109162 ⎘
Structure or type of the nucleic acid; Chemical structure of the backbone Phosphorothioates
COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN
#3902Antisense oligonucleotide to inhibit melanoma inhibitory activity, MIA
#3903Spinal muscular atrophy (SMA) treatment via targeting of splice site inhibitory sequences
#3904Anti-microRNA oligonucleotide molecules
#3905Compositions and methods for inhibiting expression of Eg5 gene
#3906Therapeutic compositions
#3907Compositions and their uses directed to hepcidin
#3908THERAPEUTIC DRUG COMBINATIONS AND DELIVERY SYSTEMS COMPRISING C-RAF KINASE ANTISENSE POLYNUCLEOTIDES FOR TREATING OCULAR DISEASES AND DISORDERS
#3909Oligonucleotide and the use thereof for modulating an isoform C beta-1 protein-kinase in the form of a skin depigmentation agent
#3910Compositions and methods for modulation of Mcl-1 expression
#3911Modulation of telomere length by oligonucleotides having a G-core sequence
#3912Rna Interference Mediated Inhibition of Severe Acute Respiratory Syndrome (Sars) Gene Expression Using Short Interfering Nucleic Acid
#3913MODULATION OF THYROID HORMONE RECEPTOR INTERACTOR 3 EXPRESSION
#3914Immunomodulatory formulations and methods for use thereof
#3915Compositions and methods for non-parenteral delivery of oligonucleotides
#3916Compounds and Methods for Rna Interference of the P65 Subunit of Nf-Kappa-B
#3917Soluble TNF receptors and their use in treatment of disease
#3918Methods to treat or prevent hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity
#3919Antisense compounds targeted to connexins and methods of use thereof
#3920Modulation of glucagon receptor expression
#3921MODULATION OF GLUCAGON RECEPTOR EXPRESSION
#3922MODULATION OF GLUCAGON RECEPTOR EXPRESSION
#3923MODULATION OF GLUCAGON RECEPTOR EXPRESSION
#3924Heat shock RNA
#3925MODULATION OF ACE2 EXPRESSION
#3926Immunostimulatory nucleic acids
#3927Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments
#3928ANTIGENIC COMPOSITION
#3929Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
#3930Therapeutically useful synthetic oligonucleotides
#3931Interfering Rna Duplex Having Blunt-Ends And 3'-Modifications
#3932Liposomal phosphodiester, phophorothioate, and p-ethoxy oligonucleotides
#3933Data correction apparatus, data correction method, magnetic resonance imaging apparatus and X-ray CT apparatus
#3934Pharmaceutical composition
#3935Short interfering RNA (siRNA) analogues
#3936Regulatory segments of the human gene for telomerase reverse transcriptase
#3937DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3938DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3939Modulation of ace2 expression
#3940Rna interference mediated inhibition of nogo and nogo receptor gene expression using short interfering nucleic acid (sina)
#3941Methods for regulating hematopoiesis using CpG-oligonucleotides
#3942DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3943DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3944DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3945DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3946Immunostimulatory oligonucleotide multimers
#3947Protected monomers
#3948Antisense IAP nucleobase oligomers and uses thereof
#3949MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE
#3950DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3951DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3952DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3953RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#3954DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3955DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3956DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3957Nucleotide sequences promoting the trans-membrane transport of nucleic acids
#3958Antisense oligonucleotides (ODN) against Smad7 and uses in medical field thereof
#3959Modified polynucleotides for use in rna interference
#3960DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3961RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
#3962Method of treating neurodegenerative disease
#3963COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA
#3964Compositions and their uses directed to IL-4R alpha
#3965Methods and compositions for treating neurological disease
#3966Modulation of survivin expression
#3967Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
#3968RNAi modulation of HIF-1 and therapeutic uses thereof
#3969Antisense IAP oligonucleotides and uses thereof
#3970Immunostimulatory oligoribonucleotides
#3971Antisense IAP nucleobase oligomers and uses thereof
#3972Compositions and methods for the modulation of the expression of B7 protein
#3973Antisense oligonucleotide having anticancerous activity
#3974DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION
#3975Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
#3976Antisense IAP oligonucleotides and uses thereof
#3977Oligonucleotides targeting prion diseases
#3978Methods for slowing familial ALS disease progression
#3979Modulation of gene expression by oligomers targeted to chromosomal DNA
#3980Dbait and uses thereof
#3981Inhibition of histone deacetylase
#3982Splice switch oligomers for TNF superfamily receptors and their use in treatment of disease
#3983Compositions and methods for inhibiting expression of Nav1.8 gene
#3984G-rich polynucleotides for the treatment of Huntington's Disease
#3985Methods and compositions for treating neurological disease
#3986Cancer diagnosis and therapy
#3987Compositions and methods for inhibiting expression of Huntingtin gene
#3988Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina)
#3989Modulation of glucagon receptor expression
#3990Immunostimulatory nucleic acid molecules
#3991NF-kB oligonucleotide decoy molecules
#3992Modulation of glucocorticoid receptor expression
#3993Immunostimulatory nucleic acid molecules
#3994Aptamer medicinal chemistry
#3995Modulation of eIF4E expression
#3996Pure miRNA Sample Preparation Method
#3997Antisense modulation of superoxide dismutase 1, soluble expression
#3998Estrogen receptor-related receptor alpha (ERRalpha) and cartilage formation
#3999Chimeric immunomodulatory compounds and methods of using the same—IV
#4000Methods for use in modulating miR-122a
#4001Antisense modulation of fibroblast growth factor receptor 3 expression
#4002Antisense IAP nucleobase oligomers and uses thereof
#4003RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA
#4004RNAi modulation of the Rho-A gene in research models
#4005Antisense oligonucleotides (ODN) against Smad7 and uses thereof in medical field
#4006iRNA agents targeted to the Rho-A gene
#4007Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
#4008Immunostimulatory nucleic acids for the treatment of asthma and allergy
#4009Antisense IAP nucleobase oligomers and uses thereof
#4010Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
#4011Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
#4012Polypeptide compounds for inhibiting angiogenesis and tumor growth
#4013Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
#4014Modulation of SOCS-3 expression
#4015Modulation of HIF1alpha and HIF2alpha expression
#4016Modulation of endothelial lipase expression
#4017Antiviral oligonucleotides having a conserved G4 core sequence
#4018Double stranded compositions comprising a 3′-endo modified strand for use in gene modulation
#4019NF-kappaB oligonucleotide decoy molecules
#4020Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
#4021Antisense permeation enhancers
#4022RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4023RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4024RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4025RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4026RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4027RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4028Antisense modulation of superoxide dismutase 1, soluble expression
#4029STAT3 decoy oligonucleotides and uses therefor
#4030RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4031RNA interference mediated ihibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4032RNAi modulation of the BCR-ABL fusion gene and uses thereof
#4033Combinatorial selection of phosphorothioate aptamers for RNases
#4034Modulation of apolipoprotein (A) expression
#4035RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4036Method of diagnosing colon and gastric cancers
#4037RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4038Compositions and methods for treatment of prostate and other cancers
#4039RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4040Modulation of apolipoprotein c-III expression
#4041Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
#4042Modulation of STAT 6 expression for the treatment of airway hyperresponsiveness
#4043Transforming growth factor-beta response element decoys and methods
#4044Combined therapy utilizing reduction of DNA methyltransferase expression and/or activity and interferon
#4045Oligomeric compounds and compositions for use in modulation of pri-mirnas
#4046Potent LNA oligonucleotides for the inhibition of HIF-1A expression
#4047Modulation of HIF-1 beta expression
#4048Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
#4049RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4050RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4051Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina)
#4052Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
#4053RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
#4054Antisense oligonucleotides directed to ribonucleotide reductase r2 and uses thereof in the treament of cancer
#4055Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
#4056Modulation of insulin like growth factor I receptor expression
#4057Synthesis, deprotection, analysis & purification of RNA & ribozymes
#4058Methods and products for treating hypertension by modulation of TRPC3 channel activity
#4059Antisense oligonucleotide modulation of STAT3 expression
#4060RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4061RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4062RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4063RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
#4064RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
#4065RNAi modulation of the Nogo-L or Nogo-R gene and uses thereof
#4066Pharmaceutical compositions comprising an oligonucleotide as an active agent
#4067Delivery of polynucleotide agents to the central nervous system
#4068Immunostimulatory oligonucleotides
#4069Antisense modulation of farnesoid X receptor expression
#4070Diagnosis and treatment of malignant neoplasms
#4071Lna-cpg conjugates
#4072Cancer markers and detection methods
#4073Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
#4074Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
#4075Treatment of mycobacterium tuberculosis with antisense oligonucleotides
#4076Antisense oligonucleotide against human acetylcholinesterase (AChE) and uses thereof
#4077Antisense oligonucleotides targeting folate receptor alpha, and the use thereof
#4078RNAi probes targeting cancer-related proteins
#4079Ribozyme therapy for the treatment of proliferative skin and eye diseases
#4080Modification of MyD88 splicing using modified oligonucleotides
#4081Antisense modulation of integrin beta 4 binding protein expression
#4082Thio-siRNA aptamers
#4083Composite polynucleic acid therapeutics
#4084Oligonucleotide inhibitors of MBD2/DNA demethylase and uses thereof
#4085Modulation of glucocorticoid receptor expression
#4086Antisense modulation of CD40 ligand expression
#4087RNA interference mediated inhibition hairless of (HR) gene expression using short interfering nucleic acid (siNA)
#4088Immunostimulatory nucleic acids for the treatment of asthma and allergy
#4089LNA oligonucleotides and the treatment of cancer
#4090Modulation of SLC26A2 expression
#4091Method for prevention or treatment of diseases or disorders related to excessive formation of vascular tissue or blood vessels
#4092Enzymatic nucleic acid treatment of diseases or conditions related to levels of IKK-gamma and PKR
#4093Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
#4094Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#4095Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
#4096Antisense oligonucleotide modulation of raf gene expression
#4097RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
#4098Liposomes containing oligonucleotides
#4099Semi-soft C-class immunostimulatory oligonucleotides
#4100Antiviral oligonucleotides
#4101Down-regulation of target-gene with pei/single-stranded oligoribonucleotide complexes
#4102Combinations of antisense oligonucleotides directed against thymidylate synthase mrna and uses thereof
#4103Decoy compositions for treating and preventing brain diseases and disorders
#4104Production of functional proteins: balance of shear stress and gravity
#4105Amino-LNA, thio-LNA and alpha-L-oxy-LN
#4106Use of mob-5 in pain
#4107RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA)
#4108Effective and stable DNA enzymes
#4109Antisense modulation of vegf co-regulated chemokine-1 expression
#4110High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens
#4111Remedy and preventive for diseases caused by NF-kB
#4112RNAi modulation of ApoB and uses thereof
#4113Aptamer-mediated intracellular delivery of therapeutic oligonucleotides
#4114Conjugates of photosensitizers and oligonucleotides for selective photochemiotherapy
#4115Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
#4116Therapies for the regulation of insulin and glucose using RLIP76
#4117Therapies for seizure disorders using RLIP76
#4118Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
#4119Nuclease resistant double-stranded ribonucleic acid
#4120Immunostimulatory nucleic acid molecules
#4121Antisense oligonucleotides for identifying drug targets and enhancing cancer therapies
#4122Compositions and methods for inhibiting expression of anti-apoptotic genes
#4123Conjugates for use in hepatocyte free uptake assays
#4124High affinity nucleic acid ligands of complement system proteins
#4125Antisense modulation of matrix metalloproteinase 1 expression
#4126Antisense and antigene therapeutics with improved binding properties and methods for their use
#4127Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
#4128Methods of detecting opioid growth factor receptor (OGFr) in tissue
#4129Oligomeric compounds effecting drosha-mediated cleavage
#4130Delivery of polynucleotides
#4131Enhanced antisense oligonucleotides
#4132Oligoribonucleotides for the treatment of degenerative skin conditions by RNA interference
#4133Immunostimulatory sequence oligonucleotides and methods of using the same
#4134Methods for treating and preventing infectious disease
#4135Antisense modulation of hematopoietic cell protein tyrosine kinase expression
#4136Sensitization of cells to cytotoxic agents using oligonucleotides directed to nucleotide excision repair or transcritpion coupled repair genes
#4137Oligonucleotides labeled with stable isotopes and a method for detecting the same
#4138Compositions and methods for treatment of prostate and other cancers
#4139Antisense oligonucleotides directed to genes regulated by trapoxin-induced HDAC inhibition
#4140Antibody to telomerase reverse transcriptive
#4141Methods for modulating lipoprotein and cholesterol levels in humans
#4142Treatment of neurological disorders by dsrna administration
#4143Antisense modulation of c/ebp beta expression
#4144Oligoribonucleotide derivatives for specific inhibition of gene expression
#4145Modulation of glucocorticoid receptor expression
#4146Antisense modulation of PTP1B expression
#4147RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#4148Antisense modulation of C-reactive protein expression
#4149Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes
#4150Immunostimulatory nucleic acids for inducing IL-10 responses
#4151RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
#4152Nucleic acid microspheres, production and delivery thereof
#4153Immunostimulatory oligonucleotide multimers
#4154Antiandrogen oligonucleotides usable for the treatment of dermatological androgen-related disorders relating to androgen metabolism, their pharmaceutical compositions, their uses and treatment method
#4155Effects of apolipoprotein B inhibition on gene expression profiles in animals
#4156Double-stranded oligonucleotides
#4157Bispecific oligonucleotide for the treatment of CNS malignancies
#4158Immunostimulatory nucleic acid molecules
#4159Therapy inhalation involving antisense oligonucleotides for treating idiopathic pulmonary fibrosis
#4160Oligomeric compounds having modified phosphate groups
#4161RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
#4162SNPs of apolipoprotein B and modulation of their expression
#4163Antisense oligonucleotides for treating atopic diseases and neoplastic cell proliferation
#4164Modulation of growth hormone receptor expression and insulin-like growth factor expression
#4165Antisense modulation of ptpn12 expression
#4166RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
#4167Immunostimulatory nucleic acid molecules
#4168Immunostimulatory nucleic acid molecules
#4169Modulation of Aurora B expression
#4170Immunostimulatory nucleic acid molecules
#4171Antisense modulation of p70 S6 kinase expression
#4172RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA)
#4173Immunostimulatory nucleic acid molecules
#41742′, 5′-oligoadenylate analogs
#4175Modulation of glucose-6-phosphatase translocase expression
#4176Method for the prophylaxis and/or treatment of medical disorders
#4177Antisense modulation of interleukin 12 P35 subunit expression
#4178Methods and compositions for the treatment of cancer with oligonucleotides directed against Egr-1
#4179RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA)
#4180Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
#4181Modulation of pumilio 1 expression
#4182Modulation of Nanos 1 expression
#4183RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering RNA
#4184Sequential delivery of oligomeric compounds
#4185Antisense modulation of cellular apoptosis susceptibity gene expression
#4186Intracellular interleukin-1 receptor antagonist and uses thereof
#4187Inhibitor nucleic acids
#4188RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
#4189Immunostimulation by chemically modified RNA
#4190Polypeptide compounds for inhibiting angiogenesis and tumor growth
#4191Double stranded constructs comprising one or more short strands hybridized to a longer strand
#4192Modulation of transthyretin expression
#4193C-class oligonucleotide analogs with enhanced immunostimulatory potency
#4194Immunostimulatory nucleic acid molecules
#4195Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
#4196Modulation of STAT 6 expression
#4197Immunostimulatory nucleic acid molecules
#4198RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
#4199Immunostimulatory nucleic acid molecules
#4200RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)