ClassID:

109170

C12N2310/321 - page 5 - CPC Classification

Classification description:

Structure or type of the nucleic acid; Chemical structure of the sugar 2'-O-R Modification

Recent Application in this class:
#1201
20220042013
2022-02-10

Compositions and their uses directed to huntingtin

#1202
20220042012
2022-02-10

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT (IGFALS) AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1203
20220034907
2022-02-03

NEUROFILAMENT PROTEIN FOR GUIDING THERAPEUTIC INTERVENTION IN AMYOTROPHIC LATERAL SCLEROSIS

#1204
20220033825
2022-02-03

POLYNUCLEOTIDE AGENTS TARGETING PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) AND METHODS OF USE THEREOF

#1205
20220033817
2022-02-03

Targeting Ligands

#1206
20220033815
2022-02-03

SYSTEMIC IN VIVO DELIVERY OF OLIGONUCLEOTIDES

#1207
20220033814
2022-02-03

METHODS FOR THE TREATMENT OF TRINUCLEOTIDE REPEAT EXPANSION DISORDERS ASSOCIATED WITH MLH1 ACTIVITY

#1208
20220033434
2022-02-03

ANDROGEN RECEPTOR NUCLEIC ACIDS AND USES THEREOF

#1209
20220025377
2022-01-27

PRODUCTS AND COMPOSITIONS

#1210
20220025368
2022-01-27

BISPECIFIC ANTISENSE OLIGONUCLEOTIDES FOR DYSTROPHIN EXON SKIPPING

#1211
20220025367
2022-01-27

NOVEL RNA COMPOSITIONS AND METHODS FOR INHIBITING ANGPTL8

#1212
20220025366
2022-01-27

Compounds and methods for reducing prion expression

#1213
20220017906
2022-01-20

RNAI CONSTRUCTS FOR INHIBITING PNPLA3 EXPRESSION AND METHODS OF USE THEREOF

#1214
20220017902
2022-01-20

METHODS AND COMPOSITIONS FOR TREATING A SERPINC1-ASSOCIATED DISORDER

#1215
20220016173
2022-01-20

Genetically engineered t cells with regnase-1 and/or TGFBRII disruption have improved functionality and persistence

#1216
20220010310
2022-01-13

An lncRNA integrates a DNA-PK-mediated DNA damage response and vascular senescence

#1217
20220002731
2022-01-06

Oligonucleotides for treatment of angiopoietin like 4 (ANGPTL4) related diseases

#1218
20220002726
2022-01-06

METHODS OF SAFE ADMINISTRATION OF AN IRF5 ANTISENSE OLIGONUCLEOTIDE

#1219
20220002724
2022-01-06

AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF

#1220
20220002722
2022-01-06

NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF LPA IN A CELL

#1221
20220002719
2022-01-06

OLIGONUCLEOTIDE-MEDIATED SENSE CODON REASSIGNMENT

#1222
20210403917
2021-12-30

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE

#1223
20210403914
2021-12-30

Specific siRNA molecules, composition and use thereof for the treatment of triple negative breast cancer

#1224
20210402007
2021-12-30

POLYNUCLEOTIDE AGENTS TARGETING HYDROXYACID OXIDASE (GLYCOLATE OXIDASE, HAO1) AND METHODS OF USE THEREOF

#1225
20210401871
2021-12-30

OLIGONUCLEOTIDES TO TREAT EYE DISEASE

#1226
20210401869
2021-12-30

Antisense Compounds Targeting Genes Associated with Cystic Fibrosis

#1227
20210395754
2021-12-23

Splice-switching oligonucleotides and methods of use

#1228
20210395752
2021-12-23

VDAC1 SILENCING MOLECULES AND USE THEREOF

#1229
20210395747
2021-12-23

METHODS AND COMPOSITIONS FOR TREATMENT OF FRONTOTEMPORAL DEMENTIA

#1230
20210395740
2021-12-23

Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity

#1231
20210395734
2021-12-23

COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION

#1232
20210395733
2021-12-23

Monocarboxylate transporter (MCT) antisense oligonucleotide (ASO) inhibitors for use as therapeutics in the treatment of cancer

#1233
20210388363
2021-12-16

Modulators and modulation of the receptor for advanced glycation end-products RNA

#1234
20210388360
2021-12-16

COMPOSITIONS AND METHODS FOR INHIBITION OF EXPRESSION OF PROTEIN C (PROC) GENES

#1235
20210388359
2021-12-16

OLIGONUCLEOTIDE FORMULATION METHOD

#1236
20210388355
2021-12-16

Dosages and methods for delivering lipid formulated nucleic acid molecules

#1237
20210388353
2021-12-16

Oligomers

#1238
20210380988
2021-12-09

Reducing Prominin2-Mediated Resistance to Ferroptotic Cell Death

#1239
20210380986
2021-12-09

RNA DRUGS AND METHOD OF TREATING AGE-RELATED DISEASE

#1240
20210380985
2021-12-09

17ß-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13) iRNA Compositions And Methods Of Use Thereof

#1241
20210380984
2021-12-09

Compositions and methods for inhibiting ALDH2 expression

#1242
20210380982
2021-12-09

Antisense oligonucleotide-based progranulin augmentation therapy in neurodegenerative diseases

#1243
20210380980
2021-12-09

Methods and Compositions for the ADAR-Mediated Editing of SERPINA1

#1244
20210371861
2021-12-02

Multi-Targeting Nucleic Acid Constructs Composed Of Multiple Oligonucleotides That Modulate Gene Expression Through Complimentary Interactions With Targets

#1245
20210371860
2021-12-02

OLIGONUCLEOTIDES FOR MODULATING MYH7 EXPRESSION

#1246
20210369762
2021-12-02

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

#1247
20210369757
2021-12-02

Methods for treating or preventing ophthalmological conditions

#1248
20210363524
2021-11-25

OLIGONUCLEOTIDES FOR SNCA MODULATION

#1249
20210363523
2021-11-25

OLIGONUCLEOTIDES FOR MAPT MODULATION

#1250
20210363518
2021-11-25

MODIFIED GUIDE RNAS FOR CRISPR GENOME EDITING

#1251
20210363222
2021-11-25

Soluble TNF Receptors and Their Use in Treatment of Disease

#1252
20210361692
2021-11-25

Compositions and methods for treating transthyretin (TTR) mediated amyloidosis

#1253
20210355497
2021-11-18

COMPOUNDS AND METHODS FOR REDUCING FXI EXPRESSION

#1254
20210355493
2021-11-18

OLIGONUCLEOTIDE MEDIATED NO-GO DECAY

#1255
20210355492
2021-11-18

CARGO LOADED EXTRACELLULAR VESICLES

#1256
20210355491
2021-11-18

OLIGONUCLEOTIDES FOR MSH3 MODULATION

#1257
20210348169
2021-11-11

Methods for treating aging and skin disorders using nucleic acids targeting TYR or MMP1

#1258
20210348166
2021-11-11

IMMUNOTHERAPY OF CANCER

#1259
20210348162
2021-11-11

Compositions and methods for inhibiting expression of the LECT2 gene

#1260
20210347825
2021-11-11

Substances for targeting various selected organs or tissues

#1261
20210346509
2021-11-11

GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof

#1262
20210340538
2021-11-04

Compositions and methods for prevention of bladder fibrosis

#1263
20210340535
2021-11-04

Dual-acting siRNA based modulation of C9orf72

#1264
20210340534
2021-11-04

Mixed Tricyclo-DNA, 2'-Modified RNA Oligonucleotide Compositions and Uses Thereof

#1265
20210340529
2021-11-04

Single-stranded RNA-editing oligonucleotides

#1266
20210340171
2021-11-04

ANTISENSE NUCLEIC ACIDS

#1267
20210338835
2021-11-04

Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles

#1268
20210332361
2021-10-28

Aptamer therapeutics useful in the treatment of complement-related disorders

#1269
20210332358
2021-10-28

MINIATURIZED HAIRPIN RNAi TRIGGERS (mxRNA) AND METHODS OF USES THEREOF

#1270
20210330692
2021-10-28

CCR7 aptamers and uses thereof

#1271
20210324386
2021-10-21

Compositions and methods for increasing expression of SCN2A

#1272
20210322563
2021-10-21

MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FIBRODYSPLASIA OSSIFICANS PROGRESSIVA

#1273
20210317462
2021-10-14

Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies

#1274
20210317458
2021-10-14

POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF

#1275
20210317457
2021-10-14

ANTISENSE OLIGONUCLEOTIDE (ASO) MOLECULES AND USES THEREOF FOR CORONAVIRUS DISEASES

#1276
20210317456
2021-10-14

Nucleic Acid Compounds for Binding Immunoglobulin G

#1277
20210317452
2021-10-14

SERPINA1 iRNA compositions and methods of use thereof

#1278
20210317451
2021-10-14

Compositions and methods for modulating neuronal excitability and motor behavior

#1279
20210315918
2021-10-14

Compounds and Methods for Modulation of Transcript Processing

#1280
20210310006
2021-10-07

Angiotensinogen (AGT) iRNA compositions and methods of use thereof

#1281
20210309996
2021-10-07

Antisense oligomers for treatment of conditions and diseases

#1282
20210308274
2021-10-07

MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING FRIEDREICH'S ATAXIA

#1283
20210301294
2021-09-30

RNAi agents for inhibiting expression of PNPLA3, pharmaceutical compositions thereof, and methods of use

#1284
20210301292
2021-09-30

Compositions of Asymmetric Interfering RNA and Uses Thereof

#1285
20210301290
2021-09-30

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

#1286
20210299266
2021-09-30

Compositions and methods of treating muscle dystrophy

#1287
20210292763
2021-09-23

COMPOSITIONS AND METHODS FOR THE TREATMENT OF COMPLICATIONS AND DISORDERS RELATING TO VON WILLEBRAND FACTOR

#1288
20210292756
2021-09-23

Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

#1289
20210285003
2021-09-16

Methods for treating hypercholesterolemia

#1290
20210285002
2021-09-16

Oligonucleotides targeting frataxin and related methods

#1291
20210284680
2021-09-16

ANTISENSE NUCLEIC ACIDS

#1292
20210283164
2021-09-16

Methods for treating hepatitis B infection

#1293
20210277403
2021-09-09

Methods and compositions for targeting PD-L1

#1294
20210277400
2021-09-09

Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof

#1295
20210277397
2021-09-09

Compounds and methods for modulating UBE3A-ATS

#1296
20210277392
2021-09-09

CHEMICALLY-MODIFIED GUIDE RNAS TO IMPROVE CRISPR-CAS PROTEIN SPECIFICITY

#1297
20210269806
2021-09-02

IL-1 BETA TARGETING SPHERICAL NUCLEIC ACIDS

#1298
20210269797
2021-09-02

METHODS AND COMPOSITIONS FOR TARGETING PD-L1

#1299
20210267893
2021-09-02

Artificial exosome composition and related methods

#1300
20210261966
2021-08-26

TREATMENT OF CARDIOMYOPATHY THROUGH MODULATION OF HYPOXIA-INDUCED eRNA ACTIVITY

#1301
20210261965
2021-08-26

SMAC/Diablo inhibitors useful for treating cancer

#1302
20210261959
2021-08-26

Complement component C3 iRNA compositions and methods of use thereof

#1303
20210254076
2021-08-19

TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1304
20210254071
2021-08-19

Oligonucleotide comprising an inosine for treating DMD

#1305
20210254063
2021-08-19

SERPINC1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1306
20210254062
2021-08-19

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF

#1307
20210254059
2021-08-19

LINKAGE MODIFIED OLIGOMERIC COMPOUNDS

#1308
20210252039
2021-08-19

Compounds and methods for increasing STMN2 expression

#1309
20210246449
2021-08-12

Antisense oligonucleotides and their use for treating Pendred syndrome

#1310
20210246447
2021-08-12

Factor XII (Hageman Factor) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), and Kininogen 1 (KNG1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1311
20210246443
2021-08-12

Antisense oligonucleotides to restore dysferlin protein expression in dysferlinopathy patient cells

#1312
20210238608
2021-08-05

Oligonucleotides for modulating SCN9A expression

#1313
20210238606
2021-08-05

PCSK9 targeting oligonucleotides for treating hypercholesterolemia and related conditions

#1314
20210238603
2021-08-05

BETA CATENIN NUCLEIC ACID INHIBITOR MOLECULE

#1315
20210238591
2021-08-05

Selective antisense compounds and uses thereof

#1316
20210236534
2021-08-05

Compositions and methods for the treatment of expanded repeat-associated disorders

#1317
20210230603
2021-07-29

RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS

#1318
20210230599
2021-07-29

STEM-LOOP COMPOSITIONS AND METHODS FOR INHIBITING INTERLEUKIN-8

#1319
20210230598
2021-07-29

OLIGONUCLEOTIDES FOR CONTROLLING TAU SPLICING, AND USES THEREOF

#1320
20210230596
2021-07-29

RIG-I Agonists and Methods of Using Same

#1321
20210228730
2021-07-29

MUSCLE-TARGETING COMPLEXES AND USES THEREOF

#1322
20210228614
2021-07-29

LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1323
20210222176
2021-07-22

POLYNUCLEOTIDE AGENTS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) AND METHODS OF USE THEREOF

#1324
20210222173
2021-07-22

Compositions and Methods for Lactate Dehydrogenase (LDHA) Gene Editing

#1325
20210222169
2021-07-22

ANTISENSE NUCLEIC ACIDS

#1326
20210222168
2021-07-22

METHODS FOR REACTIVATING GENES ON THE INACTIVE X CHROMOSOME

#1327
20210222166
2021-07-22

LNA BASED NANODEVICE

#1328
20210214728
2021-07-15

COMPOSITIONS FOR DELIVERY OF CARGO TO CELLS

#1329
20210214725
2021-07-15

COMPOSITIONS FOR MODULATING EXPRESSION OF C9ORF72 ANTISENSE TRANSCRIPT

#1330
20210207228
2021-07-08

Gamma herpesvirus circular RNA

#1331
20210207146
2021-07-08

Compositions and methods for modulating growth hormone receptor expression

#1332
20210207140
2021-07-08

Non-liposomal systems for nucleic acid delivery

#1333
20210207136
2021-07-08

MYOCARDIAL DYSFUNCTION THERAPEUTIC AGENT

#1334
20210198739
2021-07-01

METHODS FOR DETERMINING THE PRESENCE OR RISK OF DEVELOPING FACIOSCAPULOHUMERAL DYSTROPHY (FSHD)

#1335
20210198676
2021-07-01

TEMPERATURE CONTROLLED DNA POLYMERASE INHIBITORS

#1336
20210198666
2021-07-01

ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF

#1337
20210198306
2021-07-01

Antisense nucleic acids

#1338
20210189401
2021-06-24

Method of allele specific silencing for the treatment of autosomal dominant Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

#1339
20210189400
2021-06-24

Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof

#1340
20210189394
2021-06-24

Targeting ligands for therapeutic compounds

#1341
20210189391
2021-06-24

Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof

#1342
20210180085
2021-06-17

Transgene cassettes designed to express a human MECP2 gene

#1343
20210180061
2021-06-17

Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA

#1344
20210180060
2021-06-17

MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD

#1345
20210180057
2021-06-17

MODULATORS OF ENaC EXPRESSION

#1346
20210180055
2021-06-17

Systems and methods for gene modification

#1347
20210180053
2021-06-17

SYNTHETIC RNAS AND METHODS OF USE

#1348
20210179720
2021-06-17

Nucleic acid-polypeptide compositions and uses thereof

#1349
20210179659
2021-06-17

ANTISENSE NUCLEIC ACIDS

#1350
20210171956
2021-06-10

Glucokinase (GCK) iRNA compositions and methods of use thereof

#1351
20210171955
2021-06-10

Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

#1352
20210171954
2021-06-10

Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

#1353
20210169921
2021-06-10

Modulation of factor 11 expression

#1354
20210163951
2021-06-03

METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER

#1355
20210163950
2021-06-03

TREATMENT OF ANGIOPOIETIN LIKE 7 (ANGPTL7) RELATED DISEASES

#1356
20210163949
2021-06-03

Modulation of alternative MDM2 splicing

#1357
20210163943
2021-06-03

Compositions and Methods for Hydroxyacid Oxidase 1 (HAO1) Gene Editing for Treating Primary Hyperoxaluria Type 1 (PH1)

#1358
20210163942
2021-06-03

Agents useful in treating facioscapulohumeral muscular dystrophy

#1359
20210163941
2021-06-03

AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

#1360
20210163938
2021-06-03

MRNA driven expression of RNA editors for treatment of pathologies

#1361
20210155937
2021-05-27

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE

#1362
20210155936
2021-05-27

Modulation of gene expression and screening for deregulated protein expression

#1363
20210155935
2021-05-27

Modulators of EZH2 expression

#1364
20210155926
2021-05-27

siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS

#1365
20210147856
2021-05-20

Gene editing methods with increased knock-in efficiency

#1366
20210147849
2021-05-20

REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS

#1367
20210147847
2021-05-20

Aptamers for targeted activation of T cell-mediated immunity

#1368
20210147840
2021-05-20

SiRNAs with vinylphosphonate at the 5′ end of the antisense strand

#1369
20210147839
2021-05-20

Antisense nucleic acids

#1370
20210147838
2021-05-20

Selective Antisense Compounds and Uses Thereof

#1371
20210139913
2021-05-13

Antisense oligonucleotides useful in treatment of Pompe disease

#1372
20210139912
2021-05-13

RNAI CONSTRUCTS FOR INHIBITING PNPLA3 EXPRESSION AND METHODS OF USE THEREOF

#1373
20210139901
2021-05-13

Two-tailed self-delivering siRNA

#1374
20210139900
2021-05-13

Modulation of Huntington expression

#1375
20210139895
2021-05-13

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER

#1376
20210139894
2021-05-13

Treatment of Fuchs' endothelial corneal dystrophy

#1377
20210139884
2021-05-13

Reverse transcriptase for nucleic acid sequencing

#1378
20210130823
2021-05-06

COMPOSITIONS AND METHODS

#1379
20210128748
2021-05-06

Three-dimensional self-assembled nucleic acid nanoparticles and use thereof

#1380
20210123075
2021-04-29

COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY

#1381
20210123054
2021-04-29

Oligonucleotides for modulating Tau expression

#1382
20210123051
2021-04-29

Uses for prevention or treatment of brain diseases using microRNA

#1383
20210123050
2021-04-29

Antisense oligonucleotides for the treatment of usher syndrome type 2

#1384
20210123035
2021-04-29

Modified double-stranded donor templates

#1385
20210115442
2021-04-22

O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES

#1386
20210115439
2021-04-22

Antisense oligonucleotides for the treatment of Stargardt disease

#1387
20210113603
2021-04-22

MicroRNA (miRNA) and Downstream Targets for Diagnostic and Therapeutic Purposes

#1388
20210108212
2021-04-15

RNAi constructs for inhibiting ASGR1 expression and methods of use thereof

#1389
20210108211
2021-04-15

MODULATORS OF GROWTH HORMONE RECEPTOR

#1390
20210108207
2021-04-15

OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF

#1391
20210108206
2021-04-15

RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS

#1392
20210108205
2021-04-15

MicroRNA Compounds and Methods for Modulating MIR-122

#1393
20210108204
2021-04-15

RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy

#1394
20210108203
2021-04-15

Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

#1395
20210108200
2021-04-15

BRANCHED LIPID CONJUGATES OF siRNA FOR SPECIFIC TISSUE DELIVERY

#1396
20210102203
2021-04-08

Compositions and methods for modulating MECP2 expression

#1397
20210102201
2021-04-08

Method of nonspecific target capture of nucleic acids

#1398
20210100829
2021-04-08

RNAi agents for hepatitis B virus infection

#1399
20210095290
2021-04-01

Angiotensinogen (AGT) iRNA compositions and methods of use thereof

#1400
20210095284
2021-04-01

Modified oligonucleotides for use in treatment of tauopathies

#1401
20210095282
2021-04-01

Modified Oligonucleotides for Treatment of Polycystic Kidney Disease

#1402
20210095281
2021-04-01

Modulation of transthyretin expression

#1403
20210095279
2021-04-01

Methods and compositions for the specific inhibition of antithrombin 3 (AT3) by double-stranded RNA

#1404
20210093736
2021-04-01

Methods for Preventing Cardiovascular Events Through Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Reduction

#1405
20210087568
2021-03-25

Modified Guide RNAs for Gene Editing

#1406
20210087567
2021-03-25

Therapeutic oligonucleotides

#1407
20210087566
2021-03-25

Compositions and methods for modulating apolipoprotein (a) expression

#1408
20210087563
2021-03-25

Methods and compositions for treating inflammatory diseases

#1409
20210087559
2021-03-25

Modulation of frataxin expression

#1410
20210087558
2021-03-25

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE

#1411
20210079395
2021-03-18

Modulators of APOL1 expression

#1412
20210079394
2021-03-18

TRANSCRIPTION MODULATION IN ANIMALS USING CRISPR/CAS SYSTEMS DELIVERED BY LIPID NANOPARTICLES

#1413
20210079393
2021-03-18

ANTISENSE OLIGONUCLEOTIDES FOR RNA EDITING

#1414
20210079392
2021-03-18

Inhibition of mir-22 miRNA by APT-110

#1415
20210079391
2021-03-18

Antisense oligonucleotide compositions

#1416
20210079389
2021-03-18

GUIDE RNA WITH CHEMICAL MODIFICATIONS

#1417
20210079387
2021-03-18

CLEAVAGE-RESISTANT DONOR NUCLEIC ACIDS AND METHODS OF USE

#1418
20210071181
2021-03-11

PHARMACEUTICAL COMPOSITION

#1419
20210062199
2021-03-04

Methods and compositions for inhibiting expression of LDHA

#1420
20210062198
2021-03-04

Interfering RNA molecules

#1421
20210062195
2021-03-04

RNA interference in ocular indications

#1422
20210062194
2021-03-04

Single stranded oligonucleotides inhibiting endocytosis

#1423
20210054383
2021-02-25

Oligonucleotides for modulating TMEM106B expression

#1424
20210047646
2021-02-18

Compositions Comprising Immune System Activators and Method of Using Same

#1425
20210047640
2021-02-18

COMPOSITIONS AND METHODS FOR TREATING HYPERTRIGLYCERIDEMIA

#1426
20210041823
2021-02-11

SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT

#1427
20210041459
2021-02-11

Methods of treating spinal muscular atrophy

#1428
20210040482
2021-02-11

Antisense molecules and methods for treating pathologies

#1429
20210032631
2021-02-04

Compositions and Methods for Correcting Limb Girdle Muscular Dystrophy Type 2C Using Exon Skipping

#1430
20210032620
2021-02-04

Oligonucleotide compositions and methods thereof

#1431
20210032282
2021-02-04

Nucleic acid complex, method for forming nucleic acid hybridization, pharmaceutical composition, nucleic acid probe, and complementary-strand nucleic acid complex

#1432
20210024932
2021-01-28

Splice-switching oligonucleotides and methods of use

#1433
20210024926
2021-01-28

Fully stabilized asymmetric siRNA

#1434
20210024924
2021-01-28

Nuclease systems for genetic engineering

#1435
20210024923
2021-01-28

COMPOSITIONS AND METHODS FOR MODULATING TTR EXPRESSION

#1436
20210024915
2021-01-28

METHOD FOR ACTIVATING P21 GENE EXPRESSION

#1437
20210017522
2021-01-21

COMPOSITIONS AND THEIR USES DIRECTED TO HUNTINGTIN

#1438
20210017518
2021-01-21

Modified tracrRNAs gRNAs, and uses thereof

#1439
20210017217
2021-01-21

Nucleic acid aptamers to treat histone-induced disease states

#1440
20210010004
2021-01-14

Inhibition of polyomavirus replication

#1441
20210010002
2021-01-14

Nucleic acid molecules for pseudouridylation

#1442
20210002643
2021-01-07

Methods and compositions for modulating apolipoprotein (a) expression

#1443
20210002642
2021-01-07

Methods for modulating FMR1 expression

#1444
20210002640
2021-01-07

LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS FOR SURVIVAL OF MOTOR NEURON (SMA) INHIBITORS

#1445
20200407725
2020-12-31

Methods and compositions for macrophage polarization

#1446
20200407718
2020-12-31

Antisense oligonucleotides rescue aberrant splicing of ABCA4

#1447
20200399640
2020-12-24

Treatment of angiopoietin like 7 (ANGPTL7) related diseases

#1448
20200399639
2020-12-24

Detection of microbial endotoxins in oral samples using aptamers

#1449
20200399638
2020-12-24

Oligonucleotides matching COL7A1 exon 73 for epidermolysis bullosa therapy

#1450
20200392511
2020-12-17

TMPRSS6 iRNA compositions and methods of use thereof

#1451
20200392509
2020-12-17

Conjugated antisense compounds and their use

#1452
20200392508
2020-12-17

RNAi-MEDIATED INHIBITION OF HIF1A FOR TREATMENT OF OCULAR ANGIOGENESIS

#1453
20200392499
2020-12-17

Short interfering nucleic acid (siNA) compositions

#1454
20200392493
2020-12-17

Oligomeric compounds comprising bicyclic nucleotides and uses thereof

#1455
20200392489
2020-12-17

Uses for prevention or treatment of brain diseases using microrna

#1456
20200392488
2020-12-17

Method for screening splicing variants or events

#1457
20200392486
2020-12-17

RNA-editing oligonucleotides and uses thereof

#1458
20200385723
2020-12-10

Anti-C9ORF72 oligonucleotides and related methods

#1459
20200385717
2020-12-10

Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure

#1460
20200385713
2020-12-10

RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF

#1461
20200384033
2020-12-10

CRISPR-CAS9 modified CD34+ human hematopoietic stem and progenitor cells and uses thereof

#1462
20200384032
2020-12-10

METHOD FOR INCREASING FETAL HEMOGLOBIN EXPRESSION LEVEL

#1463
20200377893
2020-12-03

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE

#1464
20200369766
2020-11-26

LAG3 binding peptides

#1465
20200362353
2020-11-19

Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression

#1466
20200362348
2020-11-19

USE OF SINGLE-STRANDED ANTISENSE OLIGONUCLEOTIDE IN PREVENTION OR TREATMENT OF GENETIC DISEASES INVOLVING A TRINUCLEOTIDE REPEAT EXPANSION

#1467
20200362343
2020-11-19

METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT

#1468
20200362341
2020-11-19

OLIGONUCLEOTIDES FOR TISSUE SPECIFIC APOE MODULATION

#1469
20200354723
2020-11-12

Compositions for modulating SOD-1 expression

#1470
20200353097
2020-11-12

Modified RNAi agents

#1471
20200348286
2020-11-05

Oligonucleotides for inducing paternal UBE3A expression

#1472
20200340028
2020-10-29

Enzymatic methods to generate high yields of sequence specific rna with extreme precision

#1473
20200339998
2020-10-29

COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF

#1474
20200339991
2020-10-29

Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof

#1475
20200339987
2020-10-29

ASSAYS AND METHODS FOR DETERMINING EXPRESSION OF THE LECT2 GENE

#1476
20200339985
2020-10-29

EXON SKIPPING COMPOSITIONS FOR TREATING MUSCULAR DYSTROPHY

#1477
20200339980
2020-10-29

High Specificity Genome Editing Using Chemically Modified Guide RNAs

#1478
20200339979
2020-10-29

METHOD FOR IMPROVING FETAL HEMOGLOBIN EXPRESSION

#1479
20200338109
2020-10-29

Methods for treating hepatitis B infection

#1480
20200338108
2020-10-29

Methods for treating hepatitis B infection

#1481
20200332299
2020-10-22

RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (SINA)

#1482
20200332298
2020-10-22

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS

#1483
20200332292
2020-10-22

Dual Targeting siRNA Agents

#1484
20200332289
2020-10-22

GAPMER OLIGONUCLEOTIDES COMPRISING A PHOSPHORODITHIOATE INTERNUCLEOSIDE LINKAGE

#1485
20200325478
2020-10-15

Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro

#1486
20200325473
2020-10-15

Compositions and methods for modulating Ataxin 3 expression

#1487
20200325455
2020-10-15

Engineered producer cell lines and methods of making and using the same

#1488
20200318119
2020-10-08

Compositions and Methods for Inhibiting Expression of the PCSK9 Gene

#1489
20200318118
2020-10-08

Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA

#1490
20200318116
2020-10-08

Compositions and their uses directed to huntingtin

#1491
20200318111
2020-10-08

RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES

#1492
20200318109
2020-10-08

LNA-G process

#1493
20200308586
2020-10-01

Thiomorpholino oligonucleotides for the treatment of muscular dystrophy

#1494
20200308578
2020-10-01

RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality

#1495
20200299698
2020-09-24

Xanthine dehydrogenase (XDH) IRNA compositions and methods of use thereof

#1496
20200299692
2020-09-24

Oligonucleotide compositions and methods thereof

#1497
20200299690
2020-09-24

RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3)

#1498
20200299689
2020-09-24

MODIFIED CPF1 GUIDE RNA

#1499
20200297754
2020-09-24

Compositions and methods for inhibiting HMGB1 expression

#1500
20200291407
2020-09-17

TREATMENT OF GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO GDNF