engineered cleavage half-domains
#6612Methods and compositions for the targeted modification of a genome
#6613Methods and compositions for the targeted modification of a mouse genome
#6614Methods and compositions for genome engineering
#6615Therapeutic uses of genome editing with CRISPR/Cas systems
#6616Therapeutic nuclease compositions and methods
#6617Endoribonuclease and methods of use thereof
#6618Method for producing hyperactive transposase mutants
#6619Biocontrol
#6620Methods for analyzing lariat RNA
#6621Rationally Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity
#6622Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
#6623Method for synthesizing a nuclease with reduced off-site cleavage
#6624Composition and methods of oxygenation of nucleic acids containing 5-methylpyrimidine
#6625Nuclease-mediated regulation of gene expression
#6626Bacterial mutants with improved transformation efficiency
#6627Treatment of disease conditions via administration of DNA repair enzyme
#6628Delivery of negatively charged proteins using cationic lipids
#6629METHOD FOR RETARDING UNHEALTHY MANIFESTATIONS BROUGHT BY AGEING OF HUMAN BEINGS
#6630Polypeptide fragments comprising endonuclease activity and their use
#6631Nucleic acid-free thermostable enzymes and methods of production thereof
#6632Labeled biomolecular compositions and methods for the production and uses thereof
#6633Methods of treating cancer using angiogenin or an angiogenin agonist
#6634Insertion of charge in the hydrophobic interior of proteins as a strategy for engineering pH-sensitive switches
#6635Hybridization- independent labeling of repetitive DNA sequence in human chromosomes
#6636ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOF
#6637Enzyme composition for DNA end repair, adenylation, phosphorylation
#6638Methods and compositions for inactivating glutamine synthetase gene expression
#6639CRISPR-Cas component systems, methods and compositions for sequence manipulation
#6640Genetic correction of mutated genes
#6641Delivery system for functional nucleases
#6642Use of cationic lipids to deliver CAS9
#6643Extended DNA-sensing GRNAS
#6644MRNA-sensing switchable gRNAs
#6645Switchable gRNAs comprising aptamers
#6646Cas9-FokI fusion proteins and uses thereof
#6647Cas9-recombinase fusion proteins and uses thereof
#6648FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#6649Repeat variable diresidues for targeting nucleotides
#6650Compositions for linking DNA-binding domains and cleavage domains
#6651Tuning microbial populations with programmable nucleases
#6652Methods and compositions for treatment of a genetic condition
#6653Engineered transcription activator-like effector (TALE) domains and uses thereof
#6654RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
#6655Recognition sequences for I-CreI-derived meganucleases and uses thereof
#6656RNA-directed DNA cleavage by the Cas9-crRNA complex
#6657CRISPR/CAS SYSTEM-BASED NOVEL FUSION PROTEIN AND ITS APPLICATIONS IN GENOME EDITING
#6658METHODS FOR IDENTIFYING A TARGET SITE OF A CAS9 NUCLEASE
#6659Methods for identifying a target site of a Cas9 nuclease
#6660Therapeutic nuclease compositions and methods
#6661Method to overcome DNA chemical modifications sensitivity of engineered tale DNA binding domains
#6662Nucleic acid for treatment or prevention of immunodeficiency virus infection
#6663Enzyme-pore constructs
#6664ENGINEERED NUCLEASES AND THEIR USES FOR NUCLEIC ACID ASSEMBLY
#6665Dry powder formulations of dNase I
#6666REF nuclease for site-specific REF-mediated DNA cleavage
#6667CHIMERIC POLYPEPTIDES AND THEIR USE
#6668MONOMER ARCHITECTURE OF TAL NUCLEASE OR ZINC FINGER NUCLEASE FOR DNA MODIFICATION
#6669Method for preparing immobilized angiogenin
#6670Inhalable liquid formulations of DNase I
#6671DNASE I POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, METHODS OF PRODUCING DNASE I AND USES THEREOF IN THERAPY
#6672Evaluation and improvement of nuclease cleavage specificity
#6673Compositions and methods for identifying hydroxymethylcytosine in a DNA
#6674RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
#6675NPP1 fusion proteins
#6676Endonucleases
#6677Methods and compositions for targeted cleavage and recombination
#6678TAL-MEDIATED TRANSFER DNA INSERTION
#6679Correction of Crb1 mutations
#6680Method for fragmenting genomic DNA using CAS9
#6681Nucleic acids for cloning and expressing multiprotein complexes
#6682Nucleic acid enrichment using Cas9
#6683RNA-DIRECTED DNA CLEAVAGE AND GENE EDITING BY CAS9 ENZYME FROM NEISSERIA MENINGITIDIS
#6684RNA-guided human genome engineering
#6685Solubility enhancing peptide and use thereof
#6686Methods of inhibiting Alu RNA and therapeutic uses thereof
#6687Methods and compositions for modulating immune tolerance
#6688MCPIP as wound therapy
#6689TAL effector-mediated DNA modification
#6690Cytotoxic ribonuclease variants
#6691TAL EFFECTOR-MEDIATED DNA MODIFICATION
#6692IN SILICO AFFINITY MATURATION
#6693Linker-bridged gene or domain fusion reverse transcriptase enzyme
#6694Protein having nuclease activity, fusion proteins and uses thereof
#6695Vectors harboring toxic genes, methods and uses therefor
#6696Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
#6697Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
#6698Sequence-specific MRNA interferase and uses thereof
#6699Trichoplusia ni piggybac transposases with reduced integration activity
#6700HBV polymerase mutants
#6701Method for inducing a tolerogenic immune response
#6702Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
#6703CRISPR/Cas systems for genomic modification and gene modulation
#6704Method for increasing plant biomass using an exogenous gene encoding a thermophilic restriction enzyme
#6705Compositions and methods directed to CRISPR/Cas genomic engineering systems
#6706METHOD FOR EXPRESSING DEOXYRIBONUCLEASE IN PLANTS
#6707Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
#6708SENSATION-IMPROVING AGENT
#6709Methods and compositions for enhancing nuclease-mediated gene disruption
#6710Method for increasing the efficiency of double-strand-break induced mutagenesis
#6711CRISPR-Cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
#6712Evaluation and improvement of nuclease cleavage specificity
#6713RNA Interferases and Methods of Use Thereof
#6714CRISPR-Cas systems and methods for altering expression of gene products
#6715THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
#6716COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION
#6717Compositions and methods comprising sequences having meganuclease activity
#6718Methods and compositions for targeted single-stranded cleavage and targeted integration
#6719Nuclease fusion protein and uses thereof
#6720Method for analyzing methylation of a genome
#6721Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
#6722ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
#6723Peptide with the enzymatic activity of a Dicer-like protein, a method for preparing short RNA molecules, and use thereof
#6724Methods and Products for Producing Engineered Mammalian Cell Lines With Amplified Transgenes
#6725Therapeutic nuclease compositions and methods
#6726Bacterial anti-phage defense systems
#6727CRISPR-Cas systems and methods for altering expression of gene products
#6728VECTOR FOR GENE THERAPY
#6729Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
#6730ADENO-ASSOCIATED-VIRUS REP SEQUENCES, VECTORS AND VIRUSES
#6731High fidelity restriction endonucleases
#6732High fidelity restriction endonucleases
#6733DNA-binding proteins and uses thereof
#6734DNA-binding proteins and uses thereof
#6735DNA-binding proteins and uses thereof
#6736Antimicrobial Activity Enhancing Agent
#6737Therapeutic ribonucleases
#6738Methods and compositions for gene inactivation
#6739Nucleic acid silencing sequences
#6740METHOD, COMPOSITION, AND REAGENT KIT FOR TARGETED GENOMIC ENRICHMENT
#6741Compositions and Methods for Oxygenation of Nucleic Acids Containing 5-Methylpyrimidine
#6742Mapping cytosine modifications
#6743Compositions and methods for the transfer of a hexosamine to a modified nucleotide in a nucleic acid
#6744Engineered cleavage half-domains
#6745Recombinant and methods of use
#6746NEW TALE-PROTEIN SCAFFOLDS AND USES THEREOF
#6747METHOD FOR ENHANCING THE CLEAVAGE ACTIVITY OF I-CREI DERIVED MEGANUCLEASES
#6748Method of treating lysosomal storage diseases
#6749Compositions, methods and related uses for cleaving modified DNA
#6750Means and methods to induce apomixis in plants
#6751Sequence-specific engineered ribonuclease H and the method for determining the sequence preference of DNA-RNA hybrid binding proteins
#6752Method of removing nucleic acid contamination in reverse transcription and amplification reactions
#6753Immobilized transposase complexes for DNA fragmentation and tagging
#6754Methods and compositions for treatment of a genetic condition
#6755Mutant endonuclease V enzymes and applications thereof
#6756FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#6757FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
#6758Modified RNAse H and detection of nucleic acid amplification
#6759dsRNA endoribonucleases
#6760Transcription activator-like effector nucleases (TALENs)
#6761Methods and compositions for targeted cleavage and recombination
#6762Methods and compositions for treatment of a genetic condition
#6763Transformable strains, method for producing transformable strains
#6764Method of treating eosinophilia by administering an immunomodulating peptide
#6765Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
#6766Targeted deletion of cellular DNA sequences
#6767Therapeutic nuclease compositions and methods
#6768Cytotoxic ribonuclease variants
#6769Methods and compositions for modulating PD1
#6770Method of treating lysosomal storage diseases using nucleases and a transgene
#6771Stitched polypeptides
#6772Methods of and compositions for inhibiting the proliferation of mammalian cells
#6773Labeled biomolecular compositions and methods for the production and uses thereof
#6774Restriction endonucleases and their uses
#6775Fusion Molecules of Rationally-Designed DNA-Binding Proteins and Effector Domains
#6776Cytotoxic ribonuclease variants
#6777NOVEL ANTI-VIRAL THERAPEUTIC
#6778Nuclease inhibitors and methods for their use
#6779Control of Cyanate in Aqueous Urea Solutions by Non-1,2-Ethylene Diamine Like Compounds for the Protection of Protein/Peptide Carbamylation
#6780Nucleic acid-free thermostable enzymes and methods of production thereof
#6781Synthetic pathway enzymes for the production of argyrins
#6782Inhibition of human immunodeficiency virus integrase reaching dimer formation utilizing single-chain variable antibodies
#6783NPP1 fusion proteins
#6784Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences
#6785Methods for producing a complex transgenic trait locus
#6786Targeted integration and expression on exogenous nucleic acid sequences
#6787Novel Restriction Endonucleases, DNA Encoding These Endonucleases and Methods for Identifying New Endonucleases with the Same or Varied Specificity
#6788Rationally Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity
#6789Materials and methods for the synthesis of error-minimized nucleic acid molecules
#6790GENOME ENGINEERING VIA DESIGNED TAL EFFECTOR NUCLEASES
#6791METHODS AND COMPOSTITIONS FOR GENE EDITING OF A PATHOGEN
#6792Direct cloning
#6793ENDONUCLEASE FOR GENOME EDITING
#6794Regulated genetic suicide mechanism compositions and methods
#6795Method for treating oncological diseases
#6796I-CREI HOMING ENDONUCLEASE VARIANTS HAVING NOVEL CLEAVAGE SPECIFICITY AND USE THEREOF
#6797Methods and compositions for generating complex trait loci
#6798Modified DNA-binding proteins and uses thereof
#6799High fidelity restriction endonucleases
#6800Extracellularly secreted nuclease
#6801Meganuclease variants cleaving a DNA target sequence from the rhodopsin gene and uses thereof
#6802Pollen preferred promoters and methods of use
#6803Methods and compositions for regulation of transgene expression
#6804Methods and compositions for regulation of transgene expression
#6805Methods of improving the introduction of DNA into bacterial cells
#6806THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
#6807Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
#6808Compositions and methods of treating head and neck cancer
#6809Hyperactive piggybac transposases
#6810Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism
#6811I-CREI VARIANTS WITH NEW SPECIFICITY AND METHODS OF THEIR GENERATION
#6812Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
#6813Genome editing using targeting endonucleases and single-stranded nucleic acids
#6814Nucleotide-specific recognition sequences for designer TAL effectors
#6815Nucleotide-Specific Recognition Sequences For Designer TAL Effectors
#6816Nucleotide-specific recognition sequences for designer TAL effectors
#6817Methods and compositions for modification of the HPRT locus
#6818Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases
#6819Endoribonuclease compositions and methods of use thereof
#6820Methods and compositions for synthetic RNA endonucleases
#6821High fidelity restriction endonucleases
#6822Method for the generation of compact TALE-nucleases and uses thereof
#6823High fidelity restriction endonucleases
#6824High fidelity restriction endonucleases
#6825High fidelity restriction endonucleases
#6826High fidelity restriction endonucleases
#6827High fidelity restriction endonucleases
#6828High fidelity restriction endonucleases
#6829Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
#6830Inhibitors of influenza endonuclease activity and tools for their discovery
#6831Methods and compositions for the treatment of cancer
#6832RNA Interferases and Methods of Use Thereof
#6833MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A RAG GENE AND USES THEREOF
#6834MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM A XP GENE AND USES THEREOF
#6835MEGANUCLEASE VARIANTS CLEAVING A DNA TARGET SEQUENCE FROM THE HPRT GENE AND USES THEREOF
#6836Compounds and methods for biofilm disruption and prevention
#6837MEGANUCLEASE RECOMBINATION SYSTEM
#6838Gammaretrovirus Associated With Cancer
#6839Synthetic Binding Proteins
#6840Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use
#6841PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
#6842MUTEINS OF THE BACTERIOPHAGE LAMBDA INTEGRASES
#6843Cytotoxic ribonuclease variants
#6844PREPARATION OF RESTRICTION ENDONUCLEASES IN IVCS USING FRET AND FACS SELECTION
#6845USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6846Methods of Generating Zinc Finger Nucleases Having Altered Activity
#6847Anti-cancer therapeutic strategy to overcome cancer resistance and to enable tailoring treatment to patients
#6848Chimeric Endonucleases and Uses Thereof
#6849USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6850Cytotoxic ribonuclease variants
#6851Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#6852Angiogenin Expression in Plants
#6853Methods and compositions for gene inactivation
#6854RNAI IN BUDDING YEAST
#6855Methods and compositions for gene inactivation
#6856USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6857Compositions, methods and related uses for cleaving modified DNA
#6858Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations
#6859ZINC-FINGER NUCLEASE AND RNA INTERFERENCE MEDIATED INACTIVATION OF VIRAL GENOMES
#6860Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
#6861USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6862USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
#6863Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
#6864Chimeric endonucleases and uses thereof
#6865ISOLATION OF PROTEINS INVOLVED IN POSTTRANSCRIPTIONAL GENE SILENCING AND METHODS OF USE
#6866Methods of improving the introduction of DNA into bacterial cells
#6867HOMOLOGOUS RECOMBINATION IN THE OOCYTE
#6868Therapeutic ribonucleases
#6869Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
#6870Chimeric rat produced using rat embryonic stem cells in the presence of an ES cell differentiation suppressant
#6871VIRAL VECTORS ENCODING A DNA REPAIR MATRIX AND CONTAINING A VIRION-ASSOCIATED SITE SPECIFIC MEGANUCLEASE FOR GENE TARGETING
#6872CULTURING AND GENETIC MANIPULATIONS OF THERMOTOGA SPP.
#6873Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity
#6874Rationally-designed meganucleases with altered sequence specificity and heterodimer formation
#6875DNase expression in recombinant host cells
#6876MEGANUCLEASE VARIANTS CLEAVING AT LEAST ONE TARGET IN THE GENOME OF A RETROVIRUS AND USES THEREOF
#6877I- meganuclease variants with modified specificity, method of preparation and uses thereof
#6878Method for incorporating internal polar and ionizable groups in proteins
#6879Restriction endonucleases, DNA encoding these endonucleases and methods for indentifying new endonucleases with the same or varied specificity
#6880Nucleic acid silencing sequences
#6881Restriction/modification polypeptides, polynucleotides, and methods
#6882Optimized endonucleases and uses thereof
#6883Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
#6884Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site
#6885Modified DNase compositions and methods of use thereof
#6886Therapeutic nuclease compositions and methods
#6887Targeted chromosomal mutagenesis using zinc finger nucleases
#6888Method of using heparin binding motif for treating asthma
#6889ZINC FINGER NUCLEASE MODIFICATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) MUTANT FIBROBLASTS AND IPSCS
#6890TAL effector-mediated DNA modification
#6891METHODS AND COMPOSITIONS FOR TREATING OCCULAR DISORDERS
#6892Compositions, methods and related uses for cleaving modified DNA
#6893Methods and compositions for gene correction
#6894METHOD FOR GENOME EDITING
#6895Tal effector-mediated DNA modification
#6896TAL effector-mediated DNA modification
#6897Genetically modified rat models for severe combined immunodeficiency (SCID)
#6898Transposition of maize elements in vertebrates
#6899Selection and enrichment of proteins using in vitro compartmentalization
#6900MEGANUCLEASE VARIANTS CLEAVING THE GENOME OF A PATHOGENIC NON-INTEGRATING VIRUS AND USES THEREOF